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1. 发明授权

US5618831A Composition and method for treating cancer 失效
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US5618831A
公开(公告)日：1997-04-08
申请号：US242834
申请日：1994-05-16
申请人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
发明人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/505
CPC分类号： A61K31/541 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506
摘要： A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译：一种用于治疗动物癌症的药物组合物，其包含：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物。（I）其中Z1和Z2可以相同或不同，分别代表形成5-或6-元环所必需的原子团; R 1，R 2和R 3可以相同或不同，表示烷基或芳基; L1和L2各自表示次甲基或取代的次甲基; X表示药学上可接受的阴离子; k表示电荷平衡所需的数字; n表示0或1; 和（B）药学上可接受的载体或稀释剂。

2. 发明授权

US5360803A Composition and method for treating cancer 失效
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US5360803A
公开(公告)日：1994-11-01
申请号：US972935
申请日：1992-11-06
申请人： Tadao Shishido , Lan B. Chen
发明人： Tadao Shishido , Lan B. Chen
IPC分类号： A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/555 , A61P35/00 , C07D277/20 , C07D277/34 , C07D277/66 , C07D277/84 , C07D401/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D421/14 , C07D471/04 , C07D513/04
CPC分类号： A61K31/44 , A61K31/42 , A61K31/425 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/555
摘要： A pharmaceutical composition for treatment of cancer comprises:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I) ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, each represents O, S, Se, --CH.dbd.CH--, ##STR2## Y.sub.1 represents O, S, Se, or ##STR3## R.sub.1 and R.sub.3, which may be the same or different, each represents an alkyl group;R.sub.2 represents an alkyl group, an aryl group or a heterocyclic group;Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;L.sub.1 represents a methine group or L.sub.1 and R.sub.3 may combine and form a 5- or 6-membered ring;R.sub.4 and R.sub.5, which may be the same or different, each represents a alkyl group;R.sub.6 and R.sub.7, which may be the same or different, each represents an alkyl group or an aryl group;Q represents a pharmaceutically acceptable anion;l represents 1 or 2;m and n, which may be the same or different, each represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译：用于治疗癌症的药物组合物包括：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物，其中X1和X2可以是相同或不同，各自表示O，S，Se，-CH = CH-， Y1表示O，S，Se或者可以相同或不同的R 1和R 3各自表示烷基组; R2表示烷基，芳基或杂环基; Z 1和Z 2可以相同或不同，表示形成5-或6-元环所必需的原子团; L1表示次甲基或L1和R3可以结合形成5-或6-元环; R 4和R 5可以相同或不同，各自表示烷基; R 6和R 7可以相同或不同，各自表示烷基或芳基; Q表示药学上可接受的阴离子; l表示1或2; m和n可以相同或不同，各自表示0或1; 和（B）药学上可接受的载体或稀释剂。

3. 发明授权

US5015567A Method for producing silver halide photographic emulsion and silver halide photographic material 失效
标题翻译：制备卤化银照相乳剂和卤化银照相材料的方法
公开(公告)号：US5015567A
公开(公告)日：1991-05-14
申请号：US308964
申请日：1989-02-10
申请人： Shuzo Suga , Tadao Shishido , Hiroyuki Mifune , Yoshiro Kawashima
发明人： Shuzo Suga , Tadao Shishido , Hiroyuki Mifune , Yoshiro Kawashima
IPC分类号： G03C1/005 , G03C1/08 , G03C1/09 , G03C1/10
CPC分类号： G03C1/08 , G03C1/09
摘要： A silver halide photographic emulsion is subjected to sulfur or gold-sulfur sensitization in the presence of a combination of (1) at least one of an organic thioether compound or a tetrasubstituted thiourea and (2) a nitrogen-containing heterocyclic compound, to achieve the prevention of pressure desensitization and safelight aptitude deterioration.
摘要翻译：在（1）有机硫醚化合物或四取代硫脲中的至少一种和（2）含氮杂环化合物的组合的存在下，将卤化银照相乳剂进行硫或金 - 硫敏化，以达到防止压力脱敏和安全防范能力恶化。

