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1. 发明申请

US20120225817A1 THERAPEUTIC AGENT FOR GASTROINTESTINAL DISEASE 审中-公开
标题翻译：胃肠病治疗药物
公开(公告)号：US20120225817A1
公开(公告)日：2012-09-06
申请号：US13505627
申请日：2010-11-10
申请人： Teruo Nishida , Makoto Inui , Kenji Matsuura , Masatsugu Nakamura , Takashi Nagano
发明人： Teruo Nishida , Makoto Inui , Kenji Matsuura , Masatsugu Nakamura , Takashi Nagano
IPC分类号： A61K38/07 , A61P29/00 , A61P1/00 , C07K5/103 , A61P1/04
CPC分类号： A61K38/07 , C07K5/1013 , C07K5/1016
摘要： The present invention provides a therapeutic agent and a prophylactic agent for a gastrointestinal disease. A peptide having an amino acid sequence represented by Ser-Ser-Ser-Arg or a pharmaceutically acceptable salt thereof promotes wound healing in a gastrointestinal mucosal tissue, and is therefore useful as a therapeutic agent or a prophylactic agent for a gastrointestinal disease. Further, when (a) a peptide having an amino acid sequence represented by Ser-Ser-Ser-Arg or a pharmaceutically acceptable salt thereof and (b) a peptide having an amino acid sequence represented by Phe-Gly-Leu-Met-NH2 or a pharmaceutically acceptable salt thereof are administered in combination, these medicaments act synergistically and can significantly promote wound healing in a gastrointestinal mucosal tissue.
摘要翻译：本发明提供了治疗剂和胃肠道疾病的预防剂。具有由Ser-Ser-Ser-Arg表示的氨基酸序列的肽或其药学上可接受的盐在胃肠粘膜组织中促进伤口愈合，因此可用作胃肠道疾病的治疗剂或预防剂。此外，（a）具有Ser-Ser-Ser-Arg表示的氨基酸序列的肽或其药学上可接受的盐和（b）具有由Phe-Gly-Leu-Met-NH 2表示的氨基酸序列的肽或其药学上可接受的盐组合施用，这些药物协同作用并且可显着促进胃肠粘膜组织中的伤口愈合。

2. 发明申请

US20090005317A1 Methods for treating a corneal disorder and promoting skin wound healing 有权
标题翻译：治疗角膜障碍并促进皮肤伤口愈合的方法
公开(公告)号：US20090005317A1
公开(公告)日：2009-01-01
申请号：US11725761
申请日：2007-03-20
申请人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
发明人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
IPC分类号： A61K38/08 , A61K38/07 , A61K38/10 , A61P17/00 , A61P27/02
CPC分类号： A61K38/30 , A61K9/0048 , C07K5/1013 , C07K5/1016 , C07K14/65
摘要： A method for treating a corneal disorder or for promoting skin wound healing comprising administering to a patient in need thereof a composition containing pharmaceutically effective amounts of (i) a first peptide comprising an amino acid sequence containing the following consecutive amino acids: Ser-Ser-Ser-Arg (SEQ ID NO: 1), or an analog thereof or a pharmaceutically acceptable salt thereof and (ii) a second peptide comprising an amino acid sequence containing the following consecutive amino acids with a terminal —NH2 group: Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 2), or an analog thereof or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.
摘要翻译：一种治疗角膜病症或促进皮肤伤口愈合的方法，包括向有需要的患者施用含有药学有效量的组合物（i）包含含有以下连续氨基酸的氨基酸序列的第一肽：Ser-Ser- Ser-Arg（SEQ ID NO：1）或其类似物或其药学上可接受的盐，和（ii）包含具有末端-NH 2基团的下列连续氨基酸的氨基酸序列的第二肽：Phe-Gly- Leu-Met-NH 2（SEQ ID NO：2）或其类似物或其药学上可接受的盐以及药学上可接受的载体。

