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1. 发明申请

US20080009053A1 Modified Ethylenediamine-N, N'-Disuccinate: Ethylnediamine Lyase 有权
标题翻译：改性乙二胺-N，N'-琥珀酸盐：乙二胺裂解酶
公开(公告)号：US20080009053A1
公开(公告)日：2008-01-10
申请号：US11569339
申请日：2004-05-20
申请人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
发明人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
IPC分类号： C12N9/88 , C07H21/00 , C07K1/00 , C12N1/20
CPC分类号： C12N9/88 , C12P13/04
摘要： The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of one or more amino acid residues, and has an ethylenediamine-N,N′-disuccinate:ethylenediamine lyase activity.
摘要翻译：本发明提供了改性的乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶。本发明还提供了包含SEQ ID NO：1所示的氨基酸序列的蛋白质; 或包含通过缺失，取代或添加一个或多个氨基酸残基而衍生自SEQ ID NO：1所示氨基酸序列的氨基酸序列的蛋白质，并且具有乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶活性。

2. 发明授权

US08728792B2 Modified ethylenediamine-N, N′-disuccinate: ethylenediamine lyase 有权
标题翻译：改性乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶
公开(公告)号：US08728792B2
公开(公告)日：2014-05-20
申请号：US12691443
申请日：2010-01-21
申请人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
发明人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
IPC分类号： C12N9/88 , C12P13/00 , C07H21/04
CPC分类号： C12N9/88 , C12P13/04
摘要： The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of one or more amino acid residues, and has an ethylenediamine-N,N′-disuccinate:ethylenediamine lyase activity.
摘要翻译：本发明提供了改性的乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶。本发明还提供了包含SEQ ID NO：1所示的氨基酸序列的蛋白质; 或包含通过缺失，取代或添加一个或多个氨基酸残基而衍生自SEQ ID NO：1所示氨基酸序列的氨基酸序列的蛋白质，并且具有乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶活性。

3. 发明授权

US07674611B2 Modified ethylenediamine-N, N′-disuccinate: ethylenediamine lyase 有权
标题翻译：改性乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶
公开(公告)号：US07674611B2
公开(公告)日：2010-03-09
申请号：US11569339
申请日：2004-05-20
申请人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
发明人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
IPC分类号： C12N9/88 , C12P13/00 , C07H21/04
CPC分类号： C12N9/88 , C12P13/04
摘要： The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of one or more amino acid residues, and has an ethylenediamine-N,N′-disuccinate:ethylenediamine lyase activity.
摘要翻译：本发明提供了改性的乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶。本发明还提供了包含SEQ ID NO：1所示的氨基酸序列的蛋白质; 或包含通过缺失，取代或添加一个或多个氨基酸残基而衍生自SEQ ID NO：1所示氨基酸序列的氨基酸序列的蛋白质，并且具有乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶活性。

4. 发明授权

US08895285B2 Modified ethylenediamine-N, N′-disuccinate: ethylenediamine lyase 有权
公开(公告)号：US08895285B2
公开(公告)日：2014-11-25
申请号：US13547973
申请日：2012-07-12
申请人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
发明人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
IPC分类号： C12N9/88 , C12N1/00 , C12N15/00 , C12P13/00 , C07H21/04
CPC分类号： C12N9/88 , C12P13/04
摘要： The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of one or more amino acid residues, and has an ethylenediamine-N,N′-disuccinate:ethylenediamine lyase activity.

