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1. 发明申请

US20130142767A1 COMPOSITION CONTAINING REDUCED COENZYME Q10, AND MANUFACTURING AND STABILISING METHODS THEREFOR 审中-公开
标题翻译：含有降低COENZYME Q10的组合物及其制备和稳定化方法
公开(公告)号：US20130142767A1
公开(公告)日：2013-06-06
申请号：US13642375
申请日：2011-04-20
申请人： Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K31/122 , A23L1/29 , A61K8/35
CPC分类号： A61K31/122 , A23K20/111 , A23L33/00 , A23L33/10 , A23P10/30 , A61K8/347 , A61K8/355 , A61K9/4858 , A61K47/10 , A61K2800/92 , A61Q19/00
摘要： The present invention relates to a method of producing reduced coenzyme Q10, including reducing oxidized coenzyme Q10 using a reducing agent in terpenes that can highly dissolve oxidized coenzyme Q10 and reduced coenzyme Q10 in the co-existence of at least one kind of additive selected from the group consisting of alcohols, water, a surfactant and diacylglycerol. In addition, the present invention relates to a composition comprising terpenes, a reducing agent, reduced coenzyme Q10 and at least one kind selected from the group consisting of alcohols, water, a surfactant and diacylglycerol, and a method of stabilizing reduced coenzyme Q10 comprising preparing the composition.
摘要翻译：本发明涉及一种还原型辅酶Q10的制造方法，其包括使用萜烯中的还原剂还原氧化型辅酶Q10，所述还原型辅酶Q10可以在选自以下的至少一种添加剂的共存中高度溶解氧化型辅酶Q10和还原型辅酶Q10 由醇，水，表面活性剂和二酰基甘油组成的组。此外，本发明涉及包含萜烯，还原剂，还原型辅酶Q10和选自醇，水，表面活性剂和二酰基甘油中的至少一种的组合物，以及稳定还原型辅酶Q10的方法，包括制备组成。

2. 发明授权

US09040747B2 Method for producing reduced coenzyme Q10, method for stabilizing same, and composition comprising same 有权
标题翻译：还原型辅酶Q10的制造方法，其稳定化方法及其组合物
公开(公告)号：US09040747B2
公开(公告)日：2015-05-26
申请号：US13501692
申请日：2010-10-15
申请人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A23L1/30 , A23L1/00 , A23L1/305 , A61K9/10 , A61K31/122 , A61K47/10 , C07C41/26 , C07C41/46
CPC分类号： A23L1/30 , A23L33/10 , A23L33/175 , A23P10/30 , A23V2002/00 , A61K9/10 , A61K31/122 , A61K47/10 , C07C41/26 , C07C41/46 , C07C43/23 , A23V2250/314
摘要： An object of the present invention is to provide a substance characterized by ability to reduce oxidized coenzyme Q10 and ability to stabilize reduced coenzyme Q10, which contains nutrients, has a favorable taste, and is excellent in general versatility, and a method for using the same. The present invention relates to a method for producing reduced coenzyme Q10 comprising reducing oxidized coenzyme Q10 with a particular amino acid. The present invention also relates to a method for stabilizing reduced coenzyme Q10 in the presence of a particular amino acid and a composition stabilized by the method.
摘要翻译：本发明的目的是提供一种特征在于能够减少氧化型辅酶Q10和使含有营养成分的还原型辅酶Q10稳定，具有良好的味道，通用性优异的能力的物质及其使用方法。本发明涉及还原型辅酶Q10的制备方法，其包括用特定氨基酸还原氧化型辅酶Q10。本发明还涉及在特定氨基酸和通过该方法稳定的组合物存在下稳定还原型辅酶Q10的方法。

