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1. 发明授权

US5213974A Fermentation process for preparing antibiotics mureidomycins A, B, C and D 失效
标题翻译：制备抗生素mureidomycins A，B，C和D的发酵过程
公开(公告)号：US5213974A
公开(公告)日：1993-05-25
申请号：US660414
申请日：1991-02-22
申请人： Tatsuo Haneishi , Masatoshi Inukai , Keiko Shimizu , Fujio Isono , Yoshiharu Sakaida , Takeshi Kinoshita
发明人： Tatsuo Haneishi , Masatoshi Inukai , Keiko Shimizu , Fujio Isono , Yoshiharu Sakaida , Takeshi Kinoshita
IPC分类号： C12P1/06
CPC分类号： C12P1/06 , Y10S435/886
摘要： The process for producing mureidomycin A, B, C or D or a salt thereof by cultivating Streptomyces flavidovirens SANK 60486, FERM BP-1347, in a culture medium therefor and isolating mureidomycin A, B, C or D or a salt thereof from the cultured broth.
摘要翻译：通过在其培养基中培养黄色链霉菌SANK 60486，FERM BP-1347，生产mureidomycin A，B，C或D或其盐的方法，并从培养的培养基中分离mureidomycin A，B，C或D或其盐肉汤。

2. 发明授权

US5039663A Antibiotics called "mureidomycins A, B, C, and D" and their therapeutic use 失效
标题翻译：抗生素称为“mureidomycins A，B，C和D”及其治疗用途
公开(公告)号：US5039663A
公开(公告)日：1991-08-13
申请号：US253450
申请日：1988-10-04
申请人： Tatsuo Haneishi , Masatoshi Inukai , Keiko Shimizu , Fujio Isono , Yoshiharu Sakaida , Takeshi Kinoshita
发明人： Tatsuo Haneishi , Masatoshi Inukai , Keiko Shimizu , Fujio Isono , Yoshiharu Sakaida , Takeshi Kinoshita
IPC分类号： C12P1/06
CPC分类号： C12P1/06
摘要： Novel compounds, called mureidomycins A, B, C and D, may be prepared by cultivation of a suitable microorganism of the genus Streptomyces, especially Streptomyces flavidovirens SANK 60486 (FERM P-8636, FERM BP-1347). These represent a wholly new class of antibiotics, which are valuable in the treatment of infections caused by a variety of bacteria, notably of the genus Pseudomonas.
摘要翻译：称为mureidomycins A，B，C和D的新化合物可以通过培养链霉菌属（Streptomyces），特别是黄色链霉菌（Streptomyces flavidovirens）SANK 60486（FERM P-8636，FERM BP-1347）的合适的微生物来制备。这些代表了一类全新的抗生素，对于治疗由多种细菌，特别是假单胞菌属引起的感染是有价值的。

3. 发明授权

US5041423A Antibiotics of the mureidomycin group, their preparation, and their therapeutic use 失效
标题翻译： mureidomycin组的抗生素，其制备及其治疗用途
公开(公告)号：US5041423A
公开(公告)日：1991-08-20
申请号：US273199
申请日：1988-11-17
申请人： Tatsuo Haneishi , Masatoshi Inukai , Keiko Shimizu , Fujio Isono , Yoshiharu Sakaida , Takeshi Kinoshita
发明人： Tatsuo Haneishi , Masatoshi Inukai , Keiko Shimizu , Fujio Isono , Yoshiharu Sakaida , Takeshi Kinoshita
IPC分类号： A61K38/00 , C07D405/04 , C07D405/14 , C07K5/02
CPC分类号： C07D405/04 , C07D405/14 , C07K5/0217 , A61K38/00
摘要： New antibiotics of the mureidomycin group have the formula ##STR1##wherein X represents the group ##STR2##and wherein R represents hydrogen, an alkyl group having from 1 to 10 carbon atoms, an alkenyl group having from 2 to 7 carbon atoms, an alkynyl group having from 3 to 7 carbon atoms, an aryl group having from 6 to 10 carbon atoms, an aralkyl group having from 7 to 10 carbon atoms, or one of the said aryl or aralkyl groups substituted with at least one substituent selected from halogen and alkyl groups having from 1 to 5 carbon atoms. The compound in which X represents 8-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin E and the compound in which X represents 6-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin F. This group of compounds and their pharmaceutically acceptable esters and salts are useful as antibiotics for the treatment of bacterial infections. Mureidomycins E and F can be obtained by fermentation of a suitable Streptomyces strain, in particular Streptomyces flaviodovirens SANK 60486 (BIKOKEN JOHKI 1347; FERM BP-1347). Alternatively, all of the compounds can be obtained synthetically by reacting the previously known compound mureidomycin A with an aldehyde of the formulaR--CHO.

