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1. 发明授权

US07988991B2 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US07988991B2
公开(公告)日：2011-08-02
申请号：US10469612
申请日：2002-03-07
申请人： Tetsuro Tateishi , Takaaki Terahara , Naruhito Higo
发明人： Tetsuro Tateishi , Takaaki Terahara , Naruhito Higo
IPC分类号： A61F13/02
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/216 , A61K31/48 , A61K47/32
摘要： A patch agent of the present invention comprises a support, and an adhesive layer laid on the support and containing an adhesive base and a drug, wherein the adhesive base contains an acrylic polymer substantially having no carboxyl and no hydroxyl in molecules thereof, and a rubber-based polymer, so as to achieve sufficiently high skin permeability of the drug and preparation properties. Accordingly, the present invention enables administration of the drug through skin to be implemented with drug administration effect at a sufficiently high level and on a stable basis.
摘要翻译：本发明的贴剂包括载体和铺设在载体上并含有粘合剂基质和药物的粘合剂层，其中所述粘合剂基底含有基本上不含羧基的丙烯酸聚合物，并且在其分子中不含羟基，并且橡胶的聚合物，以达到足够高的药物的皮肤渗透性和制备性能。因此，本发明能够以足够高的水平和稳定的基础通过皮肤进行药物给药作用的施用。

2. 发明申请

US20080038328A1 Pasting Preparation 审中-公开
标题翻译：粘贴准备
公开(公告)号：US20080038328A1
公开(公告)日：2008-02-14
申请号：US11597517
申请日：2005-05-30
申请人： Naruhito Higo , Tetsuro Tateishi , Takaaki Terahara
发明人： Naruhito Higo , Tetsuro Tateishi , Takaaki Terahara
IPC分类号： A61K9/70 , A61K31/216 , A61K31/445 , A61K31/48 , A61K47/12 , A61K47/30
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K47/12
摘要： The patch preparation of the present invention is a patch preparation comprising a backing and an adhesive layer provided on the backing; wherein, the adhesive layer contains (A) a volatile organic acid and (B) a basic drug; the molar concentration ratio [(MA)/(MB)] between the molar concentration (MA) of the component (A) and the molar concentration (MB) of the component (B) in the adhesive layer is 0.5 or more; and the component (B) contains a basic drug formed as an ion pair with an anion component.
摘要翻译：本发明的贴片制剂是一种贴片制剂，其包括背衬和设置在背衬上的粘合剂层; 其中粘合剂层含有（A）挥发性有机酸和（B）碱性药物; 组分（A）的摩尔浓度（M SUB A）之间的摩尔浓度比[（M SUB）/（M B B）] 粘合剂层中组分（B）的摩尔浓度（M B B）为0.5以上; 并且组分（B）含有形成为具有阴离子组分的离子对的碱性药物。

3. 发明申请

US20070190123A1 Cover material and plaster with cover material 审中-公开
标题翻译：覆盖材料和石膏与封面材料
公开(公告)号：US20070190123A1
公开(公告)日：2007-08-16
申请号：US10587832
申请日：2005-01-31
申请人： Kazunosuke Aida , Arata Toshimitsu , Takaaki Terahara , Naruhito Higo
发明人： Kazunosuke Aida , Arata Toshimitsu , Takaaki Terahara , Naruhito Higo
IPC分类号： A61F13/02
CPC分类号： A61K9/7084 , A61F2013/00646 , A61L15/44 , A61L2300/40 , A61L2300/608
摘要： The present invention provides a cover material 10, adapted to be attached to skin in a manner covering over the entirety of a patch 20, comprising a pressure-sensitive adhesive layer 12 on one side of a support 11, wherein said patch 20 comprises a drug-containing layer 22 for contacting with the skin, said layer being provided on a support film 21 with a thickness of 12-30 μm, and wherein the cover material 10 is adapted to be attached to said support film 21 and a region of the skin around said patch 20 in such a manner that the pressure-sensitive adhesive layer 12 contacts with the edges of the drug-containing layer 22, and the pressure-sensitive adhesive layer 12 comprises a pressure-sensitive adhesive obtained by polymerizing vinyl acetate or N-vinyl-2-pyrrolidone and a (meth)acrylic acid alkyl ester with a C8 alkyl group as essential monomer components. According to the invention, it is possible to provide a cover material capable of reducing irritation to an affected area such as skin when a patch employing a drug such as pergolide mesylate is covered and affixed to the affected area.
摘要翻译：本发明提供了一种覆盖材料10，其适于以覆盖整个贴片20的方式附着到皮肤上，其包括在支撑体11的一侧上的压敏粘合剂层12，其中所述贴片20包括药物容纳层22，用于与皮肤接触，所述层设置在厚度为12-30μm的支撑膜21上，并且其中覆盖材料10适于附着到所述支撑膜21和皮肤区域围绕所述贴片20，使得压敏粘合剂层12与药物含有层22的边缘接触，并且压敏粘合剂层12包含通过聚合乙酸乙烯酯或N-乙烯基缩水甘油酯获得的压敏粘合剂，乙烯基-2-吡咯烷酮和具有C8烷基作为必需单体成分的（甲基）丙烯酸烷基酯。根据本发明，可以提供一种覆盖材料，其能够在使用药物例如甲磺酸格列德里特的贴剂覆盖并固定在受影响的区域时能够减少对患部的皮肤的刺激。

