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1. 发明申请

US20110243850A1 PROBE FOR A BIOLOGICAL SPECIMEN AND LABELLING METHOD AND SCREENING METHOD USING THE PROBE 审中-公开
标题翻译：用于生物样本和标记方法的探索和使用探针的筛选方法
公开(公告)号：US20110243850A1
公开(公告)日：2011-10-06
申请号：US13133381
申请日：2009-12-24
申请人： Taichi Shintou , Takeshi Miyazaki , Masashi Hirose , Taketoshi Okubo , Kohei Watanabe , Tsuyoshi Nomoto , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
发明人： Taichi Shintou , Takeshi Miyazaki , Masashi Hirose , Taketoshi Okubo , Kohei Watanabe , Tsuyoshi Nomoto , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
IPC分类号： A61K49/00 , C07D417/10 , C07D417/14 , C07D209/94 , C07D403/10 , C07D413/10 , C07D409/10 , C07D401/10 , C07D405/10 , G01N1/30
CPC分类号： A61K51/0453 , A61K49/0002 , A61K49/0008 , A61K49/0021 , A61K49/006 , A61K49/10 , C07D209/08 , C07D209/86 , C07D209/94 , C07D401/08 , C07D403/06 , C07D403/08 , C07D413/08 , C07D417/06 , C07D417/14 , C09B23/0091 , C09B23/04 , C09B23/105 , G01N33/582 , G01N2333/4603 , G01N2500/10
摘要： Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I).
摘要翻译：本发明提供了一种用于标记本身并且清楚地观察生物体中的特定细胞和特定细胞器官之一的生物样本的新型探针，所述探针具有优异的光谱特性并且显示出优异的储存稳定性。用于生物样品的探针作为活性剂含有至少一种由通式（I）表示的化合物。

2. 发明授权

US08460639B2 Probe for a hair cell, and labelling method for a hair cell using the probe for a hair cell 有权
标题翻译：针对毛细胞的探针，以及使用毛细胞探针的毛细胞的标记方法
公开(公告)号：US08460639B2
公开(公告)日：2013-06-11
申请号：US12644472
申请日：2009-12-22
申请人： Tsuyoshi Nomoto , Takeshi Miyazaki , Kohei Watanabe , Taichi Shintou , Kaoru Takahashi , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
发明人： Tsuyoshi Nomoto , Takeshi Miyazaki , Kohei Watanabe , Taichi Shintou , Kaoru Takahashi , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
IPC分类号： A61B5/00
CPC分类号： G01N33/5005 , A61K49/0032 , A61K49/0041 , A61K49/006 , C09B11/24 , C09B23/0016 , C09B23/0058 , C09B23/0066 , C09B23/0075 , C09B23/06 , C09B23/105 , C09B23/107 , G01N33/5044 , G01N33/6893 , G01N2800/14 , G01N2800/20
摘要： Provided are a novel probe for a hair cell for clearly identifying various conditions of a hair cell, and a labelling method for a hair cell using the probe for a hair cell, more particularly, a probe for a hair cell containing, as an active agent, a staining compound represented by the general formula (I)
摘要翻译：本发明提供一种用于毛细胞的新型探针，用于清楚地识别毛细胞的各种条件，以及使用毛细胞探针的毛细胞的标记方法，更具体地，涉及含有作为活性成分的毛细胞的探针，由通式（I）表示的染色化合物，

3. 发明申请

US20110236310A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD 审中-公开
标题翻译：内标组织的标签组合物，标记物的标记方法和筛选方法
公开(公告)号：US20110236310A1
公开(公告)日：2011-09-29
申请号：US13133357
申请日：2009-12-24
申请人： Kohei Watanabe , Taichi Shintou , Tsuyoshi Nomoto , Takeshi Miyazaki , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
发明人： Kohei Watanabe , Taichi Shintou , Tsuyoshi Nomoto , Takeshi Miyazaki , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
IPC分类号： A61K49/00 , C07D221/18 , A61K51/04 , C07D491/14 , C09B1/54 , C07D311/82 , C07D417/06 , A61K51/08
CPC分类号： A61K49/0021 , A61K49/0002 , A61K49/0039 , A61K49/0041 , A61K49/006 , C07D209/70 , C07D209/96 , C07D215/00 , C07D221/14 , C07D221/18 , C07D263/54 , C07D277/34 , C07D277/36 , C07D277/64 , C07D311/82 , C07D311/86 , C07D405/04 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14 , C07D491/052 , C07D491/12 , C07D497/10 , G01N33/5088 , G01N33/582 , G01N2333/4603
摘要： The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as exposure of an ocular tissue or injection of a staining agent into the ocular tissue or a nerve tissue linking to the ocular tissue, a method of noninvasively labeling an intraocular tissue of a living individual, and a screening method using the labeling composition for the intraocular tissues. The composition contains a compound capable of labeling at least a photoreceptor cell layer of a retina, wherein the compound is a staining compound having a particular structure as a partial structure thereof.
摘要翻译：本发明提供了一种用于生物个体的眼内组织的标记组合物，其特异性地标记眼内组织，而不需要诸如眼组织的暴露或注射染色剂的侵入性手术或连接到眼组织的神经组织眼组织，活体标记眼内组织的方法，以及使用眼内组织标记组合物的筛选方法。该组合物含有能够至少标记视网膜感光细胞层的化合物，其中该化合物是具有特定结构的染色化合物作为其部分结构。

