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1. 发明申请

US20060089488A1 Antimicrobial peptides and use thereof 有权
标题翻译：抗微生物肽及其用途
公开(公告)号：US20060089488A1
公开(公告)日：2006-04-27
申请号：US11247376
申请日：2005-10-11
申请人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.
摘要翻译：人造合成的天然不发生的抗微生物肽由本发明提供。抗微生物肽包括由以下8个氨基酸残基组成的一个单元，两个单元或更多个氨基酸序列单元：<？in-line-formula description =“In-line Formulas”end =“lead”？>（R或 Q） - （L或F或I）-IK-（L或F或I或V）-LYQ; 和/或由所述序列组成的经修改的修改序列。

2. 发明授权

US07615534B2 Antimicrobial peptides and use thereof 有权
标题翻译：抗微生物肽及其用途
公开(公告)号：US07615534B2
公开(公告)日：2009-11-10
申请号：US11247376
申请日：2005-10-11
申请人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
IPC分类号： A61K38/10
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.
摘要翻译：人造合成的天然不发生的抗微生物肽由本发明提供。抗微生物肽包括由以下8个氨基酸残基组成的一个单元，两个单元或更多个氨基酸序列单元：（R或Q） - （L或F或I）-IK-（L或F或I或V） -LYQ; 和/或由所述序列组成的经部分修饰的修饰序列。

3. 发明授权

US07674771B2 Antimicrobial peptides and utilization of the same 有权
标题翻译：抗菌肽及其利用相同
公开(公告)号：US07674771B2
公开(公告)日：2010-03-09
申请号：US10577688
申请日：2004-10-25
申请人： Tetsuhiko Yoshida , Yoshinao Yamada , Masayoshi Kume , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Yoshinao Yamada , Masayoshi Kume , Hiroki Kourai
IPC分类号： A61K38/03
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K7/08
摘要： Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting laminin binding site (LBS), or said sequence with one or a plurality of amino acid residue(s) conservatively replaced, and an amino acid sequence that can express antimicrobial activity against at least one kind of bacteria or fungi. It is desirable that the total number of amino acid residues is 100 or less.
摘要翻译：本发明提供的抗微生物肽是人造设计的抗生素肽，其不是天然存在的，并且包括由选自构成层粘连蛋白结合位点（LBS）的氨基酸序列中的至少6个连续氨基酸残基或所述具有一个或多个保守替代的氨基酸残基，以及可以表达针对至少一种细菌或真菌的抗微生物活性的氨基酸序列。氨基酸残基的总数优选为100以下。

4. 发明申请

US20070032431A1 Antimicrobial peptides and utilization of the same 有权
标题翻译：抗菌肽及其利用相同
公开(公告)号：US20070032431A1
公开(公告)日：2007-02-08
申请号：US10577688
申请日：2004-10-25
申请人： Tetsuhiko Yoshida , Yoshinao Yamada , Masayoshi Kume , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Yoshinao Yamada , Masayoshi Kume , Hiroki Kourai
IPC分类号： A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K7/08
摘要： Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting laminin binding site (LBS), or said sequence with one or a plurality of amino acid residue(s) conservatively replaced, and an amino acid sequence that can express antimicrobial activity against at least one kind of bacteria or fungi. It is desirable that the total number of amino acid residues is 100 or less.
摘要翻译：本发明提供的抗微生物肽是人造设计的抗生素肽，其不是天然存在的，并且包括由选自构成层粘连蛋白结合位点（LBS）的氨基酸序列中的至少6个连续氨基酸残基或所述具有一个或多个保守替代的氨基酸残基，以及可以表达针对至少一种细菌或真菌的抗微生物活性的氨基酸序列。氨基酸残基的总数优选为100以下。

