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1. 发明申请

US20060264361A1 Novel lysophosphatidic acid receptor 有权
标题翻译：新型溶血磷脂酸受体
公开(公告)号：US20060264361A1
公开(公告)日：2006-11-23
申请号：US10542217
申请日：2003-12-17
申请人： Takao Shimizu , Satoshi Ishii , Kyoko Noguchi
发明人： Takao Shimizu , Satoshi Ishii , Kyoko Noguchi
IPC分类号： A61K38/17 , G01N33/574 , C07K14/705
CPC分类号： G01N33/76 , C07K14/705 , G01N2333/726
摘要： It is intended to provide a novel receptor of LPA and a method of screening a drug such as an LPA receptor antagonist using the same. Use as a lysophosphatidic acid (LPA) receptor comprising a G protein-coupled protein p2y9. More specifically, use of the G protein-coupled protein p2y9 as a lysophosphatidic acid (LPA) receptor. A method of screening an agonist or an antagonist to the LPA receptor as described above by using the receptor.
摘要翻译：旨在提供LPA的新型受体和使用其来筛选药物如LPA受体拮抗剂的方法。用作包含G蛋白偶联蛋白质p2y9的溶血磷脂酸（LPA）受体。更具体地，使用G蛋白偶联蛋白质p2y9作为溶血磷脂酸（LPA）受体。通过使用受体来筛选上述LPA受体的激动剂或拮抗剂的方法。

2. 发明授权

US07666611B2 Lysophosphatidic acid receptor 有权
标题翻译：溶血磷脂酸受体
公开(公告)号：US07666611B2
公开(公告)日：2010-02-23
申请号：US10542217
申请日：2003-12-17
申请人： Takao Shimizu , Satoshi Ishii , Kyoko Noguchi
发明人： Takao Shimizu , Satoshi Ishii , Kyoko Noguchi
IPC分类号： G01N33/53 , C12Q1/00
CPC分类号： G01N33/76 , C07K14/705 , G01N2333/726
摘要： It is intended to provide a novel receptor of LPA and a method of screening a drug such as an LPA receptor antagonist using the same. Use as a lysophosphatidic acid (LPA) receptor comprising a G protein-coupled protein p2y9. More specifically, use of the G protein-coupled protein p2y9 as a lysophosphatidic acid (LPA) receptor. A method of screening an agonist or an antagonist to the LPA receptor as described above by using the receptor.
摘要翻译：旨在提供LPA的新型受体和使用其来筛选药物如LPA受体拮抗剂的方法。用作包含G蛋白偶联蛋白质p2y9的溶血磷脂酸（LPA）受体。更具体地，使用G蛋白偶联蛋白质p2y9作为溶血磷脂酸（LPA）受体。通过使用受体来筛选上述LPA受体的激动剂或拮抗剂的方法。

3. 发明授权

US07570638B2 Inter-domain routing technique using MPLS 有权
标题翻译：使用MPLS的域间路由技术
公开(公告)号：US07570638B2
公开(公告)日：2009-08-04
申请号：US11287338
申请日：2005-11-28
申请人： Takao Shimizu , Naoyuki Takahashi , Norikazu Matsukawa , Kazuhiro Iitsuka , Michio Kitade
发明人： Takao Shimizu , Naoyuki Takahashi , Norikazu Matsukawa , Kazuhiro Iitsuka , Michio Kitade
IPC分类号： H04L12/00
CPC分类号： H04L45/00 , H04L45/04 , H04L45/50
摘要： This invention is to enable inter-domain routing using MPLS. When communication is carried out passing through plural domains, respective management servers managing respective domains cooperate to carry out path constitution and optimum routing. At the path constitution, the respective management servers connect links within the respective controlling domain to constitute paths to reach a target address. When the paths are constituted, label data is notified to nodes associated with the constituted paths, and is used at the routing. At the routing, the management server controlling the source domain obtains the dynamic transmission bandwidths from the respective management servers, and identifies the routing policy from a port number of a request to be routed or the like to identify the optimum path. When the optimum path is determined, it is possible to carry out the routing using the label data held in the respective nodes.
摘要翻译：本发明是为了实现使用MPLS的域间路由。当通过多个域进行通信时，管理各个域的各个管理服务器协作来执行路径构成和最佳路由。在路径构成中，相应的管理服务器连接各个控制域内的链路，构成路径以达到目标地址。当构成路径时，将标签数据通知给与构成路径相关联的节点，并在路由中使用。在路由中，控制源域的管理服务器从相应的管理服务器获得动态传输带宽，并根据要路由的请求的端口号等来识别路由策略，以识别最佳路径。当确定最佳路径时，可以使用保存在各个节点中的标签数据来执行路由。