4. 发明申请

US20100166663A1 PROBE FOR A HAIR CELL, AND LABELLING METHOD FOR A HAIR CELL USING THE PROBE FOR A HAIR CELL 有权
标题翻译：毛发细胞的探针和使用毛发细胞的毛发细胞的标记方法
公开(公告)号：US20100166663A1
公开(公告)日：2010-07-01
申请号：US12644472
申请日：2009-12-22
申请人： Tsuyoshi Nomoto , Takeshi Miyazaki , Kohei Watanabe , Taichi Shintou , Kaoru Takahashi , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
发明人： Tsuyoshi Nomoto , Takeshi Miyazaki , Kohei Watanabe , Taichi Shintou , Kaoru Takahashi , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada , Norihiro Nishimura
IPC分类号： A61K49/00 , A61P27/16
CPC分类号： G01N33/5005 , A61K49/0032 , A61K49/0041 , A61K49/006 , C09B11/24 , C09B23/0016 , C09B23/0058 , C09B23/0066 , C09B23/0075 , C09B23/06 , C09B23/105 , C09B23/107 , G01N33/5044 , G01N33/6893 , G01N2800/14 , G01N2800/20
摘要： Provided are a novel probe for a hair cell for clearly identifying various conditions of a hair cell, and a labelling method for a hair cell using the probe for a hair cell, more particularly, a probe for a hair cell containing, as an active agent, at least one kind selected from staining compounds represented by one of the general formulae (I) and (II), and a labelling method for a hair cell using the probe for a hair cell.
摘要翻译：本发明提供一种用于毛细胞的新型探针，用于清楚地识别毛细胞的各种条件，以及使用毛细胞探针的毛细胞的标记方法，更具体地，涉及含有作为活性成分的毛细胞的探针，选自由通式（I）和（II）之一表示的染色化合物中的至少一种，以及使用毛细胞探针的毛细胞的标记方法。

5. 发明授权

US10227337B2 Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability 有权
公开(公告)号：US10227337B2
公开(公告)日：2019-03-12
申请号：US13397759
申请日：2012-02-16
申请人： Toshio Tanaka , Kohei Watanabe , Tsuyoshi Nomoto , Mie Okano , Taichi Shintou , Takeshi Miyazaki , Yuhei Nishimura , Yasuhito Shimada
发明人： Toshio Tanaka , Kohei Watanabe , Tsuyoshi Nomoto , Mie Okano , Taichi Shintou , Takeshi Miyazaki , Yuhei Nishimura , Yasuhito Shimada
IPC分类号： C07D417/06 , C07D417/14 , C09B23/04 , C09B23/06 , G01N33/50
摘要： Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).

