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1. 发明申请

US20070244153A1 Diamine Derivative, Process of Preparation Thereof, and Fungicide Comprising Diamine Derivative as an Active Ingredient 审中-公开
标题翻译：二胺衍生物，其制备方法和包含二胺衍生物作为活性成分的杀菌剂
公开(公告)号：US20070244153A1
公开(公告)日：2007-10-18
申请号：US11658098
申请日：2005-07-19
申请人： Takeshi Kakimoto , Hisato Kamekawa , Yutaka Chiba , Toshiyuki Kohno , Yumi Kobayashi , Naofumi Tomura , Natsuko Araki , Masako Yoshida , Yoji Aoki , Shinichi Banba
发明人： Takeshi Kakimoto , Hisato Kamekawa , Yutaka Chiba , Toshiyuki Kohno , Yumi Kobayashi , Naofumi Tomura , Natsuko Araki , Masako Yoshida , Yoji Aoki , Shinichi Banba
IPC分类号： A01N37/12 , A01N43/06 , A01N43/08 , A01N43/32 , A01N43/40 , A01N43/42 , C07C233/01
CPC分类号： C07D405/12 , C07C209/42 , C07C269/04 , C07C269/06 , C07C271/22 , C07C271/34 , C07C271/54 , C07C311/16 , C07C317/44 , C07C323/41 , C07C333/04 , C07C2601/08 , C07C2601/14
摘要： It is an object of the invention to provide a novel fungicide which exhibits a wide controlling spectrum against pathogens of various crops, and solves the toleration problem. The diamine derivative represented by the formula (1) and a process for preparation of the same, fungicides comprising the same as an active ingredient are disclosed: [wherein R1 is substituents such as an alkyl group having 1 to 6 carbon atoms and the like, R2 and R5 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, R3 and R4 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, or R3 and R4 may be bonded to each other to form a hydrocarbon ring having 3 to 6 carbon atoms, R6, R7, R8 and R9 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, R10 is a substituent such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, A is an oxygen atom or a sulfur atom, and Q is an aryl group or a heterocycle].
摘要翻译：本发明的目的是提供一种对各种作物的病原体具有广泛控制谱的新型杀真菌剂，并解决了耐受性问题。公开了式（1）表示的二胺衍生物及其制备方法：其中R1为具有1-6个碳原子的烷基等的取代基， R 2和R 5各自独立地为氢原子，碳原子数为1〜6的烷基等取代基，R 3和R 4各自独立地为氢原子，碳原子数1〜6的烷基等取代基，或者R 3和R 4可以彼此键合形成具有3至6个碳原子的烃环，R 6，R 7，R 8和R 9各自独立地为氢原子，具有1至6个碳原子的烷基等取代基中，R 10为氢原子，碳原子数为1〜6的烷基等取代基，A为氧原子或硫原子，Q为芳基或杂环。

2. 发明授权

US07560593B2 Process for producing nitroisourea derivatives 失效
标题翻译：制备硝基异脲衍生物的方法
公开(公告)号：US07560593B2
公开(公告)日：2009-07-14
申请号：US12278495
申请日：2007-02-07
申请人： Hisato Kamekawa , Toshiyuki Kohno , Hiroyuki Katsuta , Daisuke Ura , Kenichi Satoh
发明人： Hisato Kamekawa , Toshiyuki Kohno , Hiroyuki Katsuta , Daisuke Ura , Kenichi Satoh
IPC分类号： C07C273/18
CPC分类号： C07C273/18 , C07B43/00 , C07C275/70
摘要： Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a process for producing nitroisourea derivatives represented by the following general formula (3), which is characterized in that nitroisourea derivatives represented by the following general formula (1) and amines represented by the following general formula (2) or a salt thereof are reacted in the presence of a catalytic amount of a hydrogen carbonate,
摘要翻译：公开了生产具有杀虫活性的硝基胍衍生物所必需的硝基异脲衍生物的改进方法。具体公开了下述通式（3）表示的硝基异脲衍生物的制造方法，其特征在于，将下述通式（1）表示的硝基异
脲衍生物或下述通式（2）表示的胺或其盐在催化量的碳酸氢盐存在下反应，

