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1. 发明申请

US20080131976A1 Novel G protein coupled receptor protein, DNA its ligand 失效
标题翻译：新型G蛋白偶联受体蛋白，DNA的配体
公开(公告)号：US20080131976A1
公开(公告)日：2008-06-05
申请号：US11976414
申请日：2007-10-24
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
摘要翻译：本发明涉及大鼠小脑衍生和人类脑源性G蛋白偶联受体蛋白或其盐，其部分肽，酰胺，酯或其盐，配体，用于筛选改变结合的化合物的方法/试剂盒配体和G蛋白偶联受体蛋白质之间的性质，通过筛选获得的化合物或其G蛋白偶联受体蛋白质的抗体。

2. 发明授权

US07608409B2 Screening assay using G-protein coupled receptor protein OT7T175 失效
标题翻译：使用G蛋白偶联受体蛋白OT7T175的筛选试验
公开(公告)号：US07608409B2
公开(公告)日：2009-10-27
申请号：US11976414
申请日：2007-10-24
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： C07K14/705 , G01N33/53
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
摘要翻译：本发明涉及大鼠小脑衍生和人类脑源性G蛋白偶联受体蛋白或其盐，其部分肽，酰胺，酯或其盐，配体，用于筛选改变结合的化合物的方法/试剂盒配体和G蛋白偶联受体蛋白质之间的性质，通过筛选获得的化合物或其G蛋白偶联受体蛋白质的抗体。

3. 发明授权

US06699965B1 Peptides that activate the G-protein coupled receptor protein, 0T7T175 失效
标题翻译：激活G蛋白偶联受体蛋白的肽，0T7T175
公开(公告)号：US06699965B1
公开(公告)日：2004-03-02
申请号：US09830428
申请日：2001-04-26
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： C07K1400
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands thereto; a method/kit for screening compounds capable of altering the binding properties of the ligands to the G protein-coupled receptor proteins; the compounds or salts thereof obtained by the above screening; antibodies against the G protein-coupled receptor proteins, etc.
摘要翻译： G起源于大鼠脑干和人脑或其盐附近的蛋白质偶联受体蛋白质，或其肽片段或其酰胺，酯或其盐; 配体; 用于筛选能够改变配体与G蛋白偶联受体蛋白质的结合性质的化合物的方法/试剂盒; 通过上述筛选获得的化合物或其盐; 针对G蛋白偶联受体蛋白的抗体等

4. 发明授权

US07662574B2 Use of a G protein-coupled receptor and its cognizant ligand in the identification of compounds that affect prolactin secretion 失效
标题翻译： G蛋白偶联受体及其识别配体在鉴定影响催乳素分泌的化合物中的应用
公开(公告)号：US07662574B2
公开(公告)日：2010-02-16
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

5. 发明授权

US07192723B2 G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译： G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US07192723B2
公开(公告)日：2007-03-20
申请号：US10719587
申请日：2003-11-21
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： C07K7/08 , C07K14/47 , G01N33/566
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

6. 发明申请

US20070202550A1 Novel G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译：新型G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US20070202550A1
公开(公告)日：2007-08-30
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07H21/04 , C07K14/47 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

7. 发明授权

US07374910B2 DNA encoding galanin receptor activating peptide 失效
标题翻译：编码甘丙肽受体激活肽的DNA
公开(公告)号：US07374910B2
公开(公告)日：2008-05-20
申请号：US11376694
申请日：2006-03-15
申请人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
发明人： Tetsuya Ohtaki , Hideki Matsui , Yoshihiro Ishibashi , Kazuhiro Ogi , Chieko Kitada
IPC分类号： C01N15/11 , C01N15/63 , C01N5/10
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译：本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

8. 发明授权

US06399316B1 PACAP receptor protein, method for preparing said protein, and use thereof 失效
标题翻译： PACAP受体蛋白质，所述蛋白质的制备方法及其用途
公开(公告)号：US06399316B1
公开(公告)日：2002-06-04
申请号：US09201474
申请日：1998-11-30
申请人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
发明人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
IPC分类号： G01N3353
CPC分类号： C07K14/72 , A61K38/00 , A61K48/00
摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein, and use of the protein, DNA, and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. Further, amino acid sequences deduced from the nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.
摘要翻译：本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体以及该蛋白质，DNA及抗体的用途。从牛大脑中纯化PACAP受体蛋白。从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。此外，确定从核苷酸序列推导的氨基酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较来执行药物设计，（5）基因诊断中探针和PCR引物的制备等。

9. 发明申请

US20090318365A1 METASTIN DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：分子衍生物及其用途
公开(公告)号：US20090318365A1
公开(公告)日：2009-12-24
申请号：US12455563
申请日：2009-06-02
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivatives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译：本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转氨酶衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。

10. 发明申请

US20060287227A1 Gonadal function improving agents 有权
标题翻译：性腺功能改善剂
公开(公告)号：US20060287227A1
公开(公告)日：2006-12-21
申请号：US10547974
申请日：2004-03-11
申请人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
发明人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
IPC分类号： A61K48/00 , A61K38/24
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译：促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂，并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

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