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1. 发明申请

US20070073065A1 Substituted optically active disphosphine compound 有权
标题翻译：取代的光学活性分膦化合物
公开(公告)号：US20070073065A1
公开(公告)日：2007-03-29
申请号：US11526252
申请日：2006-09-22
申请人： Takahiro Fujiwara , Tohru Yokozawa
发明人： Takahiro Fujiwara , Tohru Yokozawa
IPC分类号： C07F9/655
CPC分类号： C07F9/65517
摘要： Provided is a method for producing an optically active compound, in more detail, for producing an optically active compound by asymmetric hydrogenation in a high yield and asymmetric yield. The present invention also provides a catalyst for asymmetric synthesis for the above production method, especially a catalyst for asymmetric hydrogenation, containing a transition metal complex. Further, the present invention provides a new diphosphine compound useful as a ligand of the above transition metal complex and a new transition metal complex containing the above diphosphine compound. The present invention relates to a diphosphine compound represented by the following formula (1): a transition metal complex using the compound, a catalyst for asymmetric synthesis comprising the above transition metal complex and a method for producing an optically active compound using the above catalyst for asymmetric synthesis.
摘要翻译：本发明提供了一种光学活性化合物的制造方法，更详细地说，通过不对称氢化以高收率和不对称的收率制造光学活性化合物。本发明还提供了用于上述制备方法的不对称合成催化剂，特别是含有过渡金属络合物的不对称氢化催化剂。此外，本发明提供了可用作上述过渡金属配合物的配体的新的二膦化合物和含有上述二膦化合物的新的过渡金属络合物。本发明涉及由下式（1）表示的二膦化合物：使用该化合物的过渡金属络合物，包含上述过渡金属配合物的不对称合成催化剂和使用上述催化剂制备光学活性化合物的方法不对称合成。

2. 发明授权

US07312347B2 Substituted optically active disphosphine compound 有权
公开(公告)号：US07312347B2
公开(公告)日：2007-12-25
申请号：US11526252
申请日：2006-09-22
申请人： Takahiro Fujiwara , Tohru Yokozawa
发明人： Takahiro Fujiwara , Tohru Yokozawa
IPC分类号： C07F15/00 , C07F9/02
CPC分类号： C07F9/65517
摘要： Provided is a method for producing an optically active compound, in more detail, for producing an optically active compound by asymmetric hydrogenation in a high yield and asymmetric yield. The present invention also provides a catalyst for asymmetric synthesis for the above production method, especially a catalyst for asymmetric hydrogenation, containing a transition metal complex. Further, the present invention provides a new diphosphine compound useful as a ligand of the above transition metal complex and a new transition metal complex containing the above diphosphine compound.The present invention relates to a diphosphine compound represented by the following formula (1): a transition metal complex using the compound, a catalyst for asymmetric synthesis comprising the above transition metal complex and a method for producing an optically active compound using the above catalyst for asymmetric synthesis.

3. 发明申请

US20070142472A1 Process for producing optically active 3-(4-hydroxyphenyl)proprionic acids 审中-公开
标题翻译：光学活性3-（4-羟基苯基）丙酸的制备方法
公开(公告)号：US20070142472A1
公开(公告)日：2007-06-21
申请号：US10578744
申请日：2004-11-26
申请人： Tohru Yokozawa , Hideo Shimizu , Takahiro Fujiwara , Yasunori Ino
发明人： Tohru Yokozawa , Hideo Shimizu , Takahiro Fujiwara , Yasunori Ino
IPC分类号： A61K31/192 , C07C65/03
CPC分类号： C07C51/412 , C07C51/09 , C07C51/36 , C07C51/43 , Y02P20/55 , C07C59/64
摘要： The present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid useful as intermediates for medicines, through short steps in good yield and with high optical purity. More specifically, the present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid of the formula (6): wherein R2 is an alkyl group; R5 to R8 are each independently a hydrogen atom or a substituent; and the symbol * is an chiral carbon atom, or a salt thereof, which comprises reacting a benzaldehyde of the formula (1): wherein R1 is a protective group; and R5 to R8 are each the same as defined above, with a glycolic acid derivative of the formula (2): wherein R3 is a hydrocarbon group; and R2 is the same as defined above, hydrolyzing the resulting product to give a cinnamic acid of the formula (4): wherein R1, R2 and R5 to R8 are each the same as defined above, or a salt thereof, and subjecting the resulting cinnamic acid (4) or a salt thereof to asymmetric hydrogenation to give an optically active phenylpropionic acid of the formula (5): wherein all the symbols are each the same as defined above, or a salt thereof, followed by deprotection.
摘要翻译：本发明涉及一种用作药物中间体的光学活性3-（4-羟基苯基）丙酸的方法，通过短的步骤以良好的收率和高的光学纯度。更具体地说，本发明涉及制备式（6）的光学活性3-（4-羟基苯基）丙酸的方法：其中R 2是烷基; R 5至R 8各自独立地为氢原子或取代基; 符号*是手性碳原子或其盐，其包括使式（1）的苯甲醛：其中R 1为保护基; 和R 5至R 8各自与上述定义相同，与式（2）的乙醇酸衍生物：其中R 3，是一个烃基; 和R 2与上述定义相同，水解所得产物，得到式（4）的肉桂酸：其中R 1，R 2， R 0和R 5至R 8各自与上述定义相同，或其盐，并将所得肉桂酸（4）或其盐不对称氢化得到式（5）的光学活性苯基丙酸：其中所有符号各自与上述定义相同，或其盐，然后脱保护。

