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1. 发明申请

US20070202168A1 COMPOSITION COMPRISES SUSTAINED-RELEASE FINE PARTICLES AND MANUFACTURING METHOD THEREOF 失效
标题翻译：组合物包含持续释放的细颗粒及其制造方法
公开(公告)号：US20070202168A1
公开(公告)日：2007-08-30
申请号：US11743616
申请日：2007-05-02
申请人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
发明人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
IPC分类号： A61K9/26
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/2018 , A61K9/5026 , A61K31/18
摘要： The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in quick-disintegrating tablets in the buccal cavity, one or more fillers selected from the group consisting of sugars or sugar alcohols, and one or more binders for quick-disintegrating tablets in the buccal cavity selected from the group consisting of sugars of high moldability and water-soluble polymer substances, and in that the sustained-release fine particles are granulated with filler and binder for quick-disintegrating tablets in the buccal cavity, and a manufacturing method thereof.
摘要翻译：本发明涉及包含持续释放微粒的组合物，其特征在于其含有可用于颊腔中快速崩解片剂的缓释微粒，一种或多种选自以下的填料：糖或糖醇和一种或多种选自高成型性糖和水溶性聚合物物质的颊腔中的快速崩解片的粘合剂，并且缓释微粒用填料和粘合剂造粒，颊腔中的快速崩解片及其制造方法。

2. 发明授权

US07255876B2 Composition comprises sustained-release fine particles and manufacturing method thereof 失效
标题翻译：组合物包含缓释微粒及其制造方法
公开(公告)号：US07255876B2
公开(公告)日：2007-08-14
申请号：US10206010
申请日：2002-07-25
申请人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
发明人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K9/46
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/2018 , A61K9/5026 , A61K31/18
摘要： The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in quick-disintegrating tablets in the buccal cavity, one or more fillers selected from the group consisting of sugars or sugar alcohols, and one or more binders for quick-disintegrating tablets in the buccal cavity selected from the group consisting of sugars of high moldability and water-soluble polymer substances, and in that the sustained-release fine particles are granulated with filler and binder for quick-disintegrating tablets in the buccal cavity, and a manufacturing method thereof.
摘要翻译：本发明涉及包含持续释放微粒的组合物，其特征在于其含有可用于颊腔中快速崩解片剂的缓释微粒，一种或多种选自以下的填料：糖或糖醇和一种或多种选自高成型性糖和水溶性聚合物物质的颊腔中的快速崩解片的粘合剂，并且缓释微粒用填料和粘合剂造粒，颊腔中的快速崩解片及其制造方法。

3. 发明授权

US07575762B2 Composition comprises sustained-release fine particles and manufacturing method thereof 失效
标题翻译：组合物包含缓释微粒及其制造方法
公开(公告)号：US07575762B2
公开(公告)日：2009-08-18
申请号：US11743616
申请日：2007-05-02
申请人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
发明人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
IPC分类号： A61K9/16 , A61K9/22 , A61K9/26 , A61K9/46
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/2018 , A61K9/5026 , A61K31/18
摘要： The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in quick-disintegrating tablets in the buccal cavity, one or more fillers selected from the group consisting of sugars or sugar alcohols, and one or more binders for quick-disintegrating tablets in the buccal cavity selected from the group consisting of sugars of high moldability and water-soluble polymer substances, and in that the sustained-release fine particles are granulated with filler and binder for quick-disintegrating tablets in the buccal cavity, and a manufacturing method thereof.
摘要翻译：本发明涉及包含持续释放微粒的组合物，其特征在于其含有可用于颊腔中快速崩解片剂的缓释微粒，一种或多种选自以下的填料：糖或糖醇和一种或多种选自高成型性糖和水溶性聚合物物质的颊腔中的快速崩解片的粘合剂，并且缓释微粒用填料和粘合剂造粒，颊腔中的快速崩解片及其制造方法。

