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1. 发明申请

US20080103124A1 Cefdinir-containing pharmaceutical composition 审中-公开
标题翻译：含头孢非尼的药物组合物
公开(公告)号：US20080103124A1
公开(公告)日：2008-05-01
申请号：US11976351
申请日：2007-10-24
申请人： Tatsunobu Yoshioka , Yoshiyuki Murakami , Noboru Yamashita , Shigemitsu Tomei , Katsumi Saito , Akira Takagi
发明人： Tatsunobu Yoshioka , Yoshiyuki Murakami , Noboru Yamashita , Shigemitsu Tomei , Katsumi Saito , Akira Takagi
IPC分类号： A61K31/00 , A61P43/00
CPC分类号： A61K31/00
摘要： A pharmaceutical composition with an enhanced bioavailability, particularly improved an oral absorption, comprising cefdinir or a pharmaceutically acceptable salt thereof and aminoalkyl methacrylate copolymer E is disclosed.
摘要翻译：公开了具有增强的生物利用度，特别是口服吸收改善的药物组合物，其包含头孢地尼或其药学上可接受的盐和甲基丙烯酸氨基烷基酯共聚物E。

2. 发明授权

US06919372B1 Sustained release pharmaceutical compositions 失效
标题翻译：持续释放药物组合物
公开(公告)号：US06919372B1
公开(公告)日：2005-07-19
申请号：US09582404
申请日：1998-12-25
申请人： Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi , Michio Hara
发明人： Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi , Michio Hara
IPC分类号： A61K9/00 , A61K9/06 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/36 , A61K47/42 , A61K47/44 , A01N43/08 , A61K31/34
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/06 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/186 , A61K47/20 , A61K47/36 , A61K47/42 , A61K47/44
摘要： The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances containing ionic compounds having opposite charges to those of ionic prostanoic acid derivatives and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic prostanoic acid derivatives and the ionic compounds having opposite charges to those of the prostanoic acid derivatives and increasing hydrophobicity of these derivatives that contain hydrophobic groups in the molecule thereof.The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the ionic prostanoic acid derivatives, irrespective of water solubility possessed by the ionic prostanoic acid derivatives.
摘要翻译：本发明涉及含离子化合物的离子药物活性物质的缓释药物组合物，其具有与离子前列腺酸衍生物相反的电荷并增加活性物质的疏水性。更具体地，本发明涉及包含离子前列腺酸衍生物和具有与前列腺酸衍生物相反电荷的离子化合物的缓释药物组合物，并且在其分子中含有疏水基团的这些衍生物的疏水性增加。本发明的药物组合物可以表现出优异的离子前列腺酸衍生物的缓释作用，而与离子前列腺酸衍生物具有的水溶性无关。

3. 发明申请

US20050054026A1 Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems 有权
标题翻译：用于长血循环的脂质 - 肽 - 聚合物缀合物和肿瘤特异性药物递送系统
公开(公告)号：US20050054026A1
公开(公告)日：2005-03-10
申请号：US10754341
申请日：2004-01-09
申请人： Maeda Atsushi , Akira Takagi , Katsumi Saito , Noboru Yamashita , Tatsnobu Yoshioka
发明人： Maeda Atsushi , Akira Takagi , Katsumi Saito , Noboru Yamashita , Tatsnobu Yoshioka
IPC分类号： A61K9/127 , C07K7/06 , C12Q1/37 , C08G63/48 , C08G63/91
CPC分类号： C07K7/06 , A61K9/1271 , Y02P20/55
摘要： The present invention relates to conjugates of a lipid, substrate peptide of an enzyme secreted from the cells of mammals, including humans, and a water-soluble polymer that can be used as colloidal carriers and the like of tissue-specific drug delivery systems, methods of producing these conjugates, peptide-water-soluble polymer conjugates optionally having protective groups that are useful as the intermediates of these conjugates, colloidal carriers made from these conjugates, and tissue-specific drug delivery systems that use these colloidal carriers.
摘要翻译：本发明涉及从哺乳动物（包括人）的细胞分泌的酶的脂质，底物肽和可用作组织特异性药物递送系统的胶体载体等的水溶性聚合物的共轭物，方法制备这些缀合物的肽 - 水溶性聚合物缀合物，其任选地具有可用作这些缀合物的中间体的保护基，由这些缀合物制备的胶体载体，以及使用这些胶体载体的组织特异性药物递送系统。

