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1. 发明授权

US06613066B1 Balloon catheter and production method therefor 有权
标题翻译：球囊导管及其制作方法
公开(公告)号：US06613066B1
公开(公告)日：2003-09-02
申请号：US09787930
申请日：2001-04-03
申请人： Kohei Fukaya , Hiromi Maeda , Takuji Nishide , Shogo Miki , Ryoji Nakano , Masato Hashiba
发明人： Kohei Fukaya , Hiromi Maeda , Takuji Nishide , Shogo Miki , Ryoji Nakano , Masato Hashiba
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M25/0043 , A61M25/0052 , A61M25/1034 , A61M2025/0004 , A61M2025/006 , A61M2025/1056 , A61M2025/1068 , A61M2025/1088 , A61M2029/025
摘要： A balloon catheter 1 is configured so as to comprise a catheter shaft 2 formed by joining a proximal-side tubular member 3 and a distal-side tubular member 4, an adapter member 6 connected to the base end of the catheter shaft 2, and a balloon 5 joined to the distal end of the catheter shaft 2. A metal coiled elastic member 10 is deployed in the internal space in the adapter member 6, so that it can move toward the distal end. This coiled elastic body 10 abuts on a ring-shaped wall part 11a formed on the outer circumferential surface of the base end of an elastic force transmitting member 11 and supports the elastic force transmitting member 11 to the distal side. The leading end of a linear member 12 that is one of the components of the elastic force transmitting member 11 reaches to an internal space 5f in the balloon and is bonded to the outer circumferential surface of a guide wire passing tube 7. Thus the elastic supporting force of the coiled elastic body 10 is transmitted via the elastic force transmitting member 11 to the distal-side sleeve part 5d of the balloon 5, and tension is imparted to the balloon 5 in the axial direction.
摘要翻译：球囊导管1被构造成包括通过连接近侧管状构件3和远端侧管状构件4形成的导管轴2，连接到导管轴2的基端的适配构件6和气囊5连接到导管轴2的远端。金属螺旋弹性构件10展开在适配构件6的内部空间中，使得其可以朝向远端移动。该螺旋弹性体10与形成在弹性力传递构件11的基端的外周面上的环状壁部11a抵接，并且将弹力传递构件11支撑在远侧。作为弹力传递部件11的一个部件的直线部件12的前端到达球囊内的内部空间5f，并且与导丝管7的外周面接合。因此，弹性支撑螺旋弹性体10的力经由弹力传递部件11传递到球囊5的前侧侧套筒部5d，并且沿轴向向球囊5施加张力。

2. 发明授权

US06960186B1 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US06960186B1
公开(公告)日：2005-11-01
申请号：US09980979
申请日：2000-05-11
申请人： Kohei Fukaya , Takuji Nishide , Ryoji Nakano , Hiromi Maeda , Shogo Miki
发明人： Kohei Fukaya , Takuji Nishide , Ryoji Nakano , Hiromi Maeda , Shogo Miki
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M31/00 , A61M37/00
CPC分类号： A61M25/1027 , A61M25/0045 , A61M25/0068 , A61M25/1002 , A61M25/1038 , A61M25/104 , A61M2025/0004 , A61M2025/0183 , A61M2025/1056 , A61M2025/1093
摘要： The present invention is a balloon catheter used primarily in treatment and surgery for the purpose of dilating lesion sites such as strictures or blockages in passages in the human body. The balloon catheter of the present invention has a structure wherein a guide wire passing tubular member is deployed passing through the interior of the expansion body, and the outer surface of the tubular member and the expansion body are concentrically fused near the distal end of the catheter. This is a balloon catheter that is characterized by the fact that the Shore hardness of the material configuring the outermost surface of the tubular member is smaller than the Shore hardness of the material configuring the expansion body. It is therefore possible to flexibly adjust the tip portion formed by securing the expansion body and the guide wire passing tubular member.
摘要翻译：本发明是一种主要用于治疗和手术的气囊导管，用于在人体的通道中扩张病变部位如狭窄或阻塞。本发明的气囊导管具有通过管状构件的导丝管穿过膨胀体内部的结构，并且管状构件和膨胀体的外表面在导管的远端附近同心地熔合。这是一种球囊导管，其特征在于，构成管状构件的最外表面的材料的肖氏硬度小于构成膨胀体的材料的肖氏硬度。因此，可以灵活地调节通过固定膨胀体和导丝通过管状构件形成的尖端部分。