4. 发明授权

US08809495B2 Peptides imparting cell permeability to lipid membrane structure and/or enhancing cell permeability of lipid membrane structure, and lipid membrane structure comprising lipid bound to such peptide as constituent lipid and having cell permeability or showing enhanced cell permeability 有权
标题翻译：赋予细胞对脂质膜结构的渗透性和/或增强脂质膜结构的细胞渗透性的肽，以及脂质膜结构，其包含结合到诸如构成脂质的肽和具有细胞渗透性或显示增强的细胞渗透性
公开(公告)号：US08809495B2
公开(公告)日：2014-08-19
申请号：US13515970
申请日：2010-12-14
申请人： Hideyoshi Harashima , Takahiro Fujiwara , Hidetaka Akita
发明人： Hideyoshi Harashima , Takahiro Fujiwara , Hidetaka Akita
IPC分类号： C07K7/06 , A61K47/42 , A61K9/127 , C07K14/47 , A61K38/00 , A61K39/00
CPC分类号： C07K7/06 , A61K9/1271 , A61K38/00 , A61K47/60 , A61K47/62 , A61K47/6911
摘要： Provided are peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure, and a lipid membrane structure which comprises, as a constituent lipid, a lipid bound to such a peptide and has cell permeability or shows enhanced cell permeability. The amino acid sequences of the peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure are represented by: LX1X2X1X1X1L, LLX2X1X1X1L and LX1X2X1X1L (wherein L represents a leucine residue; X1 represents a polar amino acid residue; and X2 represents a polar, non-charged and branched chain amino acid residue).
摘要翻译：提供赋予脂质膜结构的细胞渗透性和/或增强脂质膜结构的细胞渗透性的肽，以及脂质膜结构，其包含作为构成脂质的与这种肽结合的脂质并具有细胞渗透性或显示增强细胞渗透性。赋予细胞对脂质膜结构的渗透性和/或增强脂质膜结构的细胞渗透性的肽的氨基酸序列由以下表示：LX1X2X1X1X1L，LLX2X1X1X1L和LX1X2X1X1L（其中L表示亮氨酸残基; X1表示极性氨基酸残基; X2表示极性，非带电荷和支链氨基酸残基）。

