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1. 发明授权

US4517300A Plasmid pSAN 181 失效
标题翻译：质粒pSAN 181
公开(公告)号：US4517300A
公开(公告)日：1985-05-14
申请号：US475245
申请日：1983-03-14
申请人： Taichi Manome , Toshinori Ohmine , Takao Okazaki , Mamoru Arai
发明人： Taichi Manome , Toshinori Ohmine , Takao Okazaki , Mamoru Arai
IPC分类号： C12N15/09 , C07H21/04 , C12N15/76 , C12P19/34 , C12R1/465 , C12N1/00 , C12N15/00
CPC分类号： C12N15/76
摘要： A novel plasmid, named pSAN 181, has a molecular weight of 5.+-.0.2 megadaltons and single cleavage sites for each of the restriction endonucleases BamHI, PstI, XhoI and BglII, the positions of said sites being 0, about 0.85, about 1.15 and about 3.95 megadaltons from the cleavage site of BamHI. The plasmid is extracted from mycelia of microorganisms of the species Streptomyces fulvoviridis, especially the strain Streptomyces fulvoviridis FERM P-6279, and is useful as a vector for genetic engineering.
摘要翻译：命名为pSAN 181的新型质粒具有5 +/- 0.2兆道尔顿的分子量和每个限制性内切核酸酶BamHI，PstI，XhoI和BglII的单个切割位点，所述位点的位置为0，约0.85，约1.15 和约3.95兆巴斯从BamHI的切割位点。该质粒是从链霉菌链霉菌（Streptomyces fulvoviridis）的微生物的菌丝体中提取的，特别是菌丝霉菌菌丝霉F-P-6279菌株，可用作基因工程载体。

2. 发明授权

US4332902A Antibiotic substance 失效
标题翻译：抗生素
公开(公告)号：US4332902A
公开(公告)日：1982-06-01
申请号：US197788
申请日：1980-10-17
申请人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
发明人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P31/04 , C07G11/00 , C07K7/50 , C07K11/02 , C07K14/195 , C07K14/365 , C07K14/41 , C12P1/06 , C12R1/045 , C12N1/20
CPC分类号： C12R1/045 , C07K14/365 , C12P1/06 , Y10S435/827
摘要： A novel antibiotic substance, named "Mycoplanecin", of presently unknown structural formula, is produced by cultivating a Mycoplanecin-producing microorganism of the genus Actinoplanes, especially the Actinoplanes nov. sp. Strain No. 41042, NRRL No. 11462.
摘要翻译：目前未知的结构式的名为“Mycoplanecin”的新型抗生素物质是通过培养生长在肌球蛋白的肌球蛋白生成微生物，尤其是Actinoplanes nov。 sp。菌株41042，NRRL No.11462。

3. 发明授权

US3958481A Apparatus for cutting a moving object into a predetermined length 失效
标题翻译：用于将移动物体切割成预定长度的装置
公开(公告)号：US3958481A
公开(公告)日：1976-05-25
申请号：US594650
申请日：1975-07-10
申请人： Mamoru Arai
发明人： Mamoru Arai
IPC分类号： B26D1/58 , B65B61/06 , B26D1/56
CPC分类号： B26D1/585 , B65B61/06 , Y10T83/4737 , Y10T83/4749 , Y10T83/4766
摘要： An apparatus for cutting a moving object into pieces of a fixed length, wherein an upper cutter base disposed at a specified distance from a lower cutter base is installed on the upper portion of rods supported to be vertically movable through vertical holes formed in the lower cutter base which is supported transversely on the frame in a rotatable fashion, said upper and lower cutter bases are respectively equipped with the upper and lower cutters confronting each other, the lower ends of said rods are pivotally connected to eccentric positions on the crank discs which are supported vertically on the frame in a rotatable fashion, and said crank discs are rotated by a driving mechanism.
摘要翻译：一种用于将移动物体切割成固定长度的装置，其中设置在距离下切割器底座特定距离处的上刀具底座安装在杆的上部，杆的上部可通过形成在下刀具中的竖直孔垂直移动底座，其以可旋转的方式横向支撑在框架上，所述上下切割器基座分别配备有彼此面对的上切割器和下切割器，所述杆的下端枢转地连接到曲柄盘上的偏心位置，以可旋转的方式垂直地支撑在框架上，并且所述曲柄盘由驱动机构旋转。

