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1. 发明授权

US07267750B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07267750B2
公开(公告)日：2007-09-11
申请号：US10466561
申请日：2002-01-10
申请人： Motokazu Watanabe , Tomohiro Yamamoto , Miwa Hasegawa , Shin Ikeda , Shiro Nankai
发明人： Motokazu Watanabe , Tomohiro Yamamoto , Miwa Hasegawa , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27/327
CPC分类号： C12Q1/005 , C12Q1/004
摘要： A biosensor comprising: an electrically insulating base plate; an electrode system comprising a working electrode and a counter electrode formed on the base plate; a cover member which is joined to the base plate to form a sample solution supply pathway for supplying a sample solution to the electrode system between the cover member and the base plate; and a reagent system comprising at least an oxidoreductase and an electron mediator disposed in the sample solution supply pathway, wherein the electron mediator is provided on the base plate and the oxidoreductase is provided on the cover member such that the electron mediator and the oxidoreductase are not in contact with each other.
摘要翻译：一种生物传感器，包括：电绝缘基板; 电极系统，包括形成在所述基板上的工作电极和对电极; 盖构件，其连接到所述基板，以形成用于将样品溶液供应到所述盖构件和所述基板之间的所述电极系统的样品溶液供给路径; 以及试剂系统，其至少包含设置在样品溶液供给路径中的氧化还原酶和电子介体，其中，所述电子介体设置在所述底板上，所述氧化还原酶设置在所述覆盖部件上，使得所述电子介体和所述氧化还原酶不是彼此接触。

2. 发明授权

US06436255B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06436255B2
公开(公告)日：2002-08-20
申请号：US09764142
申请日：2001-01-19
申请人： Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/005
摘要： The present invention provides a biosensor which enables prompt quantification by facilitating introduction of a sample solution even when the amount of the sample solution is small and improving dissolution of reagents. The biosensor comprises an insulating base plate; an electrode system including at least a measuring electrode and a counter electrode formed on the base plate; a cover member integrated into the base plate to form a sample solution supply pathway for supplying a sample solution to the electrode system between the cover member and the base plate; a reaction reagent system including at least an electron mediator and an oxidoreductase; and a carrier supporting at least the electron mediator or the oxidoreductase of the reaction reagent system, wherein the carrier is partially or wholly disposed outside the sample solution supply pathway.
摘要翻译：本发明提供一种生物传感器，其即使在样品溶液量少且改善试剂溶解的情况下也能够通过促进样品溶液的引入而迅速进行定量。生物传感器包括绝缘基板; 电极系统，其至少包括形成在所述基板上的测量电极和对电极; 集成到所述基板中以形成用于将样品溶液供应到所述盖构件和所述基板之间的所述电极系统的样品溶液供给路径的盖构件; 至少包括电子介体和氧化还原酶的反应试剂系统; 和至少支持反应试剂体系的电子介体或氧化还原酶的载体，其中载体被部分或全部置于样品溶液供给路径的外部。

3. 发明授权

US06776888B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06776888B2
公开(公告)日：2004-08-17
申请号：US10089289
申请日：2002-03-26
申请人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： The present invention provides a biosensor that enables highly-accurate measurement of a sample solution including a solid component like hemocytes and has a little variation in response. The biosensor includes: an insulating base plate, an electrode system having at least a working electrode and a counter electrode provided on the base plate, a cover member that is combined with the base plate to define a sample solution supply pathway for leading a sample solution from a sample supply unit to the electrode system, a reaction reagent system including at least an oxidation-reduction enzyme and an electron mediator, and a filter disposed between the electrode system and the sample supply unit in the sample solution supply pathway. The biosensor has a space that encircles surface of the filter in an area from one end of the filter close to the sample supply unit to the other end of the filter close to the electrode system. This arrangement effectively prevents the solid component like hemocytes from flowing into the electrode system without being filtered out by the filter.
摘要翻译：本发明提供一种生物传感器，其能够高精度地测量包含像血细胞这样的固体成分的样品溶液，并且响应性变化很小。生物传感器包括：绝缘基板，至少具有工作电极和设置在基板上的对电极的电极系统，与基板结合以限定用于引导样品溶液的样品溶液供给路径的盖构件从样品供给单元到电极系统，至少包含氧化还原酶和电子介体的反应试剂系统，以及设置在样品溶液供给路径中的电极系统和样品供给单元之间的过滤器。生物传感器具有在过滤器的一端靠近样品供给单元的一个区域中的过滤器的表面周围到靠近电极系统的过滤器的另一端的空间。这种布置有效地防止诸如血细胞的固体组分流入电极系统而不被过滤器过滤掉。

