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1. 发明授权

US07629166B2 Measuring apparatus for interaction of biomolecule 失效
标题翻译：生物分子相互作用的测量装置
公开(公告)号：US07629166B2
公开(公告)日：2009-12-08
申请号：US11214948
申请日：2005-08-31
申请人： Tetsuro Miyamoto , Hiroyuki Takei , Shigenori Togashi , Ryo Miyake
发明人： Tetsuro Miyamoto , Hiroyuki Takei , Shigenori Togashi , Ryo Miyake
IPC分类号： C12M1/34
CPC分类号： G01N21/253 , G01N21/553 , G01N35/028 , G01N35/1095
摘要： In a measuring apparatus for biomolecule interaction, a fine particle sensor surface is dipped in a buffer solution in a reaction vessel to conduct spectral measurement by way of optical fibers. The buffer solution in the reaction vessel is made to enter an upper reaction vessel and discharged from a flow channel. Air is injected from a flow channel to inject a specimen from the discharge port to the reaction vessel. Then the specimen is sucked into the reaction vessel and brought into contact with the sensor surface where a ligand and an analyte in the specimen are bonded. Bonding is measured by a spectrophotometer through the optical fibers. A buffer solution is injected from the injection flow channel into the reaction vessel and the specimen is discharged out of the flow channel. The dissociation process in which the biomolecules are dissociated along with lowering of the concentration is measured.
摘要翻译：在用于生物分子相互作用的测量装置中，将细颗粒传感器表面浸入反应容器中的缓冲溶液中以通过光纤进行光谱测量。将反应容器中的缓冲溶液进入上反应容器并从流动通道排出。空气从流动通道注入，将样品从排放口注入反应容器。然后将样品吸入反应容器中，并与样品中的配体和分析物结合的传感器表面接触。通过分光光度计通过光纤测量粘合。将缓冲溶液从注射流通道注入反应容器中，并将样品从流动通道排出。测量其中生物分子随浓度降低而解离的解离过程。

2. 发明申请

US20070238162A1 Measuring apparatus for interaction of biomolecule 失效
标题翻译：生物分子相互作用的测量装置
公开(公告)号：US20070238162A1
公开(公告)日：2007-10-11
申请号：US11214948
申请日：2005-08-31
申请人： Tetsuro Miyamoto , Hiroyuki Takei , Shigenori Togashi , Ryo Miyake
发明人： Tetsuro Miyamoto , Hiroyuki Takei , Shigenori Togashi , Ryo Miyake
IPC分类号： C12M3/00
CPC分类号： G01N21/253 , G01N21/553 , G01N35/028 , G01N35/1095
摘要： In a measuring apparatus for biomolecule interaction, a fine particle sensor surface is dipped in a buffer solution in a reaction vessel to conduct spectral measurement by way of optical fibers. The buffer solution in the reaction vessel is made to enter an upper reaction vessel and discharged from a flow channel. Air is injected from a flow channel to inject a specimen from the discharge port to the reaction vessel. Then the specimen is sucked into the reaction vessel and brought into contact with the sensor surface where a ligand and an analyte in the specimen are bonded. Bonding is measured by a spectrophotometer through the optical fibers. A buffer solution is injected from the injection flow channel into the reaction vessel and the specimen is discharged out of the flow channel. The dissociation process in which the biomolecules are dissociated along with lowering of the concentration is measured.
摘要翻译：在用于生物分子相互作用的测量装置中，将细颗粒传感器表面浸入反应容器中的缓冲溶液中以通过光纤进行光谱测量。将反应容器中的缓冲溶液进入上反应容器并从流动通道排出。空气从流动通道注入，将样品从排放口注入反应容器。然后将样品吸入反应容器中，并与样品中的配体和分析物结合的传感器表面接触。通过分光光度计通过光纤测量粘合。将缓冲溶液从注射流通道注入反应容器中，并将样品从流动通道排出。测量其中生物分子随浓度降低而解离的解离过程。

