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1. 发明授权

US06683303B2 Ion trap mass spectrometer and spectrometry 失效
标题翻译：离子阱质谱仪和光谱仪
公开(公告)号：US06683303B2
公开(公告)日：2004-01-27
申请号：US10087743
申请日：2002-03-05
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/0063
摘要： An ion trap mass spectrometer and spectrometry capable of dissociating ions to be dissociated efficiently regardless of ionic species without useless time and performing high-sensitive MS/MS spectrometry, lengthens a period for applying a CID voltage in accordance with a mass number or characteristics of ions to be dissociated in proportion to a mass-to-charge ratio of ions to be dissociated to thereby optimize the application period of the supplementary AC voltage applied in superposition manner in order to dissociate specific ionic species, so that ions to be dissociated are dissociated efficiently and high-sensitive analysis of dissociated ions can be attained without useless time.
摘要翻译：离子阱质谱仪和光谱测定能够离子离子有效解离而无需离子物质无需时间，并进行高灵敏度的MS / MS光谱测定，延长了根据离子的质量数或特征施加CID电压的时间要与待离解的离子的质荷比成比例地离解，从而优化以叠加方式施加的辅助AC电压的施加周期，以便解离特定的离子物质，使得要解离的离子有效解离并且可以在没有无用的时间的情况下获得离解离子的高灵敏度分析。

2. 发明授权

US5789746A Liquid chromatograph mass spectrometry and liquid chromatograph mass spectrometer 失效
标题翻译：液相色谱质谱和液相色谱质谱仪
公开(公告)号：US5789746A
公开(公告)日：1998-08-04
申请号：US886465
申请日：1997-07-01
申请人： Yoshiaki Kato , Tadao Mimura
发明人： Yoshiaki Kato , Tadao Mimura
IPC分类号： G01N27/62 , G01N30/62 , G01N30/72 , G01N30/74 , G01N30/78 , G01N30/86 , H01J49/04 , H01J49/26 , H01J49/00
CPC分类号： G01N30/7233 , G01N2030/625 , G01N30/74
摘要： An eluant is supplied to an analyzer column, a sample solution is supplied through a sample inlet. The analyzer column separates the components of the sample solution. The separated components are eluted by the analyzer column, the eluted components are detected by an eluted component detector, the results of detection provided by the eluted component detector is processed by a data processor to produce a liquid chromatogram having peaks indicating the components of the sample. The components of the sample is supplied through a capillary pipe to an ion source and the ion source ionizes the components of the sample. A mass spectrometer subjects the ions produced by the ion source to mass analysis, an ion detector detects the ions included in a mass spectrum to produce an ion chromatogram having peaks. A time difference between the chromatograms is determined beforehand through an experiment using a standard sample, and the liquid chromatogram is shifted on its time axis by the time difference.
摘要翻译：将洗脱液供应到分析器柱，通过样品入口提供样品溶液。分析仪柱分离样品溶液的组分。分离的组分被分析器柱洗脱，洗脱组分由洗脱组分检测器检测，由洗脱组分检测器提供的检测结果由数据处理器处理，以产生具有表示样品成分的峰的液相色谱图。样品的组分通过毛细管供给到离子源，离子源将样品的组分电离。质谱仪将由离子源产生的离子进行质量分析，离子检测器检测质谱中包含的离子，产生具有峰值的离子色谱图。通过使用标准样品的实验预先确定色谱图之间的时间差，并且液相色谱在其时间轴上偏移时间差。

3. 发明授权

US06759652B2 Ion trap mass analyzing apparatus 有权
标题翻译：离子阱质量分析仪
公开(公告)号：US06759652B2
公开(公告)日：2004-07-06
申请号：US10252699
申请日：2002-09-24
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/4255
摘要： An ion-trap mass analyzing apparatus having means for generating ion-capture electric fields asymmetrical with respect to a reference plane containing a central point of a ring electrode and perpendicular to a central axis of the ring electrode in the inside of an ion trap to resonantly amplify ions rapidly to emit the ions from the ion trap in a short time to thereby permit high-sensitive high-accurate mass analysis stably regardless of the structural stability of ions as a subject of analysis.
摘要翻译：一种离子阱质量分析装置，具有用于产生相对于包含环形电极的中心点并垂直于离子阱内部的环形电极的中心轴的参考平面不对称的离子捕获电场的装置，以共振地在短时间内快速放大离子以从离子阱发射离子，从而允许高灵敏度的高精确质量分析，而不管作为分析对象的离子的结构稳定性如何。