6. 发明申请

US20110189096A1 CENTRAL NERVOUS SYSTEM TISSUE-LABELING COMPOSITION, METHOD FOR LABELING CENTRAL NERVOUS SYSTEM TISSUE, AND SCREENING METHOD USING CENTRAL NERVOUS SYSTEM TISSUE-LABELING COMPOSITION 审中-公开
标题翻译：中央神经系统组织标签组合物，标记中心神经系统组织的方法和使用中央神经系统组织标记组合物的筛选方法
公开(公告)号：US20110189096A1
公开(公告)日：2011-08-04
申请号：US13084997
申请日：2011-04-12
申请人： Kohei Watanabe , Taichi Shintou , Tsuyoshi Nomoto , Takeshi Miyazaki , Mie Okano , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada
发明人： Kohei Watanabe , Taichi Shintou , Tsuyoshi Nomoto , Takeshi Miyazaki , Mie Okano , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada
IPC分类号： A61K49/00 , C07D221/18 , C07D491/147 , C07D221/14 , C07D417/10 , C07D417/06
CPC分类号： A61K49/0032 , A61K49/0039 , A61K49/006 , C07D417/06 , G01N33/50 , G01N33/58 , G01T1/161
摘要： To provide a central nervous system tissue-labeling composition labeling the central nervous tissue system. Also, another object of the present invention is to provide a method for non-invasively labeling the central nervous tissue system. Further, another object of the present invention is to provide a screening method using the above central nervous system tissue-labeling composition. A central nervous system tissue-labeling composition containing, as an active ingredient, at least one of compounds represented by the general formula (1) or (7).
摘要翻译：提供标记中枢神经组织系统的中枢神经系统组织标记组合物。此外，本发明的另一个目的是提供一种非侵入性标记中枢神经组织系统的方法。此外，本发明的另一个目的是提供一种使用上述中枢神经系统组织标记组合物的筛选方法。一种中枢神经系统组织标记组合物，含有由通式（1）或（7）表示的至少一种化合物作为活性成分。

7. 发明授权

US08652438B2 Central nervous system labelling composition for intranasal administration and labelling method and screening method using central nervous system labelling composition for intranasal administration 有权
标题翻译：用于鼻内给药的中枢神经系统标记组合物和用于鼻内给药的中枢神经系统标记组合物的标记方法和筛选方法
公开(公告)号：US08652438B2
公开(公告)日：2014-02-18
申请号：US13084971
申请日：2011-04-12
申请人： Tsuyoshi Nomoto , Kohei Watanabe , Taichi Shintou , Takeshi Miyazaki , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada
发明人： Tsuyoshi Nomoto , Kohei Watanabe , Taichi Shintou , Takeshi Miyazaki , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/0004 , A61K49/0032 , A61K49/0041 , A61K51/0446
摘要： There is provided a central nervous system labelling composition for intranasal administration for the purpose of labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration. Additionally, there is provided a method of non-invasively labelling the central nervous system by way of an administration route that entails little transferability to the entire body. Furthermore, there is provided a screening method using a central nervous system labelling composition for intranasal administration. A central nervous system labelling composition for intranasal administration is characterized by labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration and by containing at least one compound expressed either by the general formula (1) or the general formula (2) shown below as effective component:
摘要翻译：提供了用于鼻内给药的中枢神经系统标记组合物，用于通过嗅球通过鼻涕管理从嗅觉上皮标记中枢神经系统的目的。此外，提供了一种通过对整个身体几乎不具有转移性的给药途径非侵入性地标记中枢神经系统的方法。此外，提供了一种使用中枢神经系统标记组合物进行鼻内给药的筛选方法。用于鼻内给药的中枢神经系统标记组合物的特征在于通过嗅球标记嗅觉上皮的中枢神经系统，并通过鼻内给药并含有至少一种由通式（1）或以下所示的通式（2）为有效成分：

8. 发明申请

US20120207683A1 EVALUATION PROBE FOR CENTRAL NERVOUS SYSTEM PERMEABILITY, EVALUATION METHOD FOR CENTRAL NERVOUS SYSTEM PERMEABILITY, AND SCREENING METHOD USING AN EVALUATION PROBE FOR CENTRAL NERVOUS SYSTEM PERMEABILITY 审中-公开
标题翻译：用于中央神经系统渗透性的评估探针，用于中央神经系统渗透性的评估方法和使用评估探针进行中央神经系统渗透性的筛选方法
公开(公告)号：US20120207683A1
公开(公告)日：2012-08-16
申请号：US13397759
申请日：2012-02-16
申请人： Toshio Tanaka , Kohei Watanabe , Tsuyoshi Nomoto , Mie Okano , Taichi Shintou , Takeshi Miyazaki , Yuhei Nishimura , Yasuhito Shimada
发明人： Toshio Tanaka , Kohei Watanabe , Tsuyoshi Nomoto , Mie Okano , Taichi Shintou , Takeshi Miyazaki , Yuhei Nishimura , Yasuhito Shimada
IPC分类号： A61K49/00 , G01N21/64 , C07D417/10
CPC分类号： C07D417/06 , C07D417/14 , C09B23/04 , C09B23/06 , G01N33/5082 , G01N33/5088 , G01N2333/4603 , G01N2800/28
摘要： Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).
摘要翻译：提供能够通过中枢神经系统组织光学评价物质的透过性的评价探针。还提供了使用中枢神经系统渗透性的评价探针通过中枢神经系统组织的物质的渗透性的评价方法。还提供了使用评估探针进行中枢神经系统渗透性的筛选方法。用于中枢神经系统渗透性的评估探针包括作为活性成分的至少一种由以下通式（1）表示的化合物。

