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1. 发明申请

US20130107043A1 Blood Processing Apparatus with Robust Automated Process Control 有权
标题翻译：具有鲁棒自动过程控制的血液处理设备
公开(公告)号：US20130107043A1
公开(公告)日：2013-05-02
申请号：US13679089
申请日：2012-11-16
申请人： TERUMO BCT, INC.
发明人： Christopher FLETCHER , William SWEAT , Jeremy P. KOLENBRANDER , Aditya DALVI , John R. LINDNER
IPC分类号： B04B13/00 , H04N7/18
CPC分类号： B04B13/00 , B04B5/0442 , B04B15/00 , B04B2013/006 , G01N15/042 , G01N15/05 , G01N33/491 , G06T7/0012 , G06T7/12 , G06T7/181 , G06T2207/10016 , G06T2207/20068 , G06T2207/30024 , H04N7/18
摘要： A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
摘要翻译：一种离心机，用于分离具有观察流体流动的相机的血液，以及控制该流量的控制器。通过图像处理步骤检测接口的位置，其可以包括“破坏”图像，“扩散”图像，“边缘检测”，“边缘链接”，“基于区域的确认”和“接口计算“。 “Spoiling”减少了相对于接口或相位边界的预期位置定向的正交轴上优先检查的像素数。 “扩散”平滑了界面边界的小振荡，使界面的位置更加明显。 “边缘检测”计算像素强度的变化率。 “边缘连接”连接相邻的最大值。 “基于区域的确认”创建了符合条件的区域的伪图像。 “最终边缘计算”使用伪图像中阴影变化的点，平均这些点对于界面位置的径向位移。

2. 发明申请

US20140005023A1 System for Blood Separation with Shielded Extraction Port and Optical Control 有权
标题翻译：带屏蔽提取端口和光学控制的血液分离系统
公开(公告)号：US20140005023A1
公开(公告)日：2014-01-02
申请号：US14014147
申请日：2013-08-29
申请人： Terumo BCT, Inc.
发明人： Jeremy P. KOLENBRANDER , Brian M. HOLMES , Thomas J. FELT , James R. LADTKOW
IPC分类号： G01N21/51
CPC分类号： G01N21/51 , A61M1/3693 , A61M1/3696 , A61M2202/0439 , A61M2205/3306 , B04B13/00 , B04B2013/006 , G01N2035/00495 , A61M2202/0071
摘要： A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
摘要翻译：一种离心血液分离系统，包括转子，光源，光学传感器，控制系统，分离容器和分离容器上的光学单元。所述光学单元具有径向向外延伸到所述光学单元中的第一提取端口，所述第一提取端口下游并延伸到所述光学单元超出所述第一提取端口的红细胞提取端口; 以及位于所述第一提取口和所述红细胞提取口之间的坝，具有上边缘和下边缘，其中所述第一提取口和所述红细胞提取口径向地位于所述坝的上边缘和下边缘之间。此外，具有第一直径的孔，具有小于第一直径的第二直径的内腔的第一提取端口和将孔连接到内腔的截头圆锥形通道。

3. 发明申请

US20170369844A1 Separating Composite Liquids 审中-公开
公开(公告)号：US20170369844A1
公开(公告)日：2017-12-28
申请号：US15700303
申请日：2017-09-11
申请人： Terumo BCT, Inc.
发明人： James R. LADTKOW , Geoffrey M. UHL , Jeremy P. KOLENBRANDER , Briden Ray STANTON
IPC分类号： C12N5/078 , B04B5/04 , A61M1/02 , A61M1/34 , A61M1/30 , A61M1/26 , A61M1/36
摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.

4. 发明申请

US20200325446A1 Separating Composite Liquids 审中-公开
公开(公告)号：US20200325446A1
公开(公告)日：2020-10-15
申请号：US16915818
申请日：2020-06-29
申请人： Terumo BCT, Inc.
发明人： James R. LADTKOW , Geoffrey M. UHL , Jeremy P. KOLENBRANDER , Briden Ray STANTON
IPC分类号： C12N5/078 , A61M1/26 , A61M1/30 , A61M1/02 , A61M1/34 , A61M1/36 , B04B5/04
摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.