4. 发明申请

US20070069121A1 Ion trap/time-of-flight mass spectrometer and method of measuring ion accurate mass 审中-公开
标题翻译：离子阱/飞行时间质谱仪和离子精确质量的测量方法
公开(公告)号：US20070069121A1
公开(公告)日：2007-03-29
申请号：US11606046
申请日：2006-11-30
申请人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
发明人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
IPC分类号： H01J49/00
CPC分类号： H01J49/42 , H01J49/0009 , H01J49/004 , H01J49/40
摘要： An ion trap/time-of-flight mass spectrometer, which can perform accurate mass measurement of a product ion based on MS/MS and MSn has an ion source for ionizing a sample, an ion trap capable of temporarily trapping ions, and a time-of-flight mass spectrometer. The ion source produces ions of the sample as a measurement target and ions of a reference sample each having a known mass value. A precursor ion is selected from among the ions of the measurement target sample, and the selected precursor ion is excited and fragmented in the ion trap to produce a product ion. The reference sample ions are introduced to and trapped in the ion trap. The trapped product ion and reference sample ions are expelled out of the ion trap and introduced to the time-of-flight mass spectrometer, thereby obtaining a mass spectrum.
摘要翻译：离子阱/飞行时间质谱仪可以基于MS / MS和MS进行产物离子的精确质量测量具有离子源，用于离子化样品，离子阱能力暂时捕获离子和飞行时间质谱仪。离子源产生样品的离子作为测量对象，每个参考样品的离子具有已知的质量值。从测量对象样品的离子中选择前体离子，并且将所选择的前体离子在离子阱中激发并碎裂以产生产物离子。将参考样品离子引入并捕获在离子阱中。捕获的产物离子和参考样品离子从离子阱中排出并引入飞行时间质谱仪，从而获得质谱。

5. 发明授权

US06236042B1 Method and apparatus for direct coupling of liquid chromatograph and mass spectrometer, liquid chromatography-mass spectrometry, and liquid chromatograph-mass spectrometer 有权
标题翻译：用于液相色谱和质谱仪直接偶联的方法和装置，液相色谱 - 质谱法和液相色谱 - 质谱仪
公开(公告)号：US06236042B1
公开(公告)日：2001-05-22
申请号：US09499318
申请日：2000-02-07
申请人： Yoshiaki Kato , Tadao Mimura
发明人： Yoshiaki Kato , Tadao Mimura
IPC分类号： G01D5944
CPC分类号： H01J49/145 , G01N30/7246 , G01N30/7273 , H01J49/045 , H01J49/049
摘要： A nebulized jet from a nebulizer is subjected to mechanical agitation and stirring to render the mists uniform and fine, then the droplets of the mists thus rendered uniform and fine are ionized. By accelerative collision of the resulting ions in a medium pressure chamber it is made possible to effect desolvation efficiently. Consequently, chemical noises caused by cluster ions can be greatly diminished and it is possible to attain high sensitive measurement of a sample in atmospheric pressure ionizations LC/MS.
摘要翻译：将来自喷雾器的喷雾喷雾器进行机械搅拌和搅拌以使雾化均匀且细微，从而雾化的液滴均匀且细小。通过所得到的离子在中压室中的加速碰撞，可以有效地实现去溶剂化。因此，可以大大减少由簇离子引起的化学噪声，并且可以在大气压离子化LC / MS中获得样品的高灵敏度测量。

6. 发明授权

US5859432A Method and apparatus for direct coupling of liquid chromatograph and mass spectrometer liquid, chromatography--mass spectrometry, and liquid chromatograph--mass spectrometer 失效
标题翻译：液相色谱仪和质谱仪直接耦合的方法和装置，液相色谱 - 质谱仪和液相色谱 - 质谱仪
公开(公告)号：US5859432A
公开(公告)日：1999-01-12
申请号：US707578
申请日：1996-09-05
申请人： Yoshiaki Kato , Tadao Mimura
发明人： Yoshiaki Kato , Tadao Mimura
IPC分类号： G01N27/62 , G01N30/72 , H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： H01J49/145 , G01N30/7246 , G01N30/7273 , H01J49/045 , H01J49/049
摘要： A nebulized jet from a nebulizer is subjected to mechanical agitation and stirring to render the mists uniform and fine, then the droplets of the mists thus rendered uniform and fine are ionized. By accelerative collision of the resulting ions in a medium pressure chamber it is made possible to effect desolvation efficiently. Consequently, chemical noises caused by cluster ions can be greatly diminished and it is possible to attain high sensitive measurement of a sample in atmospheric pressure ionizations LC/MS.
摘要翻译：将来自喷雾器的喷雾喷雾器进行机械搅拌和搅拌以使雾化均匀且细微，从而雾化的液滴均匀且细小。通过所得到的离子在中压室中的加速碰撞，可以有效地实现去溶剂化。因此，可以大大减少由簇离子引起的化学噪声，并且可以在大气压离子化LC / MS中获得样品的高灵敏度测量。