4. 发明授权

US4201769A Antibiotic substances No. 17927A.sub.1 and No. 17927A.sub.2 and process for producing the same 失效
标题翻译：抗生素物质17927A1和17927A2及其制备方法
公开(公告)号：US4201769A
公开(公告)日：1980-05-06
申请号：US882187
申请日：1978-02-28
申请人： Yasuhiro Itoh , Masaki Nakahara , Yo Takiguchi , Mamoru Arai , Tatsuo Haneishi , Masatoshi Inukai , Mutsuo Nakajima
发明人： Yasuhiro Itoh , Masaki Nakahara , Yo Takiguchi , Mamoru Arai , Tatsuo Haneishi , Masatoshi Inukai , Mutsuo Nakajima
IPC分类号： C12P13/00 , A61K20060101 , A61K35/74 , A61K39/00 , A61P31/04 , C07G11/00 , C07G99/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06
摘要： New antibiotic substances named substance No. 17927A.sub.2 and substance No. 17927A.sub.1 produced by cultivation of substances No. 17927A.sub.2 and No. 17927A.sub.1 -producing microorganisms belonging to the genus Streptomyces as well as pharmaceutically-acceptable salts thereof. They have broad antibacterial activities and also .beta.-lactamase inhibitory action so that they show synergistic actions with known penicillins and cephalosporins.
摘要翻译：通过种植属于链霉菌属的第17927A2号物质和第17927A1号产生微生物以及其药学上可接受的盐生产的名称为物质No.17927A2和物质号17927A1的新型抗生素物质。它们具有广泛的抗菌活性和β-内酰胺酶抑制作用，使其与已知的青霉素和头孢菌素显示协同作用。

5. 发明授权

US06472384B1 Antimicrobial compounds 有权
标题翻译：抗菌化合物
公开(公告)号：US06472384B1
公开(公告)日：2002-10-29
申请号：US09757393
申请日：2001-01-09
申请人： Masatoshi Inukai , Masakatsu Kaneko , Toshio Takatsu , Hitoshi Hotoda , Masatoshi Arai , Shunichi Miyakoshi , Masaaki Kizuka , Yasumasa Ogawa
发明人： Masatoshi Inukai , Masakatsu Kaneko , Toshio Takatsu , Hitoshi Hotoda , Masatoshi Arai , Shunichi Miyakoshi , Masaaki Kizuka , Yasumasa Ogawa
IPC分类号： A61K31553
CPC分类号： C07H19/06 , C12P17/16 , C12P17/162 , C12P17/167 , C12P19/38 , C12P19/40 , Y02P20/55
摘要： The present invention relates to ester, ether and N-alkylcarbamoyl derivatives of compound (Ia) and pharmaceutically acceptable salts thereof. These compounds exhibit excellent antibacterial activity and are useful for the treatment or prevention of bacterial infections. (wherein R1 is a hydrogen atom or a methyl group; R2a is a hydrogen atom, a protecting group for a hydroxy group, or a methyl group; R3 is a hydrogen atom or a protecting group for a hydroxy group; R4a is a hydrogen atom, a hydroxy group or a protected hydroxy group; R5 is a hydrogen atom or a protecting group for a hydroxy group; and X is a methylene group or a sulfur atom). The invention also includes compounds which are related to the aforeidentified compounds.
摘要翻译：本发明涉及化合物（Ia）的酯，醚和N-烷基氨基甲酰基衍生物及其药学上可接受的盐。这些化合物表现出优异的抗菌活性，可用于治疗或预防细菌感染（其中R1为氢原子或甲基; R2a为氢原子，羟基保护基或甲基; R3 是氢原子或羟基的保护基; R4a是氢原子，羟基或保护的羟基; R5是氢原子或羟基的保护基; X是亚甲基或硫原子）。本发明还包括与前述化合物有关的化合物。