5. 发明申请

US20140234829A1 Separating Composite Liquids 有权
标题翻译：分离复合液体
公开(公告)号：US20140234829A1
公开(公告)日：2014-08-21
申请号：US14182534
申请日：2014-02-18
申请人： TERUMO BCT, INC.
发明人： James R. LADTKOW , Geoffrey M. UHL , Jeremy P. KOLENBRANDER , Briden Ray STANTON
IPC分类号： C12N5/078
CPC分类号： C12N5/0641 , A61M1/0209 , A61M1/26 , A61M1/262 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3693 , A61M1/3696 , B04B5/0442 , B04B2005/0471
摘要： Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.
摘要翻译：描述了包括用于将复合液体分离成组件的方法和装置的实施例。实施例涉及使用柔性膜将复合液体分离成组分。在实施方案中，复合液体可包括含细胞的液体，例如全血或全血成分。在一个具体实施方案中，复合液体是血沉棕黄层。

6. 发明申请

US20140234183A1 System for Blood Separation with a Separation Chamber Having an Internal Gravity Valve 有权
标题翻译：具有内部重力阀的分离室进行血液分离的系统
公开(公告)号：US20140234183A1
公开(公告)日：2014-08-21
申请号：US14179955
申请日：2014-02-13
申请人： TERUMO BCT, INC.
发明人： Jeremy P. KOLENBRANDER , Geoffrey UHL
IPC分类号： B01L3/00
CPC分类号： B01L3/5021 , A61M1/0209 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M1/38 , B01D21/26 , B04B5/0442 , B04B2005/0471
摘要： A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, an outlet and a gravity valve inside the cell separation chamber. The valve is responsive to the gravitational field created by the speed of the rotor. When the rotor spins at high speed, the gravity valve may open the outlet at a location proximal to an axis of rotation of the rotor. When the rotor spins at a lower speed, the gravity valve may open the outlet at a location distal from the axis.
摘要翻译：一种一次性血液分离装置和离心血液处理系统，包括适于安装在离心机的转子上的血液处理室; 与处理室流体连通的截头圆锥形细胞分离室，细胞分离室在细胞分离室内具有入口，出口和重力阀。阀门响应于由转子转速产生的重力场。当转子高速旋转时，重力阀可以在靠近转子旋转轴线的位置打开出口。当转子以较低的速度旋转时，重力阀可以在远离轴线的位置打开出口。

7. 发明申请

US20130072367A1 Blood Processing Apparatus with Robust Automated Process Control 有权
标题翻译：具有鲁棒自动过程控制的血液处理设备
公开(公告)号：US20130072367A1
公开(公告)日：2013-03-21
申请号：US13679034
申请日：2012-11-16
申请人： Terumo BCT, Inc.
发明人： Christopher FLETCHER , William SWEAT , Jeremy P. KOLENBRANDER , Aditya DALVI , John R. LINDNER
IPC分类号： B04B15/00
CPC分类号： B04B13/00 , B04B5/0442 , B04B15/00 , B04B2013/006 , G01N15/042 , G01N15/05 , G01N33/491 , G06T7/0012 , G06T7/12 , G06T7/181 , G06T2207/10016 , G06T2207/20068 , G06T2207/30024 , H04N7/18
摘要： A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making to the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.
摘要翻译：一种离心机，用于分离具有观察流体流动的相机的血液，以及控制该流量的控制器。通过图像处理步骤检测接口的位置，其可以包括破坏图像，扩散图像，边缘检测，边缘链接，基于区域的确认和接口计算的步骤。扰乱减少了相对于接口或相位边界的预期位置定向的正交轴上优先检查的像素数。扩散平滑了界面边界的小振荡，使界面的位置更加明显。边缘检测计算像素强度的变化率。边缘连接连接相邻的最大值。基于区域的确认将创建符合不同区域的区域的伪图像。最终边缘计算使用伪图像中阴影变化的点，对接口位置的这些点的径向位移进行平均。

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