4. 发明申请

US20050072670A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20050072670A1
公开(公告)日：2005-04-07
申请号：US10478283
申请日：2002-12-27
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： C12Q1/00 , C12Q1/60 , G01N27/403 , G01N33/487 , G01N33/49 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , C12Q1/60 , G01N27/3272
摘要： In order to provide a biosensor with high accuracy and excellent response where plasma obtained by filtration of blood rapidly arrives at an electrode system, in a biosensor comprising: an insulating base plate; an electrode system having a working electrode and a counter electrode which are provided on the base plate; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an inlet and an air aperture; a sample solution supply part for introducing a sample solution, which is in position apart from the sample solution supply pathway; and a first filter which is disposed between the sample solution supply pathway and the sample solution supply part for filtering the sample solution, where the filtrate filtered with the first filter is supplied into the sample solution supply pathway due to capillary action, the direction in which the sample solution passes through the first filter and the direction in which the filtrate passes through the sample solution supply pathway are made cross at right angles.
摘要翻译：为了提供具有高精度和优异响应的生物传感器，其中通过过滤血液获得的血液迅速到达电极系统，在生物传感器中包括：绝缘基板; 具有设置在基板上的工作电极和对置电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层并具有入口和空气孔的样品溶液供应路径; 用于引入样品溶液的样品溶液供应部件，其处于离样品溶液供给路径的位置; 以及第一过滤器，其设置在样品溶液供给路径和样品溶液供给部之间，用于过滤样品溶液，其中用第一过滤器过滤的滤液由于毛细作用而被供给到样品溶液供给通道中，其中样品溶液通过第一过滤器，滤液通过样品溶液供应通道的方向被成直角交叉。

5. 发明授权

US06706232B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06706232B2
公开(公告)日：2004-03-16
申请号：US10363589
申请日：2003-03-04
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with hemocytes therein filtered can rapidly reach an electrode system. In a biosensor where plasma with hemocytes therein filtered with a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其被测量对象是全血，其中血细胞在其中被过滤的血浆可以快速地达到电极系统。在生物传感器中，其中用过滤器过滤血细胞的血浆由于毛细作用而被吸入样品溶液供应通道中，形成有：从底部保持过滤器的初级侧部分的第一按压部分; 用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

6. 发明授权

US06966977B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06966977B2
公开(公告)日：2005-11-22
申请号：US10350139
申请日：2003-01-24
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/00 , G01N33/487 , G01N33/49 , G01N33/543 , G01N27/327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： A sensor including an insulating base plate; an electrode system, provided on the base plate, having a measuring electrode and a counter electrode; a reaction layer including at least an oxidoreductase and an electron mediator; a sample solution supply pathway including the electrode system and the reaction layer; and a sample supply unit, wherein the sensor is so structured that, between the sample supply unit and the sample solution supply pathway, there is provided a filter having a function to filter out hemocytes and having a cross-sectional area larger than an opening of the sample solution supply pathway, and that plasma of a blood with hemocytes thereof having been filtered out is sucked into the inside of the sample solution supply pathway owing to capillary phenomena.
摘要翻译：一种传感器，包括绝缘基板; 设置在基板上的具有测量电极和对电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层的样品溶液供给路径; 以及样本供应单元，其中所述传感器的结构使得在所述样品供应单元和所述样品溶液供应通道之间提供过滤器，所述过滤器具有过滤出血细胞并且具有大于所述样品供应单元的开口的横截面积样品溶液供给路径，由于毛细血管现象，血液中已经滤出血细胞的血浆被吸入到样品溶液供给路径的内部。

7. 发明授权

US06719887B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06719887B2
公开(公告)日：2004-04-13
申请号：US10221990
申请日：2002-09-17
申请人： Miwa Hasegawa , Motokazu Watanabe , Tomohiro Yamamoto , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Motokazu Watanabe , Tomohiro Yamamoto , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： G01N33/92 , C12Q1/005 , G01N33/5438
摘要： A biosensor includes: an insulating base plate; an electrode system which is provided on the base plate and has a measurement electrode and a counter electrode; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an air aperture on the termination side thereof; a sample supply portion; and a filter which is disposed between the sample solution supply pathway and the sample supply portion and filters hemocytes, where plasma with the hemocytes therein filtered with the filter is sucked into the sample solution supply pathway due to capillarity, the central part of a secondary side portion of the filter is protruded into the sample solution supply pathway more than both the right and left ends thereof.
摘要翻译：生物传感器包括：绝缘基板; 电极系统，设置在基板上，具有测量电极和对电极; 至少包含氧化还原酶和电子介体的反应层; 样品溶液供给路径，其包括电极系统和反应层，并且在其终端侧具有空气孔; 样品供应部分; 以及过滤器，其设置在样品溶液供给路径和样品供给部之间，并且过滤血细胞，其中由过滤器过滤的血细胞的血浆由于毛细作用而被吸入样品溶液供给通道，次级侧的中心部分过滤器的一部分比其右端和左端都突出到样品溶液供给路径中。

