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1. 发明授权

US08643947B2 Confocal microscope system 有权
标题翻译：共焦显微镜系统
公开(公告)号：US08643947B2
公开(公告)日：2014-02-04
申请号：US13038834
申请日：2011-03-02
申请人： Taichirou Nezu , Takayuki Kei , Hideo Hirukawa , Yohei Kuwabara , Hironori Takai
发明人： Taichirou Nezu , Takayuki Kei , Hideo Hirukawa , Yohei Kuwabara , Hironori Takai
IPC分类号： G02B21/00
CPC分类号： G02B21/0044 , G02B21/24
摘要： There is provided a confocal microscope system configured so as to be compact in size without the needs for a large space, requiring fewer spots for adjustment. In the confocal microscope system, respective units making up the confocal microscope system are integrally housed in a protection cabinet covering the confocal microscope system, and when a specimen disposed opposite to an objective lens is moved toward an external face of the protection cabinet, a side of the external face, adjacent to an opening through which the specimen is taken in, or out, is defined as a front face, the Nipkow disk type scanner unit is disposed backward of the objective lens.
摘要翻译：提供了一种配置成尺寸紧凑而不需要大空间的共聚焦显微镜系统，需要较少的调整点。在共聚焦显微镜系统中，构成共焦显微镜系统的各单元一体地容纳在覆盖共聚焦显微镜系统的保护柜中，并且当与物镜相对设置的样本朝向保护柜的外表面移动时，与外部面相邻的外部面，被定义为前面，Nipkow盘型扫描单元设置在物镜的后方。

2. 发明申请

US20110216404A1 CONFOCAL MICROSCOPE SYSTEM 有权
标题翻译： CONFOCAL MICROSCOPE系统
公开(公告)号：US20110216404A1
公开(公告)日：2011-09-08
申请号：US13038834
申请日：2011-03-02
申请人： Taichirou Nezu , Takayuki Kei , Hideo Hirukawa , Yohei Kuwabara , Hironori Takai
发明人： Taichirou Nezu , Takayuki Kei , Hideo Hirukawa , Yohei Kuwabara , Hironori Takai
IPC分类号： G02B21/06
CPC分类号： G02B21/0044 , G02B21/24
摘要： There is provided a confocal microscope system configured so as to be compact in size without the needs for a large space, requiring fewer spots for adjustment. In the confocal microscope system, respective units making up the confocal microscope system are integrally housed in a protection cabinet covering the confocal microscope system, and when a specimen disposed opposite to an objective lens is moved toward an external face of the protection cabinet, a side of the external face, adjacent to an opening through which the specimen is taken in, or out, is defined as a front face, the Nipkow disk type scanner unit is disposed backward of the objective lens.
摘要翻译：提供了一种配置成尺寸紧凑而不需要大空间的共聚焦显微镜系统，需要较少的调整点。在共聚焦显微镜系统中，构成共焦显微镜系统的各单元一体地容纳在覆盖共聚焦显微镜系统的保护柜中，并且当与物镜相对设置的样本朝向保护柜的外表面移动时，与外部面相邻的外部面，被定义为前面，Nipkow盘型扫描单元设置在物镜的后方。

3. 发明授权

US07400446B2 Confocal microscope 失效
标题翻译：共焦显微镜
公开(公告)号：US07400446B2
公开(公告)日：2008-07-15
申请号：US11362228
申请日：2006-02-27
申请人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
发明人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
IPC分类号： G02B21/06
CPC分类号： G02B21/004 , G02B21/0044 , G02B21/0076
摘要： A confocal microscope uses fluorescent or reflected light obtained by irradiating a plurality of beam spots to a sample so as to observe the sample. The confocal microscope has a phase modulator element which modulates phase of laser light to form the beam spots, a liquid crystal element which forms a plurality of pinholes through which only the fluorescent or the reflected light is transmitted, and a control section which controls the phase modulator element and the liquid crystal element.
摘要翻译：共焦显微镜使用通过对样品照射多个束斑而获得的荧光或反射光，以观察样品。共聚焦显微镜具有调制激光相位以形成光束斑的相位调制元件，形成仅透过荧光或反射光的多个针孔的液晶元件和控制相位的控制部调制元件和液晶元件。

