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1. 发明授权

US5267562A Pulse oximeter with probe difference compensation 失效
标题翻译：带探头差异补偿的脉搏血氧仪
公开(公告)号：US5267562A
公开(公告)日：1993-12-07
申请号：US925636
申请日：1992-08-07
申请人： Teiji Ukawa , Sunao Takeda , Hideo Ozawa
发明人： Teiji Ukawa , Sunao Takeda , Hideo Ozawa
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495
CPC分类号： A61B5/14551 , A61B2562/085
摘要： A pulse oximeter of the present invention is to provide a greatly simplified in construction and a simplified procedure for performing arithmetic operations. The pulse oximeter of the present invention comprises a light-emitting diode which is provided in a probe and that illuminates a living tissue with red light of a reference wavelength, a light-emitting diode that illuminates the living tissue with infrared light, a light-receiving device that detects the optical output that remains after the living tissue absorbs the two wavelengths of red light and infrared light that have been issued from the light-emitting diodes, detectors which, on the basis of the detection output of the light-receiving device, compute the pulsating components of absorbances for the two wavelengths, a multiplier that multiplies the value from the detector by an appropriate coefficient in order to adjust that the value detected when using red light of a wavelength offset from the reference wavelength is gain-adjusted for correction to a known value obtained when using red light of the reference wavelength, a computing means that computes an absorbance ratio using both the value after gain adjustment that is delivered from the multiplier and the value from the detector, and a computing means that computes the oxygen saturation of arterial blood using the computed value. Information on the coefficient is provided by resistor which is built in the probe.
摘要翻译：本发明的脉搏血氧计是提供大大简化的结构和简化的程序来执行算术运算。本发明的脉搏血氧计包括：设置在探头中的发光二极管，用参考波长的红光照射生物体组织;发光二极管，用红外光照射生物体组织;发光二极管，接收装置，其检测在生物体组织吸收从发光二极管发出的红色光和红外光的两个波长后残留的光输出;检测器，其基于受光装置的检测输出，计算两个波长的吸光度的脉动分量，乘法器将来自检测器的值乘以适当的系数，以便调节当使用偏离参考波长的波长的红色光检测到的值被增益调整对使用参考波长的红光获得的已知值的校正，使用计算吸光度比的计算装置从乘法器递送的增益调整之后的值和来自检测器的值，以及使用计算值计算动脉血氧饱和度的计算装置。关于系数的信息由内置在探头中的电阻提供。

2. 发明授权

US5255686A Continuous noninvasive blood pressure measuring apparatus and method 失效
标题翻译：连续无创血压测量仪及方法
公开(公告)号：US5255686A
公开(公告)日：1993-10-26
申请号：US907795
申请日：1992-07-02
申请人： Sunao Takeda , Hideo Ozawa , Mitsushi Hyogo , Yoshinobu Nakae
发明人： Sunao Takeda , Hideo Ozawa , Mitsushi Hyogo , Yoshinobu Nakae
IPC分类号： A61B5/022 , A61B5/0225 , A61B5/00
CPC分类号： A61B5/0225
摘要： In a continuous noninvasive blood pressure measuring apparatus, a systolic pressure, diastolic pressure, and mean arterial pressure for calibration are measured according to the output of a pressure sensor, a cuff pressure is set lower than the diastolic pressure by a cuff pressure control section, and a reference pulse wave is obtained from the arithmetic means of a plurality of cuff pulse waves. A CPU calculates the peak value and the bottom value of the reference pulse wave, and a cuff pressure mean value corresponding to the D.C. component of the reference pulse wave, and further calculates coefficients which are used to allow the peak value, bottom value and cuff pressure mean value thus obtained to correspond to correspond to the systolic pressure, diastolic pressure, and mean arterial pressure, respectively. The CPU calculates according to the output of a temperature sensor a cuff pressure temperature compensation value for compensating for an amount of variation of the cuff pressure which varies with the temperature of the cuff. In addition, the CPU, while compensating the cuff pressure, which is read continuously, with the cuff pressure temperature compensation value, continuously calculates a blood pressure by utilizing the cuff pressure thus compensated, and the coefficients provided by the coefficient calculating section, and the cuff pulse waves read continuously.
摘要翻译：在连续无创血压测定装置中，根据压力传感器的输出来测量收缩压，舒张压和用于校准的平均动脉压，通过袖带压力控制部将袖带压设定为低于舒张压，并且从多个袖带脉冲波的运算装置获得参考脉搏波。 CPU计算参考脉搏波的峰值和底值，以及与参考脉搏波的直流分量对应的袖带压力平均值，并进一步计算用于允许峰值，底值和袖带由此获得的压力平均值分别对应于收缩压，舒张压和平均动脉压。 CPU根据温度传感器的输出计算袖带压力温度补偿值，用于补偿袖带压力的变化量随袖带的温度而变化。此外，CPU在通过袖带压力温度补偿值连续读取补偿袖带压力的同时，通过利用这样补偿的袖带压力连续计算血压，并且由系数计算部提供的系数和袖带脉搏波连续读取。