4. 发明授权

US4801524A Process for preparing silver halide emulsion and photographic light-sensitive material containing said emulsion 失效
标题翻译：制备含有所述乳液的卤化银乳剂和照相感光材料的方法
公开(公告)号：US4801524A
公开(公告)日：1989-01-31
申请号：US28040
申请日：1987-03-20
申请人： Hiroyuki Mifune , Tadao Shishido , Yoshiaki Suzuki
发明人： Hiroyuki Mifune , Tadao Shishido , Yoshiaki Suzuki
IPC分类号： G03C1/005 , G03C1/015 , G03C1/07 , G03C1/06 , G03C1/02
CPC分类号： G03C1/07 , G03C1/015 , G03C2200/06
摘要： A process for preparing a silver halide emulsion using a sulfur-containing inhibitor which substantially inhibits growth of silver halide grains is disclosed. The sulfur-containing inhibitor is inactivated by addition of an oxidizing agent capable of reducing or eliminating the inhibitory activity of the sulfur-containing inhibitor. By the process, adverse influences of the sulfur-containing inhibitor upon chemical ripening or development can be excluded.
摘要翻译：公开了一种使用基本上抑制卤化银颗粒生长的含硫抑制剂制备卤化银乳剂的方法。通过添加能够降低或消除含硫抑制剂的抑制活性的氧化剂，使含硫抑制剂失活。通过该过程，可以排除含硫抑制剂对化学成熟或发育的不利影响。

5. 发明授权

US4681838A Silver halide photographic emulsion and process for production thereof 失效
标题翻译：卤化银照相乳剂及其生产方法
公开(公告)号：US4681838A
公开(公告)日：1987-07-21
申请号：US744595
申请日：1985-06-14
申请人： Hiroyuki Mifune , Tadao Shishido , Yoshiaki Suzuki
发明人： Hiroyuki Mifune , Tadao Shishido , Yoshiaki Suzuki
IPC分类号： G03C1/005 , G03C1/015 , G03C1/035 , G03C1/08 , G03C1/16 , G03C1/18 , G03C1/22 , G03C1/26 , G03C1/34 , G03C1/02
CPC分类号： G03C1/08 , G03C1/0051 , G03C1/34 , G03C1/16 , G03C1/18 , G03C1/22 , G03C1/26 , Y10S430/144
摘要： A silver halide emulsion and a process for producing the same are disclosed. In the process, at least one compound selected from hydrogen peroxide or an adduct or precursor thereof, a peroxy acid salt, and ozone is added to an emulsion in the step prior to the end of chemical ripening. The emulsion exhibits reduced fog, improved stability with time, and improved sensitivity.
摘要翻译：公开了卤化银乳剂及其制备方法。在该方法中，在化学成熟结束之前的步骤中，向乳液中加入至少一种选自过氧化氢或其加合物或前体，过氧酸盐和臭氧的化合物。乳液显示减少的雾，随时间改善的稳定性和改进的灵敏度。

6. 发明授权

US4665017A Process for preparing silver halide emulsion and silver halide photographic light-sensitive material 失效
标题翻译：制备卤化银乳剂和卤化银照相感光材料的方法
公开(公告)号：US4665017A
公开(公告)日：1987-05-12
申请号：US679651
申请日：1984-12-07
申请人： Hiroyuki Mifune , Tadao Shishido , Yoshiaki Suzuki
发明人： Hiroyuki Mifune , Tadao Shishido , Yoshiaki Suzuki
IPC分类号： G03C1/015 , G03C1/08 , G03C1/02 , G03C1/36
CPC分类号： G03C1/015 , G03C2200/06 , G03C2200/53 , Y10S430/144
摘要： A process for preparing a silver halide emulsion wherein a sulfur-containing silver halide solvent which accelerates growth of silver halide grains and an oxidizing agent capable of reducing or eliminating the grain growth effect of the sulfur-containing silver halide solvent are used, and a silver halide photographic light-sensitive material containing the silver halide emulsion prepared by the process are disclosed. The grain growth effect of the sulfur-containing silver halide solvent can be controlled at any necessary stage without accompanying substantial deterioration in photographic properties.
摘要翻译：使用卤化银乳剂的制备方法，其中使用加速卤化银颗粒生长的含硫卤化银溶剂和能够降低或消除含硫卤化银溶剂的晶粒生长作用的氧化剂，并且使用银公开了含有通过该方法制备的卤化银乳剂的卤化物照相感光材料。含硫卤化银溶剂的晶粒生长效应可以控制在任何必需的阶段，而不会引起照相性能的显着劣化。