3. 发明申请

US20120201802A1 METHOD FOR PRODUCING REDUCED COENZYME Q10, METHOD FOR STABILIZING SAME, AND COMPOSITION COMPRISING SAME 审中-公开
标题翻译：用于生产降低的聚苯乙烯的方法Q10，其稳定化方法和包含其的组合物
公开(公告)号：US20120201802A1
公开(公告)日：2012-08-09
申请号：US13502181
申请日：2010-10-14
申请人： Takao Yamaguchi , Takaaki Jikihara , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takao Yamaguchi , Takaaki Jikihara , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A61K31/122 , A23L1/30 , C07C50/28
CPC分类号： A61K36/53 , A23L33/10 , A23L33/105 , A23L33/15 , A23P10/30 , A23V2002/00 , A61K9/4875 , A61K31/09 , A61K31/122 , A61K36/15 , A61K36/736 , A61K36/82 , C07C41/26 , C07C41/46 , C07C43/23 , A23V2250/21 , A23V2250/314
摘要： The present invention aims to provide a component having not only an ability to reduce oxidized coenzyme Q10 and an ability to stabilize reduced coenzyme Q10, but also nutrient, flavor, broad utility and the like, and a utilization method thereof. The present invention relates to a safe and convenient method of producing reduced coenzyme Q10, including reducing oxidized coenzyme Q10 by using, as a component derived from a naturally-occurring substance, which is safe for the body, any one or more components selected from the group consisting of an acerola extract, a tea extract, a rosemary extract, a pine bark extract and a Vaccinium vitis-idaea extract. In addition, the present invention also relates to a method of stabilizing reduced coenzyme Q10 in the co-presence of a component derived from a naturally-occurring substance, and a stabilized composition. Since the above-mentioned components derived from a naturally-occurring substance can also be expected to function as nutrients, the composition of the present invention is particularly useful as a pharmaceutical product, a supplement, a food with nutrient function claims, a food for specified health use, a nutritional supplement, a nutritional product, an animal drug, a cosmetic, a therapeutic drug and the like, which are required to show various effects.
摘要翻译：本发明的目的在于提供一种不仅具有减少氧化型辅酶Q10的能力和稳定还原型辅酶Q10的能力，而且还具有养分，风味，广泛用途等的成分及其利用方法。本发明涉及一种生产还原型辅酶Q10的安全且方便的方法，其包括使用作为对身体安全的天然存在物质的成分的还原氧化型辅酶Q10，任何一种或多种选自一组由槭树提取物，茶提取物，迷迭香提取物，松树皮提取物和痘苗提取物组成。此外，本发明还涉及在衍生自天然存在物质的成分的共存下稳定还原型辅酶Q10的稳定化组合物的方法。由于上述衍生自天然物质的组分也可以预期作为营养物质使用，所以本发明的组合物特别可用作药物产品，补充剂，具有营养功能要求的食品，特定食品健康用品，营养补充剂，营养产品，动物药物，化妆品，治疗药物等，需要显示各种效果。

4. 发明申请

US20120207731A1 METHOD FOR PRODUCING REDUCED COENZYME Q10, METHOD FOR STABILIZING SAME, AND COMPOSITION COMPRISING SAME 有权
标题翻译：用于生产降低的聚苯乙烯的方法Q10，其稳定化方法和包含其的组合物
公开(公告)号：US20120207731A1
公开(公告)日：2012-08-16
申请号：US13501692
申请日：2010-10-15
申请人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , C07C49/753 , A61K31/122 , C07C45/61
CPC分类号： A23L1/30 , A23L33/10 , A23L33/175 , A23P10/30 , A23V2002/00 , A61K9/10 , A61K31/122 , A61K47/10 , C07C41/26 , C07C41/46 , C07C43/23 , A23V2250/314
摘要： An object of the present invention is to provide a substance characterized by ability to reduce oxidized coenzyme Q10 and ability to stabilize reduced coenzyme Q10, which contains nutrients, has a favorable taste, and is excellent in general versatility, and a method for using the same. The present invention relates to a method for producing reduced coenzyme Q10 comprising reducing oxidized coenzyme Q10 with a particular amino acid. The present invention also relates to a method for stabilizing reduced coenzyme Q10 in the presence of a particular amino acid and a composition stabilized by the method.
摘要翻译：本发明的目的是提供一种特征在于能够减少氧化型辅酶Q10和使含有营养成分的还原型辅酶Q10稳定，具有良好的味道，通用性优异的能力的物质及其使用方法。本发明涉及还原型辅酶Q10的制备方法，其包括用特定氨基酸还原氧化型辅酶Q10。本发明还涉及在特定氨基酸和通过该方法稳定的组合物存在下稳定还原型辅酶Q10的方法。

