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1. 发明申请

US20100016597A1 Method for producing pulverized organic compound particle 有权
标题翻译：粉碎有机化合物颗粒的制造方法
公开(公告)号：US20100016597A1
公开(公告)日：2010-01-21
申请号：US12585786
申请日：2009-09-24
申请人： Takashi Hirokawa , Takahiro Tada
发明人： Takashi Hirokawa , Takahiro Tada
IPC分类号： C07D215/00 , C07D209/26 , C07D213/80 , C07J5/00 , C07C69/66 , C07J7/00 , C07D233/54 , C07C59/76 , C07D257/04 , B02C23/18
CPC分类号： A61K31/015 , A61K9/0019 , A61K9/0073 , A61K9/14 , A61K31/192 , A61K31/216 , A61K31/404 , A61K31/41 , A61K31/4174 , A61K31/4422 , A61K31/4704 , A61K31/56 , A61K31/57 , A61K31/573 , Y10T428/2982
摘要： Disclosed is a method for producing pulverized particles of a crystalline organic compound which is poorly water-soluble. Also disclosed is a pulverized organic compound particle produced by such a method. Specifically disclosed is a method for producing a poor water solubility organic compound particle for medical use, which is characterized in that a poor water solubility organic compound for medical use is mixed with a physiologically acceptable salt and a physiologically acceptable polyol, and subjected to wet milling. Also specifically disclosed is a poor water solubility organic compound particle for medical use, which is produced by such a production method.
摘要翻译：公开了一种水溶性差的结晶有机化合物的粉碎微粒的制造方法。还公开了通过这种方法制造的粉碎的有机化合物颗粒。具体公开了一种生产用于医疗用途的差的水溶性有机化合物颗粒的方法，其特征在于将用于医疗用途的难溶性有机化合物与生理上可接受的盐和生理上可接受的多元醇混合，并进行湿磨。还具体公开了通过这种制造方法制造的用于医疗用途的差的水溶性有机化合物颗粒。

2. 发明授权

US08226983B2 Method for producing pulverized organic compound particle 有权
标题翻译：粉碎有机化合物颗粒的制造方法
公开(公告)号：US08226983B2
公开(公告)日：2012-07-24
申请号：US12585786
申请日：2009-09-24
申请人： Takashi Hirokawa , Takahiro Tada
发明人： Takashi Hirokawa , Takahiro Tada
IPC分类号： A61K9/14
CPC分类号： A61K31/015 , A61K9/0019 , A61K9/0073 , A61K9/14 , A61K31/192 , A61K31/216 , A61K31/404 , A61K31/41 , A61K31/4174 , A61K31/4422 , A61K31/4704 , A61K31/56 , A61K31/57 , A61K31/573 , Y10T428/2982
摘要： Disclosed is a method for producing pulverized particles of a crystalline organic compound which is poorly water-soluble. Also disclosed is a pulverized organic compound particle produced by such a method. Specifically disclosed is a method for producing a poor water solubility organic compound particle for medical use, which is characterized in that a poor water solubility organic compound for medical use is mixed with a physiologically acceptable salt and a physiologically acceptable polyol, and subjected to wet milling. Also specifically disclosed is a poor water solubility organic compound particle for medical use, which is produced by such a production method.
摘要翻译：公开了一种水溶性差的结晶有机化合物的粉碎微粒的制造方法。还公开了通过这种方法制造的粉碎的有机化合物颗粒。具体公开了一种生产用于医疗用途的差的水溶性有机化合物颗粒的方法，其特征在于将用于医疗用途的难溶性有机化合物与生理上可接受的盐和生理上可接受的多元醇混合，并进行湿磨。还具体公开了通过这种制造方法制造的用于医疗用途的差的水溶性有机化合物颗粒。

