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1. 发明授权

US10363324B2 Pharmaceutical composition 有权
公开(公告)号：US10363324B2
公开(公告)日：2019-07-30
申请号：US15034281
申请日：2014-11-04
申请人： The South African Nuclear Energy Corporation Limited , North-West University
发明人： Anne Frederica Grobler , Jan Rijn Zeevaart
IPC分类号： A61K51/12 , A61K9/00 , A61K47/02 , A61K47/12 , A61K47/14 , A61K9/107
摘要： This invention relates to a pharmaceutical composition for parenteral or oral administration containing a radioactive compound which can be used diagnostically or therapeutically. The composition comprises a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids, and the radioactive compound.

2. 发明申请

US20160271279A1 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：US20160271279A1
公开(公告)日：2016-09-22
申请号：US15034281
申请日：2014-11-04
申请人： THE SOUTH AFRICAN NUCLEAR ENERGY CORPORATION LIMITED , NORTH-WEST UNIVERSITY
发明人： Anne Frederica Grobler , Jan Rijn Zeevaart
IPC分类号： A61K51/12 , A61K47/14 , A61K47/12 , A61K9/00 , A61K47/02
CPC分类号： A61K51/122 , A61K9/0019 , A61K9/0053 , A61K9/1075 , A61K47/02 , A61K47/12 , A61K47/14 , A61K51/1244
摘要： This invention relates to a pharmaceutical composition for parenteral or oral administration containing a radioactive compound which can be used diagnostically or therapeutically. The composition comprises a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids, and the radioactive compound.
摘要翻译：本发明涉及一种用于胃肠外或口服给药的药物组合物，其含有可用于诊断或治疗的放射性化合物。该组合物包含由溶解了一氧化二氮的水性或其他药理学上可接受的载体中的脂肪酸类成分的囊泡或微球的分散体构成的微乳液，所述脂肪酸系成分含有至少一种长链脂肪酸类选自游离脂肪酸和游离脂肪酸衍生物的物质，以及放射性化合物。

3. 发明授权

US10321681B2 Plant support formulation, vehicle for the delivery and translocation of phytologically beneficial substances and compositions containing same 有权
公开(公告)号：US10321681B2
公开(公告)日：2019-06-18
申请号：US14206251
申请日：2014-03-12
申请人： NORTH-WEST UNIVERSITY
发明人： Anne Frederica Grobler
IPC分类号： A01N37/02 , A01N43/653 , A01N25/04 , A01N37/06
摘要： A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer. The dispersion is further also characterized in that the micro-emulsion has a zeta potential of between −25 mV and −60 mV.

4. 发明授权

US09585955B2 Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines 有权
标题翻译：脂质和一氧化二氮组合作为佐剂，用于提高疫苗的疗效
公开(公告)号：US09585955B2
公开(公告)日：2017-03-07
申请号：US14075681
申请日：2013-11-08
申请人： North-West University
发明人： Anne Frederica Grobler , Abraham Frederik Kotze
IPC分类号： A61K39/39 , A61K39/05 , A61K39/205 , A61K39/29 , A61K39/00
CPC分类号： A61K39/39 , A61K39/05 , A61K39/205 , A61K39/292 , A61K2039/55544 , A61K2039/55555 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y02A50/484
摘要： The invention provides for a method of enhancing immunological responses to an antigen in a vaccine formulation, and for a vaccine formulation that provides for an enhanced immunological response to an antigen. In the method and formulation the antigen is administered with an adjuvant which adjuvant comprises a solution of nitrous oxide gas in a pharmaceutically acceptable carrier solvent for the gas and which adjuvant includes at least one fatty acid or ester or other suitable derivative thereof selected from the group consisting of oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid [C20: 5ω3], decosahexaenoic acid [C22: 6ω3], ricinoleic acid and derivatives thereof selected from the group consisting of the C1 to C6 alkyl esters thereof, the glycerol-polyethylene glycol esters thereof and the reaction product of hydrogenated natural oils composed largely of ricinoleic acid based oils, such as castor oil with ethylene oxide.
摘要翻译：本发明提供增强对疫苗制剂中的抗原的免疫应答的方法，以及提供对抗原的增强的免疫应答的疫苗制剂。在该方法和制剂中，抗原与佐剂一起施用，所述佐剂包含一氧化二氮气体在用于气体的药学上可接受的载体溶剂中的溶液，并且该佐剂包括至少一种脂肪酸或酯或选自下组的其它合适的衍生物由油酸，亚油酸，α-亚麻酸，γ-亚麻酸，花生四烯酸，二十碳五烯酸[C20：5ω3]，十二碳六烯酸[C22：6ω3]，蓖麻油酸及其衍生物组成，选自C1 其C6烷基酯，其甘油 - 聚乙二醇酯和主要由蓖麻油酸基油如蓖麻油与环氧乙烷组成的氢化天然油的反应产物。

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