7. 发明授权

US5298744A Mass spectrometer 失效
标题翻译：质谱仪
公开(公告)号：US5298744A
公开(公告)日：1994-03-29
申请号：US12469
申请日：1993-02-02
申请人： Tadao Mimura , Yoshiaki Kato , Kazumi Matsumura
发明人： Tadao Mimura , Yoshiaki Kato , Kazumi Matsumura
IPC分类号： G01N27/62 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： H01J49/0404 , G01N30/7266 , G01N30/7293 , H01J49/0468 , H01J49/165
摘要： Ions generated by an ES ion supply are introduced into a mass spectrometer portion through a small hole in a second electrode after passing through a small hole in a heated first electrode, and are analyzed by a mass spectrometer. Corresponding to heating of the first electrode, a length of the small hole in the first electrode is determined to a predetermined adequate value.
摘要翻译：通过ES离子源产生的离子通过第一电极中的小孔后通过第二电极中的小孔引入质谱仪部分，并通过质谱仪进行分析。对应于第一电极的加热，将第一电极中的小孔的长度确定为预定的适当值。

8. 发明授权

US5240616A Liquid chromatograph-direct coupled mass spectrometer 失效
标题翻译：液相色谱 - 直接耦合质谱仪
公开(公告)号：US5240616A
公开(公告)日：1993-08-31
申请号：US492321
申请日：1990-03-12
申请人： Yoshiaki Kato , Tadao Mimura
发明人： Yoshiaki Kato , Tadao Mimura
IPC分类号： G01N30/72 , H01J49/04
CPC分类号： H01J49/049 , G01N30/7246 , H01J49/0445 , G01N30/7253
摘要： A liquid chromatograph-direct coupled mass spectrometer, which comprises a liquid chromatograph section, a mass spectrometer section and an interface section coupling the liquid chromatograph section with the mass spectrometer section, the interface section being provided with a first nebulizing means for nebulizing an eluate of a hydrophobic solvent containing a sample in solution introduced from the liquid chromatograph section through a capillary continuously into a vacuum or atmospheric pressure region and the first nebulizing means being further provided with a second nebulizing means for nebulizing a hydrophilic solvent and with a heating means for heating the first and second nebulizing means has a high separability and has no limit to selection of a mobile phase solvent and an ionization solvent.
摘要翻译：一种液相色谱 - 直接耦合质谱仪，其包括液相色谱部分，质谱仪部分和将液相色谱部分与质谱仪部分结合的界面部分，界面部分设置有第一雾化装置，用于将洗脱液含有从液相色谱部分通过毛细管连续引入真空或大气压区域的溶液中的样品的疏水溶剂，第一雾化装置还设置有用于使亲水溶剂雾化的第二雾化装置和用于加热的加热装置第一和第二雾化装置具有高的分离性，并且对流动相溶剂和电离溶剂的选择没有限制。

9. 发明授权

US4996424A Atmospheric pressure ionization mass spectrometer 失效
标题翻译：大气压电离质谱仪
公开(公告)号：US4996424A
公开(公告)日：1991-02-26
申请号：US531247
申请日：1990-05-03
申请人： Tadao Mimura , Yoshiaki Kato
发明人： Tadao Mimura , Yoshiaki Kato
IPC分类号： H01J49/04
CPC分类号： H01J49/0431 , H01J49/0404 , H01J49/0472
摘要： An atmospheric pressure ionization mass spectrometer has an interface by which the mass spectrometer is coupled on-line to a liquid chromatograph. This interface comprises an atomization unit which heats and atomizes a sample carried out by a mobile phase from the liquid chromatograph. The atomization unit includes a sample introducing pipe having therein a plurality of thin passages which extend along an axis of the pipe and into which the sample is introduced for atomization.
摘要翻译：大气压电离质谱仪具有界面，质谱仪通过该界面在线耦合到液相色谱仪。该界面包括雾化单元，其从液相色谱仪加热和雾化由流动相进行的样品。雾化单元包括：样品导入管，其中具有沿着管的轴线延伸的多个细通道，并且样品被引入其中用于雾化。

10. 发明授权

US07161141B2 Ion trap/time-of-flight mass spectrometer and method of measuring ion accurate mass 有权
公开(公告)号：US07161141B2
公开(公告)日：2007-01-09
申请号：US11128261
申请日：2005-05-13
申请人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
发明人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
IPC分类号： B01D59/44 , H01J49/00 , G01D18/00 , G12B13/00
CPC分类号： H01J49/42 , H01J49/0009 , H01J49/004 , H01J49/40
摘要： An ion trap/time-of-flight mass spectrometer, which can perform accurate mass measurement of a product ion based on MS/MS and MSn has an ion source for ionizing a sample, an ion trap capable of temporarily trapping ions, and a time-of-flight mass spectrometer. The ion source produces ions of the sample as a measurement target and ions of a reference sample each having a known mass value. A precursor ion is selected from among the ions of the measurement target sample, and the selected precursor ion is excited and fragmented in the ion trap to produce a product ion. The reference sample ions are introduced to and trapped in the ion trap. The trapped product ion and reference sample ions are expelled out of the ion trap and introduced to the time-of-flight mass spectrometer, thereby obtaining a mass spectrum.

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