3. 发明申请

US20110165259A1 COMPOSITE ORGANIC COMPOUND POWDER FOR MEDICAL USE, METHOD FOR PRODUCING SAME AND SUSPENSION OF SAME 审中-公开
标题翻译：用于医疗用途的复合有机化合物粉末，其制备方法及其悬浮液
公开(公告)号：US20110165259A1
公开(公告)日：2011-07-07
申请号：US13063026
申请日：2009-09-15
申请人： Takashi Hirokawa , Takahiro Tada , Jun Nihira
发明人： Takashi Hirokawa , Takahiro Tada , Jun Nihira
IPC分类号： A61K9/50 , A61K31/216 , A61K31/192 , A61K31/41 , A61K31/417 , A61K31/56 , A61K31/405 , A61K31/7048 , A61K31/522 , A61K31/4422 , A61K31/519 , A61K31/517 , A61K31/573 , A61K31/57 , A61K31/58 , A61K31/4164 , A61K31/5513 , A61K31/5517 , A61K31/585 , A61K31/343 , A61K31/5415 , A61K31/135 , A61K31/165 , A61K31/337 , A61K31/4196 , A61K31/496 , A61K31/40 , A61K31/015 , A61P35/00
CPC分类号： A61K47/34 , A61K9/10 , A61K9/146 , A61K31/192 , A61K31/222 , A61K31/405 , A61K31/41 , A61K31/4174 , A61K31/573 , A61K47/24 , A61K47/26 , A61K47/32
摘要： [Problem to be Solved] The purpose of present invention is to provide a medicine which has low contamination with a fine-pulverizing medium, is safe and has improved bioavailability.[Solution] A method for producing a composite organic compound powder for medical use is used which comprises: mixing a poorly water-soluble and crystalline organic compound powder, a physiologically acceptable salt, a physiologically acceptable polyol, and a carboxyvinyl polymer and fine-pulverizing the organic compound powder; and removing at least the salt and the polyol during or after fine-pulverizing.
摘要翻译： [待解决的问题]本发明的目的是提供一种具有低细粉碎介质污染的药物，是安全的并且具有改善的生物利用度。 [解决方案]使用制造用于医疗用复合有机化合物粉末的方法，其包括：将难溶于水的结晶有机化合物粉末，生理学上可接受的盐，生理学上可接受的多元醇和羧基乙烯基聚合物混合并进行细粉碎有机化合物粉末; 并且在精细粉碎期间或之后至少除去盐和多元醇。

4. 发明授权

US06174477B1 Window molding, method and apparatus for producing same 失效
标题翻译：窗口成型，其制造方法和装置
公开(公告)号：US06174477B1
公开(公告)日：2001-01-16
申请号：US09253799
申请日：1999-02-22
申请人： Yuuji Nagahashi , Sumito Ichinohe , Hiroyoshi Imura , Takashi Hirokawa
发明人： Yuuji Nagahashi , Sumito Ichinohe , Hiroyoshi Imura , Takashi Hirokawa
IPC分类号： B29C4716
CPC分类号： B29C47/128 , B29C47/0023 , B29C47/003 , B29C47/124 , B60J10/16 , B60J10/22 , B60J10/25 , B60J10/265 , B60J10/70
摘要： A method for producing a window molding for an automotive vehicle having an upper molding including a leg portion, a glass limiting lip projecting from the leg portion, a head portion connected to the leg portion and the glass limiting lip and a side molding which includes the leg portion and the glass limiting lip, a strut portion connected to the leg portion, and a head portion connected to the strut portion; where a length of the strut portion and an angle between the head portion and the glass limiting lip are gradually increased from an end of said side molding connected to said upper molding to the other end is disclosed. The method includes extruding an intermediate molding from a die head, extruding an intermediate molding from a second die head, integrally connecting the first and second intermediate moldings, and continuously changing a length of the strut portion and an angle between the glass limiting lip and the head portion synchronously with the extruding operation of the first and second intermediate moldings.
摘要翻译：一种用于制造机车用窗模成型体的方法，其具有包括腿部的上模制件，从腿部突出的玻璃限制唇缘，连接到腿部的头部和玻璃限制唇缘，以及包括腿部和玻璃限制唇缘，连接到腿部的支柱部分和连接到支柱部分的头部; 公开了一种支柱部分的长度和头部和玻璃限制唇缘之间的角度从连接到所述上模制件的所述侧模具的端部逐渐增加到另一端。该方法包括从模头挤出中间模制件，从第二模头挤出中间模制件，将第一和第二中间模制件整体连接，以及连续地改变支柱部分的长度和玻璃限制唇缘与头部与第一和第二中间模制品的挤压操作同步。

5. 发明申请

US20080295414A1 Automotive weather strip 审中-公开
标题翻译：汽车天气条
公开(公告)号：US20080295414A1
公开(公告)日：2008-12-04
申请号：US12078559
申请日：2008-04-01
申请人： Naohisa Miyakawa , Takashi Hirokawa , Katsuhisa Kato
发明人： Naohisa Miyakawa , Takashi Hirokawa , Katsuhisa Kato
IPC分类号： E06B7/16
CPC分类号： B60J10/24 , B60J10/32
摘要： An automotive weather strip mounted on a flange at the peripheral edge of various openings in a vehicle body such as an automotive door, trunk, and back door includes a weather strip body. The weather strip body includes a coating layer having a hollow seal part, which is made of thermoplastic elastomer, and a core material having a substantially U-shaped cross section, which is made of a hard synthetic resin. A seal pad part made of thermoplastic elastomer is provided on the inner bottom surface of the core material having a substantially U-shaped cross section or on the coating layer provided on the inner bottom surface of the core material having a substantially U-shaped cross section. The seal pad part is formed with a large number of protrusions on the surface thereof facing to a flange.
摘要翻译：安装在诸如汽车门，行李箱和后门的车身中的各种开口的周边边缘的法兰上的汽车防风条包括防风条体。耐候条体包括由热塑性弹性体制成的具有中空密封部分的涂层和由硬质合成树脂制成的具有大致U形截面的芯材。由热塑性弹性体制成的密封垫部分设置在具有大致U形横截面的芯材的内底表面上，或者设置在芯材的内底表面上的涂层上，其基本上为U形横截面。密封垫部分在其面向凸缘的表面上形成有大量突起。