3. 发明申请

US20050004765A1 Method for estimating effect of working substance and screening method 审中-公开
标题翻译：估算工作物质影响的方法和筛选方法
公开(公告)号：US20050004765A1
公开(公告)日：2005-01-06
申请号：US10859143
申请日：2004-06-03
申请人： Tetsuro Miyamoto , Shigenori Togashi , Ryo Miyake , Naoya Sasaki
发明人： Tetsuro Miyamoto , Shigenori Togashi , Ryo Miyake , Naoya Sasaki
IPC分类号： G01N33/48 , C12Q1/02 , G01N33/15 , G01N33/50 , G06F17/30 , G06F19/00 , G06F19/12
CPC分类号： G01N33/502 , G01N33/5008 , G01N33/5082
摘要： The object of the present invention is to estimate the effect of working substances on actual living organisms such as cells and tissues. The present invention provides a method for estimation of the effect of working substance which includes the following steps (a) and (b): (a) a step of contacting a working substance with a model cell to measure a cell activity value of the model cell, and (b) a step of estimating the effect of the working substance on the target living organism when the working substance is allowed to act on the target living organism, using the cell activity value measured at the step (a) as an input value.
摘要翻译：本发明的目的是估计工作物质对细胞和组织等实际生物体的影响。本发明提供一种估计工作物质影响的方法，其包括以下步骤（a）和（b）：（a）使工作物质与模型细胞接触以测量模型的细胞活性值的步骤（b）当使用步骤（a）测量的细胞活性值作为输入时，估计工作物质对目标生物体的影响的步骤，当使所述工作物质作用于所述目标生物体时，值。

4. 发明授权

US06290908B1 Water quality meter and water monitoring system 有权
标题翻译：水质仪表和水监测系统
公开(公告)号：US06290908B1
公开(公告)日：2001-09-18
申请号：US09281098
申请日：1999-03-29
申请人： Masao Fukunaga , Tamio Ishihara , Koji Saito , Katsutoshi Yamada , Hideo Enoki , Sadao Mori , Ryo Miyake , Takao Terayama , Masatoshi Kanamaru
发明人： Masao Fukunaga , Tamio Ishihara , Koji Saito , Katsutoshi Yamada , Hideo Enoki , Sadao Mori , Ryo Miyake , Takao Terayama , Masatoshi Kanamaru
IPC分类号： G01N1500
CPC分类号： C02F1/008 , C02F2103/02 , C02F2201/008 , C02F2201/009 , C02F2209/11 , C02F2209/29 , C02F2209/40 , G01N33/1893 , Y02A20/212
摘要： A water quality meter is composed of a plurality of analyzing units for analyzing water samples introduced from a water distribution pipe, each analyzing unit including a reagent mixing cell and a measuring cell, and a liquid introducing unit integrated with the analyzing units, which is composed of a single member in which a plurality of fluid flow paths for feeding various types of liquid including the water sample into the analyzing unit are formed. Furthermore, the cells and the plurality of three-dimensional fluid flow paths formed in the single member are fabricated by a micro-fabrication technique using photo-curing resin.
摘要翻译：水质计由多个用于分析从配水管引入的水样的分析单元构成，每个分析单元包括试剂混合室和测量池，以及与分析单元一体化的液体导入单元，其组成其中形成有用于将包括水样本的各种类型的液体供给到分析单元中的多个流体流路的单个构件。此外，通过使用光固化树脂的微制造技术来制造在单个构件中形成的电池和多个三维流体流动路径。

5. 发明授权

US06197255B1 Chemical analyzing apparatus 有权
标题翻译：化学分析仪
公开(公告)号：US06197255B1
公开(公告)日：2001-03-06
申请号：US09398046
申请日：1999-09-17
申请人： Ryo Miyake , Yoshihiro Nagaoka , Akira Koide , Naruo Watanabe , Yasuhiko Sasaki , Hajime Kato , Takao Terayama , Hiroshi Mitsumaki , Hiroyasu Uchida , Takeshi Shibuya , Yasuhiro Yoshimura
发明人： Ryo Miyake , Yoshihiro Nagaoka , Akira Koide , Naruo Watanabe , Yasuhiko Sasaki , Hajime Kato , Takao Terayama , Hiroshi Mitsumaki , Hiroyasu Uchida , Takeshi Shibuya , Yasuhiro Yoshimura
IPC分类号： G01N3502
CPC分类号： G01N35/00663 , B01F11/0283 , G01N35/025 , G01N2035/00673 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A chemical analyzing apparatus comprises a reaction cell holder which holds a plurality of reaction cells that are supplied with samples and reagents at a predetermined position, a measurer for measuring characteristics of the sample, a plurality of reagent containers, a liquid deliverer provided below each of the plurality of reagent containers, one or more sound wave generators provided outside the reaction cells, and storage containers for storing cleansing liquid with different contamination states. The cleansing liquid with different contamination states is reused according to the contamination levels of the reaction cells.
摘要翻译：化学分析装置包括：反应池保持器，其保持在预定位置处供给样品和试剂的多个反应池，用于测量样品特性的测量器，多个试剂容器，下方设置的液体输送器多个试剂容器，设置在反应室外的一个或多个声波发生器和用于存储具有不同污染状态的清洁液的储存容器。具有不同污染状态的清洁液体根据反应池的污染水平重新使用。

