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1. 发明申请

US20100057093A1 INJECTOR FOR EYE 审中-公开
标题翻译：眼睛注射器
公开(公告)号：US20100057093A1
公开(公告)日：2010-03-04
申请号：US12526376
申请日：2008-02-07
申请人： Takeshi Ide , Kazuaki Yamamoto , Kohei Fukaya , Ryoji Nakano
发明人： Takeshi Ide , Kazuaki Yamamoto , Kohei Fukaya , Ryoji Nakano
IPC分类号： A61F9/00
CPC分类号： A61F2/1662 , A61B17/3468 , A61F2/148 , A61F9/0017 , A61F9/007
摘要： [PROBLEMS] To provide an injector for ophthalmology which can guide an implant easily to an transplant place without causing any damage to the implant when the implant is inserted into an eyeball. [MEANS FOR SOLVING PROBLEMS] The injector for an eye used for inserting an implant into an eyeball comprises an outer tube, and an implant holding structure arranged in the outer tube to be slidable with respect to the outer tube. The implant holding structure has an implant holding portion which can be contained in the outer tube and forms a space for containing the implant between the implant holding portion and the inner surface of the outer tube when it is contained in the outer tube. The implant holding portion projects from the outer tube when the implant holding structure is advanced and the implant can be taken out from the outer tube.
摘要翻译： [问题]提供一种用于眼科的注射器，其可以将植入物容易地引导到移植位置，而不会在将植入物插入眼球时对植入物造成任何损害。用于解决问题的手段用于将植入物插入眼球的眼睛用注射器包括外管和布置在外管中以相对于外管滑动的植入物保持结构。植入物保持结构具有植入物保持部分，该植入物保持部分可容纳在外管中并且当其被容纳在外管中时形成用于将植入物容纳在植入物保持部分和外管内表面之间的空间。当植入物保持结构前进时，植入物保持部分从外管突出，并且植入物可以从外管中取出。

2. 发明申请

US20120215153A1 TUBE DEVICE FOR INSERTION INTO LACRIMAL PASSAGE 审中-公开
标题翻译：用于插入LACRIMAL PASSAGE的管道装置
公开(公告)号：US20120215153A1
公开(公告)日：2012-08-23
申请号：US13503234
申请日：2010-10-22
申请人： Kohei Fukaya , Ryoji Nakano , Hidekazu Miyauchi
发明人： Kohei Fukaya , Ryoji Nakano , Hidekazu Miyauchi
IPC分类号： A61F9/00
CPC分类号： A61F9/00772
摘要： A tube device for insertion into a lacrimal passage, optimized according to the structure of a lacrimal passage and capable of being operated without impairing the functional effect of a lacrimal passage endoscope. A tube device for insertion into a lacrimal passage comprises a pair of tubes to be placed in the lacrimal passage. Openings are formed at both ends of the pair of tubes. A reinforcement body is disposed and held in the vicinity of each opening at a position located at a predetermined distance from the opening.
摘要翻译：用于插入泪道的管装置，根据泪道的结构进行优化，能够在不损伤泪道内窥镜的功能效果的情况下进行操作。用于插入泪道的管装置包括一对待放置在泪道中的管。开口形成在一对管的两端。加强体被设置并保持在位于距开口预定距离的位置处的每个开口附近。

