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1. 发明申请

US20150005505A1 Process for production of DFMB derivatives 有权
标题翻译：生产DFMB衍生物的方法
公开(公告)号：US20150005505A1
公开(公告)日：2015-01-01
申请号：US14377056
申请日：2012-02-20
申请人： Tao Zhang , Claude Mercier , Olivier Buisine
发明人： Tao Zhang , Claude Mercier , Olivier Buisine
IPC分类号： C07D277/64 , C07D235/10
CPC分类号： C07D277/64 , C07D235/10 , C07D263/56
摘要： A process for the production of a compound of formula (III) which comprises a step of reacting a compound of formula (I) with an excess amount of a compound of formula (II) in absence of aromatic solvent, wherein n is 0, 1, 2, 3 or 4; X is NH, O or S; each R1 group may be the same or different, and is independently selected from the group consisting of hydrogen, hydroxyl, alkoxy, alkyl, carbonyl, carboxyl, carboxylic acid ester, amido, cyano, halogenated aliphatic, nitro, and amino; and R2 group is selected from the group consisting of hydroxyl, Cl, F, Br, amino, and alkoxy.
摘要翻译：一种制备式（III）化合物的方法，其包括在不存在芳族溶剂的情况下使式（I）化合物与过量的式（II）化合物反应的步骤，其中n为0,1 ，2,3或4; X是NH，O或S; 每个R 1基团可以相同或不同，并且独立地选自氢，羟基，烷氧基，烷基，羰基，羧基，羧酸酯，酰胺基，氰基，卤代脂族，硝基和氨基; 并且R 2基团选自羟基，Cl，F，Br，氨基和烷氧基。

2. 发明授权

US09458119B2 Process for production of DFMB derivatives 有权
标题翻译：生产DFMB衍生物的方法
公开(公告)号：US09458119B2
公开(公告)日：2016-10-04
申请号：US14377056
申请日：2012-02-20
申请人： Tao Zhang , Claude Mercier , Olivier Buisine
发明人： Tao Zhang , Claude Mercier , Olivier Buisine
IPC分类号： C07D235/10 , C07D277/64 , C07D263/56
CPC分类号： C07D277/64 , C07D235/10 , C07D263/56
摘要： A process for the production of a compound of formula (III) which comprises a step of reacting a compound of formula (I) with an excess amount of a compound of formula (II) in absence of aromatic solvent, wherein n is 0, 1, 2, 3 or 4; X is NH, O or S; each R1 group may be the same or different, and is independently selected from the group consisting of hydrogen, hydroxyl, alkoxy, alkyl, carbonyl, carboxyl, carboxylic acid ester, amido, cyano, halogenated aliphatic, nitro, and amino; and R2 group is selected from the group consisting of hydroxyl, Cl, F, Br, amino, and alkoxy.

3. 发明申请

US20090221859A1 Production of Difluoroethanol 有权
标题翻译：生产二氟乙醇
公开(公告)号：US20090221859A1
公开(公告)日：2009-09-03
申请号：US12086747
申请日：2006-12-19
申请人： Olivier Buisine , Roland Jacquot
发明人： Olivier Buisine , Roland Jacquot
IPC分类号： C07C31/38
CPC分类号： C07C29/149 , C07C31/38
摘要： Difluoroethanol is produced by hydrogenation, in the presence of an effective amount of a catalyst containing at least one element of Group VIII of the Periodic Table deposited onto a solid, acidic mineral support, of an acetyl halide having the following formula (I), in which formula X is a halogen atom other than a fluorine atom:
摘要翻译：在有效量的催化剂存在下，通过氢化产生二氟乙醇，所述催化剂含有至少一种元素周期表第Ⅷ族元素沉积在具有下式（I）的乙酰卤的固体酸性矿物载体上，在该式X是除氟原子以外的卤原子：

4. 发明授权

US09067869B2 Method for preparing difluoroacetonitrile and the derivatives thereof 有权
标题翻译：二氟乙腈及其衍生物的制备方法
公开(公告)号：US09067869B2
公开(公告)日：2015-06-30
申请号：US14003118
申请日：2012-03-08
申请人： Olivier Buisine
发明人： Olivier Buisine
IPC分类号： C07C253/14 , C07C51/08
CPC分类号： C07C253/14 , C07C51/08 , C07C255/10
摘要： The present invention relates to a method for preparing difluoracetonitrile and the derivatives thereof. The method for preparing difluoroacetonitrile according to the invention is characterized in that it includes reacting halogenodifluoromethane and a source of cyanide anions in an alkaline medium. The invention also relates to the use of difluoroacetonitrile as an intermediate in the manufacture of difluoroacetic acid and the salts, esters, or amide thereof.
摘要翻译：本发明涉及二氟乙腈及其衍生物的制备方法。根据本发明的制备二氟乙腈的方法的特征在于其包括在碱性介质中使卤代二氟甲烷和氰化物阴离子源反应。本发明还涉及二氟乙腈作为制备二氟乙酸及其盐，酯或酰胺的中间体的用途。