5. 发明授权

US07482328B2 Antimicrobial polypeptide and utilization thereof 有权
标题翻译：抗菌多肽及其利用
公开(公告)号：US07482328B2
公开(公告)日：2009-01-27
申请号：US10512299
申请日：2003-04-24
申请人： Tetsuhiko Yoshida , Masayoshi Kume , Yoshinao Yamada , Yoko Matsuda , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Masayoshi Kume , Yoshinao Yamada , Yoko Matsuda , Hiroki Kourai
IPC分类号： A61K38/10 , A61K38/16
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/001 , Y02A50/481
摘要： The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This polypeptide contains in its peptide chain one or more types of nuclear localization signal sequences (NLSs) and/or one or more units of sequences prepared by partially modifying the NLS(s). The one or more units of NLSs and/or modified NLSs contain at least 5 amino acid residues in total and amount to 30% or more of the total amino acid residues constituting the peptide chain.
摘要翻译：本发明提供了人造合成的抗微生物多肽，其在天然中不发生，并且包含该多肽作为主要成分的抗微生物剂。该多肽在其肽链中含有一种或多种类型的核定位信号序列（NLS）和/或通过部分修饰NLS制备的一个或多个序列单元。 NLS和/或修饰的NLS的一个或多个单元总共含有至少5个氨基酸残基，并且占构成肽链的总氨基酸残基的30％或更多。

6. 发明申请

US20060057668A1 Antimicrobial polypeptide and utilization thereof 有权
公开(公告)号：US20060057668A1
公开(公告)日：2006-03-16
申请号：US10512299
申请日：2003-04-24
申请人： Tetsuhiko Yoshida , Masayoshi Kume , Yoshinao Yamada , Yoko Matsuda
发明人： Tetsuhiko Yoshida , Masayoshi Kume , Yoshinao Yamada , Yoko Matsuda
IPC分类号： A61K38/16 , C07H21/04 , C12P21/06 , C12N15/74 , C07K14/195
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/001 , Y02A50/481
摘要： The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This polypeptide contains in its peptide chain one or more types of nuclear localization signal sequences (NLSs) and/or one or more units of sequences prepared by partially modifying the NLS(s). The one or more units of NLSs and/or modified NLSs contain at least 5 amino acid residues in total and amount to 30% or more of the total amino acid residues constituting the peptide chain.

7. 发明申请

US20130273798A1 ANTI-ALLERGEN AGENT 审中-公开
标题翻译：抗过敏剂
公开(公告)号：US20130273798A1
公开(公告)日：2013-10-17
申请号：US13879264
申请日：2011-10-13
申请人： Yoshinao Yamada
发明人： Yoshinao Yamada
IPC分类号： D06M11/79 , D06M11/46 , D06M11/71
CPC分类号： D06M11/79 , C09D5/14 , C09D5/1618 , C09D7/62 , C09D7/67 , C09D7/69 , D06M11/46 , D06M11/71 , Y10T442/2525
摘要： Conventional tannic acid and polyphenol anti-allergen agents are known as anti-allergen agents capable of deactivating allergens such as mites and pollen, but these agents have inferior heat resistance and pose problems with coloration, discoloration and elution. The purpose of the present invention is to provide an anti-allergen agent that has excellent heat resistance, shows no coloration, and has excellent water resistance and workability.It was discovered that using an inorganic substance having a high acid site concentration with acid site concentration being defined as the number of acid sites having a pKa of 4.8 or less, it is possible to realize an anti-allergen that manifests strong anti-allergen effects, has excellent heat resistance and water resistance, shows little coloration, and has excellent workability.
摘要翻译：常规的单宁酸和多酚抗变应原剂被称为能够使诸如螨虫和花粉等过敏原失活的抗变态反应剂，但是这些试剂具有差的耐热性，造成着色，变色和洗脱的问题。本发明的目的是提供耐热性优异，不着色的抗过敏剂，耐水性和加工性优异。已经发现，使用具有酸性位点浓度高的无机物质，其酸性位点浓度定义为pKa为4.8以下的酸性位点的数量，可以实现表现出强的抗过敏效果的抗过敏原具有优异的耐热性和耐水性，显色性低，加工性优异。

