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1. 发明申请

US20100105904A1 UREA TYPE CINNAMIDE DERIVATIVE 审中-公开
标题翻译：尿素类型CINNAMIDE衍生物
公开(公告)号：US20100105904A1
公开(公告)日：2010-04-29
申请号：US12301428
申请日：2007-05-18
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Takehiko Miyagawa , Nobuaki Sato , Toshihiko Kaneko , Kogyoku Shin , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Takehiko Miyagawa , Nobuaki Sato , Toshihiko Kaneko , Kogyoku Shin , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： C07D233/64 , C07D405/12 , C07D403/10
CPC分类号： C07D233/64 , C07D249/06 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/10 , C07D405/12
摘要： Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group; X1 represents a single bond; R1 and R2 respectively represent a C1-6 alkyl group or the like which may be substituted with a substituent such as a 5- to 14-membered aromatic heterocyclic group; and R3 represents a hydrogen atom or the like.)
摘要翻译：公开了由下式（I）表示的化合物或其药理学上可接受的盐。还公开了化合物或盐作为药物产品的用途。（式中，Ar 1表示可被C 1-6烷基取代的咪唑基，Ar 2表示可被C 1-6烷氧基取代的苯基，X 1表示单键; R 1，R 2分别表示可以被诸如5至14元芳族杂环基团的取代基取代的C 1-6烷基等; R 3表示氢原子等。

2. 发明申请

US20090203697A1 HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE 审中-公开
标题翻译：杂环型CINNAMIDE衍生物
公开(公告)号：US20090203697A1
公开(公告)日：2009-08-13
申请号：US12301421
申请日：2007-05-18
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Takehiko Miyagawa , Nobuaki Sato , Toshihiko Kaneko , Kogyoku Shin , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Takehiko Miyagawa , Nobuaki Sato , Toshihiko Kaneko , Kogyoku Shin , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： A61K31/5377 , A61K31/4353 , A61K31/4439 , C07D413/10 , C07D455/02 , C07D401/10 , C07D413/14 , C07D401/14
CPC分类号： C07D249/08 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , C07D471/04
摘要： Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like; Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group or the like; X1 represents —CR3═CR4— (wherein R3 and R4 respectively represent a C1-6 alkyl group or the like); and R1 and R2 respectively represent a C1-6 alkyl group or the like.)
摘要翻译：公开了由下式（I）表示的化合物或其药理学上可接受的盐。还公开了化合物或盐作为药物产品的用途。（式中，Ar 1表示可被C 1-6烷基等取代的三唑基等，Ar 2表示可被C 1-6烷氧基等取代的苯基等） ; X1表示-CR3-CR4-（其中R3和R4分别表示C1-6烷基等），R1和R2分别表示C1-6烷基等）。

3. 发明申请

US20110086860A1 COMPOUND 审中-公开
标题翻译：复合
公开(公告)号：US20110086860A1
公开(公告)日：2011-04-14
申请号：US12974447
申请日：2010-12-21
申请人： Teiji KIMURA , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji KIMURA , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： A61K31/497 , C07D233/54 , C07D403/10 , C07D401/04 , C07D241/00 , A61K31/4164 , A61K31/4178 , A61K31/454 , A61P25/28
CPC分类号： C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要： A compound represented by Formula (I) is provided: wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc., which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group which may be substituted, or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.
摘要翻译：提供由式（I）表示的化合物：其中Ar 1表示可被1至3个取代基取代的咪唑基; Ar2表示可被1〜3个取代基取代的苯基; X1表示（1）-C≡C-或（2）双键等，其可以被取代; R1和R2表示例如可被取代的C1-6烷基或其药理学上可接受的盐及其作为药剂的用途。