6. 发明授权

US06190773B1 Self-water dispersible particle made of biodegradable polyester and process for the preparation thereof 失效
标题翻译：由可生物降解的聚酯制成的自分散水的颗粒及其制备方法
公开(公告)号：US06190773B1
公开(公告)日：2001-02-20
申请号：US09296132
申请日：1999-04-22
申请人： Shoji Imamura , Yasuyuki Watanabe , Kazuaki Tsukuda , Takashi Hirokawa , Nagao Ariga
发明人： Shoji Imamura , Yasuyuki Watanabe , Kazuaki Tsukuda , Takashi Hirokawa , Nagao Ariga
IPC分类号： B32B1502
CPC分类号： A01N25/28 , C08L63/06 , C08L63/08 , Y10T428/2982
摘要： A self-water dispersible particle made of a biodegradable polyester and a process for the preparation of an aqueous dispersion of self-water dispersible particles made of a biodegradable polyester containing a hydrophobic core material, which comprises reacting a biodegradable polyester containing hydroxyl group with a polyvalent carboxylic acid or anhydride or chloride thereof, dissolving or dispersing the biodegradable polyester having acid groups thus obtained and a hydrophobic core material in an organic solvent, adding a base to the solution with stirring to neutralize to form the salt of the biodegradable polyester, and then adding water to the solution or dispersion to undergo phase inversion emulsification are disclosed. According to the present invention, a self-water dispersible particle made of a biodegradable polyester having varied average particle diameters of the order of nanometer free of urethane bond and excellent in biodegradability, an aqueous dispersion thereof, a self-water dispersible particle made of a biodegradable polyester comprising a hydrophobic core material encapsulated therein excellent in gradual releasability such as pesticide, and a process for the simple preparation of these products without using any auxiliary stabilizing material such as emulsifying agent or any high speed agitator can be provided.
摘要翻译：由可生物降解的聚酯制成的自分散水的颗粒和由含有疏水性芯材料的可生物降解的聚酯制成的自分散水分散体的水分散体的方法，该方法包括使含有羟基的可生物降解的聚酯与多价的羧酸或其酸酐或氯化物，将由此获得的具有酸基的可生物降解的聚酯和疏水性芯材溶解或分散在有机溶剂中，在搅拌下向溶液中加入碱以中和以形成可生物降解的聚酯的盐，然后公开了向溶液或分散体中加入水以进行相转化乳化。根据本发明，由具有不同氨基甲酸酯键的纳米级的平均粒径不等的生物降解性聚酯制成的自
水分散性粒子，其生物降解性优异，其水分散体，由可以提供包含其中具有优异的逐渐释放性的疏水性芯材的生物可降解聚酯，例如农药，以及在不使用任何辅助稳定材料如乳化剂或任何高速搅拌器的情况下简单制备这些产品的方法。

7. 发明授权

US08716186B2 Agricultural and horticultural water dispersible granule 有权
标题翻译：农业和园艺水分散颗粒
公开(公告)号：US08716186B2
公开(公告)日：2014-05-06
申请号：US10543039
申请日：2004-01-21
申请人： Takashi Hirokawa , Takashi Gotou , Ichirou Urihara
发明人： Takashi Hirokawa , Takashi Gotou , Ichirou Urihara
IPC分类号： A01N25/12 , A01N25/00
CPC分类号： A01N25/14
摘要： An object of the present invention is to provide an agricultural and horticultural water dispersible granule, which shows excellent properties of disintegrating and dispersing after being put into water, and which does not cause phytotoxicity, even in the case wherein an agricultural chemical technical product having a melting or softening point of 70° C. or below, the formulation of which into water dispersible granules was difficult in the prior art, is used. The agricultural and horticultural water dispersible granule is produced by granulating a mixture containing an agricultural chemical technical product having a melting or softening point of 70° C. or below, a salt of N-acylamino acid, and an adsorbent carrier. The agricultural and horticultural water dispersible granules as described above which further contain at least one of a formaldehyde condensate of aromatic sulfonate and a lignosulfonate. The agricultural and horticultural water dispersible granules as described above which further contain N-acylmethyltaurate.
摘要翻译：本发明的目的是提供一种农业园艺水分散性颗粒，其在放入水中后显示出优异的崩解和分散性能，并且不会引起植物毒性，即使在具有熔点或软化点为70℃以下，在现有技术中难以配制成水分散性颗粒。农业和园艺水分散性颗粒通过将含有熔点或软化点为70℃以下的农药技术产品，N-酰基氨基酸盐和吸附剂载体的混合物制粒而制成。如上所述的农业和园艺水分散性颗粒，其还含有芳族磺酸盐和木质素磺酸盐的甲醛缩合物中的至少一种。如上所述的农业和园艺水分散性颗粒，其还含有N-酰基甲基牛磺酸盐。