6. 发明授权

US5079959A Analyzing system using sheath flow of sample 失效
标题翻译：使用样品的流动分析系统
公开(公告)号：US5079959A
公开(公告)日：1992-01-14
申请号：US404559
申请日：1989-09-08
申请人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki , Toshio Kaneko , Hideyuki Horiuchi , Shinichi Sakuraba , Kaori Yasuda
发明人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki , Toshio Kaneko , Hideyuki Horiuchi , Shinichi Sakuraba , Kaori Yasuda
IPC分类号： G01N15/12 , G01N15/14 , G01N35/10
CPC分类号： G01N35/1083 , G01N15/1404 , G01N2035/1086 , G01N35/1004
摘要： Particles contained in a liquid sample are analyzed by moving the particles along a detection passage past a detector using a liquid flow in the detection passage. To reduce the time required for analysis of each sample, the sample is delivered at an input location at the upstream end of the detection passage by movement of a movable container carrying the sample to the input location. Immediately after the commencement of the delivery of the liquid sample, liquid flow is caused to occur in the detection passage. Washing liquid is supplied to the input location by a liquid supplier different from the movable container which carries the sample.

7. 发明授权

US07413713B2 Reaction apparatus and mixing system 失效
标题翻译：反应装置和混合系统
公开(公告)号：US07413713B2
公开(公告)日：2008-08-19
申请号：US10283215
申请日：2002-10-30
申请人： Tadashi Sano , Ryo Miyake , Akira Koide , Norihide Saho , Akiomi Kono , Takeshi Harada
发明人： Tadashi Sano , Ryo Miyake , Akira Koide , Norihide Saho , Akiomi Kono , Takeshi Harada
IPC分类号： B01J10/00 , B01J10/02 , B01J12/00 , B01J12/02 , B01J14/00
CPC分类号： B01F15/00149 , B01F3/04503 , B01F5/0471 , B01F13/0059 , B01F15/00123 , B01F15/00344 , B01J4/001 , B01J10/002 , B01J14/00 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/2575 , Y10T436/25875
摘要： A reaction apparatus comprises a first supply flow channel having a fine flow channel cross sectional area for a liquid pressurized by a pressurizing device, a gas supply flow channel having a fine flow channel cross sectional area for supplying a gas, a two-phase flow channel having a fine flow channel cross sectional area in communication with a joined portion for the first supply flow channel and the second supply flow channel for flowing a gas/liquid two-phase fluid, a gas bubble reaction flow channel in communication with the exit of the gas/liquid two-phase channel and having a flow channel cross sectional area larger than that of the gas/liquid two-phase flow channel, and a liquid discharge flow channel for discharging the liquid in the gas bubble reaction flow channel. Therefore, in the reaction apparatus, a stable mixing ratio of a gas to a liquid can be obtained and the mixing speed of the gas to the liquid is increased.
摘要翻译：反应装置包括：第一供给流路，其具有用于由加压装置加压的液体的细流路截面积;气体供给流路，具有用于供给气体的细流路截面积;二相流路具有与用于第一供给流动通道的接合部分和用于使气体/液体两相流体流动的第二供应流动通道的细流动通道横截面积，与气体/液体两相流体流动的气泡反应流动通道，气体/液体两相通道，并且具有大于气/液二相流动通道的流动通道横截面积，以及用于排出气泡反应流动通道中的液体的液体排出流动通道。因此，在反应装置中，可以获得气体与液体的稳定的混合比，并且气体与液体的混合速度提高。