4. 发明授权

US07349152B2 Three-dimensional confocal microscope system 失效
标题翻译：三维共焦显微镜系统
公开(公告)号：US07349152B2
公开(公告)日：2008-03-25
申请号：US10916411
申请日：2004-08-12
申请人： Takayuki Kei
发明人： Takayuki Kei
IPC分类号： G02B21/00
CPC分类号： G02B21/008 , Y10S359/90
摘要： This invention is characterized by the following feature. A three-dimensional confocal microscope system for performing image processing based on image pickup data of sliced images of a sample outputted from a confocal scanner and thus acquiring a three-dimensional image of the sample, the system comprising a correction unit for correcting brightness of the sliced images on the basis of depth of the sample. Thus, a three-dimensional confocal microscope system that corrects changes in the brightness of the image due to the depth of the sample and thus achieves uniform brightness of the image at any point in the direction of depth can be realized.
摘要翻译：本发明的特征在于以下特征。一种三维共焦显微镜系统，用于基于从共聚焦扫描仪输出的样本的切片图像的图像拾取数据进行图像处理，从而获取样本的三维图像，该系统包括校正单元，根据样品的深度切片图像。因此，可以实现校正由于样品的深度而导致的图像的亮度变化并因此在深度方向上的任何点实现均匀的图像的亮度的三维共焦显微镜系统。

5. 发明授权

US08128870B2 Drug discovery screening apparatus 失效
标题翻译：药物发现筛选仪
公开(公告)号：US08128870B2
公开(公告)日：2012-03-06
申请号：US12704865
申请日：2010-02-12
申请人： Taichirou Nedu , Kouichi Yamamoto , Takayuki Kei , Toshiyuki Suzuki
发明人： Taichirou Nedu , Kouichi Yamamoto , Takayuki Kei , Toshiyuki Suzuki
IPC分类号： G01N35/02 , G01N35/04
CPC分类号： G01N35/02 , G01N35/0099 , G01N35/028 , G01N2035/042 , G01N2035/0462 , G01N2035/0465 , Y10T436/113332 , Y10T436/114165
摘要： A drug discovery screening apparatus improves a testing operation efficiency. The drug discovery screening apparatus comprises an image measurement unit, an incubator unit integrally connected to the image measurement unit, a fixed stage disposed at the incubator unit, first conveyance for taking out one of plates stored in a carousel of the incubator unit and conveying the plate onto the fixed stage, second conveyance for taking out the plate conveyed onto the fixed stage and conveying the plate onto an XY stage disposed at the image measurement unit, and a control unit. The second conveyance comprises first and second conveyance arms, respectively supported horizontally by a conveyance unit support section, which convey the plates onto the fixed stage and XY stage so as to allow the respective plates to cross each other.
摘要翻译：药物发现筛选装置提高了检测操作的效率。药物发现筛选装置包括图像测量单元，与图像测量单元一体连接的培养箱单元，设置在培养器单元的固定台，用于取出存储在培养箱单元的转盘中的板之一，并输送将板移动到固定台上，第二传送装置用于取出传送到固定台上的板，并将板传送到设置在图像测量单元上的XY台上，以及控制单元。第二输送装置包括第一和第二输送臂，分别由输送单元支撑部分水平地支撑，该输送臂将板传送到固定台和XY台上，以允许相应的板彼此交叉。