3. 发明授权

US06613066B1 Balloon catheter and production method therefor 有权
标题翻译：球囊导管及其制作方法
公开(公告)号：US06613066B1
公开(公告)日：2003-09-02
申请号：US09787930
申请日：2001-04-03
申请人： Kohei Fukaya , Hiromi Maeda , Takuji Nishide , Shogo Miki , Ryoji Nakano , Masato Hashiba
发明人： Kohei Fukaya , Hiromi Maeda , Takuji Nishide , Shogo Miki , Ryoji Nakano , Masato Hashiba
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M25/0043 , A61M25/0052 , A61M25/1034 , A61M2025/0004 , A61M2025/006 , A61M2025/1056 , A61M2025/1068 , A61M2025/1088 , A61M2029/025
摘要： A balloon catheter 1 is configured so as to comprise a catheter shaft 2 formed by joining a proximal-side tubular member 3 and a distal-side tubular member 4, an adapter member 6 connected to the base end of the catheter shaft 2, and a balloon 5 joined to the distal end of the catheter shaft 2. A metal coiled elastic member 10 is deployed in the internal space in the adapter member 6, so that it can move toward the distal end. This coiled elastic body 10 abuts on a ring-shaped wall part 11a formed on the outer circumferential surface of the base end of an elastic force transmitting member 11 and supports the elastic force transmitting member 11 to the distal side. The leading end of a linear member 12 that is one of the components of the elastic force transmitting member 11 reaches to an internal space 5f in the balloon and is bonded to the outer circumferential surface of a guide wire passing tube 7. Thus the elastic supporting force of the coiled elastic body 10 is transmitted via the elastic force transmitting member 11 to the distal-side sleeve part 5d of the balloon 5, and tension is imparted to the balloon 5 in the axial direction.
摘要翻译：球囊导管1被构造成包括通过连接近侧管状构件3和远端侧管状构件4形成的导管轴2，连接到导管轴2的基端的适配构件6和气囊5连接到导管轴2的远端。金属螺旋弹性构件10展开在适配构件6的内部空间中，使得其可以朝向远端移动。该螺旋弹性体10与形成在弹性力传递构件11的基端的外周面上的环状壁部11a抵接，并且将弹力传递构件11支撑在远侧。作为弹力传递部件11的一个部件的直线部件12的前端到达球囊内的内部空间5f，并且与导丝管7的外周面接合。因此，弹性支撑螺旋弹性体10的力经由弹力传递部件11传递到球囊5的前侧侧套筒部5d，并且沿轴向向球囊5施加张力。

4. 发明申请

US20070250157A1 Stent For Placement In Body 审中-公开
标题翻译：支架放置在身体
公开(公告)号：US20070250157A1
公开(公告)日：2007-10-25
申请号：US11574879
申请日：2005-09-01
申请人： Takuji Nishide , Yuki Takiguchi , Ryoji Nakano , Kohei Fukaya , Masaji Kawatsu
发明人： Takuji Nishide , Yuki Takiguchi , Ryoji Nakano , Kohei Fukaya , Masaji Kawatsu
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0076 , A61F2230/0054 , A61F2250/0035 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2300/61
摘要： It is intended to easily provide a stent for placement in body which can hold an increased amount of a drug without causing cracking or peeling in the coating layer with the dilation of the stent and from which the drug can be sustainedly released as far as possible. Namely, a stent for placement in body having a coating layer mainly comprising a drug and a polymer in at least a part of the stent surface wherein the coating layer consists of an inner layer and an outer layer, the weight ratio of drug/polymer, which is defined based on the weights of the drug and the polymer contained in each layer, of the inner layer is higher than that of the outer layer, and the outer layer contains an efficacious amount of the drug.
摘要翻译：旨在容易地提供用于放置在体内的支架，其能够容纳增加量的药物，而不会随着支架的扩张而在涂层中引起裂纹或剥离，并且药物可以尽可能地持续释放。即，用于放置在本体中的支架，其具有主要包含药物的涂层和在支架表面的至少一部分中的聚合物，其中所述涂层由内层和外层组成，药物/聚合物的重量比，内层中含有的药物重量和各层中所含的聚合物的含量高于外层，外层含有有效量的药物。

5. 发明申请

US20070038289A1 Stent to be placed in vivo 审中-公开
标题翻译：支架置于体内
公开(公告)号：US20070038289A1
公开(公告)日：2007-02-15
申请号：US10563488
申请日：2004-07-23
申请人： Takuji Nishide , Ryoji Nakano , Shinya Yoshida , Kohei Fukaya , Masaji Kawatsu
发明人： Takuji Nishide , Ryoji Nakano , Shinya Yoshida , Kohei Fukaya , Masaji Kawatsu
IPC分类号： A61F2/90
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2230/0054
摘要： As a treatment for angiostenosis, angioplasty (PTA or PTCA) of expanding a small-sized balloon in a vessel has been commonly conducted. However, this treatment easily causes repeated stenosis (restenosis) after the treatment. Placement of a stent in a vessel is also effective in decreasing restenosis, but this treatment may also cause restenosis. The present invention provides a stent containing a poly (lactide-co-glycolide) or both a poly (lactide-co-glycolide) and an immunosuppressive agent in at least a portion of a surface of the stent, and further containing a material nondegradable in vivo.
摘要翻译：作为血管狭窄症的治疗方法，通常进行血管成形术（PTA或PTCA）扩大血管中的小型气球。然而，这种治疗容易导致治疗后重复狭窄（再狭窄）。支架置于血管中也有效减少再狭窄，但这种治疗也可能引起再狭窄。本发明提供一种在支架表面的至少一部分中含有聚（丙交酯 - 共 - 乙交酯）或聚（丙交酯 - 共 - 乙交酯）和免疫抑制剂两者的支架，并且还含有不可降解的材料体内。