3. 发明申请

US20090018363A1 PROCESS FOR PRODUCING NITROISOUREA DERIVATIVES 失效
标题翻译：生产硝酸衍生物的方法
公开(公告)号：US20090018363A1
公开(公告)日：2009-01-15
申请号：US12278495
申请日：2007-02-07
申请人： Hisato Kamekawa , Toshiyuki Kohno , Hiroyuki Katsuta , Daisuke Ura , Kenichi Satoh
发明人： Hisato Kamekawa , Toshiyuki Kohno , Hiroyuki Katsuta , Daisuke Ura , Kenichi Satoh
IPC分类号： C07C249/00
CPC分类号： C07C273/18 , C07B43/00 , C07C275/70
摘要： Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a process for producing nitroisourea derivatives represented by the following general formula (3), which is characterized in that nitroisourea derivatives represented by the following general formula (1) and amines represented by the following general formula (2) or a salt thereof are reacted in the presence of a catalytic amount of a hydrogen carbonate,
摘要翻译：公开了生产具有杀虫活性的硝基胍衍生物所必需的硝基异脲衍生物的改进方法。具体公开了下述通式（3）表示的硝基异脲衍生物的制造方法，其特征在于，将下述通式（1）表示的硝基异
脲衍生物或下述通式（2）表示的胺或其盐在催化量的碳酸氢盐存在下反应，

4. 发明申请

US20060057660A1 Method for measuring protein NMR 审中-公开
标题翻译：蛋白质NMR测定方法
公开(公告)号：US20060057660A1
公开(公告)日：2006-03-16
申请号：US11199192
申请日：2005-08-09
申请人： Yaeta Endou , Toshiyuki Kohno , Hayato Morita
发明人： Yaeta Endou , Toshiyuki Kohno , Hayato Morita
IPC分类号： C12Q1/37 , C12P21/06
CPC分类号： G01N24/08 , G01R33/465
摘要： An object of the present invention is to provide a means for highly efficiently or quickly evaluating or determining the three-dimensional structure of a protein by conducting multidimensional multinuclear NMR measurement without performing a step of separating and purifying the synthesized labeled protein from other labeled proteins. The present invention provides a method for analyzing proteins, which comprises: synthesizing a protein of interest under conditions in which 90% or more of the synthesized labeled proteins constitute the protein of interest, when proteins are synthesized using a nucleic acid encoding the protein of interest as a template and also using substrate amino acids, a part or all of which have been labeled in such a way that NMR measurement is possible; and performing the NMR measurement using the above-described labeled proteins.
摘要翻译：本发明的目的是提供通过进行多维多核NMR测量来高效或快速地评估或确定蛋白质的三维结构的方法，而不进行从其它标记的蛋白质分离和纯化合成的标记蛋白质的步骤。本发明提供了一种分析蛋白质的方法，其包括：当使用编码感兴趣的蛋白质的核酸合成蛋白质时，在其中90％或更多的合成的标记蛋白质构成感兴趣的蛋白质的条件下合成感兴趣的蛋白质作为模板并且还使用底物氨基酸，其部分或全部已经以可测量NMR测量的方式被标记; 并使用上述标记的蛋白进行NMR测定。

5. 发明授权

US4003346A Rotary piston internal combustion engine 失效
标题翻译：旋转活塞内燃机
公开(公告)号：US4003346A
公开(公告)日：1977-01-18
申请号：US514906
申请日：1974-10-15
申请人： Toshiyuki Kohno
发明人： Toshiyuki Kohno
IPC分类号： F01C1/22 , F02B53/00 , F02B55/16 , F02B53/04
CPC分类号： F01C1/22 , F02B55/16 , F02B2053/005 , F02B53/00 , Y02T10/17
摘要： A rotary engine having a housing defining an internal rotor chamber between a trochoidally shaped peripheral wall and a pair of side walls is provided with a peripheral port through which a rich air-fuel mixture is supplied, and a side port, through which air is supplied, with the side port being arranged forwardly of the peripheral port taken in the direction of rotor rotation. The peripheral port opens into the combustion chamber of the engine through the peripheral wall and the side port opens through one of the side walls. The degree of opening of the side port changes in accordance with rotor rotation and when the rotor is within a certain angular range following the top dead center position during the intake stroke of its rotational cycle, both ports are open into the combustion chamber defined between the housing and the rotor.
摘要翻译：一种具有壳体，该壳体限定了位于齿状周缘壁与一对侧壁之间的内部转子室，该外壳设置有供给富空燃混合物的外围端口和供给空气的侧端口侧端口被设置在沿转子旋转方向截取的外围端口的前方。外围端口通过周壁进入发动机的燃烧室，侧端口通过一个侧壁打开。侧端口的开度根据转子旋转而变化，并且当转子在其旋转周期的进气冲程期间在上止点位置之后处于一定角度范围内时，两个口都打开到在外壳和转子。