4. 发明申请

US20080154028A1 Novel calcium-independent phospholipases A2, genes thereof and promoter of the same 失效
标题翻译：新型钙依赖性磷脂酶A2，其基因和启动子相同
公开(公告)号：US20080154028A1
公开(公告)日：2008-06-26
申请号：US11984901
申请日：2007-11-26
申请人： Takao Shimizu , Koji Kishimoto , Yasuyoshi Watanabe
发明人： Takao Shimizu , Koji Kishimoto , Yasuyoshi Watanabe
IPC分类号： C07H21/04 , C07H1/00
CPC分类号： C12N9/20
摘要： Novel calcium-independent phospholipases A2; genes encoding the same; an antibody against them; an inherent promoter or a regulator gene which comprises a base sequence occurring in intron and inducing site-specific expression in response to an external stimulus; a method of expressing a target protein in response to an external stimulus; and an organism having this gene transferred thereinto. Novel calcium-independent phospholipases A2 having an amino acid sequence represented by SEQ ID NO: 1, 3 or 5 or an amino acid sequence derived from such an amino acid sequence by the substitution, deletion or addition of one or more amino acids; a gene having a base sequence occurring in an intron and being capable of initiating RNA transcription due to an external stimulus such as a stimulus with kainic acid or an electrical stimulus; a method of regulating expression by using the gene; and an organism having the gene transferred thereinto.
摘要翻译：新的不依赖钙的磷脂酶A 2 < 编码基因的基因; 抗体; 固有的启动子或调节基因，其包含在内含子中出现的碱基序列并响应于外部刺激诱导位点特异性表达; 响应于外部刺激而表达靶蛋白的方法; 和转移有该基因的生物体。具有由SEQ ID NO：1,3或5表示的氨基酸序列的新型不依赖钙依赖性磷脂酶A 2或通过取代，缺失或添加衍生自该氨基酸序列的氨基酸序列一个或多个氨基酸; 具有在内含子中存在的碱基序列并且能够由于诸如用红藻氨酸或电刺激的刺激的外部刺激引发RNA转录的基因; 通过使用该基因调节表达的方法; 以及将基因转移到其中的生物体。

5. 发明授权

US07332318B2 Calcium-independent phospholipases A2, genes thereof and promoter of the same 失效
标题翻译：钙依赖性磷脂酶A2，其基因及其启动子
公开(公告)号：US07332318B2
公开(公告)日：2008-02-19
申请号：US10468519
申请日：2001-07-13
申请人： Takao Shimizu , Koji Kishimoto , Yasuyoshi Watanabe
发明人： Takao Shimizu , Koji Kishimoto , Yasuyoshi Watanabe
IPC分类号： C12N9/20 , C12Q1/34 , C07K1/00
CPC分类号： C12N9/20
摘要： Novel calcium-independent phospholipases A2; genes encoding the same; an antibody against them; an inherent promoter or a regulator gene which comprises a base sequence occurring in intron and inducing site-specific expression in response to an external stimulus; a method of expressing a target protein in response to an external stimulus; and an organism having this gene transferred thereinto. Novel calcium-independent phospholipases A2 having an amino acid sequence represented by SEQ ID NO: 1, 3 or 5 or an amino acid sequence derived from such an amino acid sequence by the substitution, deletion or addition of one or more amino acids; a gene having a base sequence occurring in an intron and being capable of initiating RNA transcription due to an external stimulus such as a stimulus with kainic acid or an electrical stimulus; a method of regulating expression by using the gene; and an organism having the gene transferred thereinto.
摘要翻译：新的不依赖钙的磷脂酶A 2 < 编码基因的基因; 抗体; 固有的启动子或调节基因，其包含在内含子中出现的碱基序列并响应于外部刺激诱导位点特异性表达; 响应于外部刺激而表达靶蛋白的方法; 和转移有该基因的生物体。具有由SEQ ID NO：1,3或5表示的氨基酸序列的新型不依赖钙依赖性磷脂酶A 2或通过取代，缺失或添加衍生自该氨基酸序列的氨基酸序列一个或多个氨基酸; 具有在内含子中存在的碱基序列并且能够由于诸如用红藻氨酸或电刺激的刺激的外部刺激引发RNA转录的基因; 通过使用该基因调节表达的方法; 以及将基因转移到其中的生物体。