4. 发明申请

US20060110433A1 Adhesive patch 审中-公开
标题翻译：胶贴
公开(公告)号：US20060110433A1
公开(公告)日：2006-05-25
申请号：US10526065
申请日：2003-08-07
申请人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
发明人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
IPC分类号： A61K31/48 , A61F13/02 , A61L15/16
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive base agent and pergolide and/or a pharmaceutically acceptable salt thereof, wherein the adhesive base agent comprises an acrylic polymer including no substantial carboxyl group and hydroxyl group and having self-adhesion properties and a rubber polymer, and the weight ratio of the content of the acrylic polymer to the content of the rubber polymer is from 1:1 to 1:9.
摘要翻译：一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂基剂和高氯代内酯和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂基剂包含不含实质性羧基和羟基的丙烯酸聚合物并且具有自粘性和橡胶聚合物，并且丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:1至1:9。

5. 发明申请

US20070082037A1 Transdermal preparations and method for relieving side effects in pergolide therapy 审中-公开
标题翻译：透皮制剂和缓释百草苷治疗副作用的方法
公开(公告)号：US20070082037A1
公开(公告)日：2007-04-12
申请号：US10577746
申请日：2004-10-29
申请人： Arata Toshimitsu , Kazunosuke Aida , Takaaki Terahara , Naruhito Higo
发明人： Arata Toshimitsu , Kazunosuke Aida , Takaaki Terahara , Naruhito Higo
IPC分类号： A61K31/48 , A61K9/70
CPC分类号： A61K9/7061 , A61K9/7076 , A61K31/48
摘要： It is intended to provide pergolide-containing transdermal preparations having reducreduced side effects and exerting sufficient therapeutic effects. Namely, a pergolide-containing transdermal preparation which is capable of achieving a plasma AUC ratio of pergolide or the like to at least one pergolide metabolite of 1:0.5 to 1:5; and/or transdermal preparation containing pergolide and/or a pharmaceutically acceptable salt thereof which is capable of achieving a ratio (A/B) of the maximum plasma level (A) of pergolide and/or a pharmaceutically acceptable salt thereof to the plasma level (B) thereof in the next administration of less than 2.
摘要翻译：旨在提供具有降低的副作用并施加足够治疗效果的含有pergolide的透皮制剂。即，含有速溶胶的透皮制剂，能够实现速溶胶等的血浆AUC比例为1:0.5至1:5的至少一种pergolide代谢物; 和/或透皮制剂，其含有速溶胶和/或其药学上可接受的盐，其能够实现血浆白蛋白的最大血浆水平（A）和/或其药学上可接受的盐与血浆水平的比（A / B） B）在下一次给药时不到2次。

6. 发明授权

US6139866A Tape formulation for percutaneous administration containing fentanyi 失效
标题翻译：含有芬太尼的经皮给药胶带制剂
公开(公告)号：US6139866A
公开(公告)日：2000-10-31
申请号：US981475
申请日：1998-01-13
申请人： Hideharu Chono , Takaaki Terahara , Tatsuaki Suzuki , Naruhito Higo
发明人： Hideharu Chono , Takaaki Terahara , Tatsuaki Suzuki , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/19 , A61K31/4453 , A61K31/4468 , A61K47/12 , A61L15/22 , A61L15/58 , A61P23/02 , A61P29/00 , A61L9/70 , A61L15/00 , A61L15/16 , A61L31/38
CPC分类号： A61K9/7053 , A61K31/4453 , A61K31/4468 , A61K47/12 , A61K9/7061 , A61K9/7076
摘要： A tape formulation for percutaneous administration containing fentanyl which comprises fentanyl or a salt thereof, a pressure sensitive adhesive and sodium acetate, is disclosed. The salt of fentanyl is preferably fentanyl citrate. The tape formulation of the present invention is little irritation to the skin and excellent in the percutaneous permeation of fentanyl and has a high stability even after the passage of time.
摘要翻译： PCT No.PCT / JP97 / 01595 Sec。 371日期1998年1月13日 102（e）日期1998年1月13日PCT提交1997年5月13日PCT公布。公开号WO97 / 42952 日本1997年11月20日公开了含有芬太尼或其盐，压敏粘合剂和乙酸钠的经皮给药的胶带制剂。芬太尼的盐优选为柠檬酸芬太尼。本发明的胶带配方对皮肤刺激性很小，芬太尼的经皮渗透性优异，即使经过时也具有高稳定性。