3. 发明授权

US06706010B1 Balloon catheter and method of production thereof 失效
标题翻译：球囊导管及其生产方法
公开(公告)号：US06706010B1
公开(公告)日：2004-03-16
申请号：US09529081
申请日：2000-04-07
申请人： Shogo Miki , Kohei Fukaya , Takuji Nishide , Masato Hashiba , Ryoji Nakano , Hiromi Maeda
发明人： Shogo Miki , Kohei Fukaya , Takuji Nishide , Masato Hashiba , Ryoji Nakano , Hiromi Maeda
IPC分类号： A61M300
CPC分类号： A61M25/1034 , A61M25/0054 , A61M25/1036 , A61M25/1038 , A61M2025/1061 , A61M2025/1093
摘要： It is an object of the present invention to provide a balloon catheter in which the inner tube is prevented from slackening after balloon inflation, improving the rewrapping of the balloon, discontinuity in the rigidity of the joined portions of the outer tube and the balloon is lessened, which prevents breakage, and the catheter advances through blood vessels better and passes more easily through narrow segments, preventing the catheter from “accordioning” and enhancing insertion force transmission. The balloon catheter pertaining to the present invention has a catheter shaft (1) with a double-tube structure comprising an outer tube (4) and an inner tube (5), and a balloon (3) disposed at the distal end portion of this catheter shaft (1). A guide tube (11) having an outside diameter smaller than the inside diameter of the outer tube (4) and having an inside diameter larger than the outside diameter of the inner tube (5) is disposed at least at the distal end portion of the outer tube (4) so as to form a double-tube with the outer tube (4), and the inner tube (5) is not fixed, but passes through the interior of the guide tube (11) in the axial direction.
摘要翻译：本发明的目的是提供一种球囊导管，其中防止内囊在球囊膨胀后松弛，改善球囊的重新包裹，外管和球囊的接合部分的刚度不连续性减小防止断裂，并且导管更好地前进通过血管，并且更容易地通过狭窄的区段，防止导管“手风琴”并增强插入力传递。本发明的气囊导管具有导管轴（1），其具有包括外管（4）和内管（5）的双管结构，以及设置在该管的前端部的气囊（3）导管轴（1）。具有比外管（4）的内径小的内径比内管（5）的外径大的外径的导管（11）至少设置在内管外管（4）形成与外管（4）的双管，内管（5）不固定，但沿轴向通过导管（11）的内部。

4. 发明申请

US20070250157A1 Stent For Placement In Body 审中-公开
标题翻译：支架放置在身体
公开(公告)号：US20070250157A1
公开(公告)日：2007-10-25
申请号：US11574879
申请日：2005-09-01
申请人： Takuji Nishide , Yuki Takiguchi , Ryoji Nakano , Kohei Fukaya , Masaji Kawatsu
发明人： Takuji Nishide , Yuki Takiguchi , Ryoji Nakano , Kohei Fukaya , Masaji Kawatsu
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0076 , A61F2230/0054 , A61F2250/0035 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2300/61
摘要： It is intended to easily provide a stent for placement in body which can hold an increased amount of a drug without causing cracking or peeling in the coating layer with the dilation of the stent and from which the drug can be sustainedly released as far as possible. Namely, a stent for placement in body having a coating layer mainly comprising a drug and a polymer in at least a part of the stent surface wherein the coating layer consists of an inner layer and an outer layer, the weight ratio of drug/polymer, which is defined based on the weights of the drug and the polymer contained in each layer, of the inner layer is higher than that of the outer layer, and the outer layer contains an efficacious amount of the drug.
摘要翻译：旨在容易地提供用于放置在体内的支架，其能够容纳增加量的药物，而不会随着支架的扩张而在涂层中引起裂纹或剥离，并且药物可以尽可能地持续释放。即，用于放置在本体中的支架，其具有主要包含药物的涂层和在支架表面的至少一部分中的聚合物，其中所述涂层由内层和外层组成，药物/聚合物的重量比，内层中含有的药物重量和各层中所含的聚合物的含量高于外层，外层含有有效量的药物。

