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1. 发明申请

US20140243392A1 MicroRNA-Based Methods and Assays for Osteosarcoma 有权
标题翻译：基于微RNA的骨肉瘤的方法和测定
公开(公告)号：US20140243392A1
公开(公告)日：2014-08-28
申请号：US14240178
申请日：2012-09-07
申请人： Takahiro Ochiya , Tomohiro Fujiwara
发明人： Takahiro Ochiya , Tomohiro Fujiwara
IPC分类号： C12N15/113 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/113 , A61B5/055 , A61B5/4504 , A61B6/032 , A61B6/505 , A61B10/025 , C12N2310/113 , C12N2310/141 , C12N2310/3231 , C12N2320/11 , C12N2320/31 , C12Q1/6886 , C12Q2600/178 , G01N33/5011
摘要： Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
摘要翻译：提供了用于诊断，治疗和监测骨肉瘤的方法和组合物。发现与癌症干细胞（CSCs）或肿瘤起始细胞（TIC）相关的某些微小RNA（miRNA）对于骨肉瘤的反义有助于抑制肿瘤生长和转移，延长存活期。 miR-133a的反义寡核苷酸与标准化疗如顺铂联合用于治疗骨肉瘤。

2. 发明授权

US09322016B2 MicroRNA-based methods and assays for osteosarcoma 有权
标题翻译：用于骨肉瘤的基于微RNA的方法和测定
公开(公告)号：US09322016B2
公开(公告)日：2016-04-26
申请号：US14240178
申请日：2012-09-07
申请人： Takahiro Ochiya , Tomohiro Fujiwara
发明人： Takahiro Ochiya , Tomohiro Fujiwara
IPC分类号： A61K48/00 , C12N15/113 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/113 , A61B5/055 , A61B5/4504 , A61B6/032 , A61B6/505 , A61B10/025 , C12N2310/113 , C12N2310/141 , C12N2310/3231 , C12N2320/11 , C12N2320/31 , C12Q1/6886 , C12Q2600/178 , G01N33/5011
摘要： Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
摘要翻译：提供了用于诊断，治疗和监测骨肉瘤的方法和组合物。发现与癌症干细胞（CSCs）或肿瘤起始细胞（TIC）相关的某些微小RNA（miRNA）对于骨肉瘤的反义有助于抑制肿瘤生长和转移，延长存活期。 miR-133a的反义寡核苷酸与标准化疗如顺铂联合用于治疗骨肉瘤。

3. 发明申请

US20140341882A1 PHARMACEUTICAL PRODUCT FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于预防或治疗阿尔茨海默病的药物产品
公开(公告)号：US20140341882A1
公开(公告)日：2014-11-20
申请号：US14344420
申请日：2012-09-07
申请人： Takahiro Ochiya
发明人： Takahiro Ochiya
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A61K35/28 , C12Y304/24011
摘要： The present invention provides a therapeutic agent for Alzheimer's disease. The therapeutic agent contains membrane vesicles (exosomes) of adipose tissue-derived mesenchymal stem cells, and the membrane vesicles (exosomes) contain neprilysin. Through the research by the inventors of the present invention, it was revealed that exosomes secreted by human adipose tissue-derived mesenchymal stem cells contain neprilysin, which degrades amyloid-β as a pathogenic protein of Alzheimer's disease. When exosomes secreted by human adipose tissue-derived mesenchymal stem cells were administered to the brains of Alzheimer's disease model mice, the generation of amyloid-β was inhibited.
摘要翻译：本发明提供了阿尔茨海默病的治疗剂。治疗剂含有脂肪组织来源的间充质干细胞的膜囊泡（外来体），膜囊泡（外来体）含有血培养液。通过本发明的发明人的研究，揭示了由人脂肪组织衍生的间充质干细胞分泌的外来体含有上皮蛋白，其降解淀粉样蛋白 - 作为阿尔茨海默氏病的致病蛋白质。当将人脂肪组织来源的间充质干细胞分泌的外来体施用于阿尔茨海默病模型小鼠的脑中时，淀粉样蛋白的生成被抑制。

4. 发明申请

US20130236891A1 METHOD AND COMPOSITION FOR THE TREATMENT, PREVENTION, AND DIAGNOSIS OF CANCER CONTAINING OR DERIVED FROM CANCER STEM CELLS 审中-公开
标题翻译：用于治疗，预防和诊断包含或从癌症干细胞衍生的癌症的方法和组合
公开(公告)号：US20130236891A1
公开(公告)日：2013-09-12
申请号：US13817763
申请日：2011-01-24
申请人： Takahiro Ochiya
发明人： Takahiro Ochiya
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/1137 , A61K31/7105 , C12N2310/14 , C12N2310/3513 , C12N2310/531 , C12N2320/32 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Y204/99018 , G01N33/574 , G01N33/57415 , G01N2333/91097
摘要： The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.
摘要翻译：本发明提供了用于治疗，预防和诊断含有或衍生自癌症干细胞的癌症的方法和组合物。