6. 发明申请

US20060268934A1 Multicast control technique using MPLS 失效
标题翻译：使用MPLS的组播控制技术
公开(公告)号：US20060268934A1
公开(公告)日：2006-11-30
申请号：US11289501
申请日：2005-11-30
申请人： Takao Shimizu , Yuichi Hotta , Yoko Torii , Seiji Matsuoka , Yuichi Fujita , Masanobu Shimakura , Maki Harada
发明人： Takao Shimizu , Yuichi Hotta , Yoko Torii , Seiji Matsuoka , Yuichi Fujita , Masanobu Shimakura , Maki Harada
IPC分类号： H04L12/56
CPC分类号： H04L45/00 , H04L12/185 , H04L41/0896 , H04L43/0882 , H04L45/16 , H04L45/50
摘要： In this invention, an idea of the reverse direction label switched path (RLP) in Multi-Protocol Label Switching (MPLS) is applied to the multicast transmission to improve the management transmission in the multicast transmission, and to easily carry out an additional connection and disconnection. Specifically, in the reverse direction symmetric routing Label switched Path (LP), a virtual label in addition to an input label and an output label is used for the reverse direction routing. However, in this invention, instead of the virtual label, a multicast address to which a client terminal, which is connected to a head of the path on the reverse direction routing, and corresponds to a leaf in the multicast tree, is connected, is registered, as a multicast index, in routers on the path. Then, when receiving a multicast packet including a label and a multicast address, an output label corresponding to the received label is identified, thereby a destination link is identified.
摘要翻译：在本发明中，将多协议标签交换（MPLS）中的反向标签交换路径（RLP）的思想应用于组播传输，以改善组播传输中的管理传输，并且容易地执行附加连接和断开。具体地说，在反方向对称路由标签交换路径（LP）中，除了输入标签之外的虚拟标签和输出标签用于反向路由。然而，在本发明中，代替虚拟标签，连接到反向路由上的路径的头部并且对应于多播树中的叶的客户端的连接的多播地址是在路由器上注册，作为组播索引。然后，当接收到包括标签和多播地址的多播分组时，识别与接收到的标签相对应的输出标签，从而识别目的地链路。

7. 发明授权

US07014672B2 Carrying vehicle, manufacturing apparatus, and carrying system 失效
标题翻译：携带车辆，制造设备和搬运系统
公开(公告)号：US07014672B2
公开(公告)日：2006-03-21
申请号：US10462732
申请日：2003-06-17
申请人： Hiroyuki Ishihara , Takao Shimizu , Takashi Nakao , Ryosuke Tahara , Hidetoshi Takeuchi
发明人： Hiroyuki Ishihara , Takao Shimizu , Takashi Nakao , Ryosuke Tahara , Hidetoshi Takeuchi
IPC分类号： B01D46/10 , B65B1/04
CPC分类号： H01L21/67724 , B01D50/00 , H01L21/67017 , H01L21/67736 , Y10S55/18 , Y10S55/29 , Y10S55/46
摘要： According to the present invention, in a carrying system comprising a carrying vehicle and a manufacturing apparatus the interior of which is kept cleaner than a surrounding environment, manufactured articles to be transferred are prevented from being contaminated by foreign matter or the like attached to transfer ports. A carrying vehicle includes a running unit 14 that runs along a predetermined carrying path, a cleaning unit 12 that supplies cleaned air, a housing section 13 to which the cleaned air is supplied and in which manufactured articles are housed, a transfer port 11 which is formed in a side of a housing and through which a manufactured article is loaded into or unloaded from the housing section 13, and an air injecting section 19A that blows out air toward the transfer port 11.
摘要翻译：根据本发明，在包括运载车辆和制造装置的承载系统中，其内部保持比周围环境更清洁，防止被转移的制品被附着到输送口的异物等被污染。运送车辆包括沿着预定运送路径延伸的运行单元14，提供净化空气的清洁单元12，供应清洁空气的容纳部分13，容纳有制成品的传送口11，形成在壳体的一侧，并且制造品从壳体部分13装载或卸载;以及空气喷射部分19A，其向输送口11吹出空气。