7. 发明授权

US08691267B2 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US08691267B2
公开(公告)日：2014-04-08
申请号：US10525646
申请日：2003-08-07
申请人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
发明人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/405 , A61K31/4422 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate-vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
摘要翻译：一种贴剂，包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层，其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和碱性含氮聚合物，包括碱性氮，并且在常温下不具有附着性。

8. 发明申请

US20050260255A1 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US20050260255A1
公开(公告)日：2005-11-24
申请号：US10525646
申请日：2003-08-07
申请人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
发明人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/405 , A61K31/4422 , A61K31/48 , A61K47/06 , A61K47/12 , A61K47/32
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/405 , A61K31/4422 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate—vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
摘要翻译：一种贴剂，包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层，其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和碱性含氮聚合物，包括碱性氮，并且在常温下不具有附着性。

9. 发明申请

US20050163831A1 Patch for transdermal administration 审中-公开
标题翻译：补片用于透皮给药
公开(公告)号：US20050163831A1
公开(公告)日：2005-07-28
申请号：US11046687
申请日：2005-02-01
申请人： Atsutoshi Ikesue , Norifumi Tateishi , Kengo Uemura , Takaaki Terahara , Naruhito Higo , Michinori Sakai
发明人： Atsutoshi Ikesue , Norifumi Tateishi , Kengo Uemura , Takaaki Terahara , Naruhito Higo , Michinori Sakai
IPC分类号： A61K9/70 , A61K31/42 , A61K31/724 , A61K31/365
CPC分类号： A61K9/7061 , A61K31/42
摘要： A patch for transdermal administration having a sufficiently high transdermal permeation property of a COX-2 inhibitor to exert a superior antiinflammatory effect, the patch for transdermal administration comprising a backing and an adhesive layer which is placed on at least one side of the backing and comprises an adhesive base agent and a drug, wherein the drug is valdecoxib or a pharmaceutically acceptable salt thereof.
摘要翻译：一种用于透皮给药的贴剂，其具有足够高的COX-2抑制剂的透皮渗透性能以发挥优异的抗炎作用，用于透皮给药的贴片包括背衬和粘合剂层，其被放置在背衬的至少一侧上，并且包括粘合剂基剂和药物，其中药物是伐地考昔或其药学上可接受的盐。

10. 发明授权

US5866157A Matrix patch formulation 失效
标题翻译：基质贴剂配方
公开(公告)号：US5866157A
公开(公告)日：1999-02-02
申请号：US836975
申请日：1997-05-29
申请人： Naruhito Higo , Ken-ichi Komori , Takaaki Terahara
发明人： Naruhito Higo , Ken-ichi Komori , Takaaki Terahara
IPC分类号： A61K9/06 , A61K9/70 , A61K31/445 , A61K47/12 , A61P17/00 , A61P27/16 , A61P37/08 , A61P43/00 , A61F13/02
CPC分类号： A61K9/7053 , A61K9/7076
摘要： A matrix type patch formulation which comprises an adhesive layer containing a physiological active substance, an organic acid, a hydrophobic high molecular material, a tackifying resin, a plasticizer and an absorption enhancer, is disclosed. The adhesive layer preferably contains 0.1 to 20% (w/w) of the physiological active substance, 0.01 to 15% (w/w) of the organic acid, 15 to 60% (w/w) of the hydrophobic high molecular material, 10 to 70% (w/w) of the tackifying resin, 10 to 60% (w/w) of the plasticizer and 0.01 to 20% (w/w) of the absorption enhancer. The organic acid is preferably an aliphatic carboxylic acid, an aromatic carboxylic acid, an alkyl sulfonic acid, an alkyl sulfonic acid derivative, cholic acid derivative or a water-soluble inorganic salt thereof. The matrix type patch formulation of the present invention can increase the percutaneous absorbability of the physiological active substance and is extremely reduced in skin irritation.
摘要翻译： PCT No.PCT / JP95 / 01073 Sec。 371日期1997年5月29日 102（e）日期1997年5月29日PCT提交1995年6月1日PCT公布。 WO96 / 16642 PCT出版物日本1996年6月6日公开了一种包含含有生理活性物质，有机酸，疏水性高分子材料，增粘树脂，增塑剂和吸收增强剂的粘合剂层的基质型贴剂制剂。粘合层优选含有0.1〜20％（w / w）的生理活性物质，0.01〜15％（w / w）的有机酸，15〜60％（w / w）的疏水性高分子材料， 10〜70％（w / w）的增粘树脂，10〜60％（w / w）的增塑剂和0.01〜20％（w / w）的吸收促进剂。有机酸优选为脂肪族羧酸，芳香族羧酸，烷基磺酸，烷基磺酸衍生物，胆酸衍生物或其水溶性无机盐。本发明的基质型贴片制剂可以增加生理活性物质的经皮吸收性，并且皮肤刺激性极度降低。

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