5. 发明申请

US20120252881A1 THERAPEUTIC AGENT FOR TUMOR 有权
标题翻译：肿瘤治疗剂
公开(公告)号：US20120252881A1
公开(公告)日：2012-10-04
申请号：US13498771
申请日：2010-10-01
申请人： Takahiro Ochiya , Ryou-u Takahashi
发明人： Takahiro Ochiya , Ryou-u Takahashi
IPC分类号： A61K31/7088 , A61P35/00 , A61K31/713
CPC分类号： A61K31/7088 , A61K31/713 , C12N15/113 , C12N2310/141 , C12N2330/10 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： The present invention provides a therapeutic agent for a tumor, particularly a therapeutic agent for drug-resistant cancer, an agent for suppression or prophylaxis of tumor metastasis, and an agent for suppression or prophylaxis of cancer recurrence, containing a nucleic acid containing miR27b or a nucleotide having a nucleotide sequence having an identity of 70% or more with the nucleotide sequence shown by SEQ ID NO: 1 and having a function equivalent to miR27b.
摘要翻译：本发明提供了一种用于肿瘤的治疗剂，特别是耐药性癌症的治疗剂，抑制或预防肿瘤转移的药剂，以及抑制或预防癌症复发的药物，其含有含有miR27b或具有与SEQ ID NO：1所示的核苷酸序列同一性为70％以上且具有与miR27b相当的功能的核苷酸序列的核苷酸。

6. 发明授权

US07736893B2 Nanobio device of imitative anatomy structure 有权
标题翻译：模拟解剖结构的Nanobio装置
公开(公告)号：US07736893B2
公开(公告)日：2010-06-15
申请号：US11353603
申请日：2006-02-14
申请人： Masanao Munekane , Hiroyuki Wada , Kouji Iwasaki , Toshiaki Fujii , Takahiro Ochiya , Yusuke Yamamoto , Takumi Teratani
发明人： Masanao Munekane , Hiroyuki Wada , Kouji Iwasaki , Toshiaki Fujii , Takahiro Ochiya , Yusuke Yamamoto , Takumi Teratani
IPC分类号： C12N5/00
CPC分类号： G01N33/5088 , Y10T436/11
摘要： Objects to be achieved by the invention are to provide a nanobio device in which cultured cells are organized at a high-level in a state near in vivo, and to provide a method of using the nanobio device of imitative anatomy structure. The nanobio device of imitative anatomy structure of the invention is obtained by manufacturing a substrate with a bio-compatible substance and arranging a plurality of types of cells thereon in a desired array. A method of manufacturing a nanobio device in the invention includes a step of manufacturing a substrate for a nanobio device by a micromachine processing technique and a step of arranging a plurality of cultured cells on the substrate in a desired array with laser optical tweezers.
摘要翻译：通过本发明实现的目的是提供一种纳米生物装置，其中培养细胞在体内接近的状态下组织在高水平，并提供使用模拟解剖结构的纳米装置的方法。本发明的模拟解剖结构的纳米装置通过用生物相容性物质制造衬底并以期望的阵列布置多种类型的细胞而获得。在本发明中制造纳米装置的方法包括通过微机械加工技术制造纳米装置用基板的步骤，以及使用激光光学镊子以期望的阵列在基板上排列多个培养细胞的步骤。

7. 发明申请

US20090253780A1 COMPOSITIONS AND METHODS RELATED TO miR-16 AND THERAPY OF PROSTATE CANCER 审中-公开
标题翻译：与miR-16和前列腺癌治疗相关的组合物和方法
公开(公告)号：US20090253780A1
公开(公告)日：2009-10-08
申请号：US12412087
申请日：2009-03-26
申请人： Fumitaka Takeshita , David Brown , Takahiro Ochiya
发明人： Fumitaka Takeshita , David Brown , Takahiro Ochiya
IPC分类号： A61K31/7088 , C12N5/02
CPC分类号： A61K31/7088 , C12N15/113 , C12N2310/141 , C12N2320/32 , C12N2330/10
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-16, using miR-16 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译：本发明涉及用于鉴定miR-16调节的基因或遗传途径的方法和组合物，其使用miR-16调节基因或基因途径，使用该分布在评估患者的状况和/或以适当的方式治疗患者时 miRNA。