6. 发明申请

US20080293150A1 Nmr Signal Assignment Method 审中-公开
标题翻译： Nmr信号分配方法
公开(公告)号：US20080293150A1
公开(公告)日：2008-11-27
申请号：US10588152
申请日：2005-02-02
申请人： Toshiyuki Kohno
发明人： Toshiyuki Kohno
IPC分类号： G01N33/68
CPC分类号： G01N24/08 , G01R33/465
摘要： It is an object of the present invention to provide a method of efficiently and rapidly determining the assignment of signals obtained by the 1H-15N HSQC measurement or the like, and a method of efficiently and rapidly identifying the three-dimensional structure of a target protein using the above method or a method of identifying the binding site of a protein of interest to a ligand, in place of the conventional signal assignment method, which requires a protein with a concentration several to 10 times higher than the lowest concentration of a protein capable of being observed by a high sensitive 1H-15N HSQC measurement method. In the present invention, 15N/13C double-labeled amino acids, 15N-labeled amino acids, and non-labeled amino acids are systematically combined and used as substrates with respect to every amino acids constituting a protein of interest, so as to synthesize multiple proteins (20 types or 39 types of proteins at the maximum), and the NMR measurement is performed on such multiple proteins by a measurement method capable of identifying the correlation signals of two amino acid residues adjacent to each other, and then the obtained signals are compared.
摘要翻译：本发明的目的是提供一种有效和快速地确定通过1H-15N HSQC测量等获得的信号的分配的方法，以及有效和快速地鉴定靶蛋白的三维结构的方法使用上述方法或鉴定目的蛋白质与配体的结合位点的方法代替传统的信号分配方法，其需要的浓度高于最低浓度的蛋白质的几十倍的蛋白质通过高灵敏度的1H-15N HSQC测量方法观察到。在本发明中，将15N / 13C双标氨基酸，15N标记氨基酸和非标记氨基酸系统地组合并用作相对于构成目的蛋白质的每个氨基酸的底物，以便合成多重蛋白质（最多20种或39种蛋白质），并且通过能够鉴定彼此相邻的两个氨基酸残基的相关信号的测量方法对这样的多种蛋白进行NMR测定，然后获得的信号为比较。

7. 发明申请

US20090281352A1 PROCESS FOR PRODUCTION OF ETHYLENEDIAMINE DERIVATIVES HAVING HALOGENATED CARBAMATE GROUP AND ACYL GROUP, AND INTERMEDIATES FOR PRODUCTION OF THE DERIVATIVES 审中-公开
标题翻译：生产含有碳酸酯基和亚氨基的乙烯基胺衍生物的方法，以及生产衍生物的中间体
公开(公告)号：US20090281352A1
公开(公告)日：2009-11-12
申请号：US12295167
申请日：2007-03-27
申请人： Hideki Umetani , Toshiyuki Kohno
发明人： Hideki Umetani , Toshiyuki Kohno
IPC分类号： C07C269/06 , C07C271/02
CPC分类号： C07D231/14 , C07B53/00 , C07C269/04 , C07C269/06 , C07C271/20 , C07C271/22 , C07D207/09 , C07D207/16 , C07D307/85 , C07D403/12
摘要： Ethylenedamine derivatives having a halogenated carbamate group and an acyl group can be produced by performing the catalytic hydrogenation of an aminonitrile having a halogen-substituted carbamate group in the presence of an acid and then performing the acylation of the resulting product. The aminonitrile (i.e., a starting material) can be prepared in a high yield by performing the halogenated carbamatation of an amino acid amide in the presence of water and then reacting the resulting product with a deoxidizing agent such as a vilsmeier reagent.
摘要翻译：具有卤代氨基甲酸酯基和酰基的乙烯胺衍生物可以通过在酸存在下进行具有卤素取代的氨基甲酸酯基的氨基腈的催化氢化，然后进行所得产物的酰化来制备。可以通过在水存在下进行氨基酰胺的卤化氨基甲酸酯化，然后使所得产物与脱氧剂如维尔斯迈尔试剂反应，以高产率制备氨基腈（即原料）。

