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1. 发明申请

US20060100668A1 Selective nerve fiber stimulation 有权
标题翻译：选择性神经纤维刺激
公开(公告)号：US20060100668A1
公开(公告)日：2006-05-11
申请号：US11234877
申请日：2005-09-22
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Nitza Gal-On Shoham , Avraham Biran , Omry Ben-Ezra , Ron Dabby , Yossi Gross
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Nitza Gal-On Shoham , Avraham Biran , Omry Ben-Ezra , Ron Dabby , Yossi Gross
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36071 , A61N1/36114
摘要： Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.
摘要翻译：提供了用于治疗受试者的状况的装置，包括适于与被检体的自主神经联接的电极装置，以及控制单元。所述控制单元适于驱动所述电极装置向所述神经施加刺激电流，所述刺激电流能够诱导所述神经的第一组和第二组神经纤维中的治疗方向的动作电位，并驱动所述电极能够抑制在第二组神经纤维中沿治疗方向行进的诱导作用电位的神经抑制电流的装置，第二组神经纤维中的神经纤维的直径通常大于第一组神经纤维中的神经纤维的直径组。还描述了其它实施例。

2. 发明申请

US20080119898A1 Nitric oxide synthase-affecting parasympathetic stimulation 审中-公开
标题翻译：一氧化氮合酶影响副交感神经刺激
公开(公告)号：US20080119898A1
公开(公告)日：2008-05-22
申请号：US11977923
申请日：2007-10-25
申请人： Tamir Ben-David , Nitza Gal-on Shoham , Ehud Cohen , Rami Biran , Omry Ben-Ezra
发明人： Tamir Ben-David , Nitza Gal-on Shoham , Ehud Cohen , Rami Biran , Omry Ben-Ezra
IPC分类号： A61N1/00
CPC分类号： A61N1/0556 , A61N1/205 , A61N1/36114
摘要： Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.
摘要翻译：提供了用于治疗受试者的状况的装置，包括适于与被检体的自主神经联接的电极装置，以及控制单元。所述控制单元适于驱动所述电极装置向所述神经施加刺激电流，所述刺激电流能够诱导所述神经的第一组和第二组神经纤维中的治疗方向的动作电位，并驱动所述电极能够抑制在第二组神经纤维中沿治疗方向行进的诱导作用电位的神经抑制电流的装置，第二组神经纤维中的神经纤维的直径通常大于第一组神经纤维中的神经纤维的直径组。还描述了其它实施例。

3. 发明申请

US20080132964A1 Selective nerve fiber stimulation for treating heart conditions 审中-公开
公开(公告)号：US20080132964A1
公开(公告)日：2008-06-05
申请号：US11981369
申请日：2007-10-30
申请人： Ehud Cohen , Shai Ayal , Tamir Ben-David , Omry Ben-Ezra , Yossi Gross
发明人： Ehud Cohen , Shai Ayal , Tamir Ben-David , Omry Ben-Ezra , Yossi Gross
IPC分类号： A61N1/36 , A61N1/39 , A61N1/365
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

4. 发明授权

US08224444B2 Intermittent electrical stimulation 有权
标题翻译：间歇性电刺激
公开(公告)号：US08224444B2
公开(公告)日：2012-07-17
申请号：US11975654
申请日：2007-10-19
申请人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen , Shai Ayal
发明人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen , Shai Ayal
IPC分类号： A61N1/00
CPC分类号： A61N1/36114
摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.
摘要翻译：提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。还描述了其它实施例。

5. 发明授权

US07634317B2 Techniques for applying, calibrating, and controlling nerve fiber stimulation 失效
标题翻译：应用，校准和控制神经纤维刺激的技术
公开(公告)号：US07634317B2
公开(公告)日：2009-12-15
申请号：US11062324
申请日：2005-02-18
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/00
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.
摘要翻译：提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。还描述了其它实施例。