9. 发明申请

US20110182810A1 CENTRAL NERVOUS SYSTEM LABELLING COMPOSITION FOR INTRANASAL ADMINISTRATION AND LABELLING METHOD AND SCREENING METHOD USING CENTRAL NERVOUS SYSTEM LABELLING COMPOSITION FOR INTRANASAL ADMINISTRATION 有权
标题翻译：中央神经系统标签组合物，用于内窥镜管理和标记方法和筛选方法，使用中央神经系统标签组合物进行管理管理
公开(公告)号：US20110182810A1
公开(公告)日：2011-07-28
申请号：US13084971
申请日：2011-04-12
申请人： Tsuyoshi Nomoto , Kohei Watanabe , Taichi Shintou , Takeshi Miyazaki , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada
发明人： Tsuyoshi Nomoto , Kohei Watanabe , Taichi Shintou , Takeshi Miyazaki , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada
IPC分类号： A61K51/04 , A61K49/10
CPC分类号： A61K49/0004 , A61K49/0032 , A61K49/0041 , A61K51/0446
摘要： There is provided a central nervous system labelling composition for intranasal administration for the purpose of labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration. Additionally, there is provided a method of non-invasively labelling the central nervous system by way of an administration route that entails little transferability to the entire body. Furthermore, there is provided a screening method using a central nervous system labelling composition for intranasal administration. A central nervous system labelling composition for intranasal administration is characterized by labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration and by containing at least one compound expressed either by the general formula (1) or the general formula (2) shown below as effective component:
摘要翻译：提供了用于鼻内给药的中枢神经系统标记组合物，用于通过嗅球通过鼻涕管理从嗅觉上皮标记中枢神经系统的目的。此外，提供了一种通过对整个身体几乎不具有转移性的给药途径非侵入性地标记中枢神经系统的方法。此外，提供了一种使用中枢神经系统标记组合物进行鼻内给药的筛选方法。用于鼻内给药的中枢神经系统标记组合物的特征在于通过嗅球标记嗅觉上皮的中枢神经系统，并通过鼻内给药并含有至少一种由通式（1）或以下所示的通式（2）为有效成分：

10. 发明授权

US08243266B2 Sample observation system and sample observation process 有权
标题翻译：样品观察系统和样品观察过程
公开(公告)号：US08243266B2
公开(公告)日：2012-08-14
申请号：US12788136
申请日：2010-05-26
申请人： Kohei Watanabe , Tsuyoshi Nomoto , Takeshi Miyazaki , Toshio Tanaka , Yasuhito Shimada
发明人： Kohei Watanabe , Tsuyoshi Nomoto , Takeshi Miyazaki , Toshio Tanaka , Yasuhito Shimada
IPC分类号： G01N1/10
CPC分类号： G01N35/00
摘要： A sample observation system and a sample observation process are provided which do not need any special manipulation or treatment to limit the motion of the sample or adjust the orientation of the sample when observing the sample, and enable observation of samples simply from wider direction than ever. A sample observation system of a sample whose vertical direction is defined by gravity, wherein the system at least includes a sample holder having at least one penetrating hole for retaining a liquid containing the sample; an observation unit for observing the sample; and an angle adjusting unit for varying the angle of the observation unit to the direction of the gravity which acts on the sample in a condition in which the sample holder and the observation unit have a fixed relative angle therebetween.
摘要翻译：提供样品观察系统和样品观察过程，其不需要任何特殊的操作或处理来限制样品的运动或在观察样品时调整样品的取向，并且能够简单地从宽的方向观察样品。样品的样品观察系统，其垂直方向由重力限定，其中所述系统至少包括具有至少一个用于保持含有样品的液体的穿透孔的样品保持器; 用于观察样品的观察单元; 以及角度调整单元，用于在样本保持器和观察单元之间具有固定的相对角度的状态下，改变观察单元与作用在样本上的重力方向的角度。

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