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1. 发明授权

US5824822A Phospphine-phosinite compound and process for preparing 4-�(R)-1'-formylethyl!-azetidin-2-one derivatives using the same 失效
标题翻译：磷酸 - 磷酸盐化合物和使用其制备4 - [（R）-1'-甲酰乙基] - 氮杂环丁-2-酮衍生物的方法
公开(公告)号：US5824822A
公开(公告)日：1998-10-20
申请号：US677226
申请日：1996-07-09
申请人： Takao Saito , Akifumi Yoshida , Kazuhiko Matsumura , Takashi Miura , Hidenori Kumobayashi
发明人： Takao Saito , Akifumi Yoshida , Kazuhiko Matsumura , Takashi Miura , Hidenori Kumobayashi
IPC分类号： C07D205/08 , C07F9/09 , C07F9/50 , C07F9/655 , C07F9/02 , C07D205/00
CPC分类号： C07F9/65517 , C07D205/08 , C07F9/5022 , Y02P20/55
摘要： A phosphine-phosphinite compound represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent a substituted or unsubstituted phenyl group or a substituted or unsubstituted naphthyl group, and a process for preparing a 4-�(R)-1'-formylethyl!azetidin-2-one derivative using the compound (I). The compound (I), either in combination, or as a complex, with a transition metal compound, is useful as a catalyst for asymmetric hydroformylation and makes it possible to easily synthesize an important intermediate for carbapenem antibiotics or a precursor thereof at high regioselectivity and diastereo-selectivity.
摘要翻译：由式（I）表示的膦 - 磷化合物：其中R 1和R 2可以相同或不同，各自表示取代或未取代的苯基或取代或未取代的萘基，用于使用化合物（I）制备4 - [（R）-1'-甲酰乙基]氮杂环丁-2-酮衍生物。与过渡金属化合物组合或作为络合物的化合物（I）可用作不对称加氢甲酰化的催化剂，并且可以容易地以高区域选择性合成碳青霉烯类抗生素或其前体的重要中间体，非对映选择性。

2. 发明授权

US5859249A 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative by asymmetrically hydrogenating the same 失效
标题翻译： 2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物，其制备方法，以及通过不对称氢化其制备光学活性2-苯基-2-（2'-哌啶基）乙酸酯衍生物的方法
公开(公告)号：US5859249A
公开(公告)日：1999-01-12
申请号：US895428
申请日：1997-07-16
申请人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
发明人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
IPC分类号： C07C229/34 , C07C271/22 , C07D211/70 , C07D211/02 , C07D211/32
CPC分类号： C07C229/34 , C07C271/22 , C07D211/70
摘要： Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative which is a major intermediate for an antidepressant. The 2-phenyl-2-(2'-piperidinylidene)acetate derivative is manufactured by cyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoate derivative. The optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative is manufactured by asymmetrically hydrogenating the 2-phenyl-2-(2'-piperidinylidene)acetate derivative in the presence of a complex of a Group VIII transition metal or an acid.
摘要翻译：公开了适用于2-苯基-2-（2'-哌啶基）乙酸酯衍生物的原料的2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物及其制造方法。还公开了作为抗抑郁药的主要中间体的光学活性2-苯基-2-（2'-哌啶基）乙酸酯衍生物的制造方法。通过使7-（N-取代的氨基）-3-氧代-2-庚酸酯衍生物环化制备2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物。光学活性的2-苯基-2-（2'-哌啶基）乙酸酯衍生物是通过在第VIII族过渡金属络合物存在下不对称氢化2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物制备的，酸。