7. 发明授权

US3940271A Color photographic light-sensitive material 失效
标题翻译：彩色摄影感光材料
公开(公告)号：US3940271A
公开(公告)日：1976-02-24
申请号：US439675
申请日：1974-02-04
申请人： Masayoshi Kawai , Tadao Shishido , Shoji Ishiguro , Tadao Sakai
发明人： Masayoshi Kawai , Tadao Shishido , Shoji Ishiguro , Tadao Sakai
IPC分类号： G03C1/00 , G03B33/00 , G03C7/24 , G11B7/243 , G11B7/244 , G03C1/76 , G03C5/32 , G03C7/00
CPC分类号： G03C7/24
摘要： A color photographic light-sensitive material comprising a support having coated thereon at least one light-sensitive silver halide emulsion layer containing a yellow dye-forming coupler, at least one light-sensitive silver halide emulsion layer containing a magenta dye-forming coupler, at least one light-sensitive silver halide emulsion layer containing a cyan dye-forming coupler, and at least one light-sensitive silver halide emulsion layer containing a compound having a thioether bond directly connected to a nitrogen-containing heterocyclic ring.
摘要翻译：一种彩色照相感光材料，其包括在其上涂覆有至少一种含有黄色染料形成成色剂的感光卤化银乳剂层的载体，至少一种含有品红色染料形成成色剂的感光卤化银乳剂层，含有青色染料成色剂的至少一种感光卤化银乳剂层和至少一种含有具有与含氮杂环直接连接的硫醚键的化合物的感光卤化银乳剂层。

8. 发明授权

US4418037A Color indicator composition and film for detecting hydrogen peroxide 失效
标题翻译：用于检测过氧化氢的颜色指示剂组合物和膜
公开(公告)号：US4418037A
公开(公告)日：1983-11-29
申请号：US369718
申请日：1982-04-19
申请人： Harumi Katsuyama , Tadao Shishido
发明人： Harumi Katsuyama , Tadao Shishido
IPC分类号： G01N33/50 , C12Q1/00 , C12Q1/28 , G01N31/22 , G01N33/52 , G01N33/66
CPC分类号： C12Q1/28 , C12Q2326/00 , C12Q2326/50 , Y10S435/805 , Y10S436/904 , Y10T436/144444 , Y10T436/206664
摘要： In a multilayer analysis film for detecting hydrogen peroxide by dry process which comprises a support and a reagent layer having contained therein a color indicator composition comprising peroxidase and a substance capable of causing a optically detectable change in the presence of hydrogen peroxide and peroxidase, the color indicator composition is characterized by further containing specific pyrogallol derivatives. Such pyrogallol derivatives improve stability during storage of such a multilayer analysis film.
摘要翻译：在用于通过干法检测过氧化氢的多层分析膜中，其包含载体和试剂层，其中含有包含过氧化物酶的颜色指示剂组合物和能够在过氧化氢和过氧化物酶存在下引起可光学检测的变化的物质，颜色指标组合物的特征在于还含有特定的连苯三酚衍生物。这种连苯三酚衍生物改善了在这种多层分析膜的储存期间的稳定性。