6. 发明授权

US06960186B1 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US06960186B1
公开(公告)日：2005-11-01
申请号：US09980979
申请日：2000-05-11
申请人： Kohei Fukaya , Takuji Nishide , Ryoji Nakano , Hiromi Maeda , Shogo Miki
发明人： Kohei Fukaya , Takuji Nishide , Ryoji Nakano , Hiromi Maeda , Shogo Miki
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M31/00 , A61M37/00
CPC分类号： A61M25/1027 , A61M25/0045 , A61M25/0068 , A61M25/1002 , A61M25/1038 , A61M25/104 , A61M2025/0004 , A61M2025/0183 , A61M2025/1056 , A61M2025/1093
摘要： The present invention is a balloon catheter used primarily in treatment and surgery for the purpose of dilating lesion sites such as strictures or blockages in passages in the human body. The balloon catheter of the present invention has a structure wherein a guide wire passing tubular member is deployed passing through the interior of the expansion body, and the outer surface of the tubular member and the expansion body are concentrically fused near the distal end of the catheter. This is a balloon catheter that is characterized by the fact that the Shore hardness of the material configuring the outermost surface of the tubular member is smaller than the Shore hardness of the material configuring the expansion body. It is therefore possible to flexibly adjust the tip portion formed by securing the expansion body and the guide wire passing tubular member.
摘要翻译：本发明是一种主要用于治疗和手术的气囊导管，用于在人体的通道中扩张病变部位如狭窄或阻塞。本发明的气囊导管具有通过管状构件的导丝管穿过膨胀体内部的结构，并且管状构件和膨胀体的外表面在导管的远端附近同心地熔合。这是一种球囊导管，其特征在于，构成管状构件的最外表面的材料的肖氏硬度小于构成膨胀体的材料的肖氏硬度。因此，可以灵活地调节通过固定膨胀体和导丝通过管状构件形成的尖端部分。

7. 发明授权

US06706010B1 Balloon catheter and method of production thereof 失效
标题翻译：球囊导管及其生产方法
公开(公告)号：US06706010B1
公开(公告)日：2004-03-16
申请号：US09529081
申请日：2000-04-07
申请人： Shogo Miki , Kohei Fukaya , Takuji Nishide , Masato Hashiba , Ryoji Nakano , Hiromi Maeda
发明人： Shogo Miki , Kohei Fukaya , Takuji Nishide , Masato Hashiba , Ryoji Nakano , Hiromi Maeda
IPC分类号： A61M300
CPC分类号： A61M25/1034 , A61M25/0054 , A61M25/1036 , A61M25/1038 , A61M2025/1061 , A61M2025/1093
摘要： It is an object of the present invention to provide a balloon catheter in which the inner tube is prevented from slackening after balloon inflation, improving the rewrapping of the balloon, discontinuity in the rigidity of the joined portions of the outer tube and the balloon is lessened, which prevents breakage, and the catheter advances through blood vessels better and passes more easily through narrow segments, preventing the catheter from “accordioning” and enhancing insertion force transmission. The balloon catheter pertaining to the present invention has a catheter shaft (1) with a double-tube structure comprising an outer tube (4) and an inner tube (5), and a balloon (3) disposed at the distal end portion of this catheter shaft (1). A guide tube (11) having an outside diameter smaller than the inside diameter of the outer tube (4) and having an inside diameter larger than the outside diameter of the inner tube (5) is disposed at least at the distal end portion of the outer tube (4) so as to form a double-tube with the outer tube (4), and the inner tube (5) is not fixed, but passes through the interior of the guide tube (11) in the axial direction.
摘要翻译：本发明的目的是提供一种球囊导管，其中防止内囊在球囊膨胀后松弛，改善球囊的重新包裹，外管和球囊的接合部分的刚度不连续性减小防止断裂，并且导管更好地前进通过血管，并且更容易地通过狭窄的区段，防止导管“手风琴”并增强插入力传递。本发明的气囊导管具有导管轴（1），其具有包括外管（4）和内管（5）的双管结构，以及设置在该管的前端部的气囊（3）导管轴（1）。具有比外管（4）的内径小的内径比内管（5）的外径大的外径的导管（11）至少设置在内管外管（4）形成与外管（4）的双管，内管（5）不固定，但沿轴向通过导管（11）的内部。