4. 发明授权

US06872405B2 Quick-disintegrating tablet in buccal cavity and manufacturing method thereof 失效
公开(公告)号：US06872405B2
公开(公告)日：2005-03-29
申请号：US10142081
申请日：2002-05-08
申请人： Yuuki Takaishi , Takao Mizumoto , Yoshinori Masuda
发明人： Yuuki Takaishi , Takao Mizumoto , Yoshinori Masuda
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0056
摘要： The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and/or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point. Moreover, the present invention relates to a method of manufacturing a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent and a saccharide with a relatively lower melting point than the drug and the diluent, which comprises (a) the process whereby tablet starting materials including a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent are molded under the low pressure necessary for retaining the shape of a tablet, (b) the process whereby the molded product obtained in process (a) is heated to at least the temperature at which this saccharide with a low melting point will melt, and (c) the process whereby the molded product obtained in process (b) is cooled to at least the temperature at which the molten saccharide with a low melting point solidifies. The present invention presents a quick-disintegrating tablet in the buccal cavity that can be used for practical purposes in that it has almost the same properties as conventional oral pharmaceutical tablets, that is, it has sufficient tablet strength that it can be used with automatic unit dosing machines, and it is produced by conventional tableting machines, and a manufacturing method thereof. Moreover, the present invention presents a quick-disintegrating tablet in the buccal cavity which, in comparison to conventional quick-disintegrating tablets in the buccal cavity, has increased tablet strength and an improved friability without prolonging the disintegration time in the buccal cavity, and a manufacturing method thereof.

5. 发明申请

US20050100599A1 Quick disintegrating tablet in buccal cavity and manufacturing method thereof 审中-公开
公开(公告)号：US20050100599A1
公开(公告)日：2005-05-12
申请号：US11009644
申请日：2004-12-09
申请人： Yuuki Takaishi , Takao Mizumoto , Yoshinori Masuda
发明人： Yuuki Takaishi , Takao Mizumoto , Yoshinori Masuda
IPC分类号： A61K9/00 , A61K9/20 , A61K9/14
CPC分类号： A61K9/0056
摘要： The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and/or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point. Moreover, the present invention relates to a method of manufacturing a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent and a saccharide with a relatively lower melting point than the drug and the diluent, which comprises (a) the process whereby tablet starting materials including a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent are molded under the low pressure necessary for retaining the shape of a tablet, (b) the process whereby the molded product obtained in process (a) is heated to at least the temperature at which this saccharide with a low melting point will melt, and (c) the process whereby the molded product obtained in process (b) is cooled to at least the temperature at which the molten saccharide with a low melting point solidifies. The present invention presents a quick-disintegrating tablet in the buccal cavity that can be used for practical purposes in that it has almost the same properties as conventional oral pharmaceutical tablets, that is, it has sufficient tablet strength that it can be used with automatic unit dosing machines, and it is produced by conventional tableting machines, and a manufacturing method thereof. Moreover, the present invention presents a quick-disintegrating tablet in the buccal cavity which, in comparison to conventional quick-disintegrating tablets in the buccal cavity, has increased tablet strength and an improved friability without prolonging the disintegration time in the buccal cavity, and a manufacturing method thereof.

6. 发明申请

US20050100598A1 Quick disintegrating tablet in buccal cavity and production process thereof 审中-公开
标题翻译：颊腔快速崩解片及其制作方法
公开(公告)号：US20050100598A1
公开(公告)日：2005-05-12
申请号：US10961875
申请日：2004-10-07
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
IPC分类号： A61K9/00 , A61K9/20 , A61K47/26 , A61K47/36 , H04L12/44 , H04L29/06 , H04L29/08
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译：本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后正在形成片剂，并且被加湿和干燥。本发明中的片剂是为了提供在保存的水分中的稳定性，因为无定形糖在制造过程中被加湿干燥后，在不可逆反应中变为结晶状态。本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。

7. 发明授权

US06589554B1 Tablets quickly disintegrating in the oral cavity and process for producing the same 失效
标题翻译：片剂在口腔中迅速崩解，并制备其
公开(公告)号：US06589554B1
公开(公告)日：2003-07-08
申请号：US09646249
申请日：2000-09-14
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
IPC分类号： A61K920
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译：本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后是形成片剂，并且其被加湿和干燥。本发明的片剂是为了在保存的时候提供对水分的稳定性，因为无定形糖在制造过程中被加湿干燥后在非可逆反应中变为结晶状态。本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。

8. 发明授权

US06656492B2 Quick disintegrating tablet in buccal cavity and manufacturing method thereof 失效
公开(公告)号：US06656492B2
公开(公告)日：2003-12-02
申请号：US09896820
申请日：2001-06-28
申请人： Atushi Kajiyama , Tetsuya Tamura , Takao Mizumoto , Hitoshi Kawai , Tatsuya Takahashi
发明人： Atushi Kajiyama , Tetsuya Tamura , Takao Mizumoto , Hitoshi Kawai , Tatsuya Takahashi
IPC分类号： A61F1300
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/1635 , A61K9/1652
摘要： The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50˜approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5˜approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier (preferably containing water-insoluble polymer, particularly at least aqueous ethyl cellulose suspension (preferably containing plasticizer)) to a high concentration in terms of solid concentration in a solvent that is pharmaceutically acceptable and then spray drying this liquid using a rotating disk-type spray dryer, with the disk operating at low speed, and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising said particles.