5. 发明申请

US20070038289A1 Stent to be placed in vivo 审中-公开
标题翻译：支架置于体内
公开(公告)号：US20070038289A1
公开(公告)日：2007-02-15
申请号：US10563488
申请日：2004-07-23
申请人： Takuji Nishide , Ryoji Nakano , Shinya Yoshida , Kohei Fukaya , Masaji Kawatsu
发明人： Takuji Nishide , Ryoji Nakano , Shinya Yoshida , Kohei Fukaya , Masaji Kawatsu
IPC分类号： A61F2/90
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2230/0054
摘要： As a treatment for angiostenosis, angioplasty (PTA or PTCA) of expanding a small-sized balloon in a vessel has been commonly conducted. However, this treatment easily causes repeated stenosis (restenosis) after the treatment. Placement of a stent in a vessel is also effective in decreasing restenosis, but this treatment may also cause restenosis. The present invention provides a stent containing a poly (lactide-co-glycolide) or both a poly (lactide-co-glycolide) and an immunosuppressive agent in at least a portion of a surface of the stent, and further containing a material nondegradable in vivo.
摘要翻译：作为血管狭窄症的治疗方法，通常进行血管成形术（PTA或PTCA）扩大血管中的小型气球。然而，这种治疗容易导致治疗后重复狭窄（再狭窄）。支架置于血管中也有效减少再狭窄，但这种治疗也可能引起再狭窄。本发明提供一种在支架表面的至少一部分中含有聚（丙交酯 - 共 - 乙交酯）或聚（丙交酯 - 共 - 乙交酯）和免疫抑制剂两者的支架，并且还含有不可降解的材料体内。

6. 发明授权

US07247147B2 Medical balloon catheter 有权
标题翻译：医疗气囊导管
公开(公告)号：US07247147B2
公开(公告)日：2007-07-24
申请号：US10415997
申请日：2001-11-08
申请人： Takuji Nishide , Kohei Fukaya , Masato Hashiba
发明人： Takuji Nishide , Kohei Fukaya , Masato Hashiba
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61M25/0045 , A61M25/0054
摘要： The medical balloon catheter of the present invention comprises a catheter shaft composed of a distal end shaft and a proximal end shaft and a balloon on the distal end of the distal end shaft, wherein the proximal end shaft is composed of a single member and the distal end portion of the proximal end shaft is lower in rigidity than the other parts thereof. The present invention also provides a medical balloon catheter having a structure in which a tube for passing a guidewire inside thereof is arranged so as to pass inside the balloon and the balloon and tube are fused together in the vicinity of the distal end of the catheter, wherein the ratio of the outer diameter of the small-diameter portion on the distal end side of the tube to the outer diameter of the proximal end portion is no less than 0.85.
摘要翻译：本发明的医用气囊导管包括由前端轴和近端轴构成的导管轴和远端轴的远端上的气囊，其中，近端轴由单个构件和远端构成近端轴的端部刚性低于其他部分。本发明还提供一种医疗气囊导管，其具有将导线内部通过的管布置成在气囊内部通过的结构，并且气球和管在导管的远端附近熔合在一起，其中，所述管的前端侧的小直径部的外径与所述基端部的外径之比为0.85以上。

7. 发明申请

US20120215153A1 TUBE DEVICE FOR INSERTION INTO LACRIMAL PASSAGE 审中-公开
标题翻译：用于插入LACRIMAL PASSAGE的管道装置
公开(公告)号：US20120215153A1
公开(公告)日：2012-08-23
申请号：US13503234
申请日：2010-10-22
申请人： Kohei Fukaya , Ryoji Nakano , Hidekazu Miyauchi
发明人： Kohei Fukaya , Ryoji Nakano , Hidekazu Miyauchi
IPC分类号： A61F9/00
CPC分类号： A61F9/00772
摘要： A tube device for insertion into a lacrimal passage, optimized according to the structure of a lacrimal passage and capable of being operated without impairing the functional effect of a lacrimal passage endoscope. A tube device for insertion into a lacrimal passage comprises a pair of tubes to be placed in the lacrimal passage. Openings are formed at both ends of the pair of tubes. A reinforcement body is disposed and held in the vicinity of each opening at a position located at a predetermined distance from the opening.
摘要翻译：用于插入泪道的管装置，根据泪道的结构进行优化，能够在不损伤泪道内窥镜的功能效果的情况下进行操作。用于插入泪道的管装置包括一对待放置在泪道中的管。开口形成在一对管的两端。加强体被设置并保持在位于距开口预定距离的位置处的每个开口附近。

