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1. 发明授权

US5064760A Process for the production of an imidazoledione compound by a strain of Streptomyces hygroscopicus 失效
标题翻译：通过溶菌酶抑制剂生产咪唑烷化合物的方法
公开(公告)号：US5064760A
公开(公告)日：1991-11-12
申请号：US537510
申请日：1990-06-13
申请人： Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Takao Okazaki , Manbu Tohjigamori , Katsuhiko Kawakubo
发明人： Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Takao Okazaki , Manbu Tohjigamori , Katsuhiko Kawakubo
IPC分类号： A01N63/02 , A01N63/00 , C07G11/00 , C12N1/20 , C12P1/06 , C12R1/55
CPC分类号： C12P1/06 , Y10S435/898
摘要： A new compound, named Substance No. 51262, may be produced by cultivating a suitable microorganism of the genus Streptomyces, especially the new strain SANK 63584 (FERM BP-958). Said compound has herbicidal and growth retardant properties. Said compound has the following structural formula: ##STR1##

2. 发明授权

US4952234A Imidazoledione compounds useful as herbicides 失效
标题翻译：可用作除草剂的咪唑二酮化合物
公开(公告)号：US4952234A
公开(公告)日：1990-08-28
申请号：US227433
申请日：1988-07-29
申请人： Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Takao Okazaki , Manbu Tohjigamori , Katsuhiko Kawakubo
发明人： Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Takao Okazaki , Manbu Tohjigamori , Katsuhiko Kawakubo
IPC分类号： A01N63/02 , A01N63/00 , C07G11/00 , C12N1/20 , C12P1/06 , C12R1/55
CPC分类号： C12P1/06 , Y10S435/898
摘要： A new compound, named Substance No. 51262, may be produced by cultivating a suitable microorganism of the genus Streptomyces, especially the new strain SANK 63584 (FERM BP-958). Said compound has herbicidal and growth retardant properties. Said compound has the following structural formula: ##STR1##
摘要翻译：可以通过培养链霉菌属的合适的微生物，特别是新菌株SANK 63584（FERM BP-958）来生产名为物质号51262的新化合物。所述化合物具有除草和生长阻滞性能。所述化合物具有以下结构式：

3. 发明授权

US5013550A Antibiotics called "chloropolysporins B and C", a process for their preparation, and their therapeutic and veterinary use 失效
标题翻译：抗生素称为“氯霉素B和C”，其制备方法及其治疗和兽医用途
公开(公告)号：US5013550A
公开(公告)日：1991-05-07
申请号：US475688
申请日：1990-02-06
申请人： Tatsuo Haneishi , Takao Okazaki , Akio Torikata , Mutsuo Nakajima
发明人： Tatsuo Haneishi , Takao Okazaki , Akio Torikata , Mutsuo Nakajima
IPC分类号： C12P21/02 , A61K35/74 , A61K38/00 , C07K9/00 , C07K14/195 , C07K14/41 , C12P21/04 , C12R1/01
CPC分类号： C12R1/01 , C07K9/008 , A61K38/00
摘要： Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). They may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.

4. 发明授权

US4918054A Antibiotics called `chloropolysporins B and C`, a process for their preparation, and their therapeutic and veterinary use 失效
标题翻译：抗生素称为“氯霉素B和C”，其制备方法及其治疗和兽医用途
公开(公告)号：US4918054A
公开(公告)日：1990-04-17
申请号：US379656
申请日：1989-07-11
申请人： Tatsuo Haneishi , Takao Okazaki , Akio Torikata , Mutsuo Nakajima , Ryuzo Enokita , Toshiaki Katayama , Seigo Iwado
发明人： Tatsuo Haneishi , Takao Okazaki , Akio Torikata , Mutsuo Nakajima , Ryuzo Enokita , Toshiaki Katayama , Seigo Iwado
IPC分类号： C12P21/02 , A61K35/74 , A61K38/00 , C07K9/00 , C07K14/195 , C07K14/41 , C12P21/04 , C12R1/01
CPC分类号： C12R1/01 , C07K9/008 , A61K38/00
摘要： Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of miroorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). They may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.
摘要翻译：称为氯霉素B和C的新化合物及其盐具有抗生素性质，并且似乎是含有氯的糖肽抗生素类的成员。它们可以通过培养合适的微孢子虫微生物菌株而产生，特别是微孢子虫（Micropolyspora sp。）。 SANK 60983（FERM BP-538）。它们可以与用于治疗用途的常规药学上可接受的载体或稀释剂组合，或并入可食用赋形剂如饲料或水中，用作生长促进剂，特别是用于农场动物。

