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1. 发明授权

US5686606A UCF116 compounds 失效
标题翻译： UCF116化合物
公开(公告)号：US5686606A
公开(公告)日：1997-11-11
申请号：US682514
申请日：1996-07-12
申请人： Tamio Mizukami , Mikito Itoh , Mitsunobu Hara , Hirofumi Nakano , Yumiko Aotani , Keiko Ochiai , Shiro Akinaga , Akira Mihara
发明人： Tamio Mizukami , Mikito Itoh , Mitsunobu Hara , Hirofumi Nakano , Yumiko Aotani , Keiko Ochiai , Shiro Akinaga , Akira Mihara
IPC分类号： C07D225/06 , C12P17/10 , A61K31/415
CPC分类号： C07D225/06 , C12P17/10
摘要： The present invention relates to UCF116 compounds represented by the formula (I) : ##STR1## wherein an example of Q.sup.1 representation is ##STR2## and an example of Q.sup.2 representation is ##STR3## which have antibacterial and antitumor activity and are useful as antibacterial and antitumor agents.
摘要翻译： PCT No.PCT / JP95 / 02325 Sec。 371日期：1996年7月12日 102（e）日期1996年7月12日PCT提交1995年11月14日PCT公布。公开号WO96 / 15114 日期：1996年5月23日本发明涉及由式（I）表示的UCF116化合物：其中Q1表示的实例是活性并可用作抗细菌剂和抗肿瘤剂。

2. 发明授权

US5717110A UCH15 compounds 失效
标题翻译： UCH15化合物
公开(公告)号：US5717110A
公开(公告)日：1998-02-10
申请号：US836314
申请日：1997-05-12
申请人： Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Hirofumi Nakano , Shingo Kakita , Youichi Uosaki , Keiko Ochiai , Tadashi Ashizawa , Akira Mihara
发明人： Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Hirofumi Nakano , Shingo Kakita , Youichi Uosaki , Keiko Ochiai , Tadashi Ashizawa , Akira Mihara
IPC分类号： C07D207/34 , C07D207/00
CPC分类号： C07D207/34
摘要： This invention relates to UCH15 compounds of the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a hydroxyl group.
摘要翻译： PCT No.PCT / JP96 / 02587第 371日期：1997年5月12日 102（e）日期1997年5月12日PCT提交1996年9月11日PCT公布。公开号WO97 / 10208 PCT 日本公开号为1997年3月20日本发明涉及式（I）的UCH15化合物：其中R 1表示氢原子或羟基。

3. 发明授权

US5663298A UCK14 compounds 失效
标题翻译： UCK14化合物
公开(公告)号：US5663298A
公开(公告)日：1997-09-02
申请号：US730348
申请日：1996-10-15
申请人： Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Ritsuko Katahira , Atsuhiro Hasegawa , Keiko Ochiai , Shiro Akinaga
发明人： Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Ritsuko Katahira , Atsuhiro Hasegawa , Keiko Ochiai , Shiro Akinaga
IPC分类号： A61K38/00 , C07K5/06 , A01N43/02 , C07K5/00 , C12N1/00
CPC分类号： C07K5/06026 , A61K38/00
摘要： The present invention relates to UCK14 compounds having antitumor activity which are represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or --COOC(CH.sub.3).sub.3 ; and R.sup.2 and R.sup.3 are taken together to form --CH.sub.2 --, or each R.sup.2 and R.sup.3 independently are hydrogen,and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及具有抗肿瘤活性的UCK14化合物，其由下式表示：其中R 1为氢或-COOC（CH 3）3; 并且R 2和R 3一起形成-CH 2 - ，或每个R 2和R 3独立地是氢，及其药学上可接受的盐。