8. 发明申请

US20060189485A1 Water dispersible granules for agricultural and horticultural use 有权
标题翻译：用于农业和园艺用途的水分散颗粒
公开(公告)号：US20060189485A1
公开(公告)日：2006-08-24
申请号：US10543039
申请日：2004-01-21
申请人： Takashi Hirokawa , Takashi Gotou , Ichirou Urihara
发明人： Takashi Hirokawa , Takashi Gotou , Ichirou Urihara
IPC分类号： A01N25/12
CPC分类号： A01N25/14
摘要： An object of the present invention is to provide an agricultural and horticultural water dispersible granule, which shows excellent properties of disintegrating and dispersing after being put into water, and which does not cause phytotoxicity, even in the case wherein an agricultural chemical technical product having a melting or softening point of 70° C. or below, the formulation of which into water dispersible granules was difficult in the prior art, is used. The agricultural and horticultural water dispersible granule is produced by granulating a mixture containing an agricultural chemical technical product having a melting or softening point of 70° C. or below, a salt of N-acylamino acid, and an adsorbent carrier. The agricultural and horticultural water dispersible granules as described above which further contain at least one of a formaldehyde condensate of aromatic sulfonate and a lignosulfonate. The agricultural and horticultural water dispersible granules as described above which further contain N-acylmethyltaurate.
摘要翻译：本发明的目的是提供一种农业园艺水分散性颗粒，其在放入水中后显示出优异的崩解和分散性能，并且不会引起植物毒性，即使在具有熔点或软化点为70℃以下，在现有技术中难以配制成水分散性颗粒。农业和园艺水分散性颗粒通过将含有熔点或软化点为70℃以下的农药技术产品，N-酰基氨基酸盐和吸附剂载体的混合物制粒而制成。如上所述的农业和园艺水分散性颗粒，其还含有芳族磺酸盐和木质素磺酸盐的甲醛缩合物中的至少一种。如上所述的农业和园艺水分散性颗粒，其还含有N-酰基甲基牛磺酸盐。

9. 发明授权

US06106047A Window molding, method and apparatus for producing same 失效
标题翻译：窗口成型，其制造方法和装置
公开(公告)号：US06106047A
公开(公告)日：2000-08-22
申请号：US912807
申请日：1997-08-19
申请人： Yuuji Nagahashi , Sumito Ichinohe , Hiroyoshi Imura , Takashi Hirokawa
发明人： Yuuji Nagahashi , Sumito Ichinohe , Hiroyoshi Imura , Takashi Hirokawa
IPC分类号： B29C47/06 , B29C47/12 , B60J10/00 , B60J10/02
CPC分类号： B29C47/128 , B29C47/0023 , B29C47/003 , B29C47/124 , B60J10/16 , B60J10/22 , B60J10/25 , B60J10/265 , B60J10/70
摘要： A window molding installed at a clearance between a front window and a window frame of an automotive vehicle has an upper molding and a side molding continuous in the longitudinal direction. The side molding has a strut portion which is formed between a head portion for covering the clearance and a leg portion inserted to the clearance so that a length of the strut portion and an angle between the head portion and a glass limiting lip connected to the leg portion are gradually increased from an end of the side molding connected to the upper molding to the other end. The window molding is produced by extrusion molding by means of an apparatus using a fixed die head and a movable die head.
摘要翻译：安装在机动车辆的前窗和窗框之间的间隙处的窗模具具有上模制件和在纵向方向上连续的侧模。侧面模制件具有支撑部分，该支柱部分形成在用于覆盖间隙的头部和插入间隙的腿部之间，使得支柱部分的长度和头部与连接到腿部的玻璃限制唇之间的角度部分从连接到上部模制件的侧模具的端部逐渐增加到另一端。通过使用固定模头和可动模头的装置通过挤压成型制造窗模。

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