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1. 发明授权

US08565896B2 Electrode cuff with recesses 有权
标题翻译：带凹槽的电极袖口
公开(公告)号：US08565896B2
公开(公告)日：2013-10-22
申请号：US12952058
申请日：2010-11-22
申请人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
发明人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
IPC分类号： A61N1/05
CPC分类号： A61N1/0556
摘要： An electrode assembly includes one or more electrode contact surfaces, and a cuff, to which the contact surfaces are fixed, and which comprises an electrically insulating material, is configured to assume open and closed positions, and, when in the closed position, is shaped so as to define a plurality of planar cross sections perpendicular to a longitudinal axis of the cuff, distributed continuously along an entire length of the cuff along the longitudinal axis, such that the perpendicular cross sections define respective inner closed curves that together define an inner surface that defines and completely surrounds a volume that extends along the entire length of the cuff. The inner closed curves of at least two of the perpendicular cross sections would cross, and not merely intersect, one another if superimposed while preserving orientation and position of the perpendicular cross sections with respect to the cuff. Other embodiments are also described.
摘要翻译：一种电极组件包括一个或多个电极接触表面，以及一个接触表面被固定在其上并且包括电绝缘材料的箍带构造成呈现开和关的位置，并且当处于关闭位置时，以便限定垂直于袖带的纵向轴线的多个平面横截面，其沿着所述袖带的整个长度沿着所述纵向轴线连续分布，使得所述垂直横截面限定相应的内部闭合曲线，所述内部闭合曲线一起限定内部表面其限定并完全围绕沿袖带的整个长度延伸的体积。至少两个垂直横截面的内部闭合曲线将彼此交叉而不是彼此相交，如果在保持相对于袖带的垂直横截面的取向和位置的情况下叠加。还描述了其它实施例。

2. 发明申请

US20120130463A1 ELECTRODE CUFF WITH RECESSES 有权
标题翻译：电极插座
公开(公告)号：US20120130463A1
公开(公告)日：2012-05-24
申请号：US12952058
申请日：2010-11-22
申请人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
发明人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
IPC分类号： A61N1/05
CPC分类号： A61N1/0556
摘要： An electrode assembly includes one or more electrode contact surfaces, and a cuff, to which the contact surfaces are fixed, and which comprises an electrically insulating material, is configured to assume open and closed positions, and, when in the closed position, is shaped so as to define a plurality of planar cross sections perpendicular to a longitudinal axis of the cuff, distributed continuously along an entire length of the cuff along the longitudinal axis, such that the perpendicular cross sections define respective inner closed curves that together define an inner surface that defines and completely surrounds a volume that extends along the entire length of the cuff. The inner closed curves of at least two of the perpendicular cross sections would cross, and not merely intersect, one another if superimposed while preserving orientation and position of the perpendicular cross sections with respect to the cuff. Other embodiments are also described.
摘要翻译：一种电极组件包括一个或多个电极接触表面，以及一个接触表面被固定在其上并且包括电绝缘材料的箍带构造成呈现开和关的位置，并且当处于关闭位置时，以便限定垂直于袖带的纵向轴线的多个平面横截面，其沿着所述袖带的整个长度沿着所述纵向轴线连续分布，使得所述垂直横截面限定相应的内部闭合曲线，所述内部闭合曲线一起限定内部表面其限定并完全围绕沿袖带的整个长度延伸的体积。至少两个垂直横截面的内部闭合曲线将彼此交叉而不是彼此相交，如果在保持相对于袖带的垂直横截面的取向和位置的情况下叠加。还描述了其它实施例。

3. 发明授权

US08718791B2 Electrode cuffs 有权
标题翻译：电极袖口
公开(公告)号：US08718791B2
公开(公告)日：2014-05-06
申请号：US12947608
申请日：2010-11-16
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/36114
摘要： Apparatus is provided for application to a nerve of a subject, including an electrode cuff, which includes a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities, such that at least one of the cavities is an empty cavity that does not have an electrode positioned therein. Other embodiments are also described.
摘要翻译：提供了用于施用于受试者神经的装置，包括电极箍，其包括壳体，其被构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔住房。一个或多个电极在少于所有的空腔中固定到壳体，使得至少一个空腔是不具有位于其中的电极的空腔。还描述了其它实施例。

4. 发明申请

US20080125827A1 Selective nerve fiber stimulation for treating heart conditions 审中-公开
标题翻译：选择性神经纤维刺激治疗心脏病
公开(公告)号：US20080125827A1
公开(公告)日：2008-05-29
申请号：US11978440
申请日：2007-10-29
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/365
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.
摘要翻译：提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