3. 发明授权

US09304088B2 Method and apparatus for measuring PH of solution 有权
标题翻译：测量溶液PH值的方法和装置
公开(公告)号：US09304088B2
公开(公告)日：2016-04-05
申请号：US13400106
申请日：2012-02-19
申请人： Mitsuhiro Oura , Teruo Okano , Tatsuya Shimizu , Hirotsugu Kubo , Sunao Takeda , Shinji Yamamori
发明人： Mitsuhiro Oura , Teruo Okano , Tatsuya Shimizu , Hirotsugu Kubo , Sunao Takeda , Shinji Yamamori
IPC分类号： G01N21/80 , G01N31/22 , G01N21/31 , C12M1/34
CPC分类号： G01N21/80 , C12M41/26 , G01N21/3151 , G01N31/221 , G01N2201/0627 , G01N2201/1211
摘要： A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.
摘要翻译：测量溶液的pH的方法包括：在测量区域中的溶液脉动的同时，从混合有指示剂的溶液的测量区域的一侧发射两个波长的光束; 在所述测量区域中的所述溶液脉动的同时，在所述测量区域的另一侧上接收所发射的光束的透射光束和反射光束中的至少一个; 基于所接收的所述透射光束和所述反射光束中的至少一个，获得所述两个波长的吸光度; 从所获得的吸光度获得吸光度比; 并且基于所获得的吸光度比和预先存储的吸光度比/ pH值对应数据库来计算溶液的pH值。

4. 发明授权

US08420028B2 Cell isolation apparatus 有权
标题翻译：细胞分离装置
公开(公告)号：US08420028B2
公开(公告)日：2013-04-16
申请号：US13214774
申请日：2011-08-22
申请人： Akane Suzuki , Takahiro Shioyama , Sunao Takeda
发明人： Akane Suzuki , Takahiro Shioyama , Sunao Takeda
IPC分类号： A61B10/00
CPC分类号： G01N1/286 , G01N1/38 , G01N15/14 , G01N2001/085 , G01N2001/2866
摘要： A cell isolation apparatus includes: a cylinder member that is inserted into a container into which a reagent is to be introduced; a net which is stretched over the cylinder member; a tissue acquiring unit that is projected from the cylinder member; and a bottom lid portion that is configured by a bottomed pipe in which a first hole that communicates an interior with an exterior is formed, and that is fitted to a bottom portion of the cylinder member in a state where the net and the tissue acquiring unit are accommodated.
摘要翻译：细胞隔离装置包括：插入到待引入试剂的容器中的圆筒构件; 在气缸构件上拉伸的网; 组织获取单元，其从所述圆筒构件突出; 以及底盖部，其由形成有与内部连通的第一孔的有底管构成，并且在所述网和所述组织获取单元的状态下嵌合到所述筒构件的底部，被容纳。

