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1. 发明申请

US20050070542A1 5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds 审中-公开
标题翻译： 5-芳基 - 吡唑并[4,3-d]嘧啶，吡啶和吡嗪及相关化合物
公开(公告)号：US20050070542A1
公开(公告)日：2005-03-31
申请号：US10933700
申请日：2004-09-03
申请人： Kevin Hodgetts , Stanly John , Neil Moorcroft , Greg Shutske , Bernd Kaiser , Yasuchika Yamaguchi , Ping Ge , Raymond Horvath
发明人： Kevin Hodgetts , Stanly John , Neil Moorcroft , Greg Shutske , Bernd Kaiser , Yasuchika Yamaguchi , Ping Ge , Raymond Horvath
IPC分类号： A61K31/519 , A61K31/53 , C07D471/04 , C07D487/02 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： 5-aryl-Pyrazolo[4,3-d]pyrimidines, 6-aryl-Pyrazolo[3,4-d]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了作为CRF 1受体的选择性调节剂的5-芳基 - 吡唑并[4,3-d]嘧啶，6-芳基 - 吡唑并[3,4-d]嘧啶和相关化合物以及其它化学相关化合物。这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

2. 发明申请

US20050113379A1 Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands 审中-公开
标题翻译：杂芳基稠合吡啶，吡嗪和嘧啶作为CRF1受体配体
公开(公告)号：US20050113379A1
公开(公告)日：2005-05-26
申请号：US10933834
申请日：2004-09-03
申请人： Ping Ge , Raymond Horvath , Lu Yan Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao , Stanly John , Neil Moorcroft , Greg Shutske
发明人： Ping Ge , Raymond Horvath , Lu Yan Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao , Stanly John , Neil Moorcroft , Greg Shutske
IPC分类号： A61K31/437 , A61K31/4375 , A61K31/4985 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/522 , C07D473/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , C07D487/04
摘要： Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了作为CRF 1受体的选择性调节剂的取代的杂芳基稠合的吡啶，吡嗪和嘧啶化合物。这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

3. 发明申请

US20070043056A1 5-Substituted-2-arylpyrazines 审中-公开
标题翻译： 5-取代的2-芳基吡嗪
公开(公告)号：US20070043056A1
公开(公告)日：2007-02-22
申请号：US11585405
申请日：2006-10-23
申请人： Taeyoung Yoon , Ping Ge , Stephane De Lombaert , Raymond Horvath , Dario Doller , Kevin Hodgetts , Lu Yan Zhang , Bernd Kaiser , Xuechun Zhang , Cunyu Zhang , Jim Darrow , Yasuchika Yamaguchi
发明人： Taeyoung Yoon , Ping Ge , Stephane De Lombaert , Raymond Horvath , Dario Doller , Kevin Hodgetts , Lu Yan Zhang , Bernd Kaiser , Xuechun Zhang , Cunyu Zhang , Jim Darrow , Yasuchika Yamaguchi
IPC分类号： A61K31/4965 , A61K31/497 , C07D403/04
CPC分类号： C07D241/12 , C07D241/18 , C07D241/20 , C07D241/26 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04
摘要： Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供新的5-取代-2-芳基吡嗪化合物。这些化合物可以作为CRF受体的选择性调节剂。本文提供的5-取代-2-芳基吡嗪化合物可用于治疗许多CNS和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。提供的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

4. 发明申请

US20060199823A1 Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands 审中-公开
标题翻译：杂芳基稠合吡啶，吡嗪和嘧啶作为CRF1受体配体
公开(公告)号：US20060199823A1
公开(公告)日：2006-09-07
申请号：US11389646
申请日：2006-03-24
申请人： Ping Ge , Raymond Horvath , Lu Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao
发明人： Ping Ge , Raymond Horvath , Lu Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了作为CRF 1受体的选择性调节剂的取代的杂芳基稠合的吡啶，吡嗪和嘧啶化合物。这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

