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1. 发明授权

US5248813A Enantiomeric resolution 失效
标题翻译：对映体分辨率
公开(公告)号：US5248813A
公开(公告)日：1993-09-28
申请号：US960660
申请日：1992-10-14
申请人： Thanikavelu Manimaran , G. Patrick Stahly , R. Carl Herndon, Jr.
发明人： Thanikavelu Manimaran , G. Patrick Stahly , R. Carl Herndon, Jr.
IPC分类号： C07B57/00 , C07C51/487
CPC分类号： C07C51/487 , C07B57/00
摘要： A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties:(1) has at least one eutectic point;(2) a composition that is not at the eutectic point; and(3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid.Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.
摘要翻译：描述了获得芳基取代的脂肪族羧酸的基本上纯的对映异构体的方法。该方法首先利用从动力学拆分，非对映体结晶或不对称合成方法获得的芳基取代的脂族羧酸的对映体富集混合物。该富集的混合物与产生具有以下性质的盐的碱反应：（1）具有至少一个共晶点; （2）不在共晶点的组成; 和（3）比所述芳基取代的羧酸的共晶组成更接近外消旋组合物的共晶组合物。分离基本上纯的对映异构体盐，留下含有溶剂的母液和富集在另一对映异构体中的芳基取代的脂族羧酸。

2. 发明授权

US5278337A Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids 失效
标题翻译：芳基取代的脂族羧酸的对映异构体拆分
公开(公告)号：US5278337A
公开(公告)日：1994-01-11
申请号：US960620
申请日：1992-10-14
申请人： Thanikavelu Manimaran , G. Patrick Stahly , R. Carl Herndon, Jr.
发明人： Thanikavelu Manimaran , G. Patrick Stahly , R. Carl Herndon, Jr.
IPC分类号： C07B57/00 , C07C51/487
CPC分类号： C07B57/00 , C07C51/487
摘要： A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties:1) has at least one eutectic point;2) a composition that is not at the eutectic point; and3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid.Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.
摘要翻译：描述了获得芳基取代的脂肪族羧酸的基本上纯的对映异构体的方法。该方法首先利用从动力学拆分，非对映体结晶或不对称合成方法获得的芳基取代的脂族羧酸的对映体富集混合物。该富集的混合物与产生具有以下性质的盐的碱反应：1）具有至少一个共晶点; 2）不在共晶点的组成; 和3）比所述芳基取代的羧酸的共晶组成更接近外消旋组合物的共晶组合物。分离基本上纯的对映异构体盐，留下含有溶剂的母液和富集在另一对映异构体中的芳基取代的脂族羧酸。

3. 发明授权

US5442117A Enantiomeric resolution 失效
标题翻译：对映体分辨率
公开(公告)号：US5442117A
公开(公告)日：1995-08-15
申请号：US165619
申请日：1993-12-13
申请人： G. Patrick Stahly , Thanikavelu Manimaran
发明人： G. Patrick Stahly , Thanikavelu Manimaran
IPC分类号： C07C209/88 , C07B57/00
CPC分类号： C07C209/88
摘要： A process for obtaining a substantially pure enantiomer of an hydrocarbyl amine is described. The process utilizes first an enantiomerically enriched mixture the of hydrocarbyl amine obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with an inorganic acid producing a salt that has the following properties:1) has at least one eutectic point;2) a composition that is not at the eutectic point; and3) a eutectic composition that is closer to the racemiccomposition than is the eutectic composition of saidhydrocarbyl, or be a solid where the salt is a liquid. A substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and the hydrocarbyl amine enriched in the other enantiomer.
摘要翻译：描述了获得烃基胺基本上纯的对映异构体的方法。该方法首先利用由动力学拆分，非对映体结晶或不对称合成方法获得的烃基胺的对映体富集混合物。使富集的混合物与产生具有以下性质的盐的无机酸反应：1）具有至少一个共晶点; 2）不在共晶点的组成; 和3）比所述烃基的共晶组成更接近外消旋组合物的共晶组合物，或者是其中盐是液体的固体。分离出基本上纯的对映异构体盐，留下含有溶剂的母液和富含另一对映异构体的烃基胺。