4. 发明授权

US3949070A New antibiotic substance, its preparation and its use as growth promoting agents 失效
标题翻译：新型抗生素物质，其制备及其用作生长促进剂
公开(公告)号：US3949070A
公开(公告)日：1976-04-06
申请号：US545391
申请日：1975-01-30
申请人： Mamoru Arai , Akio Torikata , Hisayoshi Fukatsu , Noritoshi Kitano , Toshiaki Matsuzawa
发明人： Mamoru Arai , Akio Torikata , Hisayoshi Fukatsu , Noritoshi Kitano , Toshiaki Matsuzawa
IPC分类号： A61K35/00
CPC分类号： A61K31/7024 , A23K20/195 , A23K50/30 , A23K50/75
摘要： Antibiotic substance named "Pholipomycin" which is useful as a growth promoting agent for domestic animals, poultries and the like and produced by the cultivation of a new microorganism, Streptomyces lividoclavatus strain No. 3176, NRRL 8022.
摘要翻译：名叫“倍利宝霉素”的抗生素物质可用作家畜，禽类等的生长促进剂，通过培养新的微生物链霉菌菌株3176，NRRL8022产生。

5. 发明授权

US4374764A Macrolide antibiotic 失效
标题翻译：大环内酯类抗生素
公开(公告)号：US4374764A
公开(公告)日：1983-02-22
申请号：US199238
申请日：1980-10-21
申请人： Mamoru Arai , Tatsuo Haneishi , Mutsuo Nakajima
发明人： Mamoru Arai , Tatsuo Haneishi , Mutsuo Nakajima
IPC分类号： A61K38/00 , A61P31/04 , A61P31/06 , C07K1/02 , C07K1/113 , C07K7/06 , C07K14/195 , C07K14/41 , C12P21/02 , C12R1/045 , C07C103/52
CPC分类号： C12R1/045 , C07K7/06 , A61K38/00 , Y10S930/17 , Y10S930/19
摘要： Macrolide antibiotics are derivatives of the compound Mycoplanecin and have the formula: ##STR1## (in which R represents a hydrogen atom or an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group). The compound in which R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group can be prepared by reducing Mycoplanecin and the compound in which R represents a hydrogen atom can be prepared by the hydrolysis of Mycoplanecin or of the compound of formula (I) in which R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group.
摘要翻译：大环内酯类抗生素是化合物Mycoplanecin的衍生物，具有下式：其中R表示氢原子或N-（α-羟基丁酰）-N-甲基缬氨酰基）。其中R表示N-（α-羟基丁酰基）-N-甲基缬氨酰基的化合物可以通过降低Mycoplanecin来制备，其中R表示氢原子的化合物可以通过水解平均支原体或式 I），其中R表示N-（α-羟基丁酰基）-N-甲基缬氨酰基。

6. 发明授权

US4336249A Antibiotic substance 失效
公开(公告)号：US4336249A
公开(公告)日：1982-06-22
申请号：US41501
申请日：1979-05-22
申请人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
发明人： Mamoru Arai , Akio Torikata , Ryuzou Enokita , Tatsuo Haneishi , Mutsuo Nakajima
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P31/04 , C07G11/00 , C07K7/50 , C07K11/02 , C07K14/195 , C07K14/365 , C07K14/41 , C12P1/06 , C12R1/045 , A61K35/00
CPC分类号： C12R1/045 , C07K14/365 , C12P1/06 , Y10S435/827
摘要： A novel antibiotic substance, named "Mycoplanecin", of presently unknown structural formula, is produced by cultivating a Mycoplanecin-producing microorganism of the genus Actinoplanes, especially the Actinoplanes nov. sp. Strain No. 41042, NRRL No. 11462.