5. 发明申请

US20070010689A1 Optically active 3,3'-dithiobis(2-amino-2methylpropionic acid) derivative and process for producing optically active 2-amino-3-mercapto-2-methylpropionic acid derivative 审中-公开
标题翻译：光活性的3,3'-二硫代双（2-氨基-2-甲基丙酸）衍生物和光学活性2-氨基-3-巯基-2-甲基丙酸衍生物的制备方法
公开(公告)号：US20070010689A1
公开(公告)日：2007-01-11
申请号：US10570791
申请日：2004-08-18
申请人： Shingo Matsumoto , Hiroshi Murao , Takao Yamaguchi , Masashi Izumida , Yasuyoshi Ueda
发明人： Shingo Matsumoto , Hiroshi Murao , Takao Yamaguchi , Masashi Izumida , Yasuyoshi Ueda
IPC分类号： C07C323/50
CPC分类号： C07D403/12 , C07B2200/07 , C07C319/06 , C07C323/58 , C07D233/76 , C12P7/52 , C12P11/00 , C12P41/002
摘要： The present invention provides a useful novel intermediate and a novel synthetic process that can highly prevent contamination by various impurities to an optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof useful as an intermediate for pharmaceuticals and the like and provides a process for easily and efficiently producing a high purity optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof on an industrial production scale. A process of producing a high purity 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof includes reductively cleaving a sulfur-sulfur bond of an intermediate, which is a high purity optically active 3,3′-dithiobis(2-amino-2-methylpropionic acid) derivative substantially free of impurities. Thus, a resulting optically active 2-amino-3-mercapto-2-methylpropionic acid derivative can be produced without generating impurities as by-products which are difficult to remove.
摘要翻译：本发明提供了一种有用的新型中间体和新型合成方法，其可以高度防止各种杂质污染2-氨基-3-巯基-2-甲基丙酸衍生物的光学活性R或S异构体或其盐，其用作药物等的中间体，并且以工业生产规模提供容易且有效地制备2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的高纯度光学活性R或S异构体的方法。制备高纯度2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的方法包括还原性地裂解作为高纯度光学活性3,3'-二硫代双（2）的中间体的硫 - 硫键 - 氨基-2-甲基丙酸）衍生物。因此，得到的光学活性2-氨基-3-巯基-2-甲基丙酸衍生物可以不产生作为难以除去的副产物的杂质。

6. 发明申请

US20130309338A1 BIOLOGICALLY ACTIVE SUBSTANCE-CONTAINING WATER-SOLUBILIZING PREPARATION AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：生物活性物质含水溶解制剂及其制备方法
公开(公告)号：US20130309338A1
公开(公告)日：2013-11-21
申请号：US13982841
申请日：2012-01-31
申请人： Takao Yamaguchi , Toshinori Ikehara
发明人： Takao Yamaguchi , Toshinori Ikehara
IPC分类号： A61K47/14 , A61K36/287 , A61K36/484
CPC分类号： A61K36/484 , A61K9/0095 , A61K9/08 , A61K36/287 , A61K47/14 , A61K2236/00 , A61K2300/00
摘要： An object of the present invention is to provide a water-solubilizing preparation that is obtained by convenient steps without use of a special apparatus such as a high-pressure homogenizer, does not impair the original properties of a water-based material even after being added to the material, has high dispersibility and transparency and excellent heat resistance and acid resistance, and can maintain stability. The water-solubilizing preparation of the present invention is a biologically active substance-containing water-solubilizing preparation comprising 1 to 50% by weight of an oily ingredient (A) containing a biologically active substance and oil, 10 to 98% by weight of a polyglycerin fatty acid ester (B) having an HLB value of 12.5 or larger, and 1 to 40% by weight of a surfactant (C) having an HLB value of 7 to 11.8.
摘要翻译：本发明的目的是提供一种通过方便的步骤而不使用诸如高压均化器的特殊装置获得的水溶性制剂，即使在添加后也不损害水性材料的原始性能对材料，具有高分散性和透明性，优异的耐热性和耐酸性，并能保持稳定性。本发明的水溶性制剂是含有1〜50重量％含有生物活性物质和油的油性成分（A）的含有生物活性物质的水溶性制剂，10〜98重量％ HLB值为12.5以上的聚甘油脂肪酸酯（B）和HLB值为7〜11.8的表面活性剂（C）为1〜40重量％。

