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1. 发明授权

US07361341B2 Methods of treating cancer using antibodies that immunospecifically bind to trail receptors 有权
标题翻译：使用免疫特异性结合尾静脉受体的抗体治疗癌症的方法
公开(公告)号：US07361341B2
公开(公告)日：2008-04-22
申请号：US11391384
申请日：2006-03-29
申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12P21/08 , C07K16/00 , C07H21/04
CPC分类号： C07K16/2878 , C07K2317/56 , C07K2317/622 , C07K2317/73
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体具有例如用于治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或变体或相关分子，其免疫特异性结合TRAIL受体TR4。

2. 发明授权

US07348003B2 Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors 有权
标题翻译：使用免疫特异性结合TRAIL受体的抗体治疗癌症的方法
公开(公告)号：US07348003B2
公开(公告)日：2008-03-25
申请号：US10986047
申请日：2004-11-12
申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12P21/08 , C07K16/00 , C07H21/04
CPC分类号： A61K39/395 , A61K31/00 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

3. 发明申请

US20090226429A1 Antibodies That Immunospecifically Bind to TRAIL Receptors 审中-公开
标题翻译：免疫特异性结合TRAIL受体的抗体
公开(公告)号：US20090226429A1
公开(公告)日：2009-09-10
申请号：US12016372
申请日：2008-01-18
申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： A61K39/395 , C12N5/06
CPC分类号： C07K16/2878 , A61K39/39558 , A61K2039/505 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

4. 发明授权

US07064189B2 Antibodies that immunospecifically bind to trail receptors 有权
公开(公告)号：US07064189B2
公开(公告)日：2006-06-20
申请号：US10139785
申请日：2002-05-07
申请人： Theodora Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K31/00 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

5. 发明申请

US20120121606A1 ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN 审中-公开
标题翻译：免疫组织化学染色体B淋巴细胞刺激蛋白的抗体
公开(公告)号：US20120121606A1
公开(公告)日：2012-05-17
申请号：US13356314
申请日：2012-01-23
申请人： Steven M. Ruben , Steven C. Barash , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Steven C. Barash , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： A61K39/395 , C12N9/96 , C12N15/13 , A61P25/00 , G01N33/566 , A61P37/06 , A61P29/00 , C07K16/24 , C12N5/10
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

6. 发明授权

US08101181B2 Antibodies that immunospecifically bind to B lymphocyte stimulator protein 有权
标题翻译：免疫特异性结合B淋巴细胞刺激蛋白的抗体
公开(公告)号：US08101181B2
公开(公告)日：2012-01-24
申请号：US12552915
申请日：2009-09-02
申请人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： A61K39/395
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

7. 发明授权

US07138501B2 Antibodies that immunospecifically bind BLyS 有权
标题翻译：免疫特异性结合BLyS的抗体
公开(公告)号：US07138501B2
公开(公告)日：2006-11-21
申请号：US09880748
申请日：2001-06-15
申请人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

8. 发明授权

US07879328B2 Antibodies that immunospecifically bind to B lymphocyte stimulator 有权
标题翻译：免疫特异性结合B淋巴细胞刺激物的抗体
公开(公告)号：US07879328B2
公开(公告)日：2011-02-01
申请号：US11054515
申请日：2005-02-10
申请人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395
CPC分类号： C07K16/2875 , A61K35/12 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K2317/21 , C07K2317/622 , G01N33/5008 , G01N33/5011 , G01N33/5052 , G01N33/5091 , G01N33/564 , G01N33/574 , G01N33/68
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

9. 发明授权

US07220840B2 Antibodies that immunospecifically bind to B lymphocyte stimulator protein 有权
标题翻译：免疫特异性结合B淋巴细胞刺激蛋白的抗体
公开(公告)号：US07220840B2
公开(公告)日：2007-05-22
申请号：US10293418
申请日：2002-11-14
申请人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： G01N33/564 , A61K35/12 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

10. 发明授权

US09187548B2 Antibodies that immunospecifically bind to B lymphocyte stimulator protein 有权
公开(公告)号：US09187548B2
公开(公告)日：2015-11-17
申请号：US13356314
申请日：2012-01-23
申请人： Steven M. Ruben , Steven C. Barash , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Steven C. Barash , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07H21/04 , C07K14/705 , A61K47/48 , A61K49/00 , C07K14/52 , C07K16/28 , G01N33/564 , A61K39/00
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

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