5. 发明申请

US20080015196A1 Imidazopyrazines, Imidazopyridines, and Imidazopyrimidines as Crf1 Receptor Ligands 审中-公开
标题翻译：咪唑并吡嗪，咪唑并吡啶和咪唑并嘧啶作为Crf1受体配体
公开(公告)号：US20080015196A1
公开(公告)日：2008-01-17
申请号：US11578254
申请日：2005-04-15
申请人： Dario Doller , Lu Zhang , Ping Ge , Yasuchika Yamaguchi , Raymond Horvath , Xuechun Zhang
发明人： Dario Doller , Lu Zhang , Ping Ge , Yasuchika Yamaguchi , Raymond Horvath , Xuechun Zhang
IPC分类号： A61K31/495 , C07D471/00 , C07D487/02 , G01N33/566
CPC分类号： C07D487/04 , C07D471/04
摘要： Novel aryl substituted imidazopyrazines, imidazopyrimidines, and imidazopyridines are provided. Such compounds can act as selective modulators of CRF receptors. The imidazopyrazines, imidazopyrimidines, and imidazopyridines compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供了新的芳基取代的咪唑并吡嗪，咪唑并嘧啶和咪唑并吡啶。这些化合物可以作为CRF受体的选择性调节剂。本文提供的咪唑并吡嗪，咪唑并嘧啶和咪唑并吡啶化合物可用于治疗许多CNS和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。提供的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

6. 发明申请

US20070225287A1 Substituted Arylpyrazines 审中-公开
标题翻译：取代的芳基吡嗪
公开(公告)号：US20070225287A1
公开(公告)日：2007-09-27
申请号：US11675648
申请日：2007-02-16
申请人： Taeyoung Yoon , Ping Ge , Raymond Horvath , Stephane DeLombaert , Kevin Hodgetts , Dario Doller , Cunyu Zhang
发明人： Taeyoung Yoon , Ping Ge , Raymond Horvath , Stephane DeLombaert , Kevin Hodgetts , Dario Doller , Cunyu Zhang
IPC分类号： A61K31/4965 , A61K31/496 , A61K31/497 , A61K31/5355
CPC分类号： C07D401/04 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5355 , C07D241/12 , C07D241/18 , C07D241/20 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/04
摘要： Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF1 receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.
摘要翻译：提供了芳基吡嗪化合物，包括可以以高亲和力和对CRF 1受体（包括人CRF 1受体）的高选择性结合的芳基吡嗪。因此，本发明包括治疗与CRF 1受体相关的疾病和疾病的方法，包括CNS相关疾病和疾病，特别是情感障碍和疾病，以及急性和慢性神经障碍和疾病。

7. 发明申请

US20050215559A1 Substituted arylpyrazines 失效
标题翻译：取代的芳基吡嗪
公开(公告)号：US20050215559A1
公开(公告)日：2005-09-29
申请号：US11107148
申请日：2005-04-15
申请人： Taeyoung Yoon , Ping Ge , Raymond Horvath , Stephane DeLombaert , Kevin Hodgetts , Dario Doller , Cunyu Zhang
发明人： Taeyoung Yoon , Ping Ge , Raymond Horvath , Stephane DeLombaert , Kevin Hodgetts , Dario Doller , Cunyu Zhang
IPC分类号： A61K31/4965 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P9/10 , A61P9/12 , A61P15/00 , A61P19/10 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D241/00 , C07D241/12 , C07D241/18 , C07D241/20 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D239/02
CPC分类号： C07D401/04 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5355 , C07D241/12 , C07D241/18 , C07D241/20 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/04
摘要： Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF1 receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.
摘要翻译：提供了芳基吡嗪化合物，包括可以以高亲和力和对CRF 1受体（包括人CRF 1受体）的高选择性结合的芳基吡嗪。因此，本发明包括治疗与CRF 1受体相关的疾病和疾病的方法，包括CNS相关疾病和疾病，特别是情感障碍和疾病，以及急性和慢性神经障碍和疾病。

8. 发明申请

US20080107608A1 5-Substituted-2-Arylpyridines 审中-公开
标题翻译： 5-取代的2-芳基吡啶
公开(公告)号：US20080107608A1
公开(公告)日：2008-05-08
申请号：US11749840
申请日：2007-05-17
申请人： Ping Ge , Taeyoung Yoon , Luyan Zhang , Raymond Horvath
发明人： Ping Ge , Taeyoung Yoon , Luyan Zhang , Raymond Horvath
IPC分类号： A61K31/44 , A61K31/4412 , A61K31/444 , A61K9/12 , A61P1/00 , A61P25/24 , C07D213/02
CPC分类号： C07D213/68 , C07D213/65 , C07D213/69 , C07D213/74 , C07D213/82 , C07D413/04
摘要： Novel 5-substituted-2-arylpyridine compounds are provided. Such compounds can act as selective modulators of CRP receptors. The 5-substituted-2-arylpyridine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
摘要翻译：提供新的5-取代-2-芳基吡啶化合物。这些化合物可以作为CRP受体的选择性调节剂。本文提供的5-取代-2-芳基吡啶化合物可用于治疗许多CNS和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。还提供了治疗这种疾病以及包装的药物组合物的方法。提供的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。给出了在受体定位研究中使用化合物的方法。

