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1. 发明申请

US20070043056A1 5-Substituted-2-arylpyrazines 审中-公开
标题翻译： 5-取代的2-芳基吡嗪
公开(公告)号：US20070043056A1
公开(公告)日：2007-02-22
申请号：US11585405
申请日：2006-10-23
申请人： Taeyoung Yoon , Ping Ge , Stephane De Lombaert , Raymond Horvath , Dario Doller , Kevin Hodgetts , Lu Yan Zhang , Bernd Kaiser , Xuechun Zhang , Cunyu Zhang , Jim Darrow , Yasuchika Yamaguchi
发明人： Taeyoung Yoon , Ping Ge , Stephane De Lombaert , Raymond Horvath , Dario Doller , Kevin Hodgetts , Lu Yan Zhang , Bernd Kaiser , Xuechun Zhang , Cunyu Zhang , Jim Darrow , Yasuchika Yamaguchi
IPC分类号： A61K31/4965 , A61K31/497 , C07D403/04
CPC分类号： C07D241/12 , C07D241/18 , C07D241/20 , C07D241/26 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04
摘要： Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供新的5-取代-2-芳基吡嗪化合物。这些化合物可以作为CRF受体的选择性调节剂。本文提供的5-取代-2-芳基吡嗪化合物可用于治疗许多CNS和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。提供的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

2. 发明授权

US07179807B2 5-substituted-2-arylpyrazines 失效
标题翻译： 5-取代-2-芳基吡嗪
公开(公告)号：US07179807B2
公开(公告)日：2007-02-20
申请号：US10645312
申请日：2003-08-20
申请人： Taeyoung Yoon , Ping Ge , Stéphane De Lombaert , Raymond F. Horvath , Dario Doller , Kevin J. Hodgetts , Lu Yan Zhang , Bernd Kaiser , Xuechun Zhang , Yasuchika Yamaguchi , Cunyu Zhang , Jim Darrow
发明人： Taeyoung Yoon , Ping Ge , Stéphane De Lombaert , Raymond F. Horvath , Dario Doller , Kevin J. Hodgetts , Lu Yan Zhang , Bernd Kaiser , Xuechun Zhang , Yasuchika Yamaguchi , Cunyu Zhang , Jim Darrow
IPC分类号： A61K31/535 , A61K31/497 , A61K31/4965 , C07D413/00 , C07D403/00
CPC分类号： C07D241/12 , C07D241/18 , C07D241/20 , C07D241/26 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04
摘要： Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators or CRF receptors. Compounds of the invention are provided by the following formula: The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and periphercal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided.Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供新的5-取代-2-芳基吡嗪化合物。这些化合物可以作为选择性调节剂或CRF受体。本发明化合物由下式提供：本文提供的5-取代-2-芳基吡嗪化合物可用于治疗多种CNS和外周疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。提供的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

3. 发明申请

US20050113379A1 Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands 审中-公开
标题翻译：杂芳基稠合吡啶，吡嗪和嘧啶作为CRF1受体配体
公开(公告)号：US20050113379A1
公开(公告)日：2005-05-26
申请号：US10933834
申请日：2004-09-03
申请人： Ping Ge , Raymond Horvath , Lu Yan Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao , Stanly John , Neil Moorcroft , Greg Shutske
发明人： Ping Ge , Raymond Horvath , Lu Yan Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao , Stanly John , Neil Moorcroft , Greg Shutske
IPC分类号： A61K31/437 , A61K31/4375 , A61K31/4985 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/522 , C07D473/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , C07D487/04
摘要： Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了作为CRF 1受体的选择性调节剂的取代的杂芳基稠合的吡啶，吡嗪和嘧啶化合物。这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

4. 发明申请

US20060199823A1 Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands 审中-公开
标题翻译：杂芳基稠合吡啶，吡嗪和嘧啶作为CRF1受体配体
公开(公告)号：US20060199823A1
公开(公告)日：2006-09-07
申请号：US11389646
申请日：2006-03-24
申请人： Ping Ge , Raymond Horvath , Lu Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao
发明人： Ping Ge , Raymond Horvath , Lu Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了作为CRF 1受体的选择性调节剂的取代的杂芳基稠合的吡啶，吡嗪和嘧啶化合物。这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

5. 发明申请

US20050070542A1 5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds 审中-公开
标题翻译： 5-芳基 - 吡唑并[4,3-d]嘧啶，吡啶和吡嗪及相关化合物
公开(公告)号：US20050070542A1
公开(公告)日：2005-03-31
申请号：US10933700
申请日：2004-09-03
申请人： Kevin Hodgetts , Stanly John , Neil Moorcroft , Greg Shutske , Bernd Kaiser , Yasuchika Yamaguchi , Ping Ge , Raymond Horvath
发明人： Kevin Hodgetts , Stanly John , Neil Moorcroft , Greg Shutske , Bernd Kaiser , Yasuchika Yamaguchi , Ping Ge , Raymond Horvath
IPC分类号： A61K31/519 , A61K31/53 , C07D471/04 , C07D487/02 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： 5-aryl-Pyrazolo[4,3-d]pyrimidines, 6-aryl-Pyrazolo[3,4-d]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了作为CRF 1受体的选择性调节剂的5-芳基 - 吡唑并[4,3-d]嘧啶，6-芳基 - 吡唑并[3,4-d]嘧啶和相关化合物以及其它化学相关化合物。这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

