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1. 发明申请

US20050261370A1 Process for producing of an aminoalkylsulfonic acid and a method of salt exchange for a salt thereof 失效
标题翻译：氨基烷基磺酸的制备方法及其盐的盐交换方法
公开(公告)号：US20050261370A1
公开(公告)日：2005-11-24
申请号：US10526438
申请日：2003-08-27
申请人： Takuhiro Kimura , Tsutomo Tani , Reiji Miyahara
发明人： Takuhiro Kimura , Tsutomo Tani , Reiji Miyahara
IPC分类号： C07C303/22 , C07C303/32 , C07C309/14 , A61K31/205 , C07C39/13
CPC分类号： C07C303/22 , C07C303/32 , C07C309/14
摘要： A process for producing an aminoalkylsulfonic acid of formula [2]: wherein R1 and R2 are each independently hydrogen, alkyl, aryl or aralkyl; and R3 and R4 are each independently hydrogen or alkyl, comprising reacting an aminoalkylsulfonate salt of formula [1]: wherein M is alkali metal, organic ammonium or ammonium ion; and R1 to R4 are as described above, an aqueous solution thereof, or a solution dissolving any one of them in a water-soluble organic solvent, selected from alcohols having 1 to 3 carbon, carboxylic acids having 2 to 12 carbon and dimethylformamide, with an organic acid; and a method of salt exchange for an aminoalkylsulfonate salt of formula [1′]: wherein M′ is alkali metal, organic ammonium or ammonium ion; and R1 and R4 are as described above, comprising reacting the aminoalkylsulfonate salt formula [2] with a hydroxide of formula [6]: M′OH [6]wherein M′ is as described above, in alcohol or water.
摘要翻译：制备式[2]的氨基烷基磺酸的方法：其中R 1和R 2各自独立地为氢，烷基，芳基或芳烷基; R 3和R 4各自独立地为氢或烷基，包括使式[1]的氨基烷基磺酸盐：其中M是碱金属，有机铵或铵离子; 和R 1至R 4如上所述，其水溶液或将它们中的任何一种溶解在水溶性有机溶剂中的溶液，所述溶液选自具有 1至3个碳，具有2至12个碳原子和二甲基甲酰胺的羧酸与有机酸; 和式[1']的氨基烷基磺酸盐的盐交换方法：其中M'是碱金属，有机铵或铵离子; R 1和R 4如上所述，包括使式[2]的氨基烷基磺酸盐与式[6]的氢氧化物反应：<β在线式 description =“In-line Formulas”end =“lead”？> M'OH [6] <？in-line-formula description =“In-line Formulas”end =“tail”？>其中M'如上所述，在酒精或水中。

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