3. 发明授权

US5801271A 7-(n-substituted amino)-2-phenylheptanoic acid derivative and process for manufacturing the same 失效
标题翻译： 7-（正取代氨基）-2-苯基庚酸衍生物及其制造方法
公开(公告)号：US5801271A
公开(公告)日：1998-09-01
申请号：US895429
申请日：1997-07-16
申请人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
发明人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
IPC分类号： B01J31/02 , B01J31/22 , C07B61/00 , C07C229/34 , C07C269/06 , C07C271/18 , C07C271/22 , C07C303/28 , C07C309/73 , C07C271/06
CPC分类号： C07C271/22 , C07C229/34 , Y02P20/55
摘要： Disclosed is a 7-(N-substituted amino)-3-oxo-2-phenylheptanoate derivative, 7-(N-substituted amino)-3-hydroxy-2-phenylheptanoate derivative, and 7-(N-substituted amino)-3-benzenesulfonyloxy-2-phenylheptanoate derivative, which are quite important major intermediates for an antidepressant. The 7-(N-substituted amino)-3-oxo-2-phenylheptanoate derivative can be manufactured by condensing an enolate of phenylacetates with a 5-(N-substituted amino) pentanoate derivative.
摘要翻译：公开了7-（N-取代氨基）-3-氧代-2-苯基庚酸酯衍生物，7-（N-取代氨基）-3-羟基-2-苯基庚酸酯衍生物和7-（N-取代氨基）-3 - 苯磺酰氧基-2-苯基庚酸酯衍生物，它们是抗抑郁药的重要主要中间体。 7-（N-取代氨基）-3-氧代-2-苯基庚酸酯衍生物可以通过将苯乙酸酯的烯醇化物与5-（N-取代的氨基）戊酸酯衍生物缩合来制备。

4. 发明授权

US5371214A 4-(1,1-dialkoxycarbonylalkyl)azetidin-2-one derivative and process for producing 4-(1-carboxyalkyl)azetidin-2-one derivative using the same 失效
标题翻译： 4-（1,1-二烷氧基羰基烷基）吖丁啶-2-酮衍生物和使用其制备4-（1-羧基烷基）吖丁啶-2-酮衍生物的方法
公开(公告)号：US5371214A
公开(公告)日：1994-12-06
申请号：US987779
申请日：1992-12-09
申请人： Takashi Miura , Toshiyuki Murayama , Akifumi Yoshida , Toyohiko Kobayashi
发明人： Takashi Miura , Toshiyuki Murayama , Akifumi Yoshida , Toyohiko Kobayashi
IPC分类号： C07D205/08
CPC分类号： C07D205/08 , Y02P20/55
摘要： A 4-(1,1-dialkoxycarbonylalkyl )azetidin-2-one derivative represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are identical or different and each represents an alkyl group, an alkenyl group, or an aralkyl group, R.sup.3 represents a lower alkyl group, R.sup.4 represents a hydrogen atom or a hydroxyl-protective group, and R.sup.5 represents a hydrogen atom or an amino-protective group, and a process for producing a 4-(1-carboxyalkyl)azetidin-2-one derivative represented by formula (II) useful as an intermediate for 1.beta.-alkylcarbapenem-type antibacterials: ##STR2## wherein R.sup.3 represents a lower alkyl group and R.sup.4 represents a hydrogen atom or a hydroxyl-protective group, which comprises de-esterifying and decarboxylating the derivative represented by formula (I), and in the case where an amino-protective group is present in the derivative of formula (I), eliminating the protective group from the derivative, are disclosed.
摘要翻译：由式（I）表示的4-（1,1-二烷氧基羰基烷基）氮杂环丁-2-酮衍生物：其中R 1和R 2相同或不同，各自表示烷基，烯基或芳烷基，R3表示低级烷基，R4表示氢原子或羟基保护基，R5表示氢原子或氨基保护基，以及制备4-（1-羧基烷基）氮杂环丁烷基的方法，可用作1β-烷基碳青霉烯型抗菌剂的中间体的式（II）表示的2-酮衍生物：其中R3表示低级烷基，R4表示氢原子或羟基保护基，其中包括使由式（I）表示的衍生物脱酯化和脱羧，并且在式（I）的衍生物中存在氨基保护基的情况下，从衍生物中除去保护基。