6. 发明授权

US07964646B2 3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译： 3,4-DI取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体
公开(公告)号：US07964646B2
公开(公告)日：2011-06-21
申请号：US11500739
申请日：2006-08-08
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
IPC分类号： C07C233/00 , A01N37/18
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译：公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。

7. 发明授权

US5712034A Cables protected against corrosion for a rubber article 失效
标题翻译：橡胶制品的电缆防腐蚀
公开(公告)号：US5712034A
公开(公告)日：1998-01-27
申请号：US671399
申请日：1996-06-26
申请人： Hendrik Stevens , Bernd Kaiser , Klaus Kleinhoff
发明人： Hendrik Stevens , Bernd Kaiser , Klaus Kleinhoff
IPC分类号： B60C9/00 , D07B1/06 , D02G3/00 , B32B15/00 , F16G1/00
CPC分类号： D07B1/0666 , B60C9/0007 , B60C9/0057 , D07B1/0646 , D07B2201/2011 , D07B2201/2012 , D07B2201/2013 , D07B2201/2023 , D07B2205/3071 , D07B2205/3089 , D07B2401/2025 , D07B2501/2046 , D07B2501/2076 , Y10T428/2933 , Y10T428/294 , Y10T428/2942 , Y10T428/2944
摘要： A rubber article has a body consisting of rubber and a reinforcement structure with cables embedded in the rubber body. The cables have at least one inner layer with at least one first filament wherein at least one first filament consists of a metallic alloy. The outermost layer has second filaments embedded adhesively in the rubber body. All of the first and second filaments that consist of a metallic alloy are coated with a corrosion-protective coating. The corrosion-protective coating for at least one of the first filaments consists of an intrinsically conductive polymer.
摘要翻译：橡胶制品具有由橡胶构成的主体和具有嵌入在橡胶体中的电缆的加强结构。电缆具有至少一个具有至少一个第一细丝的内层，其中至少一个第一细丝由金属合金组成。最外层具有粘附在橡胶体中的第二丝。由金属合金组成的所有第一和第二长丝涂覆有防腐蚀涂层。用于至少一个第一长丝的防腐蚀涂层由本征导电聚合物组成。

8. 发明授权

US5544544A Throttle trigger device for an internal combustion engine of a working tool 失效
标题翻译：用于工作工具内燃机的节气门触发装置
公开(公告)号：US5544544A
公开(公告)日：1996-08-13
申请号：US355852
申请日：1994-12-14
申请人： Klaus Hoppner , Bernd Kaiser
发明人： Klaus Hoppner , Bernd Kaiser
IPC分类号： F02D9/02 , F02D11/02 , G01D1/04 , G05G5/08
CPC分类号： F02D11/02 , Y10T74/20238 , Y10T74/2063
摘要： A throttle trigger device for an internal combustion engine of a working tool has a throttle trigger connected to the handle of the working tool so as to be pivotable about a pivot axis. A throttle trigger lock is connected to the handle of the working tool so as to be pivotable about a pivot axis. A spring is connected between the throttle trigger and the throttle trigger lock. The throttle trigger, the throttle trigger lock, and the spring form a unitary part. The spring rests at an abutment of the handle at least when under load such that the spring is divided into functionally independent sections, whereby a first section extends between the abutment and the throttle trigger and a second section extends between the abutment and the throttle trigger lock.
摘要翻译：用于工作工具的内燃机的节气门触发装置具有连接到作业工具的把手的节流触发器，以便绕枢转轴线枢转。节气门触发器锁连接到作业工具的把手，以便绕枢转轴线枢转。节气门触发器和节气门触发器锁之间连接一个弹簧。油门触发器，油门扳机锁和弹簧形成一体的部件。弹簧至少在负载下处于手柄的邻接处，使得弹簧被分成功能上独立的部分，由此第一部分在邻接部和节气门触发器之间延伸，并且第二部分在支座和节气门触发锁之间延伸。

9. 发明申请

US20070021494A1 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译： 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体
公开(公告)号：US20070021494A1
公开(公告)日：2007-01-25
申请号：US11500739
申请日：2006-08-08
申请人： Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
发明人： Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
IPC分类号： A61K31/4709 , A61K31/4436 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/381 , C07D409/02 , C07D413/02 , C07D417/02
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译：公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。

10. 发明授权

US07947720B2 3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译： 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体
公开(公告)号：US07947720B2
公开(公告)日：2011-05-24
申请号：US12352781
申请日：2009-01-13
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
IPC分类号： C07D261/04 , C07D327/04 , A01N43/80 , A01N43/06
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译：公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。

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