4. 发明授权

US5304524A Asymmetric hydrogenation of aromatic-substituted olefins using organoruthenium catalyst 失效
标题翻译：使用有机钌催化剂对芳族取代烯烃进行不对称氢化
公开(公告)号：US5304524A
公开(公告)日：1994-04-19
申请号：US958525
申请日：1992-10-08
申请人： W. Dirk Klobucar , Charles H. Kolich , Thanikavelu Manimaran , Tse-Chong Wu
发明人： W. Dirk Klobucar , Charles H. Kolich , Thanikavelu Manimaran , Tse-Chong Wu
IPC分类号： B01J31/22 , B01J31/24 , B01J31/00
CPC分类号： B01J31/2295 , B01J31/2234 , B01J31/24 , B01J31/2452 , B01J2231/645 , B01J2531/0266 , B01J2531/821 , B01J31/0235 , B01J31/30
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译：公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。

5. 发明授权

US5015764A Preparation of optically active aliphatic carboxylic acids 失效
标题翻译：光学活性脂族羧酸的制备
公开(公告)号：US5015764A
公开(公告)日：1991-05-14
申请号：US539121
申请日：1990-06-18
申请人： Thanikavelu Manimaran , Fred J. Impastato
发明人： Thanikavelu Manimaran , Fred J. Impastato
IPC分类号： C07B57/00 , C07C51/42 , C07C51/487 , C07C57/30 , C07C59/64 , C07C67/60 , C07C69/734
CPC分类号： C07C67/60 , C07C51/487
摘要： A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises (i) forming a salt solution comprising said racemic mixture of a C.sub.1 to C.sub.6 linear or branched aliphatic carboxylic acid and an organic or inorganic base (ii) treating said salt solution with one-half molar equivalent of a chiral organic nitrogenous base having a base strength no stronger than said organic or inorganic base (iii) precipitating from the reaction solution formed in step (ii) the less soluble diastereomeric salt and (iv) separating said precipitated diastereomeric salt.

6. 发明申请

US20050143528A1 Recovery of antimony catalyst residues from bromination reaction mixtures 失效
标题翻译：从溴化反应混合物中回收锑催化剂残留物
公开(公告)号：US20050143528A1
公开(公告)日：2005-06-30
申请号：US10751060
申请日：2003-12-31
申请人： Thanikavelu Manimaran , Alvin Harkins , Samuel Dubois , Thomas Callender
发明人： Thanikavelu Manimaran , Alvin Harkins , Samuel Dubois , Thomas Callender
IPC分类号： C08F6/02 , C08F8/20 , C08F8/22 , C08F8/00
CPC分类号： C08F6/02 , C08F8/20 , Y02P20/584 , C08L25/04 , C08L25/18 , C08F12/08
摘要： A process for brominating a styrenic polymer in an organic solvent in the presence of an antimony trihalide catalyst such that a reaction mass containing brominated styrenic polymer in an organic phase is formed is improved by mixing hydrochloric acid or hydrobromic acid, or both, with said reaction mass at least once to extract antimony catalyst residues from said reaction mass as an acidic aqueous phase. Preferably, catalyst residues are recovered from the acidic aqueous phase and still more preferably, recovered antimony trihalide catalyst residues are recycled to constitute at least a portion of the antimony trihalide catalyst used in preparing the brominated styrenic polymer.
摘要翻译：在三卤化锑催化剂的存在下，在有机溶剂中溴化苯乙烯类聚合物的方法，通过将盐酸或氢溴酸或二者混合，形成有机相中含有溴化苯乙烯类聚合物的反应物质，质量至少一次以从酸性水相从所述反应物料中提取锑催化剂残余物。优选地，从酸性水相中回收催化剂残余物，还更优选回收的三卤化锑催化剂残余物被再循环以构成用于制备溴化苯乙烯聚合物的至少一部分三卤化锑催化剂。

7. 发明授权

US06300527B1 Process for the preparation of tetrabromobisphenol-A 有权
标题翻译：制备四溴双酚A的方法
公开(公告)号：US06300527B1
公开(公告)日：2001-10-09
申请号：US09614818
申请日：2000-07-12
申请人： Thanikavelu Manimaran , Hassan Y. Elnagar , Richard A. Holub , Alvin E. Harkins, Jr. , Bonnie G. McKinnie
发明人： Thanikavelu Manimaran , Hassan Y. Elnagar , Richard A. Holub , Alvin E. Harkins, Jr. , Bonnie G. McKinnie
IPC分类号： C07C3916
CPC分类号： C07C37/62 , C07C39/367
摘要： This invention relates, inter alia, to a process for the production of tetrabromobisphenol-A by the bromination of bisphenol-A and/or underbrominated bisphenol-A, which process features: a water and water-miscible organic solvent reaction medium; a relatively high reaction temperature; and the presence, in the reaction medium, of both (i) excess unreacted Br2 during the feed of bisphenol-A to the reactor, and (ii) sufficient HBr to protect the tetrabromobisphenol-A produced against undesirable color formation. Tetrabromobisphenol-A precipitates from the reaction mass and is easily recovered. Product of high purity (97% or more) and very low color (APHA of 50 or less) can be produced, even when using large excesses of bromine in the reaction.
摘要翻译：本发明尤其涉及通过双酚A和/或二溴双酚A的溴化生产四溴双酚A的方法，其特征在于：水和水可混溶的有机溶剂反应介质; 相对较高的反应温度; 以及在反应介质中存在（i）在将双酚-A进料到反应器中过量的未反应Br 2的存在，和（ii）足够的HBr以保护所产生的四溴双酚A而导致不希望的颜色形成。四溴双酚A从反应物质中沉淀出来，容易回收。即使在反应中使用大量过量的溴，也可以生产高纯度（97％以上）和非常低的颜色（APHA为50以下）的产品。