4. 发明授权

US5719179A Compound GEX1 失效
标题翻译：化合物GEX1
公开(公告)号：US5719179A
公开(公告)日：1998-02-17
申请号：US772941
申请日：1996-12-24
申请人： Tamio Mizukami , Yasushi Sakai , Tetsuo Yoshida , Youichi Uosaki , Keiko Ochiai , Shiro Akinaga
发明人： Tamio Mizukami , Yasushi Sakai , Tetsuo Yoshida , Youichi Uosaki , Keiko Ochiai , Shiro Akinaga
IPC分类号： C07D407/06 , C07D407/14 , C12P17/06 , C07D407/04 , A61K31/35
CPC分类号： C07D407/06 , C07D407/14 , C12P17/06
摘要： Disclosed is Compound GEX1 of formula (I), having excellent antitumor activity: ##STR1## wherein R.sup.1 represents hydroxy or ##STR2## R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen or hydroxy; R.sup.5 represents hydroxyl or lower alkoxy; provided that when R.sup.1 is hydroxy and R.sup.5 is methoxy, then at least one of R.sup.2, R.sup.3 and R.sup.4 is the group except for hydrogen, and pharmaceutically acceptable salts thereof.
摘要翻译：公开了具有优异抗肿瘤活性的式（I）化合物GEX1：其中R 1表示羟基或R 2，R 3和R 4各自独立地表示氢或羟基; R5代表羟基或低级烷氧基; 条件是当R 1为羟基且R 5为甲氧基时，则R 2，R 3和R 4中的至少一个为氢以外的基团，及其药学上可接受的盐。

5. 发明授权

US5665703A GE3 compound 失效
标题翻译： GE3化合物
公开(公告)号：US5665703A
公开(公告)日：1997-09-09
申请号：US567529
申请日：1995-12-05
申请人： Tamio Mizukami , Yasushi Sakai , Tetsuo Yoshida , Tsutomu Agatsuma , Keiko Ochiai , Shiro Akinaga
发明人： Tamio Mizukami , Yasushi Sakai , Tetsuo Yoshida , Tsutomu Agatsuma , Keiko Ochiai , Shiro Akinaga
IPC分类号： A61K38/00 , A61P31/04 , A61P35/00 , C07K7/06 , C07K11/00 , C07K14/195 , C07K14/41 , C07K11/02
CPC分类号： C07K7/06 , A61K38/00
摘要： A GE3 compound of the formula (I) having antibacterial and antitumor properties: ##STR1##
摘要翻译：具有抗细菌和抗肿瘤性质的式（I）的GE3化合物：其中：（I）

6. 发明授权

US5843955A Compound LK6-A 失效
标题翻译：复方LK6-A
公开(公告)号：US5843955A
公开(公告)日：1998-12-01
申请号：US723149
申请日：1996-09-30
申请人： Tatsuya Tamaoki , Hiroyuki Nagata , Isami Takahashi , Mayumi Yoshida , Yumiko Aotani , Katsuhiko Ando , Keiko Ochiai
发明人： Tatsuya Tamaoki , Hiroyuki Nagata , Isami Takahashi , Mayumi Yoshida , Yumiko Aotani , Katsuhiko Ando , Keiko Ochiai
IPC分类号： C07D471/06 , A61K31/475 , C07D471/16
CPC分类号： C07D471/06
摘要： The present invention relates to compound LK6-A represented by the formula: ##STR1## which has immunosuppressive activity, and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由下式表示的化合物LK6-A：具有免疫抑制活性的及其药学上可接受的盐。

7. 发明授权

US07037672B2 Process for producing a bran pickles flavoring solution 失效
公开(公告)号：US07037672B2
公开(公告)日：2006-05-02
申请号：US10419095
申请日：2003-04-21
申请人： Chiaki Saitoh , Atsushi Yashiro , Chikara Tokunaga , Kyoko Ozawa , Atsuko Yokoi , Nobuo Ogata , Hiroshi Katahira , Keiko Ochiai , Katsuhiko Ando
发明人： Chiaki Saitoh , Atsushi Yashiro , Chikara Tokunaga , Kyoko Ozawa , Atsuko Yokoi , Nobuo Ogata , Hiroshi Katahira , Keiko Ochiai , Katsuhiko Ando
IPC分类号： C12P1/00
CPC分类号： C12R1/15 , A23B7/10 , A23L27/24 , C12P17/04 , Y10S435/843
摘要： The present invention relates to a novel flavoring solution for making pickles having a flavor of foods pickled in rice bran paste (hereinafter referred to as a bran pickles flavoring solution), a clear bran pickles flavoring solution, processes for producing said solutions, a novel microorganism belonging to the genus Corynebacterium used for the production of said flavoring solutions, and a process for producing a solution containing a lactone wherein the lactone is selectively extracted from a culture of a lactone-producing microorganism.The present invention also relates to a novel bacterium of the genus Corynebacterium which has the ability to produce γ-dodecalactone and/or γ-dodecelactone and is useful for the production of said bran pickles flavoring solutions.