9. 发明申请

US20070128939A1 Stackable Cable Hanger 审中-公开
标题翻译：可堆叠电缆衣架
公开(公告)号：US20070128939A1
公开(公告)日：2007-06-07
申请号：US11618124
申请日：2006-12-29
申请人： David Low , Raymond Horvath , Albert Cox , Eric Nofziger , Richard Korczak
发明人： David Low , Raymond Horvath , Albert Cox , Eric Nofziger , Richard Korczak
IPC分类号： H01R9/03
CPC分类号： H02G3/30
摘要： A cable hanger having shell halves adapted to mate with each other, the shell halves each having an inner surface adapted to cooperate with the other to secure the cable within a cable space. The mating of the shell halves is releasably secured by a means for closure. A bolt hole through at least one of the shell halves allows easy mounting of the cable hanger. The shell halves each having, along a vertical mating surface, a means for interlocking adapted to interlock with the means for interlocking of a second cable hanger positioned against the cable hanger along the vertical mating surface. A connection side of the cable hanger may be adapted to have a means for latching to couple with a third cable hanger, positioned connection side to connection side with the cable hanger. The cable hanger allowing additional cables to be added without modifying the mounting of the base hanger.
摘要翻译：具有适于彼此配合的半壳的电缆吊架，每个半壳具有适于与另一个配合的内表面以将电缆固定在电缆空间内。壳半部的配合可通过封闭装置可释放地固定。通过半壳中的至少一个的螺栓孔允许电缆吊架的容易安装。沿着垂直配合表面具有适于互锁的装置的壳体半部分，其适于与沿着垂直配合表面定位成抵靠电缆吊架的第二电缆吊架互锁的装置互锁。电缆悬挂器的连接侧可以适于具有用于锁定的装置，以与与电缆吊架的连接侧定位在连接侧的第三电缆吊架连接。电缆吊架允许添加额外的电缆，而不改变底座衣架的安装。

10. 发明授权

US06955558B1 Cable and apparatus interface security device 有权
标题翻译：电缆和设备接口安全设备
公开(公告)号：US06955558B1
公开(公告)日：2005-10-18
申请号：US10709270
申请日：2004-04-26
申请人： David Low , Albert Cox , Tim Crawford , Richard Korczak , Raymond Horvath
发明人： David Low , Albert Cox , Tim Crawford , Richard Korczak , Raymond Horvath
IPC分类号： H02G15/013 , H02G15/18 , H01R13/58
CPC分类号： H02G15/18 , H01R4/70 , H02G15/013
摘要： A sealing assembly for a cable to apparatus interconnection formed bya plurality of shells adapted to mate together, surrounding the interconnection within an interconnection space. When mated together, the shells forming openings for the cable and the apparatus at an apparatus end and a cable end, respectively. A gasket mounted to each shell along a mating surface between the shells and along the openings environmentally seals the interconnection space. A locking rib projecting inward from the shell(s) may be applied to rotationally interlock a coupling nut of the interconnection with the sealing assembly. In a two shell embodiment, a locking band positioned around an outer diameter of the mated together shells with an end to end retaining means may be used to secure the shells together. Alternatively, if three shells are used, the shells may be hinged together and a retaining means applied to join the unhinged ends together.
摘要翻译：一种用于电缆到设备互连的密封组件，其由多个壳体形成，多个壳体适于配合在一起，围绕互连空间内的互连。当配合在一起时，壳体分别在设备端部和电缆端部处形成用于电缆和设备的开口。沿着壳体和开口之间的配合表面安装到每个壳体的垫圈环境地密封互连空间。可以施加从壳体向内突出的锁定肋，以将互连件的联接螺母与密封组件旋转地互锁。在两壳实施例中，可以使用围绕配合在一起的壳体的外径的端部到端部保持装置的锁定带将壳体固定在一起。或者，如果使用三个壳体，则壳体可以铰接在一起，并且施加保持装置以将未端接的端部连接在一起。

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