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1. 发明授权

US07517996B2 Azole compound 失效
标题翻译：唑类化合物
公开(公告)号：US07517996B2
公开(公告)日：2009-04-14
申请号：US11346426
申请日：2006-02-03
申请人： Takashi Yamamoto , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi Yamamoto , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
IPC分类号： C07D261/04 , A01N43/80
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要翻译：由式I表示的唑类化合物：其中环A是异恶唑等，R 1是取代或未取代的芳基等，R 2是氢原子等，R 3是取代或未取代的烷基等，和其药学上可接受的盐抑制溶血磷脂酸（LPA）的生理活性，并且可用于预防或治疗其中抑制LPA的生理活性用于预防或治疗其的疾病，例如涉及 LPA受体。

2. 发明申请

US20130041000A1 NOVEL AZOLE COMPOUND 审中-公开
公开(公告)号：US20130041000A1
公开(公告)日：2013-02-14
申请号：US13585011
申请日：2012-08-14
申请人： Takashi YAMAMOTO , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi YAMAMOTO , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
IPC分类号： A61K31/42 , A61P1/16 , C07D261/14
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.

3. 发明申请

US20090170911A1 NOVEL AZOLE COMPOUND 审中-公开
标题翻译：新型AZOLE化合物
公开(公告)号：US20090170911A1
公开(公告)日：2009-07-02
申请号：US12389711
申请日：2009-02-20
申请人： Takashi YAMAMOTO , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi YAMAMOTO , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
IPC分类号： A61K31/4192 , C07D261/14 , A61K31/42 , C07D275/02 , A61K31/425 , C07D271/00 , A61K31/4245 , C07D285/06 , C07D285/10
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要翻译：由式I表示的唑类化合物：其中环A是异恶唑等，R 1是取代或未取代的芳基等，R 2是氢原子等，R 3是取代或未取代的烷基等，和其药学上可接受的盐抑制溶血磷脂酸（LPA）的生理活性，并且可用于预防或治疗其中抑制LPA的生理活性用于预防或治疗其的疾病，例如涉及 LPA受体。

4. 发明申请

US20060194850A1 Novel azole compound 失效
标题翻译：新型唑化合物
公开(公告)号：US20060194850A1
公开(公告)日：2006-08-31
申请号：US11346426
申请日：2006-02-03
申请人： Takashi Yamamoto , Akira Chiba , Kouichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oohmuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi Yamamoto , Akira Chiba , Kouichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oohmuta , Yuko Iida , Satoshi Iwayama
IPC分类号： A61K31/433 , A61K31/4245 , A61K31/42 , A61K31/425
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要翻译：由式I表示的唑类化合物：其中环A是异恶唑等，R 1是取代或未取代的芳基等，R 2是氢原子等，R 3是取代或未取代的烷基等，和其药学上可接受的盐抑制溶血磷脂酸（LPA）的生理活性，并且可用于预防或治疗其中抑制LPA的生理活性用于预防或治疗其的疾病，例如涉及 LPA受体。

5. 发明授权

US08426588B2 Phenylalanine derivatives 有权
标题翻译：苯丙氨酸衍生物
公开(公告)号：US08426588B2
公开(公告)日：2013-04-23
申请号：US13524318
申请日：2012-06-15
申请人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： C07D253/08
CPC分类号： C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗活性。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

6. 发明申请

US20120253041A1 NEW PHENYLALANINE DERIVATIVES 有权
标题翻译：新的苯乙烯胺衍生物
公开(公告)号：US20120253041A1
公开(公告)日：2012-10-04
申请号：US13524318
申请日：2012-06-15
申请人： Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： C07D253/08
CPC分类号： C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