9. 发明授权

US4334010A Silver halide photographic light-sensitive element 失效
标题翻译：卤化银照相感光元件
公开(公告)号：US4334010A
公开(公告)日：1982-06-08
申请号：US284164
申请日：1981-07-17
申请人： Hiroyuki Mifune , Shoji Ishiguro , Tadao Shishido , Yoshiharu Fuseya , Teruaki Tsujikawa
发明人： Hiroyuki Mifune , Shoji Ishiguro , Tadao Shishido , Yoshiharu Fuseya , Teruaki Tsujikawa
IPC分类号： C07C13/20 , C07D333/22 , C07D335/02 , G03C1/34
CPC分类号： G03C1/34 , C07D333/22
摘要： A silver halide photographic light-sensitive element is described comprising a support having thereon at least one silver halide emulsion layer, wherein at least one compound represented by formula (I) is incorporated in the silver halide emulsion layer or in another hydrophilic colloid layer: ##STR1## wherein X represents a hydroxy group or a group represented by ##STR2## wherein R.sup.2 and R.sup.3 (which may be the same or different) each reprsents hydrogen, an alkyl group, or an aryl group; R.sup.1 represents a sulfur-containing saturated heterocyclic group or a group represented by -A-S-B, wherein A represents an alkylene group and B represents hydrogen, an alkyl group, or an aryl group; and Z represents an atomic group forming a 5-membered or 6-membered unsubstituted or substituted carbocyclic ring.In the silver halide photographic light-sensitive element, the so-called "latent image fading" phenomenon is prevented without accompanying degradation of other photograhic properties.
摘要翻译：描述了一种卤化银照相感光元件，其包括其上具有至少一个卤化银乳剂层的载体，其中至少一种由式（I）表示的化合物引入卤化银乳剂层或另一亲水胶体层中：图像（I）其中X表示羟基或由其表示的基团，其中R2和R3（可以相同或不同）各自代表氢，烷基或芳基; R1表示含硫的饱和杂环基或由-A-S-B表示的基团，其中A表示亚烷基，B表示氢，烷基或芳基; Z表示形成5元或6元未取代或取代的碳环的原子团。在卤化银摄影感光元件中，防止所谓的“潜像褪色”现象，而不伴随着其它光致变色性能的降低。

10. 发明授权

US4309500A Silver halide color photographic light-sensitive material 失效
标题翻译：卤化银彩色摄影感光材料
公开(公告)号：US4309500A
公开(公告)日：1982-01-05
申请号：US40822
申请日：1979-05-21
申请人： Tadao Shishido
发明人： Tadao Shishido
IPC分类号： G03C7/26 , C07D263/10 , C07D263/12 , G03C1/815 , G03C7/392 , G03C1/84
CPC分类号： C07D263/10 , G03C1/8155 , G03C7/39292
摘要： A silver halide color photographic light-sensitive material which contains at least one compound represented by the following general formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represents a hydrogen atom or an aliphatic group; R.sup.5 represents an aliphatic group or an aromatic group, R.sup.6 and R.sup.7, which may be the same or different, each represents a cyano group, a --COR.sup.8 group, a --COOR.sup.8 group or a --SO.sub.2 R.sup.9 group; and R.sup.8 represents an aliphatic group and R.sup.9 represents an aliphatic group or an aromatic group. The silver halide color photographic light-sensitive material has improved color reproduction which is not affected by differences in the ultraviolet light absorption characteristics of the camera lens.
摘要翻译：含有至少一种由以下通式（I）表示的化合物的卤化银彩色照相感光材料：其中R 1，R 2，R 3和R 4可以相同或不同，各自代表氢原子或脂族基团; R5表示脂族基或芳基，R6和R7可以相同或不同，分别表示氰基，-COR8基，-COOR8基或-SO2R9基; R 8表示脂肪族基，R 9表示脂肪族基团或芳香族基团。卤化银彩色摄影感光材料具有改善的色彩再现性，其不受相机透镜的紫外光吸收特性的差异的影响。

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