8. 发明授权

US5607848A Process for producing optically active 4-hydroxy-2-ketoglutaric acid using microorganisms 失效
标题翻译：使用微生物生产光学活性的4-羟基-2-酮戊二酸的方法
公开(公告)号：US5607848A
公开(公告)日：1997-03-04
申请号：US395707
申请日：1995-02-28
申请人： Ryoichi Katsumata , Shinichi Hashimoto , Keiko Ochiai
发明人： Ryoichi Katsumata , Shinichi Hashimoto , Keiko Ochiai
IPC分类号： C12P41/00 , C12N1/20 , C12P7/50 , C12R1/01 , C12R1/07 , C12R1/38 , C12R1/40 , C12R1/41
CPC分类号： C12R1/41 , C12P7/50 , Y10S435/822 , Y10S435/874 , Y10S435/877
摘要： The present invention provides a process for producing an optically active 4-hydroxy-2-ketoglutaric acid, by mixing glyoxylic acid, pyruvic acid and a microorganism to form the optically active 4-hydroxy-2-ketoglutaric acid in an aqueous medium.
摘要翻译：本发明提供了通过在水性介质中混合乙醛酸，丙酮酸和微生物以形成光学活性的4-羟基-2-酮戊二酸来制备光学活性的4-羟基-2-酮戊二酸的方法。

9. 发明申请

US20100120088A1 MUTANT 6-PHOSPHOGLUCONATE DEHYDROGENASE 有权
标题翻译：突变6磷酸脱氢酶脱氢酶
公开(公告)号：US20100120088A1
公开(公告)日：2010-05-13
申请号：US12430592
申请日：2009-04-27
申请人： Masato IKEDA , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
发明人： Masato IKEDA , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
IPC分类号： C12P21/00 , C12P13/04 , C12P19/30 , C12P19/00 , C12P13/06 , C12P13/08 , C12P13/22
CPC分类号： C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/227
摘要： The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s) of the amino acid sequence shown in SEQ ID NO: 1, and having GND activity; DNA encoding the polypeptide; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a microorganism carrying the DNA on the chromosome; and a process for producing a useful substance which comprises culturing the transformant or the microorganism in a medium.
摘要翻译：本发明涉及一种多肽，其具有衍生自属于棒杆菌属的微生物的6-磷酸葡糖酸脱氢酶（以下简写为GND）的修饰氨基酸序列，所述修饰是将位点（ s）对应于SEQ ID NO：1所示氨基酸序列的第158位和/或第361位氨基酸，并具有GND活性; 编码多肽的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 在染色体上携带DNA的微生物; 以及生产有用物质的方法，包括在培养基中培养转化体或微生物。

10. 发明授权

US06468780B2 Bacillus strains which produce HMG-CoA reductase inhibitors 有权
标题翻译：产生HMG-CoA还原酶抑制剂的芽孢杆菌菌株
公开(公告)号：US06468780B2
公开(公告)日：2002-10-22
申请号：US09829080
申请日：2001-04-10
申请人： Yutaka Takano , Masaru Hasegawa , Hideo Mori , Katsuhiko Ando , Keiko Ochiai , Hiroaki Motoyama , Akio Ozaki
发明人： Yutaka Takano , Masaru Hasegawa , Hideo Mori , Katsuhiko Ando , Keiko Ochiai , Hiroaki Motoyama , Akio Ozaki
IPC分类号： C12N120
CPC分类号： C12R1/07 , C12P7/62 , C12P17/06
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.
摘要翻译：公开了一种制备由通式（II-a）表示的化合物的方法：其中R 1表示氢原子，取代或未取代的烷基或碱金属; R 2表示取代或未取代的烷基或芳基） [化学式（II-a）]或化合物（II-a）的内酯形式[以下称为化合物（II-b）]] [其中包括使通式（Ia）表示的化合物 R1表示氢原子，取代或未取代的烷基或碱金属; R2表示取代或未取代的烷基或芳基）[以下称为化合物（Ia）]或化合物（Ia）的内酯形式[ （Ia）或化合物（Ib）转化为化合物（II-a）或化合物（II-a）的酶源的作用，以下称为化合物（Ib） b）在反应混合物中形成化合物（II -a）或化合物（II-b），并从反应混合物中回收化合物（II-a）或化合物（II-b）。

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