5. 发明申请

US20120123159A1 METHOD FOR PREPARING DIFLUOROACETIC ACID 有权
标题翻译：制备二元酸的方法
公开(公告)号：US20120123159A1
公开(公告)日：2012-05-17
申请号：US13381607
申请日：2010-06-28
申请人： Olivier Buisine , Alessandro Chiovato
发明人： Olivier Buisine , Alessandro Chiovato
IPC分类号： C07C51/347
CPC分类号： C07C67/10 , C07C51/09 , Y02P20/127 , C07C53/18 , C07C69/06 , C07C69/63
摘要： A method for preparing difluoroacetic acid is described. The method can include: reacting a difluoroacetic acid ester with an aliphatic carboxylic acid which, after transesterification, results in the formation of difluoroacetic acid and the corresponding carboxylic acid ester, the carboxylic acid being selected such that the ester of the carboxylic acid has a lower boiling point than that of difluoroacetic acid; and removing the ester of the carboxylic acid by distillation as the ester forms, thus enabling the difluoroacetic acid to be recovered.
摘要翻译：描述了制备二氟乙酸的方法。该方法可以包括：使二氟乙酸酯与脂族羧酸反应，酯交换后，导致二氟乙酸和相应的羧酸酯的形成，羧酸被选择使得羧酸的酯具有较低的沸点高于二氟乙酸; 并且通过蒸馏除去羧酸的酯作为酯形成，从而能够回收二氟乙酸。

6. 发明申请

US20120108836A1 METHOD FOR PREPARING FLUOROALKANESULPHINIC ACID ESTERS 有权
标题翻译：制备氟代氨基酸酸酯的方法
公开(公告)号：US20120108836A1
公开(公告)日：2012-05-03
申请号：US13266260
申请日：2010-04-29
申请人： Olivier Buisine
发明人： Olivier Buisine
IPC分类号： C07C313/04
CPC分类号： C07C313/04
摘要： A method for preparing fluoroalkanesulphinic acid esters is described. The preparation of esters of trifluoromethanesulphinic acid, commonly referred to as “triflinic acid,” is also described. A method for preparing a fluoroalkanesulphinic acid ester is also described wherein the method includes reacting a fluoroalkanesulphinic acid with an organic carbonate leading to the formation of a fluoroalkanesulphinic acid ester and carbon dioxide, which is removed during the reaction.
摘要翻译：描述了制备氟烷基亚磺酸酯的方法。还描述了通常称为“三氟酸”的三氟甲磺酸的酯的制备。还描述了制备氟烷基亚磺酸酯的方法，其中所述方法包括使氟烷基亚磺酸与有机碳酸酯反应，导致形成氟烷基亚磺酸酯和二氧化碳，其在反应期间被除去。

7. 发明授权

US08633336B2 Method for separating a carboxylic acid in salified form bearing at least one halogen atom 有权
标题翻译：分离含有至少一个卤素原子的盐化形式的羧酸的方法
公开(公告)号：US08633336B2
公开(公告)日：2014-01-21
申请号：US13003136
申请日：2009-07-08
申请人： Olivier Buisine , François Metz
发明人： Olivier Buisine , François Metz
IPC分类号： C07C53/21
CPC分类号： C07C51/412 , C07C51/48 , C07C53/21 , C07C53/18 , C07C53/19 , C07C53/16
摘要： The subject of the present invention is a method for separating a carboxylic acid in salified form bearing at least one halogen atom at the α position of the carbonyl group from a medium comprising it. The method according to the invention, for separating a carboxylic acid in salified form bearing at least one halogen atom at the α position of the carbonyl group from an aqueous medium comprising it, is characterized by the fact that the latter is brought into contact with an onium salt leading to the formation of two phases: an organic phase comprising the salt resulting from the reaction of the salt of the carboxylic acid bearing at least one halogen atom at the α position of the carbonyl group and of the onium salt leading to the displacement of the cation from the carboxylic acid by the onium, an aqueous phase comprising the various salts, in particular the one resulting from the reaction of the cation of the carboxylic acid with the anion of the onium, and by the fact that the organic and aqueous phases are then separated and that the onium salt of the carboxylic acid is recovered from the organic phase.
摘要翻译：本发明的主题是在含有羰基的α位的至少一个卤原子的盐化形式的羧酸的分离方法。根据本发明的方法，用于从含有它的水性介质中分离在羰基的α位上带有至少一个卤素原子的盐化形式的羧酸，其特征在于后者与导致形成两相的有机相：包含由在羰基的α位上带有至少一个卤素原子的羧酸的盐与导致位移的鎓盐反应而产生的盐的有机相的阳离子由羧酸由鎓形成，包含各种盐的水相，特别是由羧酸的阳离子与鎓的阴离子反应的水相，以及有机和水性然后分离相，并从有机相中回收羧酸的鎓盐。