5. 发明授权

US5574152A 4-(1,1-dialkoxycarbonylalkyl) azetidin-2-one derivative and process for producing 4-(1-carboxyalkyl) azetidin-2-one derivative using the same 失效
标题翻译： 4-（1,1-二烷氧基羰基烷基）吖丁啶-2-酮衍生物和使用其制备4-（1-羧基烷基）氮杂环丁-2-酮衍生物的方法
公开(公告)号：US5574152A
公开(公告)日：1996-11-12
申请号：US277319
申请日：1994-07-25
申请人： Takashi Miura , Toshiyuki Murayama , Akifumi Yoshida , Toyohiko Kobayashi
发明人： Takashi Miura , Toshiyuki Murayama , Akifumi Yoshida , Toyohiko Kobayashi
IPC分类号： C07D205/08 , C07D705/08 , C07B37/06
CPC分类号： C07D205/08 , Y02P20/55
摘要： A process for preferentially producing a 4-(1-carboxyalkyl) azetidin-2-one derivative represented by formula (II.beta.): ##STR1## wherein R.sup.3 represents a lower alkyl group and R.sup.4 represents a hydrogen atom or a hydroxy-protective group, which involves deesterifying and decarboxylating a 4-(1,1-dialkoxycarbonylalkyl) azetidin-2-one derivative represented by formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are identical or different and each represents an alkyl group, an alkenyl group, or an aralkyl group, R.sup.3 and R.sup.4 each has the meaning as defined above, and R.sup.5 represents an amino-protective group, and after that, eliminating the amino-protective group from the derivative, where the 4-(1-carboxyalkyl)azetidin-2-one derivative of formula (II.beta.) is present in an amount of at least 61% by mol of all 4-(1-carboxyalkyl)azetidin-2-one derivatives produced.
摘要翻译：优选制备由式（IIβ）表示的4-（1-羧基烷基）氮杂环丁-2-酮衍生物的方法：其中R 3表示低级烷基，R 4表示氢原子或羟基保护基，其包括使由式（I）表示的4-（1,1-二烷氧基羰基烷基）氮杂环丁-2-酮衍生物脱酯和脱羧基：其中R 1和R 2相同或不同，并且各自表示烷基，烯基或芳烷基，R 3和R 4各自具有如上所定义的含义，R 5表示氨基保护基，之后，从衍生物中除去氨基保护基，式（IIβ）的（1-羧基烷基）氮杂环丁-2-酮衍生物的存在量为所产生的所有4-（1-羧基烷基）氮杂环丁烷-2-酮衍生物的至少61摩尔％。

6. 发明授权

US06340751B1 Process for the preparation of 4-substituted azetidinone derivatives 失效
标题翻译：制备4-取代的氮杂环丁酮衍生物的方法
公开(公告)号：US06340751B1
公开(公告)日：2002-01-22
申请号：US09357153
申请日：1999-07-19
申请人： Takao Saito , Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
发明人： Takao Saito , Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
IPC分类号： C07F718
CPC分类号： C07D413/06 , C07D205/08 , Y02P20/55
摘要： Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): and (IV): represented by the following formula (III): MgR5R6 (III) wherein R5 represents a C1-12 alkyl group, a C2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C1-4 alkyl group, a phenyl group which may be substituted by a lower C1-4 alkyl group, a lower C1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C1-4 alkyl group, a lower C1-4 alkoxy group or a halogen atom, and R6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR7 group (R7 representing a lower C1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-&bgr;′ configuration.
摘要翻译：公开了制备4-取代的氮杂环丁酮衍生物的方法，该方法包括在镁化合物如下式（II）和（IV）所示的那些镁化合物存在下使氮杂环丁酮衍生物与酰胺化合物反应：代表通过下式（III）表示：其中R5表示C1-12烷基，C2-5烯基，可被低级C1-4烷基取代的5至8元脂环基，苯基可以被低级C 1-4烷基，低级C 1-4烷氧基或卤素原子取代的苯基，或可以被低级C 1-4烷基取代的苄基，低级C 1-4烷氧基或卤原子，R6表示卤原子，甲磺酰氧基，苯磺酰氧基，对甲苯磺酰氧基，三氟甲磺酰氧基，可被卤素原子或氰基取代的乙酰氧基或OR7基（R7表示低级C 1-4烷基，取代的o R未取代的苯基或取代或未取代的苄基）。该方法提供了制备4-取代的氮杂环丁酮衍生物的工业上优异的方法，其允许选择性制备用于合成具有所需1-β'构型的碳青霉烯类抗菌剂的中间体。