8. 发明申请

US20130004368A1 STERILIZATION-CLEANING DEVICE AND STERILIZATION-CLEANING METHOD FOR CAP 有权
标题翻译：灭菌清洁装置和灭菌清洗方法
公开(公告)号：US20130004368A1
公开(公告)日：2013-01-03
申请号：US13583864
申请日：2011-02-22
申请人： Yoshiyuki Morita , Yoshinao Yamada
发明人： Yoshiyuki Morita , Yoshinao Yamada
IPC分类号： A61L2/24 , A61L2/18
CPC分类号： A61L2/22 , A61L2/18 , A61L2202/15 , A61L2202/23 , B65B55/10 , B67B3/003
摘要： Provided is a chute-type cap sterilization-cleaning device which transfers caps and performs sterilization-cleaning by injecting sterilization-cleaning liquid from a propulsion nozzle, wherein a controller (11) and a solenoid valve for controlling a plurality of reverse propulsion nozzles (2e) are provided, and wherein when sterilization and cleaning of a cap (C) is continued at a chute portion for sterilization-cleaning while cap transfer is stopped by a dividing device, in order to relax the accumulated pressure on the cap (C) at the downstream side, the reverse propulsion nozzles (2e) performing straight injection of the sterilization-cleaning liquid toward the reverse side with respect to the transfer direction of the cap (C) are arranged along the chute portion for sterilization-cleaning so that the injected flows are in contact with the inner surfaces of several caps (C).
摘要翻译：提供一种滑槽式灭菌清洁装置，其通过从推进喷嘴喷射灭菌清洗液来转移盖子并进行灭菌清洁，其中控制器（11）和用于控制多个反向推进喷嘴（2e）的电磁阀），并且其中当帽子（C）的消毒和清洁在用于灭菌清洁的斜槽部分中继续进行，同时通过分隔装置停止帽转移时，为了放松帽（C）上的累积压力，在下游侧，相对于盖（C）的传送方向向杀菌清洗液朝向反方向直线喷射的反向推进喷嘴（2e）沿着滑槽部进行灭菌清洗，流动与几个盖（C）的内表面接触。

9. 发明申请

US20070084575A1 Composite papyraceous material 审中-公开
标题翻译：复合纸浆料
公开(公告)号：US20070084575A1
公开(公告)日：2007-04-19
申请号：US10577399
申请日：2004-10-26
申请人： Mikio Furukawa , Katsuyuki Toma , Yoshinao Yamada , Akira Ito , Norihiko Miki
发明人： Mikio Furukawa , Katsuyuki Toma , Yoshinao Yamada , Akira Ito , Norihiko Miki
IPC分类号： D21H13/26 , D21H13/22
CPC分类号： D21H13/12 , D21H13/14 , D21H13/22 , D21H13/26 , H05K1/0366 , H05K2201/015 , H05K2201/0154 , H05K2201/0278
摘要： A composite papyraceous material comprising a fibrous polytetrafluoroethylene (in particular, fibrous powder thereof) and fibrous polyimide.
摘要翻译：包含纤维状聚四氟乙烯（特别是其纤维粉末）和纤维状聚酰亚胺的复合纸浆形成材料。

10. 发明申请

US20100209530A1 ANTI-ALLERGEN AGENT 审中-公开
标题翻译：抗过敏剂
公开(公告)号：US20100209530A1
公开(公告)日：2010-08-19
申请号：US12680795
申请日：2008-09-24
申请人： Yoshinao Yamada
发明人： Yoshinao Yamada
IPC分类号： A61K33/42 , A61K33/06 , A61K33/24 , C01B25/26 , C01B39/38 , C01G30/00
CPC分类号： D06M11/46 , A61K31/7024 , A61K33/06 , A61K33/24 , A61K33/42 , A61K45/06 , D01F1/10 , D06M11/00 , D06M11/45 , D06M11/47 , D06M11/71 , D06M11/77 , D06M11/79 , D06M13/238 , D06M15/263 , D06M16/00 , D06M23/08 , A61K2300/00
摘要： The present invention provides an anti-allergen agent that has excellent heat resistance, low coloration, excellent processability, and excellent water resistance, an anti-allergen product, and a method for processing same. The anti-allergen agent of the present invention comprises as an active ingredient an inorganic solid acid, and the inorganic solid acid preferably has an acid strength as pKa of 4.0 or less. Furthermore, it preferably further comprises a polyphenol compound, and in this case it preferably comprises the inorganic solid acid at 5 to 90 wt % relative to the total amount of the inorganic solid acid and the polyphenol compound.
摘要翻译：本发明提供耐热性优异，着色性优异，加工性优异，耐水性优异，抗过敏产品及其加工方法的抗过敏剂。本发明的抗变应原剂含有作为活性成分的无机固体酸，无机固体酸的酸强度优选为pKa为4.0以下。此外，其优选还包含多酚化合物，在这种情况下，其优选包含无机固体酸相对于无机固体酸和多酚化合物的总量为5至90重量％。

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