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1. 发明申请

US20190151088A1 APPARATUS AND METHOD FOR TREATING A REGURGITANT HEART VALVE 审中-公开
公开(公告)号：US20190151088A1
公开(公告)日：2019-05-23
申请号：US16258843
申请日：2019-01-28
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia
IPC分类号： A61F2/24
摘要： A method for treating regurgitation of blood flow through a diseased heart valve is provided. The diseased heart valve including an annulus, an anterior valve leaflet, a posterior valve leaflet and a subvalvular apparatus. The method includes providing an apparatus comprising a substantially annular support member, at least one infra-annular support member securely connected thereto, and at least one anchoring element associated with the at least one infra-annular support member. The method further includes attaching the substantially annular support member to the annulus of the diseased heart valve and attaching proximal and distal ends of a prosthetic chordae tendineae to the at least one anchoring element and a papillary muscle, respectively, so that the papillary muscle is caused to move medially.

2. 发明申请

US20140207027A1 WOUND COVER APPARATUS AND METHOD 审中-公开
标题翻译：绕线罩装置及方法
公开(公告)号：US20140207027A1
公开(公告)日：2014-07-24
申请号：US14161908
申请日：2014-01-23
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Shengqiang Gao
IPC分类号： A61F13/00 , A61H7/00 , A61M1/00
CPC分类号： A61F13/00068 , A61H7/00 , A61M1/0084 , A61M1/0088
摘要： Various embodiments of a wound cover apparatus are provided. In one embodiment a wound cover apparatus includes a treatment enclosure and a vacuum seal that is external to the treatment enclosure. The vacuum seal includes a vacuum passageway and a vacuum port in fluid communication with one another. In another embodiment the apparatus further includes a treatment port in fluid communication with the treatment enclosure. The wound cover apparatus adheres to the patient by application of vacuum applied to the treatment enclosure and the vacuum seal which extends from the housing. The negative pressure applied to the wound cover apparatus creates negative stress along periwound which promotes perfusion and vascularization and induces mechanical deformation to accelerate healing.
摘要翻译：提供伤口罩装置的各种实施例。在一个实施例中，伤口覆盖装置包括治疗外壳和位于治疗外壳外部的真空密封件。真空密封件包括彼此流体连通的真空通道和真空端口。在另一个实施例中，该装置还包括与治疗外壳流体连通的治疗口。伤口覆盖装置通过施加施加到治疗外壳上的真空和从壳体延伸的真空密封而粘附到患者身上。施加到伤口覆盖装置上的负压沿着围绕产生负应力，促进灌注和血管化，并引起机械变形以加速愈合。

3. 发明授权

US11241313B2 Apparatuses and methods for at least partially supporting a valve leaflet of a regurgitant heart valve 有权
公开(公告)号：US11241313B2
公开(公告)日：2022-02-08
申请号：US16712059
申请日：2019-12-12
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Samir Kapadia , Marwane Berrada
IPC分类号： A61F2/24
摘要： An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

4. 发明授权

US11173029B2 Apparatus and method for treating a regurgitant heart valve 有权
公开(公告)号：US11173029B2
公开(公告)日：2021-11-16
申请号：US16258843
申请日：2019-01-28
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia
IPC分类号： A61F2/24
摘要： A method for treating regurgitation of blood flow through a diseased heart valve is provided. The diseased heart valve including an annulus, an anterior valve leaflet, a posterior valve leaflet and a subvalvular apparatus. The method includes providing an apparatus comprising a substantially annular support member, at least one infra-annular support member securely connected thereto, and at least one anchoring element associated with the at least one infra-annular support member. The method further includes attaching the substantially annular support member to the annulus of the diseased heart valve and attaching proximal and distal ends of a prosthetic chordae tendineae to the at least one anchoring element and a papillary muscle, respectively, so that the papillary muscle is caused to move medially.

5. 发明申请

US20150359632A1 DEVICE, SYSTEM, AND METHOD FOR TREATING A REGURGITANT HEART VALVE 审中-公开
标题翻译：用于治疗心脏瓣膜的装置，系统和方法
公开(公告)号：US20150359632A1
公开(公告)日：2015-12-17
申请号：US14737591
申请日：2015-06-12
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Samir Kapadia
IPC分类号： A61F2/24
CPC分类号： A61F2/2454 , A61F2/2442 , A61F2/2457 , A61F2230/0069
摘要： In one aspect of the present disclosure, a device for treating a regurgitant heart valve in a subject can include a flexible, elongated body having a central chordae support portion disposed between first and second arms. The first and second arms can include first and second lumens, respectively, extending longitudinally therethrough. A method of treating a regurgitant heart valve in a subject is also provided.
摘要翻译：在本公开的一个方面，用于治疗受试者中的反流性心脏瓣膜的装置可以包括柔性细长体，其具有设置在第一和第二臂之间的中心腱索支撑部分。第一和第二臂可分别包括纵向延伸穿过其中的第一和第二腔。还提供了治疗受试者的反流心脏瓣膜的方法。