5. 发明申请

US20070208143A1 Water-soluble polymer and additive for paper manufacture 有权
标题翻译：用于造纸的水溶性聚合物和添加剂
公开(公告)号：US20070208143A1
公开(公告)日：2007-09-06
申请号：US11367487
申请日：2006-03-06
申请人： Yoshiharu Kimura , Takahiro Fujiwara
发明人： Yoshiharu Kimura , Takahiro Fujiwara
IPC分类号： C08F20/56
CPC分类号： C08F20/56 , C08F2/001 , C08F2/10 , C08F220/06 , C08F220/34 , C08F220/56 , C08F222/02 , C08F230/08
摘要： The present invention provides a method for preparing a water soluble polymer, which comprises: a first step of polymerizing: (a) 60 to 99.5 mol % of at least one selected from acrylamide and methacrylamide, (b) 0.5 to 20 mol % of at least one selected from α,β-unsaturated monocarboxylic acid, α,β-unsaturated dicarboxylic acid and salts thereof, and (c) 1 to 20 mol % of at least one selected from a water soluble cationic monomer and a salt thereof, (d) 0.01 to 1 mol % of a chain transfer agent, and (e) 0.005 to 5 mol % of a crosslinkable monomer, in the presence of a persulfate-based catalyst to obtain a prepolymer; and a second step of further adding the persulfate-based catalyst to the prepolymer obtained in the first step and the residual monomer, followed by the polymerization and termination of the polymerization. Consequently, it is made possible to suppress a rapid increase in viscosity during the polymerization thereby to obtain a water soluble branched polymer having high molecular weight and low viscosity.
摘要翻译：本发明提供一种制备水溶性聚合物的方法，其包括：聚合的第一步骤：（a）60至99.5mol％的选自丙烯酰胺和甲基丙烯酰胺的至少一种，（b）0.5至20mol％的选自α，β-不饱和一元羧酸，α，β-不饱和二羧酸及其盐中的至少一种，和（c）1〜20摩尔％的选自水溶性阳离子单体及其盐中的至少一种，（d ）0.01〜1摩尔％的链转移剂，（e）0.005〜5摩尔％的交联性单体，在过硫酸盐系催化剂存在下，得到预聚物; 以及将第一步骤中得到的预聚物和残留单体进一步添加过硫酸盐系催化剂，然后聚合并终止聚合的第二工序。因此，可以抑制聚合期间的粘度的快速增加，从而得到具有高分子量和低粘度的水溶性支链聚合物。

6. 发明授权

US08551908B2 Exhaust gas purification catalyst 有权
标题翻译：废气净化催化剂
公开(公告)号：US08551908B2
公开(公告)日：2013-10-08
申请号：US13001683
申请日：2009-06-26
申请人： Akemi Satou , Masahiko Takeuchi , Keizo Hiraku , Yusuke Kawamura , Takahiro Fujiwara , Tadashi Suzuki , Naoki Takahashi
发明人： Akemi Satou , Masahiko Takeuchi , Keizo Hiraku , Yusuke Kawamura , Takahiro Fujiwara , Tadashi Suzuki , Naoki Takahashi
IPC分类号： B01J23/00 , B01J21/00
CPC分类号： B01J23/002 , B01D53/945 , B01D2255/1021 , B01D2255/1023 , B01D2255/1025 , B01D2255/206 , B01D2255/20715 , B01D2255/9022 , B01D2255/908 , B01D2257/304 , B01J23/63 , B01J23/83 , B01J23/894 , B01J35/04 , B01J37/0244 , B01J2523/00 , Y02T10/22 , B01J2523/3712 , B01J2523/3718 , B01J2523/48 , B01J2523/828 , B01J2523/824 , B01J2523/822
摘要： An exhaust gas purification catalyst includes: a lower catalyst layer that contains a ceria-zirconia mixed oxide having 50 to 70 mass % of CeO2 and 5 mass % or more of Pr2O3 and carries at least one of Pt and Pd; and an upper catalyst layer that contains at least zirconia and carries at least Rh, wherein the total amount of CeO2 per liter of the carrier base is 15 to 30 g. Because the amount of CeO2 is small, formation of H2S is suppressed and a high capability of adsorbing and releasing oxygen is brought out in spite of the small amount of CeO2.
摘要翻译：废气净化催化剂包括：含有氧化铈 - 氧化锆混合氧化物的下部催化剂层，其具有50〜70质量％的CeO 2和5质量％以上的Pr 2 O 3，并携带Pt和Pd中的至少一种; 和至少含有氧化锆并至少含有Rh的上部催化剂层，其中每升载体碱的CeO 2的总量为15〜30g。由于CeO 2的量少，因此抑制了H 2 S的形成，并且尽管CeO 2的量少，但是吸附和释放氧的能力也很高。