3. 发明授权

US08183343B2 Methods for treating a skin wound 有权
标题翻译：治疗皮肤伤口的方法
公开(公告)号：US08183343B2
公开(公告)日：2012-05-22
申请号：US12804773
申请日：2010-07-29
申请人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
发明人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
IPC分类号： A61K38/04 , C07K14/65
CPC分类号： A61K38/30 , A61K9/0048 , C07K5/1013 , C07K5/1016 , C07K14/65
摘要： A therapeutic method for treating a skin wound involving administering to a patient in need thereof a composition containing pharmaceutically effective amounts of the following components: (1) a peptide consisting of the amino acid sequence represented by Ser-Ser-Ser-Arg (SEQ ID NO: 1) or pharmaceutically acceptable salts thereof and (2) a peptide consisting of the amino acid sequence represented by Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 2) or substance P or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable additive.
摘要翻译：一种治疗皮肤伤口的治疗方法，包括向有需要的患者施用含有药学有效量的以下成分的组合物：（1）由Ser-Ser-Ser-Arg（SEQ ID NO：（2）由Phe-Gly-Leu-Met-NH 2（SEQ ID NO：2）或物质P表示的氨基酸序列或其药学上可接受的盐，以及药学上可接受的添加剂。

4. 发明授权

US07232881B2 Peptide containing Ser-Ser-Ser-Arg 有权
标题翻译：含Ser-Ser-Ser-Arg的肽
公开(公告)号：US07232881B2
公开(公告)日：2007-06-19
申请号：US10497628
申请日：2002-12-03
申请人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
发明人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
IPC分类号： C07K5/10 , A61K38/00 , A61K38/02 , A61K38/10 , A61K38/08 , A61K38/07 , C07K2/00 , C07K7/04 , C07K7/08
CPC分类号： A61K38/30 , A61K9/0048 , C07K5/1013 , C07K5/1016 , C07K14/65
摘要： A peptide, wherein the peptide is selected from the group consisting of Ser-Ser-Ser-Arg (SEQ ID NO: 1), Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro (SEQ ID NO: 4), Ser-Ser-Ser-Arg-Arg (SEQ ID NO: 5), Gly-Ser-Ser-Ser-Arg (SEQ ID NO: 6), Gly-Ser-Ser-Ser-Arg-Arg (SEQ ID NO: 7), Ala-Ser-Ser-Ser-Arg-Arg-Ala-Pro (SEQ ID NO: 8), Gly-Ser-Ser-Ser-Arg-Ala-Ala-Pro (SEQ ID NO: 9) and Gly-Ser-Ser-Ser-Arg-Ala-Ala-Ala-Pro (SEQ ID NO: 10), or a pharmaceutically acceptable salt thereof.
摘要翻译：肽，其中肽选自Ser-Ser-Ser-Arg（SEQ ID NO：1），Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro（SEQ ID NO：4），Ser-Ser-Ser-Arg-Arg（SEQ ID NO：5），Gly-Ser-Ser-Ser-Arg（SEQ ID NO：6），Gly-Ser-Ser-Ser-Arg-Arg ：Ala-Ser-Ser-Ser-Arg-Arg-Ala-Pro（SEQ ID NO：8），Gly-Ser-Ser-Ser-Arg-Ala-Ala-Pro（SEQ ID NO：9）和 Gly-Ser-Ser-Ser-Arg-Ala-Ala-Ala-Pro（SEQ ID NO：10）或其药学上可接受的盐。

5. 发明申请

US20050009752A1 Novel peptides and medicinal uses thereof 有权
标题翻译：新型肽及其药用用途
公开(公告)号：US20050009752A1
公开(公告)日：2005-01-13
申请号：US10497628
申请日：2002-12-03
申请人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
发明人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
IPC分类号： A61K9/00 , A61K38/00 , A61K38/30 , A61P17/02 , A61P27/02 , C07K5/103 , C07K5/107 , C07K14/65 , A61K38/08 , C07K7/06
CPC分类号： A61K38/30 , A61K9/0048 , C07K5/1013 , C07K5/1016 , C07K14/65
摘要： It is an object of the invention to examine the minimum unit of the exhibition of the activity of insulin-like growth factor-I and find a pharmaceutical use thereof in the fields of ophthalmology and dermatology. A joint administration of a peptide containing the amino acid sequence represented by Ser-Ser-Ser-Arg as the minimum unit of the exhibition of the activity of insulin-like growth factor-I and a peptide containing the amino acid sequence represented by Phe-Gly-Leu-Met-NH2 is effective for curing corneal disorders and can significantly promote the healing of skin wounds.
摘要翻译：本发明的目的是检查胰岛素样生长因子-I的活性展示的最小单位，并在眼科和皮肤病领域找到其药物用途。包含由Ser-Ser-Ser-Arg表示的氨基酸序列的肽的共同给药作为胰岛素样生长因子-I的活性的展开的最小单位和含有Phe- Gly-Leu-Met-NH2对于治疗角膜疾病有效，可以显着促进皮肤伤口的愈合。