6. 发明申请

US20150250589A9 APPARATUS AND METHODS FOR REPAIR OF A CARDIAC VALVE 审中-公开
标题翻译：装置和方法修复心脏瓣膜
公开(公告)号：US20150250589A9
公开(公告)日：2015-09-10
申请号：US13947332
申请日：2013-07-22
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Jose A. Navia , Mark S. Goodin
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2/91
摘要： An annuloplasty ring for repairing a cardiac valve includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion of the support member includes a plurality of wing members that extend from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and the valve annulus to secure the annuloplasty ring in the valve annulus. The annuloplasty ring may be expanded into full contact engagement with the annulus of the cardiac valve by an inflatable balloon. Methods for repairing a cardiac valve using the annuloplasty ring are also provided.
摘要翻译：用于修复心脏瓣膜的瓣环成形术环包括具有相对设置的近端部分和远端部分以及端部之间的主体部分的可扩张支撑部件。支撑构件的基端部包括从主体部延伸的多个翼构件。每个翼构件包括至少一个用于嵌入心壁的钩构件和瓣环，以将瓣环成形术环固定在瓣膜环中。瓣膜成形术环可以通过可充气气囊扩张成与心脏瓣膜的环形物完全接触接合。还提供了使用瓣环成形术修复心脏瓣膜的方法。

7. 发明申请

US20140214156A1 APPARATUS AND METHOD FOR REPLACING A DISEASED CARDIAC VALVE 有权
标题翻译：装置和方法替代一种疾病的心脏瓣膜
公开(公告)号：US20140214156A1
公开(公告)日：2014-07-31
申请号：US14230216
申请日：2014-03-31
申请人： The Cleveland Clinic Foundation
发明人： Jose L. Navia , Ji-Feng Chen , Shengqiang Gao , Brian L. Davis , Samantha Stucke
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005
摘要： An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.
摘要翻译：用于更换患病心脏瓣膜的装置可从径向收缩的构型移动到径向扩张的构型。该装置包括可扩张的支撑构件和固定在其中的假体阀。主体部分在第一和第二端部之间延伸并且包括外圆周表面，围绕圆周表面延伸的周向轴线以及通过可扩张区域彼此间隔开的多个翼构件。每个翼构件包括第一和第二端部以及在端部之间延伸的柔性中间部分。第二端部与U形体主体部一体地形成。第一端部部分与周向轴线相邻并且在径向折叠构造中基本上与外圆周表面齐平。第一端部部分在径向膨胀的构造中基本上径向延伸到外周表面。

8. 发明公开

US20230263513A1 SYSTEM, CANNULA, AND METHOD FOR DE-AIRING A PATIENT'S HEART 审中-公开
公开(公告)号：US20230263513A1
公开(公告)日：2023-08-24
申请号：US18111090
申请日：2023-02-17
申请人： THE CLEVELAND CLINIC FOUNDATION , PARKER HANNIFIN CORPORATION
发明人： Jose L. Navia , Ricardo Gonzalez , Ferguson J. Poliquin
IPC分类号： A61B17/00
CPC分类号： A61B17/00234 , A61B2017/00247
摘要： A cannula, system, and method for de-airing a patient's heart following surgery are described. The cannula includes a tubular wall having a distal end portion and a proximal end portion. The wall also has a length extending from the distal end portion to the proximal end portion. The wall at least partially defines a first lumen extending lengthwise of the wall into the distal end portion and terminating in a closed first end. The wall also at least partially defines a second lumen extending lengthwise of the wall and terminating in a closed second end. The wall is configured and dimensioned such that the cannula can be inserted into the patient's heart. A first aperture extends through the wall from the first lumen to an exterior surface of the wall. A second aperture extends through the wall from the second lumen to the exterior surface of the wall.

9. 发明授权

US10583001B2 Methods for replacing a cardiac valve 有权
公开(公告)号：US10583001B2
公开(公告)日：2020-03-10
申请号：US14048987
申请日：2013-10-08
申请人： The Cleveland Clinic Foundation
发明人： Jose L. Navia , Jose A. Navia , Carlos Oberti
IPC分类号： A61F2/24 , A61F2/848
摘要： A method for replacing a cardiac valve includes an expandable support member having oppositely disposed first and second ends, a main body portion extending between the ends, and a prosthetic valve within the main body portion. The main body portion has an annular shape for expanding into position in the annulus of the valve. The first and second ends include a plurality of upper and lower wing members movable from a collapsed condition into an extended condition for respectively engaging a first section of cardiac tissue surrounding the valve and for: engaging a portion of the native valve leaflets to pin the leaflets back against the annulus. The second end further includes at least two strut members spaced apart from each other. A respective one of the strut members is attached to at least one commissural section of the prosthetic valve to prevent prolapse of the valve leaflets.

10. 发明授权

US10010416B2 Apparatus and method for replacing a diseased cardiac valve 有权
公开(公告)号：US10010416B2
公开(公告)日：2018-07-03
申请号：US14230216
申请日：2014-03-31
申请人： The Cleveland Clinic Foundation
发明人： Jose L. Navia , Ji-Feng Chen , Shengqiang Gao , Brian L. Davis , Samantha Stucke
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005
摘要： An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

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