8. 发明申请

US20070059736A1 Bio-analysis chip, bio-analysis system and bio-analysis method 审中-公开
标题翻译：生物分析芯片，生物分析系统和生物分析方法
公开(公告)号：US20070059736A1
公开(公告)日：2007-03-15
申请号：US11450366
申请日：2006-06-12
申请人： Hisao Saito , Yasuhiko Sasaki , Ryo Miyake
发明人： Hisao Saito , Yasuhiko Sasaki , Ryo Miyake
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502715 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , G01N1/2813 , G01N2001/2833
摘要： A bio-analysis chip which is convenient in use and can promptly detect microbes with high accuracy. The bio-analysis chip comprises a collection member for collecting microbes in the atmosphere with the microbes adhering to the collection member, and a substrate in the form of a thin plate on which the collection member is mounted. The substrate has a collection member receiving section in which the collection member is placed, and a plurality of reagent reservoirs in which reagents for treating and analyzing the microbes are stored. The plurality of reagent reservoirs are connected to the collection member receiving section.
摘要翻译：一种生物分析芯片，使用方便，可以高精度地及时检测微生物。生物分析芯片包括收集构件，用于在微生物粘附到收集构件的情况下收集大气中的微生物，以及薄板形式的基板，收集构件安装在该基板上。基板具有收集部件收纳部，收纳部件被放置在该收集部件收纳部中，并存储有用于处理和分析微生物的试剂的多个试剂储存器。多个试剂储存器连接到收集构件接收部分。

9. 发明申请

US20070009387A1 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US20070009387A1
公开(公告)日：2007-01-11
申请号：US11522379
申请日：2006-09-18
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N33/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus in which a sample to be analyzed and a reagent are placed into a reaction container, and sound waves are irradiated to said reaction container so as to agitate them, wherein said chemical analysis apparatus comprises a piezoelectric element producing said sound waves, and drivers for driving said piezoelectric element, said sound waves being intermittently irradiated into said reaction container.
摘要翻译：一种化学分析装置，其中将待分析样品和试剂置于反应容器中，并且将声波照射到所述反应容器以搅拌它们，其中所述化学分析装置包括产生所述声波的压电元件，以及用于驱动所述压电元件的驱动器，所述声波被间歇地照射到所述反应容器中。

10. 发明申请

US20050087562A1 Mixed liquid manufacturing apparatus 失效
标题翻译：混合液体制造装置
公开(公告)号：US20050087562A1
公开(公告)日：2005-04-28
申请号：US10855431
申请日：2004-05-28
申请人： Akira Koide , Ryo Miyake , Yasuo Ito , Yoshishige Endo
发明人： Akira Koide , Ryo Miyake , Yasuo Ito , Yoshishige Endo
IPC分类号： A61K8/02 , A61K8/00 , B01F5/04 , B01F5/06 , B01F13/00 , B01F13/10 , B65B3/26 , B65C3/08 , B65C9/46 , B67C3/02 , B67D1/00 , B67D7/02 , B67D7/74 , B67D1/16
CPC分类号： B01F13/0066 , B01F5/0453 , B01F5/0456 , B01F5/0458 , B01F5/0475 , B01F5/0646 , B01F5/0647 , B01F13/1055 , B01F2215/0031 , B65C3/08 , B65C9/46 , B67D1/0044 , B67D1/005 , B67D7/02 , B67D7/743
摘要： A mixed liquid manufacturing apparatus comprises: an information input unit, in which information of an object, to which a mixed liquid is offered, is input; a material storage system that stores a plurality of materials for a mixed liquid; a product information system that selects kinds and quantities of the stored materials on the basis of the input information of the object, to which a mixed liquid is offered; a liquid transfer unit, by which the selected materials are taken out from the material storage system; a mixing unit, in which the materials supplied from the liquid transfer unit are mixed; an injection unit, by which the mixed liquid is injected into a mixed liquid container; an input unit, by which matters being declared on a label of the mixed liquid container are input; and a label formation unit, in which the input matters are printed on the label and the label is stuck on the mixed liquid container, and wherein the label formation unit begins printing before the injection unit completes injection of the mixed liquid into the container.
摘要翻译：混合液体制造装置包括：信息输入单元，其中输入有提供混合液体的物体的信息; 存储用于混合液体的多种材料的材料储存系统; 产品信息系统，其基于提供混合液体的对象的输入信息来选择所存储的材料的种类和数量; 液体转移单元，通过所述液体转移单元将所选择的材料从所述材料储存系统中取出; 混合单元，其中从所述液体转移单元供应的材料混合; 注射单元，通过该注射单元将混合液体注入混合液体容器中; 输入在混合液体容器的标签上声明事项的输入单元; 以及标签形成单元，其中将输入物品印刷在标签上并且标签粘贴在混合液体容器上，并且其中标签形成单元在注射单元完成将混合液体注入容器之前开始印刷。

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