7. 发明授权

US06169179A Method for manufacturing (3S,4R)-4-[(R)-1′-formylethyl]azetidin-2-one derivatives 失效
标题翻译：制备（3S，4R）-4 - [（R）-1'-甲酰乙基]氮杂环丁-2-酮衍生物的方法
公开(公告)号：US06169179A
公开(公告)日：2001-01-02
申请号：US09329335
申请日：1999-06-10
申请人： Howard Alper , Takao Saito , Takashi Miura
发明人： Howard Alper , Takao Saito , Takashi Miura
IPC分类号： C07D20500
CPC分类号： C07D205/08 , Y02P20/55
摘要： A method for manufacturing (3S,4R)-4-[(R)-1′-formylethyl]azetidin-2-one derivatives represented by formula (3) wherein R1 represents a hydrogen atom or a protective group, through asymmetric hydroformylation of 4-vinylazetidin-2-one represented by formula (1) wherein R1 has the same meaning as described above; in the presence of a rhodium complex and a (2S,4S)-diphosphine compound represented by formula (2) wherein R2 represents a phenyl group which may be substituted with 1-5 substituent(s) selected from a lower alkyl group, a lower alkoxy group, and a halogen atom. By use of both an inexpensive optically active diphosphine compound and a rhodium complex as catalysts, intermediate compounds important for carbapenem antibiotics can be manufactured with high selectivity and efficiency.
摘要翻译：制备由式（3）表示的（3S，4R）-4 - [（R）-1'-甲基乙基]氮杂环丁烷-2-酮衍生物的方法，其中R 1表示氢原子或保护基，通过不对称加氢甲酰化4 （1）表示的1-乙烯基氮杂环丁烷-2-酮，其中R1具有与上述相同的含义; 在铑络合物和由式（2）表示的（2S，4S） - 二膦化合物的存在下，其中R 2表示可被1-5个选自以下的取代基取代的苯基：低级烷基，低级烷氧基和卤素原子。通过使用廉价的光学活性二膦化合物和铑配合物作为催化剂，可以以高选择性和高效率制造对碳青霉烯类抗生素重要的中间体化合物。

8. 发明授权

US08312162B2 Information processing apparatus and information processing method 失效
标题翻译：信息处理装置和信息处理方法
公开(公告)号：US08312162B2
公开(公告)日：2012-11-13
申请号：US12869153
申请日：2010-08-26
申请人： Tsuyoshi Honma , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
发明人： Tsuyoshi Honma , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
IPC分类号： G06F15/16
CPC分类号： H04L29/08729 , H04L67/2819 , H04N21/42661 , H04N21/44004 , H04N21/44209 , H04N21/458 , H04N21/8456
摘要： There is provided an information processing apparatus including a communication unit which communicates with a distribution server that contains content data for streaming delivery, a buffer unit which temporarily stores stream data obtained from the distribution server, a storage unit which stores an inserting content, a reproduction unit which reproduces the content inserted by the storage unit, and a control unit which measures a bandwidth of the network, determines whether it is possible to reproduce until the end of a next chapter defined by a chapter point set in the content based on a buffer volume of the buffer unit and the bandwidth, and when determined it is impossible, switches the content to be produced by the reproduction unit to the inserting content.
摘要翻译：提供了一种信息处理设备，包括：通信单元，其与包含用于流传送的内容数据的分发服务器进行通信;临时存储从分发服务器获得的流数据的缓冲单元，存储插入内容的存储单元，再现由存储单元插入的内容的单元和测量网络带宽的控制单元，确定是否可以再现直到由基于缓冲器的内容中设置的章节点定义的下一章节的结尾缓冲单元的体积和带宽，并且当确定不可能时，将由再现单元产生的内容切换到插入内容。