4. 发明授权

US07880009B2 Cinnamide compound 有权
标题翻译：桂酰胺化合物
公开(公告)号：US07880009B2
公开(公告)日：2011-02-01
申请号：US11596723
申请日：2005-05-25
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： C07D405/00 , A61K31/445
CPC分类号： C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.
摘要翻译：本发明涉及由式（I）表示的化合物：其中Ar 1表示可被1〜3个取代基取代的咪唑基; Ar 2表示吡啶基，嘧啶基或可被 1〜3个取代基; X1表示（1）-C≡C-或（2）可被取代的双键等; R 1和R 2表示例如C 1-6烷基或C 3-8环烷基，可以被取代）或其药理学上可接受的盐及其作为药剂的用途。

5. 发明申请

US20060004013A1 Cinnamide compound 失效
标题翻译：桂酰胺化合物
公开(公告)号：US20060004013A1
公开(公告)日：2006-01-05
申请号：US11136355
申请日：2005-05-25
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： A61K31/498 , A61K31/4745 , A61K31/46
CPC分类号： C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents. The object of the present invention is to find a therapeutic or preventive agent for diseases caused by Aβ. According to the present invention, a therapeutic or preventive agents for diseases caused by Aβ can be provided.
摘要翻译：本发明涉及由式（I）表示的化合物：（其中Ar 1代表可被1至3个取代基取代的咪唑基; Ar 2表示吡啶基，嘧啶基或可被1至3个取代基取代的苯基; X 1表示（1）-C≡C-或（2）双键等，其可以被取代; R 1和R 2表示例如可以被取代的C 1-6烷基或C 3-8环烷基）或其药理学上可接受的盐以及作为药剂的用途。本发明的目的是找到由Abeta引起的疾病的治疗或预防剂。根据本发明，可以提供由Abeta引起的疾病的治疗或预防剂。

6. 发明申请

US20080070902A1 Cinnamide Compound 有权
标题翻译：桂酰胺化合物
公开(公告)号：US20080070902A1
公开(公告)日：2008-03-20
申请号：US11596723
申请日：2005-05-25
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： A61K31/4164 , A61K31/4439 , A61K31/445 , A61K31/535 , A61K31/55 , A61P25/28 , A61P3/00 , A61P43/00 , C07D233/66 , C07D401/10 , C07D403/10 , C07D413/10
CPC分类号： C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.
摘要翻译：本发明涉及由式（I）表示的化合物：（其中Ar 1代表可被1至3个取代基取代的咪唑基; Ar 2表示吡啶基，嘧啶基或可被1至3个取代基取代的苯基; X 1表示（1）-C≡C-或（2）双键等，其可以被取代; R 1和R 2表示例如可以被取代的C 1-6烷基或C 3-8环烷基）或其药理学上可接受的盐以及作为药剂的用途。

7. 发明授权

US07687640B2 Cinnamide compound 失效
标题翻译：桂酰胺化合物
公开(公告)号：US07687640B2
公开(公告)日：2010-03-30
申请号：US12497251
申请日：2009-07-02
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： C07D233/56 , A01N43/50
CPC分类号： C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention relates to a process for preparing a compound of formula (6a): wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents shown below; Ar2 represents a pyridinyl group, a pyrimidinyl group or a phenyl group which may be substituted with 1 to 3 substituents; and R11 represents a group selected from certain substituents.
摘要翻译：本发明涉及式（6a）化合物的制备方法：其中Ar 1表示可被1〜3个取代基取代的咪唑基， Ar 2表示吡啶基，嘧啶基或可被1〜3个取代基取代的苯基; R 11表示选自某些取代基的基团。