8. 发明授权

US08192483B2 Stent to be placed in the living body 有权
标题翻译：支架置于生物体内
公开(公告)号：US08192483B2
公开(公告)日：2012-06-05
申请号：US12089363
申请日：2006-10-04
申请人： Ryoji Nakano
发明人： Ryoji Nakano
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054 , A61F2250/0018 , A61F2250/0029 , A61F2250/0036
摘要： It is intended to provide a stent to be placed in the living body which exhibits excellent extension properties even in a flexion site of a lumen in the body and shows a low restenosis rate after being placed in the living body. A stent to be placed in the living body characterized in that, as one of the characteristics thereof, the stent is in a long and thin tubular shape having both termini, the long and thin tubular body can be extended in the radial direction from the first diameter in the compressed state to the second diameter in the extended state, the stent has a first terminal section, a second terminal section, a third central section, a fourth section located between the first terminal section and the third central section and a fifth section located between the second terminal section and the third central section, the rigidity of the fourth section is lower than the rigidity of the first terminal section and lower than the rigidity of the third central section, and the rigidity of the fifth section is lower than the rigidity of the second terminal section and lower than the rigidity of the third central section.
摘要翻译：旨在提供即使在体内的内腔的屈曲部位显示优异的伸展性的生物体中设置的支架，并且在放置于生物体后显示较低的再狭窄率。一种放置在生物体中的支架，其特征在于，作为其特征之一，支架为具有两个末端的长而薄的管状，长管状体可以从第一所述支架具有第一端子部，第二端子部，第三中央部，位于所述第一端子部和所述第三中央部之间的第四部，以及第五部位于第二端子部和第三中央部之间的第四部的刚性低于第一端子部的刚性，低于第三中央部的刚性，第五部的刚性比第二端子部的刚性低于第三中央部的刚性。

9. 发明申请

US20090043374A1 Stent to be Placed in the Living Body 审中-公开
标题翻译：支架置于生命体内
公开(公告)号：US20090043374A1
公开(公告)日：2009-02-12
申请号：US12089039
申请日：2006-10-04
申请人： Ryoji Nakano
发明人： Ryoji Nakano
IPC分类号： A61F2/86
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054
摘要： It is intended to proved a stent to be placed in the living body which shows a low restenosis rate after being placed in the body. A stent to be placed in the living body characterized in that the stent is in a long and thin almost tubular shape having both termini and provided with voids, the long and thin almost tubular body can be extended in the radial direction from the first diameter in the compressed state to be second diameter in the extended state, the strut section of the stent is in an almost square or rectangular shape, the whole surface of the stent has an outer surface, an inner surface and a side surface area corresponding to the area of the side surface is not more than 40% of the whole surface area corresponding to the area of the whole surface of the stent.
摘要翻译：旨在证明放置在生物体中的支架，放置在体内后显示出较低的再狭窄率。放置在生物体中的支架，其特征在于，所述支架是长而薄的几乎管状的，具有两个端部并且设置有空隙，所述长而薄的几乎管状体可以从第一直径沿径向方向延伸压缩状态为延伸状态下的第二直径，支架的支柱部分为近似或矩形的形状，支架的整个表面具有对应于该区域的外表面，内表面和侧表面积的侧表面不大于对应于支架整个表面的面积的整个表面积的40％。

10. 发明授权

US07056276B2 Catheter for radiation therapy 失效
公开(公告)号：US07056276B2
公开(公告)日：2006-06-06
申请号：US10333051
申请日：2001-06-15
申请人： Ryoji Nakano , Takuya Ishibashi
发明人： Ryoji Nakano , Takuya Ishibashi
IPC分类号： A61N5/00
CPC分类号： A61M25/1027 , A61M25/0054 , A61M25/1011 , A61M2025/0062 , A61M2025/1047 , A61M2025/1093 , A61N5/062 , A61N5/1002 , A61N2005/1003
摘要： In an expandable part positioned on the tip end side of the catheter, protruding parts are produced in specific regions when the expandable part is expanded through the difference in elasticity between two materials having a different elasticity to one another. The structure is made to be such that low-elasticity regions and high-elasticity regions are disposed in the expandable part, and when pressure is applied the high-elasticity regions expand more than the low-elasticity regions, thus becoming the protruding parts. Alternatively, the structure is made to be such that two materials having a different elasticity to one another are made into a two-layer structure of an inner layer and an outer layer, and voids are provided in the layer formed from the low-elasticity material, so that when pressure is applied, parts of the layer formed from the high-elasticity material corresponding to the void parts become the protruding parts.

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