7. 发明申请

US20120309937A1 PEPTIDES IMPARTING CELL PERMEABILITY TO LIPID MEMBRANE STRUCTURE AND/OR ENHANCING CELL PERMEABILITY OF LIPID MEMBRANE STRUCTURE, AND LIPID MEMBRANE STRUCTURE COMPRISING LIPID BOUND TO SUCH PEPTIDE AS CONSTITUENT LIPID AND HAVING CELL PERMEABILITY OR SHOWING ENHANCED CELL PERMEABILITY 有权
标题翻译： PEPTIDES将脂质膜结构和/或增强脂质膜结构的细胞渗透性和/或增强脂质膜结构的细胞渗透性的脂质渗透性，以及将包含脂质的脂质膜结合到这些肽作为组织脂质并具有细胞渗透性或显示增强的细胞渗透性
公开(公告)号：US20120309937A1
公开(公告)日：2012-12-06
申请号：US13515970
申请日：2010-12-14
申请人： Hideyoshi Harashima , Takahiro Fujiwara , Hidetaka Akita
发明人： Hideyoshi Harashima , Takahiro Fujiwara , Hidetaka Akita
IPC分类号： C07K1/113 , C07K1/107
CPC分类号： C07K7/06 , A61K9/1271 , A61K38/00 , A61K47/60 , A61K47/62 , A61K47/6911
摘要： Provided are peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure, and a lipid membrane structure which comprises, as a constituent lipid, a lipid bound to such a peptide and has cell permeability or shows enhanced cell permeability. The amino acid sequences of the peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure are represented by: LX1X2X1X1X1L, LLX2X1X1X1L and LX1X2X1X1L (wherein L represents a leucine residue; X1 represents a polar amino acid residue; and X2 represents a polar, non-charged and branched chain amino acid residue).
摘要翻译：提供赋予脂质膜结构的细胞渗透性和/或增强脂质膜结构的细胞渗透性的肽，以及脂质膜结构，其包含作为构成脂质的与这种肽结合的脂质并具有细胞渗透性或显示增强细胞渗透性。赋予细胞对脂质膜结构的渗透性和/或增强脂质膜结构的细胞渗透性的肽的氨基酸序列由以下表示：LX1X2X1X1X1L，LLX2X1X1X1L和LX1X2X1X1L（其中L表示亮氨酸残基; X1表示极性氨基酸残基; X2表示极性，非带电荷和支链氨基酸残基）。

8. 发明授权

US08241462B2 Papermaking internal sizing agent and use thereof 有权
标题翻译：造纸内部施胶剂及其用途
公开(公告)号：US08241462B2
公开(公告)日：2012-08-14
申请号：US12670186
申请日：2008-03-06
申请人： Kazunari Sakai , Takahiro Fujiwara , Kazushige Inaoka , Takashi Yamaguchi , Masaki Ito , Yasunobu Ooka
发明人： Kazunari Sakai , Takahiro Fujiwara , Kazushige Inaoka , Takashi Yamaguchi , Masaki Ito , Yasunobu Ooka
IPC分类号： D21H17/37 , D21H17/41 , D21H17/42 , D21H17/43 , D21H17/44 , D21H17/45
CPC分类号： D21H21/16 , D21H17/41 , D21H17/455 , D21H17/675
摘要： To provide a papermaking internal sizing agent capable of efficiently imparting sizing performance even in neutral papermaking which uses calcium carbonate as filler, and uses no aluminum sulfate or uses a small amount of aluminum sulfate, and also provide a paper or a paperboard obtained by using the papermaking internal sizing agent. The papermaking internal sizing agent comprises as an effective ingredient an amphoteric copolymer having hydrophobic groups and cationic groups, at least a part of the cationic groups being quaternized. Preferably, the amphoteric copolymer is obtained by polymerizing monomer ingredients that it essentially contain a hydrophobic monomer (A), a cationic monomer (B), and an anionic monomer (C) and that an anion equivalent of the monomer (C) is 0.1 to 90% of a cation equivalent of the monomer (B), in which a rate of quaternizing of the cationic groups is not less than 40% by mole. The paper or the paperboard contains the above papermaking internal sizing agent.
摘要翻译：提供即使在使用碳酸钙作为填料的中性造纸中也能有效赋予施胶性能，不使用硫酸铝或使用少量硫酸铝的造纸内施胶剂，并且还提供通过使用碳酸钙作为填料获得的纸或纸板造纸内部施胶剂。造纸内部施胶剂包括具有疏水基团和阳离子基团的两性共聚物作为有效成分，至少一部分阳离子基团被季铵化。优选地，两性共聚物通过使其基本上含有疏水单体（A），阳离子单体（B）和阴离子单体（C）的单体成分聚合而获得，并且单体（C）的阴离子当量为0.1〜单体（B）的阳离子当量的90％，其中阳离子基团的季铵化率不低于40摩尔％。纸或纸板包含上述造纸内部施胶剂。