5. 发明授权

US07713197B2 Pressure measuring method, pressure measuring device, and tonometer 有权
标题翻译：压力测量方法，压力测量装置和眼压计
公开(公告)号：US07713197B2
公开(公告)日：2010-05-11
申请号：US11578910
申请日：2005-03-18
申请人： Makoto Nakai , Sunao Takeda , Akihiko Uchiyama , Kenji Yanashima , Akihiro Fujita , Itaru Yoshizawa
发明人： Makoto Nakai , Sunao Takeda , Akihiko Uchiyama , Kenji Yanashima , Akihiro Fujita , Itaru Yoshizawa
IPC分类号： A61B3/16 , G01L7/00 , G01L9/00 , G01L11/00 , G01L13/00 , G01L15/00 , G01L17/00 , G01L19/00 , G01L21/00 , G01L21/02
CPC分类号： G01L9/0022 , A61B3/16 , A61B5/0051 , G01L9/008
摘要： A tonometry device includes a contact device for contacting the object, means for vibrating the contact device and the object, means for applying a voltage to the vibration means, means for measuring a current flowing through the vibration means, and an information processing means. The information processing means determines two resonance points of the device and the measured object by measuring current through the system at a plurality of vibrational frequencies. The information processing means then determines the internal pressure of the object by determining that a first pressure is higher than a second pressure by determining that the first pressure has a lower measured current than the second pressure at frequencies outside of the range of frequencies between the resonance points, and that the first pressure has a higher measured current than the second pressure at frequencies within the range of frequencies between the resonance points.
摘要翻译：测压装置包括用于接触物体的接触装置，用于振动接触装置和物体的装置，用于向振动装置施加电压的装置，用于测量流过振动装置的电流的装置，以及信息处理装置。信息处理装置通过以多个振动频率测量通过系统的电流来确定装置和被测物体的两个共振点。信息处理装置然后通过确定第一压力高于第二压力来确定对象的内部压力，通过确定第一压力具有比谐振频率范围之外的频率处的第二压力低的测量电流并且第一压力在谐振点之间的频率范围内的频率处具有比第二压力更高的测量电流。

6. 发明授权

US6008239A Triazole derivative or salt thereof 失效
标题翻译：三唑衍生物或其盐
公开(公告)号：US6008239A
公开(公告)日：1999-12-28
申请号：US135163
申请日：1998-08-17
申请人： Yasushi Kaneko , Sunao Takeda , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
发明人： Yasushi Kaneko , Sunao Takeda , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
IPC分类号： A01N43/653 , C07D249/08 , C07D521/00 , A61K31/505
CPC分类号： C07D231/12 , A01N43/653 , C07D233/56 , C07D249/08
摘要： Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a lower alkyl group or an aralkyl group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aralkyl group or an acyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a trifluoromethyl group, n stands for an integer of 0 to 2 and m stands for an integer of 1 to 5, or salt thereof; and also a pharmaceutical comprising the derivative or salt thereof as an effective ingredient. The compound as described above has a high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
摘要翻译：描述了由式（1）表示的三唑衍生物：其中R1表示低级烷基或芳烷基，R2表示氢原子，低级烷基，芳烷基或酰基，X1和X2相同或不同，各自独立地表示氢原子，卤素原子或三氟甲基，n表示0〜2的整数，m表示1〜5的整数，或其盐。以及包含其衍生物或其盐作为有效成分的药物。如上所述的化合物具有高的抗真菌活性，并且可用于预防和治疗哺乳动物真菌感染。

7. 发明授权

US5430028A 5-aminoquinolone carboxylic acid derivative and antibacterial agent containing the same as active ingredient 失效
标题翻译： 5-氨基喹诺酮羧酸衍生物和含有活性成分的抗菌剂
公开(公告)号：US5430028A
公开(公告)日：1995-07-04
申请号：US185898
申请日：1994-01-26
申请人： Terumitsu Kaihoh , Sunao Takeda , Fujiko Konno , Akihiro Shibata , Masaru Matsumoto , Takemitsu Asaoka , Hideaki Matsuda , Tadayuki Kuraishi
发明人： Terumitsu Kaihoh , Sunao Takeda , Fujiko Konno , Akihiro Shibata , Masaru Matsumoto , Takemitsu Asaoka , Hideaki Matsuda , Tadayuki Kuraishi
IPC分类号： A61K31/47 , A61K31/495 , C07D215/56 , C07D401/04 , A61K31/55 , A61K31/505 , C07D243/00 , C07D243/08
CPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , C07D401/04
摘要： A 5-aminoquinolone carboxylic acid derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means a hydrogen atom, an amino group, a linear or branched alkyl group having 1-5 carbon atoms and an alkylamino group containing a linear or branched alkyl group having 1-5 carbon atoms, R.sup.2 denotes a hydrogen atom or a linear or branched alkyl group having 1-5 carbon atoms, X stands for a halogen atom, Y means CH.sub.2, NH, CHR.sup.3 NR.sup.3, (R.sup.3 denoting a linear or branched alkyl group having 1-5 carbon atoms) or an oxygen atom, and Z stands for an oxygen atom or 2 hydrogen atoms, or a salt thereof, and an antibacterial agent containing such a derivative or salt as an active ingredient.The derivative or salt thereof exhibits strong anti-bacterial activities against Grampositive bacteria including tolerant bacteria, and is satisfactorily absorbed in a living body.
摘要翻译： PCT No.PCT / JP93 / 00694 Sec。 371日期1994年1月26日 102（e）日期1994年1月26日PCT提交1993年5月25日PCT公布。出版物WO93 / 24460 PCT 日期：1993年12月9日，下列通式（1）表示的5-氨基喹诺酮羧酸衍生物：其中R 1表示氢原子，氨基，直链或支链烷基， 5个碳原子和含有1-5个碳原子的直链或支链烷基的烷基氨基，R2表示氢原子或具有1-5个碳原子的直链或支链烷基，X表示卤素原子，Y表示CH2 ，NH，CHR 3 NR 3，（R3表示具有1-5个碳原子的直链或支链烷基）或氧原子，Z表示氧原子或2个氢原子，或其盐，以及含有这些的抗菌剂衍生物或盐作为活性成分。其衍生物或盐对包括耐受性细菌的细菌性细菌表现出强的抗菌活性，并且令人满意地吸收在生物体内。