7. 发明授权

US4370266A Mycoplanecin derivatives and their preparation 失效
标题翻译：髓鞘衍生物及其制备方法
公开(公告)号：US4370266A
公开(公告)日：1983-01-25
申请号：US250709
申请日：1981-04-03
申请人： Mamoru Arai , Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Ryuzo Enokita
发明人： Mamoru Arai , Tatsuo Haneishi , Mutsuo Nakajima , Akio Torikata , Ryuzo Enokita
IPC分类号： A61K38/00 , C07K7/06 , C12P21/04 , C07C103/52
CPC分类号： C12R1/045 , C07K7/06 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： Mycoplanecin derivatives of formula (I): ##STR1## [wherein: R represents a hydrogen atom, an N-(.alpha.-ketobutyryl)-N-methylvalyl group or an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group;R.sup.1 represents a methyl group or an ethyl group; andwhen R.sup.1 represents a methyl group, R.sup.2 represents an isobutyl group and, when R.sup.1 represents an ethyl group, R.sup.2 represents a pentyl group] have antibacterial activity which is particularly pronounced against bacteria of the genus Mycobacterium. The compounds in which R represents and N-(.alpha.-ketobutyryl)-N-methylvalyl group, named Mycoplanecin B (R.sup.1 represents a methyl group) and Mycoplanecin C (R.sup.1 represents an ethyl group), may be prepared by cultivation of a microorganism of the genus Actinoplanes, while the compounds where R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group or a hydrogen atom can be prepared by reducing the corresponding compound where R represents an N-(.alpha.-ketobutyryl)-N-methylvalyl group or by hydrolyzing the corresponding compound where R represents an N-(.alpha.-ketobutyryl)-N-methylvalyl or N-(.alpha.-hydroxybutyryl)-N-methylvalyl group, respectively.
摘要翻译：式（I）的肌钙蛋白聚糖衍生物：其中：R表示氢原子，N-（α-酮丁酰基）-N-甲基缬氨酰基或N-（α-羟基丁酰基）-N-甲基缬氨酰基 ; R1表示甲基或乙基; 当R1表示甲基时，R2表示异丁基，当R1表示乙基时，R2表示戊基]具有对分枝杆菌属细菌特别显着的抗菌活性。其中R表示的化合物和N-（α-酮丁酰基）-N-甲基缬氨酰基，命名为Mycoplanecin B（R1表示甲基）和Mycoplanecin C（R1表示乙基））可以通过培养其中R代表N-（α-羟基丁酰基）-N-甲基缬氨酰基或氢原子的化合物可以通过还原相应的化合物来制备，其中R代表N-（α-酮丁酰基）-N-甲基缬氨酰基或通过水解相应的化合物，其中R表示N-（α-酮丁酰基）-N-甲基缬氨酰基或N-（α-羟基丁酰基）-N-甲基缬氨酰基。

8. 发明授权

US4201769A Antibiotic substances No. 17927A.sub.1 and No. 17927A.sub.2 and process for producing the same 失效
标题翻译：抗生素物质17927A1和17927A2及其制备方法
公开(公告)号：US4201769A
公开(公告)日：1980-05-06
申请号：US882187
申请日：1978-02-28
申请人： Yasuhiro Itoh , Masaki Nakahara , Yo Takiguchi , Mamoru Arai , Tatsuo Haneishi , Masatoshi Inukai , Mutsuo Nakajima
发明人： Yasuhiro Itoh , Masaki Nakahara , Yo Takiguchi , Mamoru Arai , Tatsuo Haneishi , Masatoshi Inukai , Mutsuo Nakajima
IPC分类号： C12P13/00 , A61K20060101 , A61K35/74 , A61K39/00 , A61P31/04 , C07G11/00 , C07G99/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06
摘要： New antibiotic substances named substance No. 17927A.sub.2 and substance No. 17927A.sub.1 produced by cultivation of substances No. 17927A.sub.2 and No. 17927A.sub.1 -producing microorganisms belonging to the genus Streptomyces as well as pharmaceutically-acceptable salts thereof. They have broad antibacterial activities and also .beta.-lactamase inhibitory action so that they show synergistic actions with known penicillins and cephalosporins.
摘要翻译：通过种植属于链霉菌属的第17927A2号物质和第17927A1号产生微生物以及其药学上可接受的盐生产的名称为物质No.17927A2和物质号17927A1的新型抗生素物质。它们具有广泛的抗菌活性和β-内酰胺酶抑制作用，使其与已知的青霉素和头孢菌素显示协同作用。

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