9. 发明授权

US07964744B2 Method for producing a ruthenium complex 有权
标题翻译：钌络合物的制造方法
公开(公告)号：US07964744B2
公开(公告)日：2011-06-21
申请号：US12540794
申请日：2009-08-13
申请人： Hideki Nara , Noboru Sayo , Takahiro Fujiwara
发明人： Hideki Nara , Noboru Sayo , Takahiro Fujiwara
IPC分类号： C07F15/00
CPC分类号： C07F15/0053
摘要： Provided is a method for producing a ruthenium complex comprises the step of reacting a ruthenium compound represented by general formula (1): [RuX(L)(PP)]X (1), wherein Ru represents a ruthenium atom; X represents a halogen atom; L represents an arene; and PP represents an optically active bisphosphine, with a carboxylate salt represented by general formula (2): R1CO2M (2), wherein M represents a monovalent cation; and R1 represents a group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups, to produce a ruthenium complex represented by general formula (3): Ru(OCOR1)2(PP) (3), wherein R1 represents the group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups; and PP represents the optically active bisphosphine.
摘要翻译：提供一种制备钌络合物的方法，包括使通式（1）表示的钌化合物：[RuX（L）（PP）] X（1），其中Ru表示钌原子; X表示卤原子; L代表芳烃; 和PP代表光学活性双膦，与通式（2）表示的羧酸盐：R1CO2M（2），其中M表示一价阳离子; 并且R 1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1-氨基-1-苯基烷基的基团，以制备由通式（3）：Ru（OCOR1）2（PP）（3），其中R1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1- 氨基-1-苯基烷基; PP代表光学活性双膦。

10. 发明申请

US20150128572A1 EXHAUST GAS CONTROL APPARATUS FOR INTERNAL COMBUSTION ENGINE 有权
标题翻译：用于内燃机的排气控制装置
公开(公告)号：US20150128572A1
公开(公告)日：2015-05-14
申请号：US14368832
申请日：2011-12-27
申请人： Takahiro Fujiwara , Norihisa Nakagawa , Kouichi Kimura , Shuntaro Okazaki , Keisuke Nagasaka , Ichiro Kitamura , Satoshi Kamitani , Koji Morita
发明人： Takahiro Fujiwara , Norihisa Nakagawa , Kouichi Kimura , Shuntaro Okazaki , Keisuke Nagasaka , Ichiro Kitamura , Satoshi Kamitani , Koji Morita
IPC分类号： F01N3/20 , F02D41/02
CPC分类号： F01N3/2006 , F01N3/101 , F01N3/20 , F01N3/22 , F01N9/00 , F01N11/00 , F01N2240/02 , F01N2260/04 , F01N2430/08 , F01N2560/025 , F01N2560/14 , F01N2590/11 , F01N2900/10 , F02D41/0255 , Y02T10/22 , Y02T10/47
摘要： An exhaust gas control apparatus for an internal combustion engine, controls an exhaust operation of the internal combustion engine (200) provided with an exhaust gas purification catalyst (216) in an exhaust passage (215). The exhaust gas control apparatus for the internal combustion engine is provided with a warming-up device configured to warm up the exhaust gas purification catalyst; and an oxygen supplying device (220, 221) configured to supply oxygen to the exhaust gas purification catalyst after the end of the warm-up. This makes it possible to preferably desorb sulfur adsorbed to the exhaust gas purification catalyst during warm-up. It is therefore possible to suppress a reduction in purification ability of the exhaust gas purification catalyst due to sulfur coating.
摘要翻译：一种用于内燃机的排气控制装置，控制在排气通道（215）中设置有排气净化催化剂（216）的内燃机（200）的排气操作。用于内燃机的排气控制装置设置有预热装置，其被配置为预热排气净化催化剂; 以及氧气供给装置（220,221），其构造成在所述预热结束后向所述排气净化催化剂供给氧。这使得可以优选在预热期间解吸吸附到废气净化催化剂上的硫。因此，能够抑制由于硫化而导致的排气净化催化剂的净化能力的降低。

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