6. 发明授权

US06982824B2 Three-dimensional confocal microscope system 失效
标题翻译：三维共焦显微镜系统
公开(公告)号：US06982824B2
公开(公告)日：2006-01-03
申请号：US10800754
申请日：2004-03-16
申请人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
发明人： Takayuki Kei , Kenji Hachiya , Kenta Mikuriya
IPC分类号： G02B21/00
CPC分类号： G02B21/0024
摘要： The present invention is characterized in that it is possible to provide a three-dimensional confocal microscope system configured so that an objective lens can be scanned in the optical-axis direction using an actuator to obtain sliced confocal images of a sample, wherein the actuator is driven using a scanning waveform signal, which is triangular or step-like and has been corrected so that acceleration is kept virtually constant at discontinuous points of change in the scanning waveform signal, thereby consistently providing sliced confocal images of the sample.
摘要翻译：本发明的特征在于，可以提供一种三维共聚焦显微镜系统，其被配置为使得可以使用致动器在光轴方向上扫描物镜，以获得样品的切片共聚焦图像，其中致动器是使用三角形或阶梯状的扫描波形信号进行驱动，并且已被校正，使得加速度在扫描波形信号的不连续点处几乎保持不变，从而一致地提供样品的切片共聚焦图像。

7. 发明申请

US20110090553A1 CONFOCAL OPTICAL SCANNER 审中-公开
标题翻译：共焦光学扫描仪
公开(公告)号：US20110090553A1
公开(公告)日：2011-04-21
申请号：US12889577
申请日：2010-09-24
申请人： Takayuki Kei
发明人： Takayuki Kei
IPC分类号： G02B26/10
CPC分类号： G02B21/0044 , G02B21/0032 , G02B21/0076
摘要： There is provided a confocal optical scanner capable of coping with variation of optical system magnification, a bright field image, and so forth. The confocal optical scanner comprising a pinhole disc with pinholes provided thereon, and rotation means for rotating the pinhole disc for obtaining a confocal image by rotating the pinhole disc with the use of the rotation means to thereby scan with illumination light and by causing optical feedback from the illumination light passing through the pinholes to form an image, wherein the confocal optical scanner is provided with a transfer mechanism for causing the pinhole disc to undergo reciprocating transfer between a position where the pinhole disc resides in an optical path of the illumination light, and a position where the pinhole disc is evacuated from the optical path of the illumination light.
摘要翻译：提供了能够应对光学系统放大率变化，亮视场图像等的共焦光学扫描仪。共焦光学扫描器包括：设置有针孔的针孔盘;以及旋转装置，用于旋转针孔盘以通过使用旋转装置旋转针孔盘来获得共焦图像，从而通过照明光进行扫描，并且通过使来自所述照明光穿过所述针孔以形成图像，其中所述共焦光学扫描仪设置有传送机构，用于使所述针孔盘在所述针孔盘位于所述照明光的光路中的位置之间经历往复传送;以及将针孔盘从照明光的光路抽出的位置。

8. 发明申请

US20060209399A1 Confocal microscope 失效
标题翻译：共焦显微镜
公开(公告)号：US20060209399A1
公开(公告)日：2006-09-21
申请号：US11362228
申请日：2006-02-27
申请人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
发明人： Kenta Mikuriya , Takashi Yoshida , Takayuki Kei
IPC分类号： G02B21/06
CPC分类号： G02B21/004 , G02B21/0044 , G02B21/0076
摘要： A confocal microscope uses fluorescent or reflected light obtained by irradiating a plurality of beam spots to a sample so as to observe the sample. The confocal microscope has a phase modulator element which modulates phase of laser light to form the beam spots, a liquid crystal element which forms a plurality of pinholes through which only the fluorescent or the reflected light is transmitted, and a control section which controls the phase modulator element and the liquid crystal element.
摘要翻译：共焦显微镜使用通过对样品照射多个束斑而获得的荧光或反射光，以观察样品。共聚焦显微镜具有调制激光相位以形成光束斑的相位调制元件，形成仅透过荧光或反射光的多个针孔的液晶元件和控制相位的控制部调制元件和液晶元件。