4. 发明授权

US06328979B1 Sustained release medicinal compositions 失效
标题翻译：缓释药物组合物
公开(公告)号：US06328979B1
公开(公告)日：2001-12-11
申请号：US09582384
申请日：2000-06-23
申请人： Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi
发明人： Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi
IPC分类号： A61K900
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/06 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/186 , A61K47/20 , A61K47/36 , A61K47/42 , A61K47/44
摘要： The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances (excluding ionic prostanoic acid derivatives) containing ionic compounds having opposite charges to those of the active substances and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic pharmaceutically active substances and the ionic compounds having opposite charges to those of the active substances and increasing hydrophobicity of the active substances that contain hydrophobic groups in the molecule thereof. The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the active substance, irrespective of water solubility possessed by the ionic pharmaceutically active substances.
摘要翻译：本发明涉及含有与活性物质具有相反电荷的离子化合物的离子药物活性物质（不含离子前列腺酸衍生物）的持续释放药物组合物，并且活性物质的疏水性增加。更具体地，本发明涉及包含离子药物活性物质和具有与活性物质相反的电荷的离子化合物的缓释药物组合物，并且其分子中含有疏水基团的活性物质的疏水性增加。本发明的药物组合物可以表现出优异的活性物质的缓释作用，而与离子药物活性物质所具有的水溶性无关。

5. 发明授权

US07169892B2 Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems 有权
标题翻译：用于长血循环的脂质 - 肽 - 聚合物缀合物和肿瘤特异性药物递送系统
公开(公告)号：US07169892B2
公开(公告)日：2007-01-30
申请号：US10754341
申请日：2004-01-09
申请人： Maeda Atsushi , Akira Takagi , Katsumi Saito , Noboru Yamashita , Tatsnobu Yoshioka
发明人： Maeda Atsushi , Akira Takagi , Katsumi Saito , Noboru Yamashita , Tatsnobu Yoshioka
IPC分类号： A61K38/08 , C07K7/00 , C07K17/00
CPC分类号： C07K7/06 , A61K9/1271 , Y02P20/55
摘要： The present invention relates to conjugates of a lipid, substrate peptide of an enzyme secreted from the cells of mammals, including humans, and a water-soluble polymer that can be used as colloidal carriers and the like of tissue-specific drug delivery systems, methods of producing these conjugates, peptide-water-soluble polymer conjugates optionally having protective groups that are useful as the intermediates of these conjugates, colloidal carriers made from these conjugates, and tissue-specific drug delivery systems that use these colloidal carriers.
摘要翻译：本发明涉及从哺乳动物（包括人）的细胞分泌的酶的脂质，底物肽和可用作组织特异性药物递送系统的胶体载体等的水溶性聚合物的共轭物，方法制备这些缀合物的肽 - 水溶性聚合物缀合物，其任选地具有可用作这些缀合物的中间体的保护基，由这些缀合物制备的胶体载体，以及使用这些胶体载体的组织特异性药物递送系统。

6. 发明申请

US20070286898A1 Intracellular Drug Delivery Improving Liposome 审中-公开
标题翻译：细胞内药物递送改善脂质体
公开(公告)号：US20070286898A1
公开(公告)日：2007-12-13
申请号：US11661431
申请日：2005-08-30
申请人： Akira Takagi , Noboru Yamashita , Takashi Sonobe , Yasuyuki Sadzuka
发明人： Akira Takagi , Noboru Yamashita , Takashi Sonobe , Yasuyuki Sadzuka
IPC分类号： A61K9/127 , A61K47/32
CPC分类号： A61K9/1271 , A61K9/0019
摘要： [Problem] To provide a drug delivery system which is retained in the blood circulation and improves pharmacological effect of the drug in the target organ and cell. [Means for Resolution] A drug-containing liposome for use in the treatment with a liposome prepared by employing polyethylene glycol cholesteryl ether as a part of the liposome-forming agent and using said liposome-forming agent. It is possible to obtain excellent drug effect by further employing a polyethylene glycol diacylglycerol ester as a part of the liposome-forming agent.
摘要翻译： [问题]提供保留在血液循环中的药物递送系统，并且改善药物在靶器官和细胞中的药理作用。 [解决方法]使用通过使用聚乙二醇胆固醇醚作为脂质体形成剂的一部分并使用所述脂质体形成剂制备的用于用脂质体处理的药物含脂质体。通过进一步使用聚乙二醇二酰基甘油酯作为脂质体形成剂的一部分，可以获得优异的药物效果。