6. 发明申请

US20050149154A1 Nerve-branch-specific action-potential activation,inhibition, and monitoring 有权
标题翻译：神经分支特异性动作电位激活，抑制和监测
公开(公告)号：US20050149154A1
公开(公告)日：2005-07-07
申请号：US10745514
申请日：2003-12-29
申请人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
发明人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0556
摘要： A dual electrode arrangement, is provided, wherein two, preferably unidirectional, electrode configurations flank a nerve junction from which a preselected nerve branch issues, proximally and distally to the junction, with respect to the brain. The arrangement is conducive to the following: generating efferent action-potential propagations, substantially restricted to the preselected nerve branch, inhibiting afferent action-potential propagations, from the preselected nerve branch, selectively generating action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch, and selectively inhibiting action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch. The dual electrode arrangement is further conducive to monitoring naturally-occurring, efferent action-potential propagations, heading towards the preselected nerve branch, and monitoring naturally-occurring, afferent action-potential propagations, from the preselected nerve branch. The unidirectional electrode configurations may be monopolar, bipolar, tripolar, or multipolar. Communication with extracorporeal stations, and closed loop operations are also provided.
摘要翻译：提供了双电极布置，其中两个，优选单向的电极构型位于神经交界处，神经交叉点相对于脑，预选的神经分支向近端向近端和远端发出接合。该装置有利于：产生传播动作电位传播，基本上限于预选的神经分支，抑制来自预选神经分支的传入动作潜在传播，选择性地产生动作电位传播，在神经纤维的子集中基本上限于预选神经分支的预定直径范围，以及基本上限于预选神经分支的预定直径范围的神经纤维的子集中选择性抑制动作电位传播。双电极布置还有助于监测自然发生的，传出的动作电位传播，朝向预选的神经分支，并且从预选的神经分支监测天然存在的，传入的动作电位传播。单向电极配置可以是单极性，双极性，三极性或多极性。还提供与体外站的沟通和闭环操作。

7. 发明申请

US20080125827A1 Selective nerve fiber stimulation for treating heart conditions 审中-公开
标题翻译：选择性神经纤维刺激治疗心脏病
公开(公告)号：US20080125827A1
公开(公告)日：2008-05-29
申请号：US11978440
申请日：2007-10-29
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/365
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.
摘要翻译：提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

8. 发明授权

US07974693B2 Techniques for applying, configuring, and coordinating nerve fiber stimulation 有权
标题翻译：应用，配置和协调神经纤维刺激的技术
公开(公告)号：US07974693B2
公开(公告)日：2011-07-05
申请号：US11064446
申请日：2005-02-22
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/365
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3622 , A61N1/3627
摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.
摘要翻译：提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏脉冲和抗心律变能。所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。第一和第二控制单元不在一般控制之下。控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。还描述了其它实施例。

9. 发明授权

US07844346B2 Electrode assembly for nerve control 有权
标题翻译：用于神经控制的电极组件
公开(公告)号：US07844346B2
公开(公告)日：2010-11-30
申请号：US11347120
申请日：2006-02-02
申请人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
发明人： Ehud Cohen , Tamir Ben-David , Shai Ayal , Omry Ben-Ezra
IPC分类号： A61N1/375
CPC分类号： A61N1/0556
摘要： Apparatus is provided for applying current to a nerve, including a housing, that is adapted to be placed in a vicinity of the nerve. At least one electrode is fixed to the housing such that the at least one electrode does not come in direct physical contact with the nerve, and such that the electrode surrounds greater than 180 degrees of a circumference of the nerve after the placement of the housing. Two end insulating elements are fixed to the housing. The at least one electrode is between the end insulating elements. A characteristic closest end insulating element distance to a surface of the nerve is less than 0.5 mm.
摘要翻译：提供了用于将电流施加到神经的装置，包括适于放置在神经附近的壳体。至少一个电极被固定到壳体，使得至少一个电极不与神经直接物理接触，并且使得电极在放置壳体之后围绕大于180度的神经周围。两端绝缘元件固定在壳体上。至少一个电极在端部绝缘元件之间。距离神经表面最近的特征最接近的绝缘元件的距离小于0.5mm。

10. 发明授权

US07805203B2 Method for surgically implanting an electrode device 有权
标题翻译：手术植入电极装置的方法
公开(公告)号：US07805203B2
公开(公告)日：2010-09-28
申请号：US11975646
申请日：2007-10-19
申请人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/05
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3622 , A61N1/3627
摘要： A method is provided that includes surgically implanting an electrode device having a cuff and one or more electrodes mounted in the cuff, by placing the electrode device around a nerve such that the electrodes face the nerve. Conductive solution is introduced into the electrode device such that the solution is in contact with both the electrodes and the nerve. During implantation of the electrode device, an impedance is measured between one or more of the electrodes and an electrical contact point in electrical communication with the electrode device. Responsively to the impedance measurement, it is determined whether the electrode device is correctly sized for the nerve, and, if not, the electrode device is removed and another electrode device having a different size is implanted. Other embodiments are also described.
摘要翻译：提供了一种方法，其包括通过将电极装置围绕神经放置以使得电极面向神经，手术地植入具有袖带的电极装置和安装在袖带中的一个或多个电极。将导电溶液引入电极装置，使得溶液与电极和神经接触。在植入电极装置期间，测量一个或多个电极之间的阻抗和与电极装置电连通的电接触点。响应于阻抗测量，确定电极装置是否具有适当尺寸的神经，如果不是，则去除电极装置，并植入具有不同尺寸的另一电极装置。还描述了其它实施例。

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