9. 发明申请

US20100211211A1 DRUG DISCOVERY SCREENING APPARATUS 失效
标题翻译：药物发现筛选装置
公开(公告)号：US20100211211A1
公开(公告)日：2010-08-19
申请号：US12704865
申请日：2010-02-12
申请人： Taichirou Nedu , Kouichi Yamamoto , Takayuki Kei , Toshiyuki Suzuki
发明人： Taichirou Nedu , Kouichi Yamamoto , Takayuki Kei , Toshiyuki Suzuki
IPC分类号： G06F7/00 , B65G49/00
CPC分类号： G01N35/02 , G01N35/0099 , G01N35/028 , G01N2035/042 , G01N2035/0462 , G01N2035/0465 , Y10T436/113332 , Y10T436/114165
摘要： The invention is to provide a drug discovery screening apparatus capable of improving a testing operation efficiency. The drug discovery screening apparatus comprises an image measurement unit, an incubator unit integrally connected to the image measurement unit, a fixed stage disposed at the incubator unit, first conveyance means for taking out one of plates stored in a carousel of the incubator unit and conveying the plate onto the fixed stage, second conveyance means for taking out the plate conveyed onto the fixed stage and conveying the plate onto an XY stage disposed at the image measurement unit, and a control unit, wherein the second conveyance means comprises first and second conveyance arms, respectively supported horizontally by a conveyance unit support section, which convey the plates onto the fixed stage and XY stage so as to allow the respective plates to cross each other.
摘要翻译：本发明提供能够提高检测作业效率的药物发现筛选装置。药物发现筛选装置包括图像测量单元，与图像测量单元一体连接的培养箱单元，设置在培养箱单元的固定台，第一输送装置，用于取出储存在培养箱单元的转盘中的板之一和输送将板移动到固定台上，第二输送装置，用于取出输送到固定台上的板，并将板输送到设置在图像测量单元上的XY台上;控制单元，其中第二输送装置包括第一和第二输送分别由传送单元支撑部分水平地支撑的臂，其将板传送到固定台和XY台上，以允许各个板彼此交叉。

10. 发明授权

US07692856B2 Focus error detecting optical system for a microscope 有权
标题翻译：用于显微镜的聚焦误差检测光学系统
公开(公告)号：US07692856B2
公开(公告)日：2010-04-06
申请号：US11730438
申请日：2007-04-02
申请人： Kenta Mikuriya , Takayuki Kei , Yasunori Yokoyama , Naomichi Chida , Yoshiaki Naganuma
发明人： Kenta Mikuriya , Takayuki Kei , Yasunori Yokoyama , Naomichi Chida , Yoshiaki Naganuma
IPC分类号： G02B21/00
CPC分类号： G02B21/245
摘要： A focus error detecting optical system has an optical parameter which makes a focus lock-in range by a focus error signal be a value capable of detecting focus on a front surface of a cover glass and focus on a back surface thereof separately. A control section, based on the focus error signal obtained by the focus error detecting optical system, brings a focal point of an observational optical system to a focus position. Further, focus error detecting optical systems include optical units each having an optical parameter corresponding to a numerical aperture of respective objective lenses. A control section selects the optical unit of the focus error detecting optical system corresponding to the objective lens in use. The control section, using a focus error signal obtained by the selected focus error detecting optical system, brings a focal point of an observational optical system to a focus position.
摘要翻译：聚焦误差检测光学系统具有通过聚焦误差信号使焦点锁定范围成为能够检测聚焦在盖玻璃的前表面并分别聚焦在其背面上的值的光学参数。基于由聚焦误差检测光学系统获得的聚焦误差信号的控制部分将观察光学系统的焦点带到聚焦位置。此外，聚焦误差检测光学系统包括各自具有对应于各个物镜的数值孔径的光学参数的光学单元。控制部选择与使用中的物镜对应的聚焦误差检测光学系统的光学单元。使用由所选择的聚焦误差检测光学系统获得的聚焦误差信号的控制部分将观察光学系统的焦点带到聚焦位置。

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