8. 发明授权

US07667041B2 Cinnamide compound 失效
标题翻译：桂酰胺化合物
公开(公告)号：US07667041B2
公开(公告)日：2010-02-23
申请号：US11136355
申请日：2005-05-25
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Hiroaki Hagiwara
IPC分类号： C07D401/00 , A61K31/54
CPC分类号： C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents. The object of the present invention is to find a therapeutic or preventive agent for diseases caused by Aβ. According to the present invention, a therapeutic or preventive agents for diseases caused by Aβ can be provided.
摘要翻译：本发明涉及由式（I）表示的化合物：其中Ar 1表示可被1〜3个取代基取代的咪唑基; Ar 2表示吡啶基，嘧啶基或可被 1〜3个取代基; X1表示（1）-C≡C-或（2）可被取代的双键等; R 1和R 2表示例如C 1-6烷基或C 3-8环烷基，可以被取代）或其药理学上可接受的盐及其作为药剂的用途。本发明的目的是找到由A＆Bgr引起的疾病的治疗或预防剂。根据本发明，由A＆Bgr引起的疾病的治疗或预防剂; 可以提供。

9. 发明授权

US08530504B2 Pyrazolothiazole compound 失效
标题翻译：吡唑并噻唑化合物
公开(公告)号：US08530504B2
公开(公告)日：2013-09-10
申请号：US12900026
申请日：2010-10-07
申请人： Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda , Kodo Shikata , Akira Inomata
发明人： Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda , Kodo Shikata , Akira Inomata
IPC分类号： A61K31/429 , A61P25/24
CPC分类号： C07D513/04
摘要： A compound represented by the formula (I) or pharmacologically acceptable salt thereof exhibits an excellent CRF receptor antagonism wherein X is a nitrogen atom or CH; R1 is -A11-A12; A11 is a single bond or a C1-6 alkylene group; A12 is a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group, etc.; R2 is -A21-A22; A21 is a single bond or a C1-6 alkylene group; A22 is a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a non-aromatic heterocyclic group, or a heteroaryl group, etc.; R3 is a C1-6 alkyl group, a C3-6 cycloalkyl group, a C1-6 alkoxy group, a C3-6 cycloalkoxy C1-6 alkyl group, di-C1-6 alkyl amino group, a halogen atom, a cyano group, a formyl group, or a carboxyl group, etc; R4 is a hydrogen atom or a C1-6 alkoxy group; R5 is a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R6 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, or a C1-6 alkyl sulfinyl group etc.; and R7 is a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 alkylthio group.
摘要翻译：由式（I）表示的化合物或其药理学上可接受的盐表现出优异的CRF受体拮抗作用，其中X为氮原子或CH; R1为-A11-A12; A11是单键或C1-6亚烷基; A12是氢原子，C1-6烷基或C3-6环烷基等; R2为-A21-A22; A21是单键或C1-6亚烷基; A22为氢原子，C1-6烷基，C3-6环烷基，非芳族杂环基或杂芳基等; R3是C1-6烷基，C3-6环烷基，C1-6烷氧基，C3-6环烷氧基C1-6烷基，二C1-6烷基氨基，卤素原子，氰基，甲酰基或羧基等; R4是氢原子或C1-6烷氧基; R5是卤素原子，C1-6烷基或C1-6烷氧基; R6是氢原子，C1-6烷基，C1-6烷氧基，C1-6烷硫基或C1-6烷基亚磺酰基等; 且R 7为C 1-6烷基，C 1-6烷氧基或C 1-6烷硫基。

10. 发明授权

US07772249B2 Imidazo[1,2-b]pyridazine compound 失效
标题翻译：咪唑并[1,2-b]哒嗪化合物
公开(公告)号：US07772249B2
公开(公告)日：2010-08-10
申请号：US12397132
申请日：2009-03-03
申请人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物或其盐。其中R1表示氢原子，C1-6烷基，C1-6烷氧基等; R2表示卤素原子，氰基，硝基，C1-10烷基，C2-10烯基，C2-10炔基等; R3表示可以具有取代基的C 6-14芳族烃环状基团或5〜14元芳香族杂环基团。 X，Y和X彼此独立地表示N或CR4（其中R4表示氢原子，卤素原子，氰基，硝基，任意卤代的C 1-6烷基等）和在这种情况下，X，Y和Z中的至少两个表示CR 4。

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