8. 发明授权

US5190905A Asymmetric hydrogenation of aromatic-substituted olefins using metal or metal alloy catalysts 失效
标题翻译：使用金属或金属合金催化剂对芳族取代烯烃进行不对称加氢
公开(公告)号：US5190905A
公开(公告)日：1993-03-02
申请号：US716014
申请日：1991-06-17
申请人： Charles H. Kolich , Thanikavelu Manimaran , W. Dirk Klobucar
发明人： Charles H. Kolich , Thanikavelu Manimaran , W. Dirk Klobucar
IPC分类号： B01J31/24 , B01J31/28 , C07C51/36 , C07F15/00 , C07F15/02 , C07F15/04
CPC分类号： B01J31/2452 , B01J31/24 , B01J31/28 , C07C51/36 , C07F15/0053 , C07F15/025 , C07F15/045 , B01J2231/645 , B01J2531/0266 , B01J2531/62 , B01J2531/821 , B01J2531/842 , B01J2531/847
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译：公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。

9. 发明授权

US5187281A Asymmetric hydrogenation of aromatic-substituted olefins using organoiridium catalyst 失效
标题翻译：使用有机铱催化剂对芳族取代烯烃进行不对称加氢
公开(公告)号：US5187281A
公开(公告)日：1993-02-16
申请号：US716016
申请日：1991-06-17
申请人： Charles H. Kolich , Thanikavelu Manimaran , W. Dirk Klobucar
发明人： Charles H. Kolich , Thanikavelu Manimaran , W. Dirk Klobucar
IPC分类号： B01J31/16 , B01J31/22 , B01J31/24 , C07C51/36 , C07F15/00
CPC分类号： C07F15/004 , B01J31/2234 , B01J31/2452 , C07C51/36 , B01J2231/645 , B01J2531/0266 , B01J2531/827
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译：公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。

10. 发明申请

US20090054709A1 Process For Producing N-Propyl Bromide or Other Aliphatic Bromides 有权
标题翻译：生产N-丙酰溴或其他脂肪族溴的方法
公开(公告)号：US20090054709A1
公开(公告)日：2009-02-26
申请号：US12296629
申请日：2007-04-11
申请人： James E. Torres , Alvin E. Harkins, JR. , Thanikavelu Manimaran , B. Gary McKinnie
发明人： James E. Torres , Alvin E. Harkins, JR. , Thanikavelu Manimaran , B. Gary McKinnie
IPC分类号： C07C17/08
CPC分类号： C07C17/08 , C07C19/075
摘要： A process for the production of an aliphatic bromide in which the bromine atom is attached to a terminal carbon atom, which process comprises continuously feeding olefin having a terminal double bond, gaseous hydrogen bromide, and a molecular oxygen-containing gas into a liquid phase reaction medium comprised of aliphatic bromide to cause anti-Markovnikov addition of HBr to terminal olefin, the feeds being proportioned and maintained to provide a molar excess of hydrogen bromide relative to terminal olefin in the range of about 1 to about 5 percent, and a molar ratio of molecular oxygen to terminal olefin of less than 0.005. The process is especially suited for production of n-propyl bromide.
摘要翻译：一种生产其中溴原子连接到末端碳原子上的脂族溴化物的方法，该方法包括将具有末端双键的烯烃，气态溴化氢和含分子氧的气体连续进料到液相反应介质由脂肪族溴化物引起，使马可夫尼科夫将HBr加入到末端烯烃中，进料成比例并保持为相对于末端烯烃的摩尔过量的溴化氢为约1至约5％，摩尔比的分子氧与末端烯烃的摩尔比小于0.005。该方法特别适用于生产正丙基溴。

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