6. 发明授权

US06818614B2 Compounds having antifungal activity 失效
标题翻译：具有抗真菌活性的化合物
公开(公告)号：US06818614B2
公开(公告)日：2004-11-16
申请号：US10087633
申请日：2002-03-01
申请人： Tatsuya Yano , Masatoshi Inukai , Toshio Takatsu , Isshin Tanaka
发明人： Tatsuya Yano , Masatoshi Inukai , Toshio Takatsu , Isshin Tanaka
IPC分类号： A61K3812
CPC分类号： C07K11/02 , A61K38/00
摘要： A compound of the following chemical structure (I) which exhibits antifungal activity and is useful in treating and preventing fungal infectious diseases:
摘要翻译：具有以下化学结构（I）的化合物，其具有抗真菌活性并且可用于治疗和预防真菌感染性疾病：

7. 发明授权

US07157442B2 Antibacterial compound 有权
标题翻译：抗菌化合物
公开(公告)号：US07157442B2
公开(公告)日：2007-01-02
申请号：US10080191
申请日：2002-02-19
申请人： Hitoshi Hotoda , Masakatsu Kaneko , Masatoshi Inukai , Yasunori Muramatsu , Yukio Utsui , Satoshi Ohya
发明人： Hitoshi Hotoda , Masakatsu Kaneko , Masatoshi Inukai , Yasunori Muramatsu , Yukio Utsui , Satoshi Ohya
IPC分类号： A61K31/70 , A61K31/553 , A61K31/504 , C07D239/02 , C07D401/00
CPC分类号： C07H19/06
摘要： The present invention relates to a compound of formula (I) (wherein R1 and R2 represent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally substituted, R3 represents a hydrogen atom or a hydroxyl group, and X1 and X2 represent an oxygen atom or a sulfur atom, or a nitrogen atom which may be substituted), a pharmaceutically acceptable derivative thereof or a salt thereof.The present invention also relates to a pharmaceutical composition comprising a compound described above as an active ingredient for the prevention or treatment of bacterial infections.The present invention includes the use of a compound described above in order to prepare a medicament effective in the prevention or treatment of bacterial infections.The present invention is concerned with a method for the prevention or treatment of bacterial infections in warm-blooded animals comprising administering a pharmacologically effective amount of a compound described above to them
摘要翻译：本发明涉及式（I）化合物（其中R 1和R 2表示芳基，杂环基，烷基，烯基和任选被取代的R 3表示氢原子或羟基，X 1和X 2表示氧原子或硫原子或可被取代的氮原子），其药学上可接受的衍生物或其盐。本发明还涉及包含上述化合物作为预防或治疗细菌感染的活性成分的药物组合物。本发明包括使用上述化合物以制备有效预防或治疗细菌感染的药物。本发明涉及一种预防或治疗温血动物细菌感染的方法，其包括将药理学有效量的上述化合物给予它们

8. 发明授权

US06844173B2 Strain of Streptomyces griseus 失效
标题翻译：灰色链霉菌菌株
公开(公告)号：US06844173B2
公开(公告)日：2005-01-18
申请号：US10096006
申请日：2002-03-12
申请人： Masatoshi Inukai , Toshio Takatsu , Masatoshi Arai , Shunichi Miyakoshi , Masaaki Kizuka , Yasumasa Ogawa
发明人： Masatoshi Inukai , Toshio Takatsu , Masatoshi Arai , Shunichi Miyakoshi , Masaaki Kizuka , Yasumasa Ogawa
IPC分类号： C07H19/067 , A61K31/7105 , A61P31/04 , C07D407/14 , C07H19/06 , C12P17/16 , C12P19/38 , C12P19/40 , C12R1/545 , C12P17/18
CPC分类号： C07H19/06 , C12P17/16 , C12P17/162 , C12P17/167 , C12P19/38 , C12P19/40 , Y02P20/55
摘要： A microorganism strain which is Streptomyces griseus FERM BP-5420 and processes for preparing compounds by cultivating such microorganism strain.
摘要翻译：作为灰色链霉菌FERM BP-5420的微生物菌株和通过培养这种微生物菌株制备化合物的方法。

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