7. 发明授权

US08352594B2 Network monitoring device, bus system monitoring device, method and program 有权
标题翻译：网络监控设备，总线系统监控设备，方法和程序
公开(公告)号：US08352594B2
公开(公告)日：2013-01-08
申请号：US12989808
申请日：2009-06-12
申请人： Tomoki Ishii , Takao Yamaguchi , Atsushi Yoshida
发明人： Tomoki Ishii , Takao Yamaguchi , Atsushi Yoshida
IPC分类号： G06F15/173
CPC分类号： H04N7/185 , H04L43/02 , H04L43/0817 , H04L43/0864 , H04L43/0888 , H04L43/103 , H04L43/12 , H04N7/181
摘要： A network monitoring device which monitors a network in which data is transmitted through relays, includes a monitoring frequency recording unit (111) which records monitoring frequencies for monitoring transmission statuses of the relays, a selection probability generating unit (112) which generates selection probability information which is probability values for the relays, a monitoring object determining unit (113) which determines, according to the monitoring frequency and the selection probability information, a relay the transmission status of which is to be monitored, a transmission status obtaining unit (106) which obtains transmission status information indicating a transmission status on the relay determined, a transmission status recording unit (107) which records the transmission status information, an activation level calculating unit (109) which calculates, using the transmission status information, activation level indicating suitability of the monitoring on the transmission statuses of the relays, and a monitoring frequency updating unit (110) which updates, based on the activation level, the monitoring frequency, and the network monitoring device detects the change in throughput on a data transmission path highly responsively.
摘要翻译：一种监视通过中继发送数据的网络的网络监视装置，包括：监视频率记录单元，其记录用于监视所述中继的发送状态的监视频率;生成选择概率信息的选择概率生成单元，一个监视对象确定单元，根据监视频率和选择概率信息，确定其发送状态将要被监视的中继;发送状态获取单元，获取表示所确定的中继的发送状态的发送状态信息，记录了发送状态信息的发送状态记录部（107），使用发送状态信息计算表示适合性的激活电平的激活电平计算部（109）的监测继电器的状态，监视频率更新单元（110）基于激活水平更新监视频率，并且网络监视设备高度响应地检测数据传输路径上的吞吐量变化。

8. 发明授权

US08214458B2 Transmitter apparatus and transmitting method 有权
标题翻译：发射机装置及发射方法
公开(公告)号：US08214458B2
公开(公告)日：2012-07-03
申请号：US10548081
申请日：2004-02-24
申请人： Junichi Sato , Tomoaki Itoh , Takao Yamaguchi , Ichiro Takei , Daiji Ido
发明人： Junichi Sato , Tomoaki Itoh , Takao Yamaguchi , Ichiro Takei , Daiji Ido
IPC分类号： G06F15/16
CPC分类号： G06F17/30905 , H04N7/163 , H04N21/23439 , H04N21/4312 , H04N21/4314 , H04N21/4516 , H04N21/454 , H04N21/6547 , H04N21/8543
摘要： The present invention is intended to realize a screen configuration according to a propagation environment and display capability by causing a server to transmit a plurality of pieces of screen configuration information describing a spatial arrangement of contents to a reception terminal and select, when the reception terminal receives a plurality of pieces of screen configuration information, screen configuration information and display the contents according to the propagation environment of the reception terminal and conditions such as display capability.
摘要翻译：本发明旨在通过使服务器将描述内容的空间排列的多个屏幕配置信息发送到接收终端来实现根据传播环境和显示能力的屏幕配置，并且当接收终端接收时多个屏幕配置信息，屏幕配置信息，并根据接收终端的传播环境和显示能力等条件来显示内容。