5. 发明授权

US4557933A Antibiotic called "chloropolysporin", a process for its preparation, and its therapeutic and veterinary use 失效
标题翻译：抗生素称为“氯聚球蛋白”，其制备方法及其治疗和兽医用途
公开(公告)号：US4557933A
公开(公告)日：1985-12-10
申请号：US627439
申请日：1984-07-03
申请人： Tatsuo Haneishi , Takao Okazaki , Akio Torikata , Mutsuo Nakajima , Ryuzou Enokita , Toshiaki Katayama , Seigo Iwado
发明人： Tatsuo Haneishi , Takao Okazaki , Akio Torikata , Mutsuo Nakajima , Ryuzou Enokita , Toshiaki Katayama , Seigo Iwado
IPC分类号： C07G11/00 , A23K20/195 , A61K35/74 , A61P31/04 , C12P1/06 , C12P21/00 , C12R1/01
CPC分类号： C12P21/005 , A23K20/195 , C12P1/06
摘要： A novel compound, called chloropolysporin, has antibiotic properties and would appear to be a member of the class of glycopeptide antibiotics containing chlorine. It may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). It may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.
摘要翻译：一种称为氯聚球蛋白的新化合物具有抗生素特性，似乎是含有氯的糖肽类抗生素类的成员。可以通过培养合适的微孢子虫微生物菌株，特别是微孢子虫（Micropolyspora sp。 SANK 60983（FERM BP-538）。其可以与用于治疗用途的常规药学上可接受的载体或稀释剂组合，或掺入可食用赋形剂如饲料或水中，用作生长促进剂，特别是用于农场动物。

6. 发明授权

US4336249A Antibiotic substance 失效
公开(公告)号：US4336249A
公开(公告)日：1982-06-22
申请号：US41501
申请日：1979-05-22
申请人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
发明人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P31/04 , C07G11/00 , C07K7/50 , C07K11/02 , C07K14/195 , C07K14/365 , C07K14/41 , C12P1/06 , C12R1/045 , A61K35/00
CPC分类号： C12R1/045 , C07K14/365 , C12P1/06 , Y10S435/827
摘要： A novel antibiotic substance, named "Mycoplanecin", of presently unknown structural formula, is produced by cultivating a Mycoplanecin-producing microorganism of the genus Actinoplanes, especially the Actinoplanes nov. sp. Strain No. 41042, NRRL No. 11462.

7. 发明授权

US4332902A Antibiotic substance 失效
标题翻译：抗生素
公开(公告)号：US4332902A
公开(公告)日：1982-06-01
申请号：US197788
申请日：1980-10-17
申请人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
发明人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P31/04 , C07G11/00 , C07K7/50 , C07K11/02 , C07K14/195 , C07K14/365 , C07K14/41 , C12P1/06 , C12R1/045 , C12N1/20
CPC分类号： C12R1/045 , C07K14/365 , C12P1/06 , Y10S435/827
摘要： A novel antibiotic substance, named "Mycoplanecin", of presently unknown structural formula, is produced by cultivating a Mycoplanecin-producing microorganism of the genus Actinoplanes, especially the Actinoplanes nov. sp. Strain No. 41042, NRRL No. 11462.
摘要翻译：目前未知的结构式的名为“Mycoplanecin”的新型抗生素物质是通过培养生长在肌球蛋白的肌球蛋白生成微生物，尤其是Actinoplanes nov。 sp。菌株41042，NRRL No.11462。