6. 发明申请

US20110059897A1 Methods for treating a skin wound 有权
标题翻译：治疗皮肤伤口的方法
公开(公告)号：US20110059897A1
公开(公告)日：2011-03-10
申请号：US12804773
申请日：2010-07-29
申请人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
发明人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
IPC分类号： A61K38/07 , A61P17/02
CPC分类号： A61K38/30 , A61K9/0048 , C07K5/1013 , C07K5/1016 , C07K14/65
摘要： A therapeutic method for treating a skin wound involving administering to a patient in need thereof a composition containing pharmaceutically effective amounts of the following components: (1) a peptide consisting of the amino acid sequence represented by Ser-Ser-Ser-Arg (SEQ ID NO: 1) or pharmaceutically acceptable salts thereof and (2) a peptide consisting of the amino acid sequence represented by Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 2) or substance P or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable additive.
摘要翻译：一种治疗皮肤伤口的治疗方法，包括向有需要的患者施用含有药学有效量的以下成分的组合物：（1）由Ser-Ser-Ser-Arg（SEQ ID NO：（2）由Phe-Gly-Leu-Met-NH 2（SEQ ID NO：2）或物质P表示的氨基酸序列或其药学上可接受的盐，以及药学上可接受的添加剂。

7. 发明授权

US07795222B2 Methods for treating a corneal disorder and promoting skin wound healing 有权
标题翻译：治疗角膜障碍并促进皮肤伤口愈合的方法
公开(公告)号：US07795222B2
公开(公告)日：2010-09-14
申请号：US11725761
申请日：2007-03-20
申请人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
发明人： Teruo Nishida , Makoto Inui , Masatsugu Nakamura
IPC分类号： A61K38/10 , A61K38/07 , A61K38/06
CPC分类号： A61K38/30 , A61K9/0048 , C07K5/1013 , C07K5/1016 , C07K14/65
摘要： A method for treating a corneal disorder or for promoting skin wound healing comprising administering to a patient in need thereof a composition containing pharmaceutically effective amounts of (i) a first peptide comprising an amino acid sequence containing the following consecutive amino acids: Ser-Ser-Ser-Arg (SEQ ID NO: 1), or an analog thereof or a pharmaceutically acceptable salt thereof and (ii) a second peptide comprising an amino acid sequence containing the following consecutive amino acids with a terminal —NH2 group: Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 2), or an analog thereof or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.
摘要翻译：一种治疗角膜病症或促进皮肤伤口愈合的方法，包括向有需要的患者施用含有药学有效量的组合物（i）包含含有以下连续氨基酸的氨基酸序列的第一肽：Ser-Ser- Ser-Arg（SEQ ID NO：1）或其类似物或其药学上可接受的盐，和（ii）包含具有末端-NH 2基团的下列连续氨基酸的氨基酸序列的第二肽：Phe-Gly- Leu-Met-NH 2（SEQ ID NO：2）或其类似物或其药学上可接受的盐以及药学上可接受的载体。

8. 发明授权

US07071166B2 Skin wound healing promoters 失效
标题翻译：皮肤伤口愈合促进剂
公开(公告)号：US07071166B2
公开(公告)日：2006-07-04
申请号：US10344199
申请日：2001-08-10
申请人： Teruo Nishida , Katsuhiko Nakata , Masatsugu Nakamura
发明人： Teruo Nishida , Katsuhiko Nakata , Masatsugu Nakamura
IPC分类号： A61K38/00
CPC分类号： A61K38/046 , A61K38/30 , A61K2300/00
摘要： The present invention provides healing promoters for skin wounds such as rupture, abrasion, surgical incision, skin ulcer and burn. Coexistence of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 1) or Phe-Gly-Leu-Met-NH2 (SEQ ID NO: 2) with insulin-like growth factor-I exhibits a remarkable promotive action on healing the skin wounds. Accordingly, combined administration of at least one of the substance P analogs and pharmaceutically acceptable salts thereof with the insulin-like growth factor exhibits a promotive effect on epidermal extension and a promotive effect on healing the skin wounds.
摘要翻译：本发明提供皮肤伤口的愈合促进剂，例如破裂，磨损，手术切口，皮肤溃疡和烧伤。 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH 2（SEQ ID NO：1）或Phe-Gly-Leu-Met-NH 具有胰岛素样生长因子-1的2型（SEQ ID NO：2）对愈合皮肤伤口有显着的促进作用。因此，至少一种物质P类似物和其药学上可接受的盐与胰岛素样生长因子的组合给药对表皮延伸表现出促进作用，并且对愈合皮肤伤口具有促进作用。