5. 发明申请

US20100151537A1 MODIFIED ETHYLENEDIAMINE-N, N'-DISUCCINATE: ETHYLENEDIAMINE LYASE 有权
标题翻译：改性乙烯基胺-N，N-二异氰酸酯：乙烯二胺
公开(公告)号：US20100151537A1
公开(公告)日：2010-06-17
申请号：US12691443
申请日：2010-01-21
申请人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
发明人： Takanori Akiyama , Wataru Mizunashi , Tetsuji Nakamura
IPC分类号： C12P13/00 , C12N15/60 , C12N15/63 , C12N1/00 , C12N9/88
CPC分类号： C12N9/88 , C12P13/04
摘要： The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of one or more amino acid residues, and has an ethylenediamine-N,N′-disuccinate:ethylenediamine lyase activity.
摘要翻译：本发明提供了改性的乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶。本发明还提供了包含SEQ ID NO：1所示的氨基酸序列的蛋白质; 或包含通过缺失，取代或添加一个或多个氨基酸残基而衍生自SEQ ID NO：1所示氨基酸序列的氨基酸序列的蛋白质，并且具有乙二胺-N，N'-二琥珀酸盐：乙二胺裂解酶活性。

6. 发明申请

US20090215132A1 Novel amide hydrolase gene 失效
标题翻译：新型酰胺水解酶基因
公开(公告)号：US20090215132A1
公开(公告)日：2009-08-27
申请号：US10487240
申请日：2002-08-28
申请人： Osamu Katoh , Takanori Akiyama , Tetsuji Nakamura
发明人： Osamu Katoh , Takanori Akiyama , Tetsuji Nakamura
IPC分类号： C12P13/08 , C07H21/04 , C12N1/20 , C12N9/10 , C12N15/74
CPC分类号： C12P41/006 , C12N9/80 , C12P13/04
摘要： The present invention relates to an amide hydrolase which is with excellent thermostability and stereoselectively hydrolyzes an α-amino acid amide; a gene encoding the enzyme protein; a novel recombinant vector containing the gene; a transformant containing the recombinant vector; and a process for producing an L-α-amino acid using the transformant.
摘要翻译：本发明涉及具有优异的热稳定性和立体选择性水解α-氨基酸酰胺的酰胺水解酶; 编码酶蛋白的基因; 含有该基因的新型重组载体; 含有重组载体的转化体; 以及使用该转化体生产L-α-氨基酸的方法。

7. 发明授权

US07977073B2 Polynucleotide encoding a thermostable amide hydrolase and methods for producing an L-α-amino acid 失效
标题翻译：编码热稳定性酰胺水解酶的多核苷酸和产生L-α-氨基酸的方法
公开(公告)号：US07977073B2
公开(公告)日：2011-07-12
申请号：US10487240
申请日：2002-08-28
申请人： Osamu Katoh , Takanori Akiyama , Tetsuji Nakamura
发明人： Osamu Katoh , Takanori Akiyama , Tetsuji Nakamura
IPC分类号： C12P13/04 , C12P21/06 , C12N15/00 , C12N1/20 , C07H21/04
CPC分类号： C12P41/006 , C12N9/80 , C12P13/04
摘要： The present invention relates to an amide hydrolase which is with excellent thermostability and stereoselectively hydrolyzes an α-amino acid amide; a gene encoding the enzyme protein; a novel recombinant vector containing the gene; a transformant containing the recombinant vector; and a process for producing an L-α-amino acid using the transformant.
摘要翻译：本发明涉及具有优异的热稳定性和立体选择性水解α-氨基酸酰胺的酰胺水解酶; 编码酶蛋白的基因; 含有该基因的新型重组载体; 含有重组载体的转化体; 以及使用该转化体生产L-α-氨基酸的方法。