5. 发明申请

US20060100668A1 Selective nerve fiber stimulation 有权
标题翻译：选择性神经纤维刺激
公开(公告)号：US20060100668A1
公开(公告)日：2006-05-11
申请号：US11234877
申请日：2005-09-22
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Nitza Gal-On Shoham , Avraham Biran , Omry Ben-Ezra , Ron Dabby , Yossi Gross
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Nitza Gal-On Shoham , Avraham Biran , Omry Ben-Ezra , Ron Dabby , Yossi Gross
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36071 , A61N1/36114
摘要： Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.
摘要翻译：提供了用于治疗受试者的状况的装置，包括适于与被检体的自主神经联接的电极装置，以及控制单元。所述控制单元适于驱动所述电极装置向所述神经施加刺激电流，所述刺激电流能够诱导所述神经的第一组和第二组神经纤维中的治疗方向的动作电位，并驱动所述电极能够抑制在第二组神经纤维中沿治疗方向行进的诱导作用电位的神经抑制电流的装置，第二组神经纤维中的神经纤维的直径通常大于第一组神经纤维中的神经纤维的直径组。还描述了其它实施例。

6. 发明授权

US08116881B2 Electrode assembly for nerve control 有权
标题翻译：用于神经控制的电极组件
公开(公告)号：US08116881B2
公开(公告)日：2012-02-14
申请号：US11978776
申请日：2007-10-29
申请人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
发明人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/36114
摘要： Apparatus is provided for applying current to a nerve, including a housing, configured to be placed in a vicinity of the nerve. At least one electrode is fixed to the housing such that the at least one electrode does not come in direct physical contact with the nerve when the housing is placed in the vicinity of the nerve, and such that the electrode surrounds greater than 180 degrees of a circumference of the nerve after the placement of the housing. Two end insulating elements are fixed to the housing such that the at least one electrode is between the end insulating elements, and the end insulating elements come in contact or practically in contact with the nerve when the housing is placed in the vicinity of the nerve. Other embodiments are also described.
摘要翻译：提供了用于将电流施加到神经的装置，包括被配置为放置在神经附近的壳体。至少一个电极被固定到壳体，使得当壳体放置在神经附近时，至少一个电极不会与神经直接物理接触，并且使得电极围绕大于180度的放置外壳后神经的周长。两个端部绝缘元件固定到壳体上，使得至少一个电极位于端部绝缘元件之间，并且当壳体放置在神经附近时，端部绝缘元件接触或实际上与神经接触。还描述了其它实施例。

7. 发明授权

US07904151B2 Parasympathetic stimulation for treating ventricular arrhythmia 有权
标题翻译：副交感神经刺激治疗室性心律失常
公开(公告)号：US07904151B2
公开(公告)日：2011-03-08
申请号：US11975407
申请日：2007-10-19
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/39
CPC分类号： A61N1/36114 , A61N1/3621
摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.
摘要翻译：提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏脉冲和抗心律变能。所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。第一和第二控制单元不在一般控制之下。控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。还描述了其它实施例。

8. 发明授权

US07778711B2 Reduction of heart rate variability by parasympathetic stimulation 有权
标题翻译：通过副交感神经刺激减少心率变异性
公开(公告)号：US07778711B2
公开(公告)日：2010-08-17
申请号：US10719659
申请日：2003-11-20
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/00
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.
摘要翻译：提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

9. 发明申请

US20100010603A1 Electrode cuffs 审中-公开
标题翻译：电极袖口
公开(公告)号：US20100010603A1
公开(公告)日：2010-01-14
申请号：US12217930
申请日：2008-07-09
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/36114
摘要： Apparatus is provided for application to a nerve of a subject, including a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities. Other embodiments are also described.
摘要翻译：提供了将装置应用于受试者的神经，包括外壳，其构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔住房。一个或多个电极在少于所有的空腔中固定到壳体。还描述了其它实施例。

10. 发明申请

US20080140141A1 Intermittent electrical stimulation 有权
标题翻译：间歇性电刺激
公开(公告)号：US20080140141A1
公开(公告)日：2008-06-12
申请号：US11975654
申请日：2007-10-19
申请人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen , Shai Ayal
发明人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen , Shai Ayal
IPC分类号： A61N1/36
CPC分类号： A61N1/36114
摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.
摘要翻译：提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。还描述了其它实施例。

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