9. 发明授权

US06221846B1 Ophthalmic drug compositions 有权
标题翻译：眼药物组合物
公开(公告)号：US06221846B1
公开(公告)日：2001-04-24
申请号：US09202820
申请日：1999-07-15
申请人： Teruo Nishida , Katsuhiko Nakata , Masatsugu Nakamura
发明人： Teruo Nishida , Katsuhiko Nakata , Masatsugu Nakamura
IPC分类号： A67K3800
CPC分类号： C07K5/1016 , A61K9/0048 , A61K38/046 , A61K38/07 , C07K7/22 , Y10S514/912
摘要： An ophthalmic composition for treating corneal disorder which comprises Phe-Gly-Leu-Met-NH2 or a pharmaceutically acceptable salt thereof as an active ingredient. Also a composition for treating corneal disorders, particularly a composition for promoting corneal epithelial migration, which comprises Phe-Gly-Leu-Met-NH2 or a pharmaceutically acceptable salt thereof and an insulin-like growth factor I. Preferably the compositions are in the form of ophthalmic formulations.
摘要翻译：一种用于治疗角膜疾病的眼用组合物，其包含Phe-Gly-Leu-Met-NH 2或其药学上可接受的盐作为活性成分。还有一种用于治疗角膜疾病的组合物，特别是用于促进角膜上皮迁移的组合物，其包含Phe-Gly-Leu-Met-NH 2或其药学上可接受的盐和胰岛素样生长因子I.优选地，组合物为的眼科制剂。

10. 发明申请

US20120312253A1 COIL SUPPORT MEMBER 有权
标题翻译：线圈支持会员
公开(公告)号：US20120312253A1
公开(公告)日：2012-12-13
申请号：US13581265
申请日：2010-02-26
申请人： Yuuichi Kita , Teruo Nishida , Mathieu Ghesquiere
发明人： Yuuichi Kita , Teruo Nishida , Mathieu Ghesquiere
IPC分类号： F24H9/18 , F24H1/20
CPC分类号： F24H1/208 , F24H9/1809 , F28D1/0472 , F28D20/0034 , F28D2020/0078 , F28F9/0131 , Y02E60/142
摘要： A coil support member is attached to a coil inside a water storage vessel and includes multiple openings, insertion portions and a non-insertion portion. The openings are arranged in a lengthwise direction, and together with surrounding sites prevent contact between mutually adjacent loops of the tube of the coil and suppress contact between an inner surface of the water storage vessel and an outer surface of the coil. The insertion portions are formed between the openings and are inserted into an intra-coil space located radially inward of the outer surface of the coil. The non-insertion portion is positioned in an extra-coil space located radially outward of the outer surface of the coil. The insertion portions have insertion body portions preventing contact between mutually adjacent loops of the tube, and engagement portions contacting the tube from the intra-coil space and maintaining an inserted state of the insertion body portions.
摘要翻译：线圈支撑构件附接到蓄水容器内的线圈，并且包括多个开口，插入部分和非插入部分。开口沿长度方向布置，并且与周围部位一起防止线圈的管的相互相邻的环之间的接触，并且抑制储水容器的内表面和线圈的外表面之间的接触。插入部分形成在开口之间，并被插入线圈外表面径向内侧的线圈内空间。非插入部分位于线圈外表面径向外侧的额外线圈空间中。所述插入部具有防止所述管的相邻环之间的接触的插入体部，以及与所述线圈间空间接触所述管的接合部，并且保持所述插入体部的插入状态。

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