9. 发明申请

US20110128557A1 TABLET PRINTING APPARATUS AND TABLET PRODUCTION METHOD, AND TABLET 审中-公开
标题翻译：平板印刷装置和片材生产方法和片剂
公开(公告)号：US20110128557A1
公开(公告)日：2011-06-02
申请号：US12674650
申请日：2008-08-22
申请人： Noriyuki Kinoshita , Takao Mizumoto , Keizo Baba , Takashi Nishizato , Syuya Kawahama , Hideyuki Tomoda , Yoshihide Muramatsu , Shiro Hatano , Fumihiro Ogawa , Chizuo Ozawa
发明人： Noriyuki Kinoshita , Takao Mizumoto , Keizo Baba , Takashi Nishizato , Syuya Kawahama , Hideyuki Tomoda , Yoshihide Muramatsu , Shiro Hatano , Fumihiro Ogawa , Chizuo Ozawa
IPC分类号： G06K15/16 , H04N1/60 , G06K15/02
CPC分类号： A61J3/007 , B41J3/407 , B41J11/007 , B41J11/0085
摘要： There is provided a tablet printing apparatus that can perform printing at a high speed on tablets arbitrarily supplied in volume at irregular intervals and has a high printing quality. A tablet printing apparatus 1 for multicolor printing on tablets T comprises a conveying belt 24 for conveying the tablets T in a moving direction A1-A2, an inkjet printer 42 disposed in the middle of the moving direction A1-A2 of the conveying belt 24 for performing non-contact printing onto surfaces of the tablets T conveyed by the conveying belt 24, an encoder 28 and a tablet sensor 29 for detecting moving positions of the tablets T conveyed by the conveying belt 24, and a unit control substrate 32 for controlling printing timing on the tablets T of the inject printer 42 or 46 based on the moving conditions or/and the moving positions of the tablets T detected by the encoder 28 and the tablet sensor 29. The conveying bet 24 conveys the tablets T in the moving direction A1-A2 in a state that they are irregularly adsorbed and held.
摘要翻译：提供了一种能够以不规则间隔以任意方式供应的片剂高速打印并具有高印刷质量的平板印刷装置。用于片剂T上多色印刷的平板印刷装置1包括用于沿移动方向A1-A2输送药片T的输送带24，设置在输送带24的移动方向A1-A2的中间的喷墨打印机42，在由输送带24输送的药片T的表面上进行非接触印刷，用于检测由输送带24输送的药片T的运动位置的编码器28和片剂传感器29以及用于控制印刷的单元控制基板32 基于由编码器28和平板传感器29检测到的片剂T的运动状况或/和移动位置，喷射打印机42或46的平板电脑T上的定时。传送纸24将移动方向 A1-A2处于不规则地吸附和保持的状态。

10. 发明授权

US07074428B2 Quick disintegrating tablet in buccal cavity and manufacturing method thereof 失效
标题翻译：口腔快速崩解片及其制造方法
公开(公告)号：US07074428B2
公开(公告)日：2006-07-11
申请号：US10667077
申请日：2003-09-18
申请人： Atushi Kajiyama , Tetsuya Tamura , Takao Mizumoto , Hitoshi Kawai , Tatsuya Takahashi
发明人： Atushi Kajiyama , Tetsuya Tamura , Takao Mizumoto , Hitoshi Kawai , Tatsuya Takahashi
IPC分类号： A61K9/20 , A61K9/28 , A61K9/14 , A61K9/16
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/1635 , A61K9/1652
摘要： The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50 to approximately 250 μm and an apparent specific gravity of approximately 0.5 to approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and a saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier to a high concentration in terms of solid concentration in a solvent and spray drying this liquid and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising the particles.
摘要翻译：本发明涉及颊腔中的快速崩解片，其特征在于平均粒径约50至约250μm，表观比重约0.5至约1.2的含药颗粒由苦味药和 /或较差流动性药物和药物制剂载体并通过喷雾干燥获得，加入包含药物和糖的口腔内的快速崩解片剂中。此外，本发明涉及通过将苦味药和/或低流动性的药物和药物制剂载体溶解并悬浮以高浓度的方式制造具有特定平均粒径和比表观重力的含药颗粒的方法在溶剂中固体浓度的条件并喷雾干燥该液体，以及用于在包含颗粒的口腔中制造快速崩解片剂的方法。

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