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1. 发明申请

US20180142218A1 NOVEL ACYLTRANSFERASES, VARIANT THIOESTERASES, AND USES THEREOF 审中-公开
公开(公告)号：US20180142218A1
公开(公告)日：2018-05-24
申请号：US15725222
申请日：2017-10-04
申请人： TerraVia Holdings, Inc.
发明人： Jeffrey Leo Moseley , Jason Casolari , Xinhua Zhao , Aren Ewing , Aravind Somanchi , Scott Franklin , David Davis
IPC分类号： C12N9/10 , C12P7/64 , C12N15/82
CPC分类号： C12N9/1029 , C12N9/1025 , C12N15/82 , C12N2800/22 , C12P7/6463 , C12Y203/01051
摘要： Recombinant nucleic acids and vector constructs encoding acyltransferases and variant thioesterases, and the acyltransferases and variant thioesterases encoded by the nucleic acids are provided. The acyltransferases and variant thioesterases are useful in fatty acid synthesis and triacylglycerol production. Host cells that express the recombinant nucleic acids as well as methods of cultivating the host cells, methods of producing oils from the host cells are provided. The recombinant host cells and the oils produced therefrom have altered fatty acid profiles and/or triacylglycerols with altered regiospecificity.

2. 发明授权

US09649368B2 Genetically engineered microbial strains including prototheca lipid pathway genes 有权
公开(公告)号：US09649368B2
公开(公告)日：2017-05-16
申请号：US15091509
申请日：2016-04-05
申请人： TerraVia Holdings, Inc.
发明人： Scott Franklin , Shane Brubaker , George N. Rudenko , Jeffrey L. Moseley , Xinhua Zhao , Tina T. Huynh , Riyaz Bhat , Matthew Shoa-Azar , Trung H. Nguyen , Karen Espina , Aravind Somanchi
IPC分类号： A61K39/00 , C12N15/79 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/16 , C12P7/64 , C07K14/405 , C12N15/82 , C12N5/078
CPC分类号： A61K39/0011 , C07K14/405 , C12N5/0634 , C12N9/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N15/79 , C12N15/8247 , C12P7/6445 , C12P7/6463 , C12Y114/19002 , C12Y114/19006 , C12Y203/01179 , C12Y301/02014 , Y02P20/52
摘要： Genetically engineered microbial, e.g., Prototheca, cells provide microbial oil useful as a food additive and a source of renewable fuels and industrial chemicals.

3. 发明申请

US20160348119A1 Oleaginous Microalgae Having an LPAAT Ablation 审中-公开
标题翻译：具有LPAAT消融的油性微藻
公开(公告)号：US20160348119A1
公开(公告)日：2016-12-01
申请号：US15092538
申请日：2016-04-06
申请人： TerraVia Holdings, Inc.
发明人： Scott Franklin , Riyaz Bhat , Xinhua Zhao
IPC分类号： C12N15/52 , C11C1/00
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, lysophosphatidic acid acyltransferase, ketoacyl-CoA reductase, hydroxyacyl-CoA dehydratase, and/or enoyl-CoA reductase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
摘要翻译：重组DNA技术用于产生产生具有所需脂肪酸谱和区域特异性或立体特异性谱的甘油三酯油的含油重组细胞。基因操纵包括编码硬脂酰-ACP去饱和酶，δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮酰基-ACP合成酶，溶血磷脂酰基转移酶，酮酰基-CoA还原酶，羟基酰基-CoA脱水酶和/或烯酰辅酶A还原酶的那些。所生产的油可以具有增强的氧化或热稳定性，或可用作煎炸油，起酥油，卷入起酥油，回火脂肪，可可脂替代物，润滑剂或用作各种化学方法的原料。脂肪酸分布可以富集中链型，或者油可富含饱和不饱和饱和型甘油三酸酯。

4. 发明授权

US09719114B2 Tailored oils 有权
公开(公告)号：US09719114B2
公开(公告)日：2017-08-01
申请号：US13804185
申请日：2013-03-14
申请人： TerraVia Holdings, Inc.
发明人： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni
IPC分类号： C12P7/64 , C12N9/02 , C12N9/26 , C10L1/02 , A23D9/02 , C11B11/00
CPC分类号： C12P7/64 , A23D9/02 , C10L1/026 , C11B11/00 , C12N9/0071 , C12N9/2431 , C12P7/6463 , C12P7/649 , C12Y114/19002 , C12Y301/03002 , Y02E50/13 , Y02T50/678
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.