8. 发明授权

US07803578B2 Heat-resistant nitrile hydratase 有权
标题翻译：耐热腈水合酶
公开(公告)号：US07803578B2
公开(公告)日：2010-09-28
申请号：US11947955
申请日：2007-11-30
申请人： Fumiaki Watanabe , Dai Ujihara , Miki Sakai , Fujio Yu , Tetsuji Nakamura
发明人： Fumiaki Watanabe , Dai Ujihara , Miki Sakai , Fujio Yu , Tetsuji Nakamura
IPC分类号： C12P21/06 , C12N9/00 , C12N9/88 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12P13/02 , C12N9/88
摘要： The present invention provides: a protein having an improved nitrile hydratase activity, whereby heat resistance has been improved when compared with a wild-type nitrile hydratase activity, wherein the amino acid sequence of a nitrile hydratase is modified; a gene DNA encoding the above protein; a recombinant vector having the above gene DNA; a transformant or transductant having the above recombinant vector; a nitrile hydratase collected from a culture of the above transformant or transductant, and a production method thereof; and a method for producing an amide compound.
摘要翻译：本发明提供：腈水合酶活性提高的蛋白质，与野生型腈水合酶活性相比，耐水性得到改善，其中腈水合酶的氨基酸序列被修饰; 编码上述蛋白质的基因DNA; 具有上述基因DNA的重组载体; 具有上述重组载体的转化体或转导体; 从上述转化体或转导体的培养物收集的腈水合酶及其制备方法; 和酰胺化合物的制造方法。

9. 发明申请

US20090162894A1 NITRILE HYDRATASE 有权
公开(公告)号：US20090162894A1
公开(公告)日：2009-06-25
申请号：US11947955
申请日：2007-11-30
申请人： Fumiaki Watanabe , Dai Ujihara , Miki Sakai , Fujio Yu , Tetsuji Nakamura
发明人： Fumiaki Watanabe , Dai Ujihara , Miki Sakai , Fujio Yu , Tetsuji Nakamura
IPC分类号： C07H21/04 , C12N15/63 , C12N1/21 , C12P21/00
CPC分类号： C12P13/02 , C12N9/88
摘要： The present invention provides: a protein having an improved nitrile hydratase activity, whereby heat resistance has been improved when compared with a wild-type nitrile hydratase activity, wherein the amino acid sequence of a nitrile hydratase is modified; a gene DNA encoding the above protein; a recombinant vector having the above gene DNA; a transformant or transductant having the above recombinant vector; a nitrile hydratase collected from a culture of the above transformant or transductant, and a production method thereof; and a method for producing an amide compound.
摘要翻译：本发明提供：腈水合酶活性提高的蛋白质，与野生型腈水合酶活性相比，耐水性得到改善，其中腈水合酶的氨基酸序列被修饰; 编码上述蛋白质的基因DNA; 具有上述基因DNA的重组载体; 具有上述重组载体的转化体或转导体; 从上述转化体或转导体的培养物收集的腈水合酶及其制备方法; 和酰胺化合物的制造方法。

10. 发明授权

US07098889B2 System and method for a self-calibrating input device 有权
标题翻译：自校准输入装置的系统和方法
公开(公告)号：US07098889B2
公开(公告)日：2006-08-29
申请号：US10606701
申请日：2003-06-26
申请人： Takashi Inui , Tetsuji Nakamura
发明人： Takashi Inui , Tetsuji Nakamura
IPC分类号： H03G3/02 , G09G5/00
CPC分类号： G06F3/038
摘要： A device, method, and computer program product for a self-calibrating input device are provided. The input device includes a designated value change unit operable to change a designated value using a variation amount associated with the designated value, the designated value being changed using a predetermined first variation amount when a first designated value change directive is received from an operator, and a variation amount change unit operable to alter the variation amount associated with the designated value from the predetermined first variation amount to a smaller second variation amount when a second designated value change directive that is opposite the first designated value change directive is received from the operator within a predetermined variation amount change period.
摘要翻译：提供了一种用于自校准输入设备的设备，方法和计算机程序产品。所述输入装置包括指定值改变单元，其可操作以使用与所述指定值相关联的变化量来改变指定值，当从操作者接收到第一指定值改变指令时，所述指定值使用预定的第一变化量进行变化;以及变更量变更单元，用于当从所述操作者接收到与所述第一指定值变更指令相反的第二指定值变更指令时，将与所述指定值相关联的所述变更量从所述预定第一变更量变更为较小的第二变更量预定变化量变化期间。

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