8. 发明授权

US4370266A Mycoplanecin derivatives and their preparation 失效
标题翻译：髓鞘衍生物及其制备方法
公开(公告)号：US4370266A
公开(公告)日：1983-01-25
申请号：US250709
申请日：1981-04-03
申请人： Mamoru Arai , Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Ryuzo Enokita
发明人： Mamoru Arai , Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Ryuzo Enokita
IPC分类号： A61K38/00 , C07K7/06 , C12P21/04 , C07C103/52
CPC分类号： C12R1/045 , C07K7/06 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： Mycoplanecin derivatives of formula (I): ##STR1## [wherein: R represents a hydrogen atom, an N-(.alpha.-ketobutyryl)-N-methylvalyl group or an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group;R.sup.1 represents a methyl group or an ethyl group; andwhen R.sup.1 represents a methyl group, R.sup.2 represents an isobutyl group and, when R.sup.1 represents an ethyl group, R.sup.2 represents a pentyl group] have antibacterial activity which is particularly pronounced against bacteria of the genus Mycobacterium. The compounds in which R represents and N-(.alpha.-ketobutyryl)-N-methylvalyl group, named Mycoplanecin B (R.sup.1 represents a methyl group) and Mycoplanecin C (R.sup.1 represents an ethyl group), may be prepared by cultivation of a microorganism of the genus Actinoplanes, while the compounds where R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group or a hydrogen atom can be prepared by reducing the corresponding compound where R represents an N-(.alpha.-ketobutyryl)-N-methylvalyl group or by hydrolyzing the corresponding compound where R represents an N-(.alpha.-ketobutyryl)-N-methylvalyl or N-(.alpha.-hydroxybutyryl)-N-methylvalyl group, respectively.
摘要翻译：式（I）的肌钙蛋白聚糖衍生物：其中：R表示氢原子，N-（α-酮丁酰基）-N-甲基缬氨酰基或N-（α-羟基丁酰基）-N-甲基缬氨酰基 ; R1表示甲基或乙基; 当R1表示甲基时，R2表示异丁基，当R1表示乙基时，R2表示戊基]具有对分枝杆菌属细菌特别显着的抗菌活性。其中R表示的化合物和N-（α-酮丁酰基）-N-甲基缬氨酰基，命名为Mycoplanecin B（R1表示甲基）和Mycoplanecin C（R1表示乙基））可以通过培养其中R代表N-（α-羟基丁酰基）-N-甲基缬氨酰基或氢原子的化合物可以通过还原相应的化合物来制备，其中R代表N-（α-酮丁酰基）-N-甲基缬氨酰基或通过水解相应的化合物，其中R表示N-（α-酮丁酰基）-N-甲基缬氨酰基或N-（α-羟基丁酰基）-N-甲基缬氨酰基。

9. 发明授权

US3949070A New antibiotic substance, its preparation and its use as growth promoting agents 失效
标题翻译：新型抗生素物质，其制备及其用作生长促进剂
公开(公告)号：US3949070A
公开(公告)日：1976-04-06
申请号：US545391
申请日：1975-01-30
申请人： Mamoru Arai , Akio Torikata , Hisayoshi Fukatsu , Noritoshi Kitano , Toshiaki Matsuzawa
发明人： Mamoru Arai , Akio Torikata , Hisayoshi Fukatsu , Noritoshi Kitano , Toshiaki Matsuzawa
IPC分类号： A61K35/00
CPC分类号： A61K31/7024 , A23K20/195 , A23K50/30 , A23K50/75
摘要： Antibiotic substance named "Pholipomycin" which is useful as a growth promoting agent for domestic animals, poultries and the like and produced by the cultivation of a new microorganism, Streptomyces lividoclavatus strain No. 3176, NRRL 8022.
摘要翻译：名叫“倍利宝霉素”的抗生素物质可用作家畜，禽类等的生长促进剂，通过培养新的微生物链霉菌菌株3176，NRRL8022产生。

10. 发明授权

US5399711A Thiomarinol compounds 失效
标题翻译：噻马林化合物
公开(公告)号：US5399711A
公开(公告)日：1995-03-21
申请号：US124396
申请日：1993-09-20
申请人： Shuji Takahashi , Hideyuki Shiozawa , Katsumi Fujimoto , Yuji Iwano , Koichi Hirai , Akio Torikata , Takeshi Kagasaki , Kaneo Ogawa , Yoshiharu Sakaida , Kentaro Kodama , Akira Ishii
发明人： Shuji Takahashi , Hideyuki Shiozawa , Katsumi Fujimoto , Yuji Iwano , Koichi Hirai , Akio Torikata , Takeshi Kagasaki , Kaneo Ogawa , Yoshiharu Sakaida , Kentaro Kodama , Akira Ishii
IPC分类号： A61K31/40 , C07D209/02 , C07D339/04 , C07D495/04 , C12P17/18 , C12R1/00
CPC分类号： C07D495/04
摘要： Two thiomarinol derivatives, which have antibacterial and anti-mycoplasmal properties, are obtainable from microorganisms of the genus Alteromonas and are named "thiomarinol B" and "thiomarinol C". Thiomarinol B can also be prepared by the oxidation of thiomarinol.
摘要翻译：具有抗细菌和抗支原体性质的两种硫酚醇衍生物可从益生菌属的微生物获得，并被命名为“硫叶素B”和“硫酚素C”。 Thiomarinol B也可以通过噻马林醇的氧化来制备。

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