8. 发明授权

US06784874B1 Push-button switch member, portable information terminal having push-button switch member and payment system using portable information terminal 失效
标题翻译：按钮开关构件，具有按钮开关构件的便携式信息终端和使用便携式信息终端的支付系统
公开(公告)号：US06784874B1
公开(公告)日：2004-08-31
申请号：US09661558
申请日：2000-09-14
申请人： Takao Shimizu
发明人： Takao Shimizu
IPC分类号： G09G500
CPC分类号： H04M1/72533 , G06Q20/00 , G06Q20/20 , G06Q20/32 , G06Q20/327 , G06Q20/3415 , G07F7/1008 , H01H13/702 , H01H2205/026 , H01H2219/012 , H01H2219/02 , H01H2219/024 , H01H2221/07 , H01H2231/006 , H01H2300/03 , H04M1/23 , H04M1/27455 , H04M1/72519 , H04M2250/02 , Y02B90/224 , Y04S20/14
摘要： A push-button switch member comprises a touch panel having at least one push-button switch, an electronic display disposed in operative association with the push-button switch, and at least one key top portion disposed in operative association with the push-button switch. The key top portion is provided with a functional display of the push-button switch. A portable information terminal is provided with such push-button switch member and a communicator operatively connected to the push-button switch member for communicating with other equipment having a communication function through endless interactive communication. When the portable information terminal approaches the other equipment having the function communicating with the portable information terminal, functional display information stored in the other equipment is inputted into the portable information terminal through the interactive communication.
摘要翻译：按钮开关构件包括具有至少一个按钮开关的触摸面板，与按钮开关可操作地相关联地设置的电子显示器，以及设置成与按钮开关操作关联的至少一个键顶部。键顶部设置有按钮开关的功能显示。便携式信息终端设置有这样的按钮开关构件和可操作地连接到按钮开关构件的通信器，用于通过无休止的交互式通信与具有通信功能的其他设备通信。当便携式信息终端接近具有与便携式信息终端通信的功能的其他设备时，存储在其他设备中的功能显示信息通过交互式通信被输入到便携式信息终端。

9. 发明授权

US06405761B1 Expandable metal-pipe bonded body and manufacturing method thereof 失效
标题翻译：可膨胀金属管接合体及其制造方法
公开(公告)号：US06405761B1
公开(公告)日：2002-06-18
申请号：US09414534
申请日：1999-10-08
申请人： Takao Shimizu , Hirotsugu Horio , Kazushige Kito , Shigeyuki Inagaki
发明人： Takao Shimizu , Hirotsugu Horio , Kazushige Kito , Shigeyuki Inagaki
IPC分类号： F16L1100
CPC分类号： B23K20/00 , Y10S138/11
摘要： The present invention provides a metal pipe bonded body formed from a plurality of metal pipes. Each metal-pipe is formed with an elongated, pre-formed portion at each end, and a central portion, each elongated, preformed portion having a constant inside diameter greater than an inside diameter of the central portion of each metal pipe.
摘要翻译：本发明提供一种由多个金属管形成的金属管接合体。每个金属管在每个端部处形成有细长的预成形部分，以及中心部分，每个细长的预成形部分具有大于每个金属管的中心部分的内径的恒定的内径。

10. 发明授权

US06262403B1 Apparatus for aligning ends of diffusion bonded materials 失效
标题翻译：用于对准扩散接合材料的端部的装置
公开(公告)号：US06262403B1
公开(公告)日：2001-07-17
申请号：US09382122
申请日：1999-08-24
申请人： Masaki Tsuchiya , Takao Shimizu , Hiroaki Suzuki
发明人： Masaki Tsuchiya , Takao Shimizu , Hiroaki Suzuki
IPC分类号： B23K1301
CPC分类号： C21D1/10 , B23K20/00 , B23K20/02 , B23K20/023 , B23K20/028 , B23K20/26 , B23K35/001 , B23K2101/10 , C21D1/74 , Y02P10/253
摘要： A diffusion bonding method having a step of adjusting ends of material to be bonded before bonding the material after setting the materials in the diffusion bonding apparatus, whereas a diffusion bonding apparatus having a means of finishing ends of materials to be bonded so that both ends face parallel to each other.
摘要翻译：一种扩散接合方法，具有在将扩散接合装置中的材料固化之后，在将材料接合之前调整待接合材料的端部的步骤，而扩散接合装置具有将要结合的材料的端部加工成两端面彼此平行。

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