8. 发明申请

US20080318319A1 Novel Method of Nucleic Acid Transfer 审中-公开
标题翻译：核酸转移的新方法
公开(公告)号：US20080318319A1
公开(公告)日：2008-12-25
申请号：US10583277
申请日：2004-12-15
申请人： Yoshiko Minakuchi , Takahiro Ochiya
发明人： Yoshiko Minakuchi , Takahiro Ochiya
IPC分类号： C12N15/87 , C01F11/24
CPC分类号： C12N15/1136 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a method of nucleic acid transfer comprising the following steps (a) and (b): (a) contacting a nucleic acid with a cell in a medium; and (b) following the step (a), contacting the medium of (a) with a high-concentration solution of a metal salt, a nucleic acid transfer agent comprising solid metal salt or a high-concentration solution of a metal salt as an ingredient, and the like.
摘要翻译：本发明提供核酸转移方法，其包括以下步骤（a）和（b）：（a）使核酸与培养基中的细胞接触; 和（b）在步骤（a）之后，使（a）的介质与金属盐的高浓度溶液，包含固体金属盐的核酸转移剂或作为金属盐的高浓度溶液接触成分等。

9. 发明授权

US06576811B1 Transgenic rat with human normal type c-Ha-ras gene 失效
标题翻译：具有人正常型c-Ha-ras基因的转基因大鼠
公开(公告)号：US06576811B1
公开(公告)日：2003-06-10
申请号：US09140197
申请日：1998-08-26
申请人： Hiroyuki Tsuda , Makoto Asamoto , Hiroyasu Toriyama , Takahiro Ochiya , Takeo Sekiya
发明人： Hiroyuki Tsuda , Makoto Asamoto , Hiroyasu Toriyama , Takahiro Ochiya , Takeo Sekiya
IPC分类号： G01N3300
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A61K49/0008 , G01N33/5011 , G01N33/5088
摘要： The present invention provides a human c-Ha-ras proto-oncogene transgenic rat and the methods of the screening of many carcinogens and the screenings of promoters of carcinogenesis and preventive and inhibitory agents of tumors, and additionally enables the analysis of the carcinogenesis mechanism of a number of tumors.
摘要翻译：本发明提供了人c-Ha-ras原癌基因转基因大鼠和筛选许多致癌物质的方法以及致癌作用和肿瘤预防和抑制剂启动子的筛选，并且还能够分析癌细胞的致癌机制一些肿瘤。

10. 发明授权

US09309537B2 Chimeric rat produced using rat embryonic stem cells in the presence of an ES cell differentiation suppressant 有权
标题翻译：在ES细胞分化抑制剂存在下使用大鼠胚胎干细胞产生的嵌合大鼠
公开(公告)号：US09309537B2
公开(公告)日：2016-04-12
申请号：US13513100
申请日：2010-11-30
申请人： Takahiro Ochiya , Masaki Kawamata
发明人： Takahiro Ochiya , Masaki Kawamata
IPC分类号： C12N15/00 , C12N15/873 , A01K67/027 , C12N9/22 , C12N15/85 , C12N5/0735
CPC分类号： C12N15/873 , A01K67/0271 , A01K67/0276 , A01K2217/00 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , C07K2319/81 , C12N5/0606 , C12N9/22 , C12N15/85 , C12N15/8509 , C12N2500/30 , C12N2501/065 , C12N2501/15 , C12N2501/998 , C12N2501/999
摘要： The present invention provides a preparation method of a chimeric embryo and a chimeric rat, which is characterized by contacting a rat pluripotent stem cell and a host embryo in the presence of an ES cell differentiation inhibitor. The method includes (a) a step for contacting a fertilized host embryo collected from a female rat and a rat pluripotent stem cell in the presence of an ES cell differentiation suppressant, and (b) a step for culturing the host embryo in contact with the rat pluripotent stem cell to form a chimeric embryo.
摘要翻译：本发明提供嵌合胚胎和嵌合大鼠的制备方法，其特征在于在ES细胞分化抑制剂存在下使大鼠多能干细胞与宿主胚胎接触。该方法包括：（a）在ES细胞分化抑制剂存在下，将从雌性大鼠和大鼠多能干细胞收集的受精宿主胚胎接触的步骤，和（b）与所述宿主胚胎接触的步骤大鼠多能干细胞形成嵌合胚胎。

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