5. 发明授权

US09551017B2 Structuring fats and methods of producing structuring fats 有权
标题翻译：构建脂肪和生产结构脂肪的方法
公开(公告)号：US09551017B2
公开(公告)日：2017-01-24
申请号：US14975137
申请日：2015-12-18
申请人： TerraVia Holdings, Inc.
发明人： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC分类号： C12N1/12 , C12P7/64 , C12N9/02 , C12N9/10 , C12N9/16 , A23D9/00 , C07C57/03 , C07J9/00 , C12P33/00 , C12N15/82 , A23D9/013 , C11B1/00 , C12N9/24 , C12N15/113 , C12R1/89
CPC分类号： C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
摘要翻译：重组DNA技术用于产生产生具有所需脂肪酸谱和区域特异性或立体特异性谱的甘油三酯油的含油重组细胞。基因操作包括编码硬脂酰-ACP脱氧酶，δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮酰基-ACP合成酶和溶血磷脂酰基转移酶的那些。所生产的油可以具有增强的氧化或热稳定性，或可用作煎炸油，起酥油，卷入起酥油，回火脂肪，可可脂替代物，润滑剂或用作各种化学方法的原料。脂肪酸分布可以富集中链型，或者油可富含饱和不饱和饱和型甘油三酸酯。

6. 发明申请

US20160376617A1 MICROBIAL OILS WITH LOWERED POUR POINTS, DIELECTRIC FLUIDS PRODUCED THEREFROM, AND RELATED METHODS 审中-公开
标题翻译：具有较低PO点的微生物油，其生产的介电流体及相关方法
公开(公告)号：US20160376617A1
公开(公告)日：2016-12-29
申请号：US15179253
申请日：2016-06-10
申请人： TerraVia Holdings, Inc.
发明人： Scott Franklin , Walter Rakitsky , George Rudenko , Xinhua Zhao , Felipe Arana Rodriguez , Wenhua Lu , Janice Wee
IPC分类号： C12P7/64 , H01F27/32 , C12N15/79 , A23D9/02 , H01B3/20 , C12N9/42
CPC分类号： C12P7/6463 , A23D9/007 , A23D9/02 , C10M169/041 , C11B1/025 , C11B1/06 , C11B1/10 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/06 , C11B3/10 , C11B3/14 , C12N9/2442 , C12N15/79 , C12P7/6409 , C12Y301/02014 , H01B3/20 , H01F27/105 , H01F27/321
摘要： Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a lipid pathway modification enzyme, a fatty acyl-ACP thioesterase, a desaturase, a fatty acyl-CoA/aldehyde reductase, and/or an acyl carrier protein are useful in manufacturing dielectric fluids.
摘要翻译：提供了由微生物产生的脂质生产介电流体的方法和组合物，包括含油微生物和这种微生物的低成本培养方法。含有编码例如蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖分解酶，脂质途径修饰酶，脂肪酰基-ACP硫酯酶，去饱和酶，脂肪酰辅酶A /醛的外源基因的微藻细胞还原酶和/或酰基载体蛋白质可用于制造介电流体。

7. 发明申请

US20170145450A1 STRUCTURING FATS AND METHODS OF PRODUCING STRUCTRING FATS 有权
公开(公告)号：US20170145450A1
公开(公告)日：2017-05-25
申请号：US15369557
申请日：2016-12-05
申请人： TerraVia Holdings, Inc.
发明人： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC分类号： C12P7/64
CPC分类号： C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsatturated-saturated type.

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