7. 发明授权

US07949093B2 X-ray fluorescence spectrometer 有权
标题翻译： X射线荧光光谱仪
公开(公告)号：US07949093B2
公开(公告)日：2011-05-24
申请号：US12296383
申请日：2006-11-24
申请人： Yoshiyuki Kataoka , Hisayuki Kohno , Noboru Yamashita , Makoto Doi
发明人： Yoshiyuki Kataoka , Hisayuki Kohno , Noboru Yamashita , Makoto Doi
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , G01N2223/076
摘要： An X-ray fluorescence spectrometer for measuring the concentration of sulfur contained in a sample (S), by irradiating the sample (S) with primary X-rays from an X-ray tube (11), monochromating fluorescent X-rays emitted from the sample (S) with a spectroscopic device, and detecting monochromated fluorescent X-rays with an X-ray detector. The spectrometer includes the X-ray tube (11) having a target with an element including chromium, an X-ray filter (13) disposed on a path of travel of X-rays between the X-ray tube (11) and the sample (S) and having a predetermined transmittance for Cr—Kα line from the X-ray tube (11) and made of a material which is an element of which absorption edges do not exist between energies of S—Kα line and Cr—Kα line, and a proportional counter (18) having a detector gas containing a neon gas or a helium gas.
摘要翻译：一种X射线荧光光谱仪，用于通过从X射线管（11）照射样品（S）的初级X射线来测量样品（S）中所含的硫的浓度，所述X射线荧光光谱仪从样品（S），并用X射线检测器检测单色荧光X射线。光谱仪包括具有包含铬的元素的靶的X射线管（11），设置在X射线管（11）和样品之间的X射线行进路径上的X射线过滤器（13）（S），并且对于来自X射线管（11）的Cr-Kα线具有预定的透射率，并且由在S-Kα线和Cr-Kα线的能量之间不存在吸收边缘的元素的材料制成，以及具有包含氖气或氦气的检测器气体的比例计数器（18）。

8. 发明授权

US06868113B2 Receiver for spectrum spreading communication system 失效
标题翻译：接收机用于频谱扩展通信系统
公开(公告)号：US06868113B2
公开(公告)日：2005-03-15
申请号：US09803049
申请日：2001-03-12
申请人： Noboru Yamashita
发明人： Noboru Yamashita
IPC分类号： H04B1/707 , H04B7/26 , H04J13/00 , H04L7/00 , H04W56/00 , H04B1/69
CPC分类号： H04B1/7085 , H04B1/7073 , H04B1/7113
摘要： A receiver for a spread spectrum communication system includes an acquiring circuit that periodically acquires a plurality of signals received via a plurality of paths from a transmitter. The receiver also includes a plurality of tracking circuits that track the synchronization of a predetermined number of signals among the plurality of signals acquired by the acquiring circuit. The receiver additionally includes a judging circuit that judges whether present and past propagation conditions of the predetermined signals tracked by the plurality of tracking circuits are good or bad. A selecting circuit is included in the receiver to select the predetermined number of signals from the plurality of signals acquired by the acquiring circuit, based upon the present and past propagation conditions of the signals judged by the judging circuit, to allow the plurality of tracking circuits to track the predetermined number of signals selected by the selecting circuit.
摘要翻译：用于扩展频谱通信系统的接收机包括一个获取电路，其周期性地获取经由多个路径从发射机接收的多个信号。接收机还包括多个跟踪电路，跟踪由获取电路获取的多个信号中的预定数量的信号的同步。接收机另外包括判断电路，判断电路是否由多个跟踪电路跟踪的预定信号的传播条件是否良好。接收机中包括一个选择电路，用于根据由判断电路判定的信号的当前和过去的传播条件，从采集电路获取的多个信号中选择预定数量的信号，以允许多个跟踪电路以跟踪由选择电路选择的预定数量的信号。