8. 发明申请

US20120197039A1 METHOD FOR PREPARING TRIFLUOROMETHANESULPHINIC ACID 有权
标题翻译：制备三氟甲磺酸的方法
公开(公告)号：US20120197039A1
公开(公告)日：2012-08-02
申请号：US12744875
申请日：2008-11-25
申请人： Vincent Schanen , Olivier Buisine , François Metz , Bernard Besson
发明人： Vincent Schanen , Olivier Buisine , François Metz , Bernard Besson
IPC分类号： C07C313/04
CPC分类号： C07C313/04
摘要： The present invention relates to a method for preparing a highly pure trifluoromethanesulphinic acid. The method of the invention for preparing a highly pure trifluoromethanesulphinic acid, starting from an aqueous mixture comprising a trifluoromethanesulphinic acid salt, a trifluoroacetic acid salt and saline impurities resulting from the method for preparing same, is characterized in that said mixture is subjected to the following operations:- acidification such that the trifluoroacetic acid salt and the triflinic acid salt are released in an acid form,- separation of the trifluoroacetic acid and trifluoromethanesulphinic acid by distillation enabling the trifluoroacetic acid to be recovered at the top of the distillation and the trifluoromethanesulphinic acid to be recovered at the bottom of the distillation,- separation by distillation of the trifluoromethanesulphinic acid present in the distillation residue previously obtained.
摘要翻译：本发明涉及一种制备高纯度三氟甲磺酸的方法。本发明制备高纯度三氟甲磺酸的方法，其特征在于，由包含三氟甲磺酸盐，三氟乙酸盐和由其制备方法得到的盐水杂质的含水混合物开始，将所述混合物进行以下步骤操作：酸化使得三氟乙酸盐和三氟甲磺酸盐以酸的形式释放， - 通过蒸馏分离三氟乙酸和三氟甲磺酸，使三氟乙酸在蒸馏顶部回收，三氟甲磺酸在蒸馏的底部回收， - 通过蒸馏分离先前获得的蒸馏残余物中的三氟甲磺酸。

9. 发明申请

US20120190884A1 METHOD FOR PREPARING DIFLUOROACETIC ACID ESTERS 审中-公开
标题翻译：制备二异氰酸酯的方法
公开(公告)号：US20120190884A1
公开(公告)日：2012-07-26
申请号：US13388831
申请日：2010-07-29
申请人： Olivier Buisine
发明人： Olivier Buisine
IPC分类号： C07C67/14
CPC分类号： C07C67/14 , C07C69/63
摘要： A method for preparing difluoroacetic acid esters is described. The method can include reacting difluoroacetyl fluorine with an aliphatic or cycloaliphatic alcohol in the presence of a heterogeneous mineral base.
摘要翻译：描述了制备二氟乙酸酯的方法。该方法可以包括在异质矿物基质存在下使二氟乙酰氟与脂族或脂环族醇反应。

10. 发明授权

US07902409B2 Production of difluoroethanol 有权
标题翻译：生产二氟乙醇
公开(公告)号：US07902409B2
公开(公告)日：2011-03-08
申请号：US12086747
申请日：2006-12-19
申请人： Olivier Buisine , Roland Jacquot
发明人： Olivier Buisine , Roland Jacquot
IPC分类号： C07C31/38
CPC分类号： C07C29/149 , C07C31/38
摘要： Difluoroethanol is produced by hydrogenation, in the presence of an effective amount of a catalyst containing at least one element of Group VIII of the Periodic Table deposited onto a solid, acidic mineral support, of an acetyl halide having the following formula (I), in which formula X is a halogen atom other than a fluorine atom:
摘要翻译：在有效量的催化剂存在下，通过氢化产生二氟乙醇，所述催化剂含有至少一种元素周期表第Ⅷ族元素沉积在具有下式（I）的乙酰卤的固体酸性矿物载体上，在该式X是除氟原子以外的卤原子：

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