9. 发明授权

US08102761B2 Path control device, path control method, and path control program 有权
标题翻译：路径控制装置，路径控制方法和路径控制程序
公开(公告)号：US08102761B2
公开(公告)日：2012-01-24
申请号：US12920168
申请日：2009-11-24
申请人： Takao Yamaguchi , Atsushi Yoshida , Tomoki Ishii
发明人： Takao Yamaguchi , Atsushi Yoshida , Tomoki Ishii
IPC分类号： G06F11/00
CPC分类号： H04L45/22 , H04L41/147 , H04L45/02 , H04L45/28 , H04W24/04
摘要： A path control device included in a terminal device (300), which includes a path information generating unit (302) which generates path information indicating paths from a terminal (300) to a terminal (400), a path malfunction predicting unit (303) which predicts a malfunction on each of the relays, using the number of flows as a malfunction occurrence likelihood value, at least one of the relays that is a candidate for monitoring is determined for each path, and a bypass path selecting unit (304) which selects, when the malfunction is predicted on the at least one relay, a path that should be used for transmitting the data from the terminal (300) to the terminal (400), from the paths except the path including the relay on which the malfunction is predicted.
摘要翻译：包括在终端装置（300）中的路径控制装置，其包括生成表示从终端（300）到终端（400）的路径的路径信息的路径信息生成部（302），路径故障预测部（303）其中，使用所述多个流作为故障发生似然值来预测每个所述继电器的故障，为每个路径确定作为用于监视的候选的所述继电器中的至少一个;以及旁路路径选择单元，当在所述至少一个继电器上预测到故障时，选择应当用于从所述终端（300）向所述终端（400）发送所述数据的路径，所述路径除了包括所述故障的所述继电器的路径被预测。

10. 发明申请

US20110032818A1 PATH CONTROL DEVICE, PATH CONTROL METHOD, AND PATH CONTROL PROGRAM 有权
标题翻译：路径控制装置，路径控制方法和路径控制程序
公开(公告)号：US20110032818A1
公开(公告)日：2011-02-10
申请号：US12920168
申请日：2009-11-24
申请人： Takao Yamaguchi , Atsushi Yoshida , Tomoki Ishii
发明人： Takao Yamaguchi , Atsushi Yoshida , Tomoki Ishii
IPC分类号： G06F11/00
CPC分类号： H04L45/22 , H04L41/147 , H04L45/02 , H04L45/28 , H04W24/04
摘要： A path control device included in a terminal device (300), which includes a path information generating unit (302) which generates path information indicating paths from a terminal (300) to a terminal (400), a path malfunction predicting unit (303) which predicts a malfunction on each of the relays, using the number of flows as a malfunction occurrence likelihood value, at least one of the relays that is a candidate for monitoring is determined for each path, and a bypass path selecting unit (304) which selects, when the malfunction is predicted on the at least one relay, a path that should be used for transmitting the data from the terminal (300) to the terminal (400), from the paths except the path including the relay on which the malfunction is predicted.
摘要翻译：包括在终端装置（300）中的路径控制装置，其包括生成表示从终端（300）到终端（400）的路径的路径信息的路径信息生成部（302），路径故障预测部（303）其中，使用所述多个流作为故障发生似然值来预测每个所述继电器的故障，为每个路径确定作为用于监视的候选的所述继电器中的至少一个;以及旁路路径选择单元，当在所述至少一个继电器上预测到故障时，选择应当用于从所述终端（300）向所述终端（400）发送所述数据的路径，所述路径除了包括所述故障的所述继电器的路径被预测。

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