8. 再颁专利

USRE39390E1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：USRE39390E1
公开(公告)日：2006-11-14
申请号：US10924334
申请日：2002-05-17
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with which is obtained by filtering out hemocytes therein filtered in blood can rapidly reach an electrode system. In a biosensor where plasma with which is obtained by filtering out hemocytes therein filtered with by a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其测量对象为全血，等离子体<？delete-start id =“DEL-S-00001”date =“20061114”？>与<？delete -end id =“DEL-S-00001”？> <？insert-start id =“INS-S-00001”date =“20061114”？>通过过滤出<？insert-end id =“INS- S-00001“？>血细胞<？delete-start id =”DEL-S-00002“date =”20061114“？>其中过滤的<？delete-end id =”DEL-S-00002“？> 在血液中开始id =“INS-S-00002”date =“20061114”？> <？insert-end id =“INS-S-00002”？>可以快速到达电极系统。在等离子体<？delete-start id =“DEL-S-00003”date =“20061114”？>与<？delete-end id =“DEL-S-00003”？> <？insert-start id = 通过滤出<？insert-end id =“INS-S-00003”？>血细胞<？delete-start id =“DEL-S-00004”获得的“INS-S-00003”date =“20061114”？ “date =”20061114“？>用<？delete-end id =”DEL-S-00004“？> <？insert-start id =”INS-S-00004“date =”20061114“？> ？insert-end id =“INS-S-00004”？>由于毛细作用，将过滤器吸入样品溶液供给路径，形成有：从底部保持过滤器的初级侧部的第一按压部，用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

9. 发明授权

US06451372B2 Biosensor and method of producing the same 失效
标题翻译：生物传感器及其生产方法
公开(公告)号：US06451372B2
公开(公告)日：2002-09-17
申请号：US09770946
申请日：2001-01-26
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： B05D300
CPC分类号： C12Q1/002
摘要： The present invention provides a biosensor that has a reaction reagent system easily dissolved even in a sample solution containing a high concentration of a substrate and ensures rapid and highly accurate measurement. The method of forming a target reaction layer according to the present invention dissolves a material constituting the target reaction layer in a solvent of a sublimable substance to prepare a solution, applies the solution in a desired area to form the target reaction layer, freezes the applied solution, and sublimates the solvent included in a solid matter of the frozen solution under reduced pressure for removal. The resultant reaction layer has a large surface area and is easily dissolved in the sample solution to enable rapid measurement.
摘要翻译：本发明提供了一种生物传感器，其具有即使在含有高浓度基板的样品溶液中也容易溶解的反应试剂体系，并且确保快速且高精度的测量。根据本发明的形成目标反应层的方法将构成目标反应层的材料溶解在可升华物质的溶剂中以制备溶液，将溶液施加到所需区域以形成目标反应层，冻结所施加的溶液，并在减压下升华包含在冷冻溶液的固体物质中的溶剂以除去。所得反应层的表面积大，容易溶解在样品溶液中，能够快速测定。

10. 发明授权

US06821410B2 Biosensor and method of substrate quantification 失效
标题翻译：生物传感器和底物定量方法
公开(公告)号：US06821410B2
公开(公告)日：2004-11-23
申请号：US10084937
申请日：2002-03-01
申请人： Motokazu Watanabe , Miwa Hasegawa , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Miwa Hasegawa , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/26 , C12Q1/005 , C12Q1/44 , C12Q1/60
摘要： Disclosed is a highly responsive biosensor comprising a cholesterol-oxidizing enzyme and cholesterol esterase. The biosensor comprises: an electrically insulating base plate; an electrode system including a working electrode and a counter electrode formed on the base plate; a cover member joined with the base plate to define a sample supply pathway through which a sample solution is introduced from a sample supply port to the electrode system, the sample supply pathway being formed between the cover member and the base plate; and a reagent layer formed in the sample supply pathway, wherein the reagent layer contains a cholesterol-oxidizing enzyme, cholesterol esterase, an electron mediator, and a buffer having a buffering capacity in an acidic pH range.
摘要翻译：公开了一种高反应性生物传感器，其包含胆固醇氧化酶和胆固醇酯酶。生物传感器包括：电绝缘基板; 电极系统，包括形成在所述基板上的工作电极和对电极; 覆盖部件，其与所述基板接合，以限定样品供给路径，通过所述样品供给路径将样品溶液从样品供给口引入所述电极系统，所述样品供给路径形成在所述盖部件和所述基板之间; 以及在试样供给路径上形成的试剂层，其中，所述试剂层含有胆固醇 - 氧化酶，胆固醇酯酶，电子介体和在酸性pH范围内具有缓冲能力的缓冲液。

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