8. 发明申请

US20060216791A1 Method for synthesizing amino-acid-selectively labeled protein 审中-公开
标题翻译：合成氨基酸选择性标记蛋白的方法
公开(公告)号：US20060216791A1
公开(公告)日：2006-09-28
申请号：US11340800
申请日：2006-01-27
申请人： Yaeta Endou , Toshiyuki Kohno
发明人： Yaeta Endou , Toshiyuki Kohno
IPC分类号： C12P21/04
CPC分类号： C12P21/02 , G01N33/6848
摘要： An object of the present invention is to provide a method for synthesizing, in a cell-free protein synthetic system using a wheat germ extract, a protein of interest that is labeled in an amino-acid-selective manner. The present invention provides a method for carrying out a translation reaction of a protein of interest under a condition whereby a metabolic reaction of alanine to aspartic acid and glutamic acid, a metabolic reaction of aspartic acid to glutamic acid or a metabolic reaction of glutamic acid to aspartic acid and/or glutamine is inhibited, while the protein synthesis is not inhibited, when alanine, aspartic acid or glutamic acid of the protein of interest is labeled with a stable isotope in a cell-free protein synthetic system containing a wheat germ extract.
摘要翻译：本发明的目的是提供一种在使用小麦胚提取物的无细胞蛋白质合成系统中合成以氨基酸选择性方式标记的感兴趣的蛋白质的方法。本发明提供了一种在丙氨酸与天冬氨酸和谷氨酸的代谢反应，天冬氨酸对谷氨酸的代谢反应或谷氨酸的代谢反应到谷氨酸的代谢反应的条件下进行感兴趣的蛋白质的翻译反应的方法当蛋白质的丙氨酸，天冬氨酸或谷氨酸在含有小麦胚芽提取物的无细胞蛋白质合成系统中用稳定同位素标记时，天冬氨酸和/或谷氨酰胺被抑制，而蛋白质合成不被抑制。

9. 发明授权

US3964446A Rotary piston internal combustion engine 失效
标题翻译：旋转活塞内燃机
公开(公告)号：US3964446A
公开(公告)日：1976-06-22
申请号：US538165
申请日：1975-01-02
申请人： Toshiyuki Kohno , Kenichi Imaizumi
发明人： Toshiyuki Kohno , Kenichi Imaizumi
IPC分类号： F02B53/04 , F02B53/10
CPC分类号： F02B53/04 , F02B53/10 , F02B2053/005 , Y02T10/17
摘要： The inner peripheral wall of a rotary engine housing is provided with first and second port means which open into a combustion chamber of the engine as the apex seals of the rotor pass the port means in timed relationship. The first port means introduce an air-fuel mixture and the second port means, which are spaced from the first port means forwardly in the direction of rotor rotation subsequently introduce air into the chamber. Thus, a stratified charge consisting of a layer of air and a denser layer of air-fuel mixture is provided within the combustion chamber.
摘要翻译：旋转发动机壳体的内周壁设置有第一和第二端口装置，当第一和第二端口装置以定时关系通过端口装置时，该第一和第二端口装置打开到发动机的燃烧室。第一端口意味着引入空气 - 燃料混合物，并且第二端口装置与第一端口装置在转子旋转方向上向前间隔开，随后将空气引入室中。因此，在燃烧室内设置由空气层和空气 - 燃料混合物层组成的分层电荷。

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