8. 发明申请

US20120214250A1 METHOD AND APPARATUS FOR MEASURING PH OF SOLUTION 有权
标题翻译：用于测量溶液PH值的方法和装置
公开(公告)号：US20120214250A1
公开(公告)日：2012-08-23
申请号：US13400106
申请日：2012-02-19
申请人： Mitsuhiro Oura , Teruo Okano , Tatsuya Shimizu , Hirotsugu Kubo , Sunao Takeda , Shinji Yamamori
发明人： Mitsuhiro Oura , Teruo Okano , Tatsuya Shimizu , Hirotsugu Kubo , Sunao Takeda , Shinji Yamamori
IPC分类号： G01N21/59
CPC分类号： G01N21/80 , C12M41/26 , G01N21/3151 , G01N31/221 , G01N2201/0627 , G01N2201/1211
摘要： A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances ; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.
摘要翻译：测量溶液的pH的方法包括：在测量区域中的溶液脉动的同时，从混合有指示剂的溶液的测量区域的一侧发射两个波长的光束; 在所述测量区域中的所述溶液脉动的同时，在测量区域的另一侧上接收发射光束的透射光束和反射光束中的至少一个; 基于所接收的所述透射光束和所述反射光束中的至少一个，获得所述两个波长的吸光度; 从所获得的吸光度获得吸光度比; 并且基于所获得的吸光度比和预先存储的吸光度比/ pH值对应数据库来计算溶液的pH值。

9. 发明授权

US06737434B2 Imidazole derivatives or their salts 失效
标题翻译：咪唑衍生物或其盐
公开(公告)号：US06737434B2
公开(公告)日：2004-05-18
申请号：US10380828
申请日：2003-03-19
申请人： Minoru Tokizawa , Sunao Takeda , Yasushi Kaneko , Koji Kusano , Hiromichi Eto , Koichi Tachibana , Susumu Sato , Tadayoshi Taniyama
发明人： Minoru Tokizawa , Sunao Takeda , Yasushi Kaneko , Koji Kusano , Hiromichi Eto , Koichi Tachibana , Susumu Sato , Tadayoshi Taniyama
IPC分类号： C07D23360
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08
摘要： Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R1 is lower alkyl; R2 is alkyl or aralkyl; and X1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.
摘要翻译：式（1）的咪唑衍生物或其盐，含有衍生物或盐的药物，以及用于合成衍生物或盐的中间体（其中R 1为低级烷基; R 2为烷基或芳烷基; X 1为卤素）。这些化合物表现出G-CSF样活性，可代替G-CSF制剂。

10. 发明授权

US06194592B1 Triazole derivative or salt thereof, preparation process thereof and pharmaceutical containing said compound as an effective ingredient 失效
公开(公告)号：US06194592B1
公开(公告)日：2001-02-27
申请号：US09551569
申请日：2000-04-18
申请人： Sunao Takeda , Yasushi Kaneko , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
发明人： Sunao Takeda , Yasushi Kaneko , Minoru Tokizawa , Hiromichi Eto , Kazuya Ishida , Kazunori Maebashi , Masaru Matsumoto , Takemitsu Asaoka , Susumu Sato
IPC分类号： C07D30334
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D303/48
摘要： Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

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