9. 发明授权

US08007174B2 Bag-like container with spout 有权
标题翻译：袋状容器带喷口
公开(公告)号：US08007174B2
公开(公告)日：2011-08-30
申请号：US11793519
申请日：2005-06-06
申请人： Madoka Yamaguchi , Masahiro Akioka , Mutsushi Hirano , Kenji Yoshihiro , Takashi Miura
发明人： Madoka Yamaguchi , Masahiro Akioka , Mutsushi Hirano , Kenji Yoshihiro , Takashi Miura
IPC分类号： B65D33/10 , B65D33/00 , B65D33/16 , B65D30/16
CPC分类号： A61J1/2093 , A61J1/10 , B65D33/2525 , B65D33/2533 , B65D75/008 , B65D75/566 , B65D75/5805 , B65D75/5883 , B65D2575/565 , Y10S383/906
摘要： A bag-like container with a spout in which a plastic linear fastener is interposed in an upper part of the container so that when water content or the like is to be supplied after contents of a liquid food container or the like have been administered to a subject, opening and closing the linear fastener enables the water content or the like to be supplied in an uncomplicated manner without the use of a separate member such as a spout that is an open part for pouring food, water, or the like into the container.
摘要翻译：具有喷口的袋状容器，其中塑料线性紧固件插入容器的上部，使得当向液体食品容器等的内容物施用水分或类似物之后，主体，打开和关闭线性紧固件使得能够以不复杂的方式供应含水量，而不需要使用诸如作为将食品，水等倾入容器的开放部分的喷嘴的单独构件。

10. 发明申请

US20110078324A1 INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESSING METHOD 失效
标题翻译：信息处理设备和信息处理方法
公开(公告)号：US20110078324A1
公开(公告)日：2011-03-31
申请号：US12869153
申请日：2010-08-26
申请人： Tsuyoshi HONMA , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
发明人： Tsuyoshi HONMA , Akihiko Kinoshita , Hiroyuki Chiba , Takashi Miura
IPC分类号： G06F15/16
CPC分类号： H04L29/08729 , H04L67/2819 , H04N21/42661 , H04N21/44004 , H04N21/44209 , H04N21/458 , H04N21/8456
摘要： There is provided an information processing apparatus including a communication unit which communicates with a distribution server that contains content data for streaming delivery, a buffer unit which temporarily stores stream data obtained from the distribution server, a storage unit which stores an inserting content, a reproduction unit which reproduces the content inserted by the storage unit, and a control unit which measures a bandwidth of the network, determines whether it is possible to reproduce until the end of a next chapter defined by a chapter point set in the content based on a buffer volume of the buffer unit and the bandwidth, and when determined it is impossible, switches the content to be produced by the reproduction unit to the inserting content.
摘要翻译：提供了一种信息处理设备，包括：通信单元，其与包含用于流传送的内容数据的分发服务器进行通信;临时存储从分发服务器获得的流数据的缓冲单元，存储插入内容的存储单元，再现由存储单元插入的内容的单元和测量网络带宽的控制单元，确定是否可以再现直到由基于缓冲器的内容中设置的章节点定义的下一章节的结尾缓冲单元的体积和带宽，并且当确定不可能时，将由再现单元产生的内容切换到插入内容。

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