9. 发明授权

US4817487A Structure of fall board assembly of keyboard instrument 失效
标题翻译：键盘乐器落板组合结构
公开(公告)号：US4817487A
公开(公告)日：1989-04-04
申请号：US190397
申请日：1988-05-05
申请人： Noboru Yamashita
发明人： Noboru Yamashita
IPC分类号： G10B3/00 , G10C3/02
CPC分类号： G10C3/02
摘要： For preventing a fall board of a keyboard instrument from crashing against a key slip of the keyboard instrument, there is disclosed a fall board assembly comprising (a) a fall board having a boss portion and a covering plate portion extending from the boss portion and (b) a pair of rotary dampers provided between the boss portion of the fall board and side arms of the keyboard instrument, respectively, and operative to allow the fall board to move between first and second angular positions, and the keyboard is covered with the covering plate portion of the fall board in the first angular position but exposed to a player in the second angular position, wherein the rotary dampers produce a damping effect against the rotation of the fall board when the fall board rotates from the second angular position to the first angular position.
摘要翻译：为了防止键盘乐器的跌落板撞击键盘乐器的键滑块，公开了一种跌落板组件，包括：（a）具有凸起部分和从凸台部分延伸的覆盖板部分的坠落板， b）一对旋转阻尼器，分别设置在坠落板的凸起部分和键盘乐器的侧臂之间，并且可操作以允许坠落板在第一和第二角度位置之间移动，并且键盘被覆盖物所述倒塌板的板部分处于第一角度位置，但是在第二角度位置中暴露于玩家，其中当所述坠落板从所述第二角位置旋转到所述第一角位置时，所述旋转阻尼器产生抵抗所述坠落板的旋转的阻尼效果角位置。

10. 发明申请

US20090257561A1 GENERAL IMAGING SYSTEM 失效
标题翻译：一般成像系统
公开(公告)号：US20090257561A1
公开(公告)日：2009-10-15
申请号：US12516116
申请日：2007-10-11
申请人： Tomoharu Okuno , Masahiro Kawano , Mikihiko Kato , Noboru Yamashita , Goro Hirata
发明人： Tomoharu Okuno , Masahiro Kawano , Mikihiko Kato , Noboru Yamashita , Goro Hirata
IPC分类号： H05G1/58 , H05G1/02 , A61B6/08
CPC分类号： A61B6/588 , A61B6/4233 , A61B6/4464 , A61B6/4476 , A61B6/467 , A61B6/545 , A61B6/547 , A61B2034/252
摘要： To automate positioning operation of an X-ray tube so as to reduce the inspection time. Anatomical program selection means selects a surgery method/imaging object portion so that an imaging condition stored as an anatomical program in advance is called out and set in an X-ray generation device. Here, when an operation switch is pressed, control means moves drive means built in X-ray irradiation means parallel movement holding means and X-ray irradiation means rotation holding means so as to obtain the positional relationship between an X-ray tube and an FPD stored in correspondence with the anatomical program (such as SID and incident angle). The position of the FPD should be matched with the examinee. However, since the positional relationship between the X-ray tube and the FPD is almost constant in accordance with the surgery method/imaging object portion, it is possible to reduce the time required for positioning the X-ray tube by using this configuration.
摘要翻译：自动化X射线管的定位操作，以减少检查时间。解剖程序选择装置选择手术方法/成像对象部分，使得在X射线产生装置中调出并设置作为解剖学程序预先存储的成像条件。这里，当按下操作开关时，控制装置移动内置在X射线照射装置平行移动保持装置和X射线照射装置旋转保持装置中的驱动装置，以获得X射线管和FPD之间的位置关系存储与解剖程序相对应（如SID和入射角）。 FPD的位置应与受检者相匹配。然而，由于X射线管和FPD之间的位置关系根据手术方法/成像对象部分几乎是恒定的，所以可以通过使用这种配置来减少定位X射线管所需的时间。

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