8. 发明申请

US20100057093A1 INJECTOR FOR EYE 审中-公开
标题翻译：眼睛注射器
公开(公告)号：US20100057093A1
公开(公告)日：2010-03-04
申请号：US12526376
申请日：2008-02-07
申请人： Takeshi Ide , Kazuaki Yamamoto , Kohei Fukaya , Ryoji Nakano
发明人： Takeshi Ide , Kazuaki Yamamoto , Kohei Fukaya , Ryoji Nakano
IPC分类号： A61F9/00
CPC分类号： A61F2/1662 , A61B17/3468 , A61F2/148 , A61F9/0017 , A61F9/007
摘要： [PROBLEMS] To provide an injector for ophthalmology which can guide an implant easily to an transplant place without causing any damage to the implant when the implant is inserted into an eyeball. [MEANS FOR SOLVING PROBLEMS] The injector for an eye used for inserting an implant into an eyeball comprises an outer tube, and an implant holding structure arranged in the outer tube to be slidable with respect to the outer tube. The implant holding structure has an implant holding portion which can be contained in the outer tube and forms a space for containing the implant between the implant holding portion and the inner surface of the outer tube when it is contained in the outer tube. The implant holding portion projects from the outer tube when the implant holding structure is advanced and the implant can be taken out from the outer tube.
摘要翻译： [问题]提供一种用于眼科的注射器，其可以将植入物容易地引导到移植位置，而不会在将植入物插入眼球时对植入物造成任何损害。用于解决问题的手段用于将植入物插入眼球的眼睛用注射器包括外管和布置在外管中以相对于外管滑动的植入物保持结构。植入物保持结构具有植入物保持部分，该植入物保持部分可容纳在外管中并且当其被容纳在外管中时形成用于将植入物容纳在植入物保持部分和外管内表面之间的空间。当植入物保持结构前进时，植入物保持部分从外管突出，并且植入物可以从外管中取出。

9. 发明申请

US20060129229A1 Stent 审中-公开
标题翻译：支架
公开(公告)号：US20060129229A1
公开(公告)日：2006-06-15
申请号：US10546657
申请日：2004-03-05
申请人： Kohei Fukaya , Ryohji Nakano , Nobutaka Tani
发明人： Kohei Fukaya , Ryohji Nakano , Nobutaka Tani
IPC分类号： A61F2/90
CPC分类号： A61F2/915 , A61B17/320725 , A61B2017/22061 , A61F2/91 , A61F2002/8483 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155
摘要： A stent that can further reduce the incidence of repeated stenosis (restenosis) that has been experienced in conventional stents is provided. Onto the outer surface of a stent body, a structure for cutting body tissues and the like is disposed so that during stent expansion in the outward radial direction and placement, the body tissues, such as blood vessels, are cut. Thus, the stress and unrestricted damage applied to body tissues such as blood vessels can be reduced, and restenosis can be suppressed. By coating the stent with a drug, a stent having enhanced effects can be provided.
摘要翻译：提供了可以进一步降低常规支架中经历的重复狭窄（再狭窄）发生率的支架。在支架体的外表面上，设置有用于切割身体组织等的结构，使得在向外径向的支架扩张和放置时，切割诸如血管的身体组织。因此，可以减轻施加于身体组织如血管的应力和不受限制的损伤，并且可以抑制再狭窄。通过用药物涂覆支架，可以提供具有增强效果的支架。

10. 发明申请

US20100041783A1 Foam and Process for Producing the Same 审中-公开
标题翻译：泡沫及其生产工艺
公开(公告)号：US20100041783A1
公开(公告)日：2010-02-18
申请号：US12440712
申请日：2007-09-11
申请人： Masaoki Goto , Yoichi Matsumura , Shuhei Taniguchi , Miaki Shibaya , Kohei Fukaya , Takaoki Saneyasu , Masaki Ichimura
发明人： Masaoki Goto , Yoichi Matsumura , Shuhei Taniguchi , Miaki Shibaya , Kohei Fukaya , Takaoki Saneyasu , Masaki Ichimura
IPC分类号： C08J9/00
CPC分类号： A61L15/425 , C08J9/141 , C08J2207/10 , C08J2383/12 , C08J2387/00
摘要： It is intended to provide a resin foam which can be preferably used for medical use, and a flexible silicone type resin foam having a water-absorbing property. The resin foam which has a low toxicity and excellent physical properties for medical use such as moisture permeability, skin compatibility and low irritation can be obtained by using a resin which has a siloxane unit and an oxyalkylene unit in its molecular structure and does not contain a unit derived from an isocyanate group. Further, the flexible silicone type resin foam having a water-absorbing property can be obtained by allowing it to have a specific resin composition and a foam structure.
摘要翻译：旨在提供一种可优选用于医疗用途的树脂泡沫，以及具有吸水性的柔性硅树脂泡沫。通过使用在分子结构中具有硅氧烷单元和氧化烯单元的树脂，并且不含有氧化烯的树脂，可以获得具有低毒性和优异物理性能的树脂发泡体，例如透湿性，皮肤相容性和低刺激性衍生自异氰酸酯基团的单元。此外，通过使其具有特定的树脂组合物和泡沫结构，可以获得具有吸水性的柔性硅氧烷型树脂发泡体。

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