7. 发明授权

US07902179B2 Heterocyclic compounds 有权
标题翻译：杂环化合物
公开(公告)号：US07902179B2
公开(公告)日：2011-03-08
申请号：US10475097
申请日：2002-04-26
申请人： Yasuhiro Tanaka , Kohichi Fujita , Yoshitomo Chujoh , Syunsuke Fukuda , Yuka Ikenoue , Tomoyuki Tagami , Akira Chiba , Ariko Kodaira , Hideki Matsumoto , Tadakiyo Nakagawa , Tatsuhiro Yamada , Manabu Suzuki , Masahiro Murata
发明人： Yasuhiro Tanaka , Kohichi Fujita , Yoshitomo Chujoh , Syunsuke Fukuda , Yuka Ikenoue , Tomoyuki Tagami , Akira Chiba , Ariko Kodaira , Hideki Matsumoto , Tadakiyo Nakagawa , Tatsuhiro Yamada , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , Y02A50/411
摘要： A pharmaceutical composition containing a heterocyclic compound of the formula (I) wherein each symbol is as defined in the specification, an isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient has a superior TNF-α production suppressing action. Accordingly, it is useful for the prophylaxis or treatment of various diseases caused by abnormal production of TNF-α.
摘要翻译：含有式（I）的杂环化合物的药物组合物，其中每个符号如说明书中所定义，其异构体，其溶剂化物或其药学上可接受的盐作为活性成分具有优异的TNF-α产生抑制作用。因此，可以预防或治疗由TNF-α异常产生引起的各种疾病。

8. 发明授权

US07800311B2 Power supply unit, high-frequency circuit system and heater voltage control method 有权
标题翻译：电源单元，高频电路系统和加热器电压控制方式
公开(公告)号：US07800311B2
公开(公告)日：2010-09-21
申请号：US12050609
申请日：2008-03-18
申请人： Akira Chiba , Yukihira Nakazato
发明人： Akira Chiba , Yukihira Nakazato
IPC分类号： H05B39/04
CPC分类号： H01J19/16 , H01J1/13 , H01J23/04 , H01J25/34 , H03B9/08
摘要： At the time of restoration of the power supply after a power failure, a voltage higher than that in the normal operation mode is supplied to a heater. After a lapse of a predetermined time, the voltage to be supplied to the heater is switched into the voltage in the normal operation mode while a control signal for stating the operation of an electron tube is output. Alternatively, at the time of power activation, the rate of change of current flowing through a heater is determined for every period of time. When the rate of change becomes equal to or lower than a predetermined threshold, a voltage higher than that in the normal operation mode is supplied to the heater, and after a lapse of a predetermined time, the voltage to be supplied to the heater is switched into the voltage in the normal operation mode while a control signal for stating the operation of the electron tube is output.
摘要翻译：在停电后恢复供电时，向加热器供给高于正常运行模式的电压。在经过预定时间之后，在输出用于说明电子管的操作的控制信号的同时，将要供给加热器的电压切换到正常工作模式的电压。或者，在动力激活时，每一段时间确定流过加热器的电流的变化率。当变化率变得等于或低于预定阈值时，比加热器提供高于正常操作模式的电压，并且在经过预定时间之后，切换到加热器的电压被切换输出用于表示电子管的操作的控制信号的正常操作模式中的电压。

9. 发明申请

US20060223836A1 New phenylalanine derivatives 有权
公开(公告)号：US20060223836A1
公开(公告)日：2006-10-05
申请号：US11442141
申请日：2006-05-30
申请人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： A61K31/517 , C07D239/96
CPC分类号： C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.

10. 发明授权

US4742151A Ultra-high-molecular-weight polyesters 失效
标题翻译：超高分子量聚酯
公开(公告)号：US4742151A
公开(公告)日：1988-05-03
申请号：US42625
申请日：1987-04-23
申请人： Susumu Tate , Haruhiko Narusawa , Youichi Watanabe , Akira Chiba
发明人： Susumu Tate , Haruhiko Narusawa , Youichi Watanabe , Akira Chiba
IPC分类号： C08G63/183 , C08G63/185 , C08G63/02
CPC分类号： C08G63/185 , C08G63/183
摘要： A novel ultra-high-molecular-weight polyester prepared from aromatic dicarboxylic acid or alkyl ester thereof and alkylene glycol, and having intrinsic viscosity of not less than 1.5 and insoluble polymer content of not more than 10% by weight.
摘要翻译：由芳族二羧酸或其烷基酯和亚烷基二醇制备的特性粘度不低于1.5，不溶性聚合物含量不超过10重量％的新型超高分子量聚酯。

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