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1. 发明申请

US20100136524A1 TARGET PROTEIN AND TARGET GENE IN DRUG DESIGNING AND SCREENING METHOD 失效
标题翻译：药物设计和筛选方法中的目标蛋白质和目标基因
公开(公告)号：US20100136524A1
公开(公告)日：2010-06-03
申请号：US11577350
申请日：2005-10-18
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
IPC分类号： C12Q1/68 , C07D403/12 , C07D401/12 , C07K14/00 , C12N15/63
CPC分类号： C07D211/22 , C07D235/30 , C07D235/32 , C07D295/08 , C07D409/06 , C07D417/04 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.
摘要翻译：本发明提供了一种新的靶蛋白和用于药物发现的基因，并且是通过使用它们能够开发新型药剂的方法。更具体地，本发明提供CARP及其基因; 药物筛选方法（如抗过敏药物）; 疾病调节剂（如过敏性疾病）; 药物衍生物生产方法; 包含药物和CARP的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发病或发病风险的方法，对药物易感性的测定方法和用于所述方法的测定试剂盒等。

2. 发明授权

US08178077B2 Drug development target protein and target gene, and method of screening 失效
标题翻译：药物开发靶蛋白和靶基因，筛选方法
公开(公告)号：US08178077B2
公开(公告)日：2012-05-15
申请号：US11577575
申请日：2005-10-19
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
IPC分类号： A61K49/00 , A01N43/64 , C07D207/00
CPC分类号： C07C211/27 , A61K31/40 , C07H21/00 , C07J71/00 , C07K14/47 , G01N33/53 , G01N33/6896 , G01N33/9406 , G01N2800/2821
摘要： The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.
摘要翻译：本发明提供用于药物发现的新型靶蛋白和靶基因，以及能够开发使用其的新药物的方法。更具体地说，本发明提供了NCS蛋白质及其基因; 药物筛选方法（如抗中枢神经病药物）; 用于调节疾病（例如中枢神经疾病）的药剂; 药物衍生物的生产方法; 包含药物和NCS蛋白质的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发作或发病风险的方法，对药物易感性的测定方法和用于测定方法的测定试剂盒; 等等。

3. 发明申请

US20090143285A1 TARGET PROTEIN AND TARGET GENE FOR DRUG DISCOVERY AND SCREENING METHOD 审中-公开
标题翻译：用于药物发现和筛选方法的目标蛋白质和目标基因
公开(公告)号：US20090143285A1
公开(公告)日：2009-06-04
申请号：US11909634
申请日：2006-03-24
申请人： Hideaki Sueoka , Tadakazu Yamauchi , Kouichi Tsuchiya , Katsuhisa Murayama , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Kazuo Komiya , Noriyuki Inomata , Yorimasa Suwa , Ken Horiuchi
发明人： Hideaki Sueoka , Tadakazu Yamauchi , Kouichi Tsuchiya , Katsuhisa Murayama , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Kazuo Komiya , Noriyuki Inomata , Yorimasa Suwa , Ken Horiuchi
IPC分类号： A61K38/16 , C12Q1/68 , G01N33/566
CPC分类号： G01N33/5023 , G01N33/68 , G01N2500/00
摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译：本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

4. 发明申请

US20070009895A1 Method of interaction analysis and interaction analyzer 审中-公开
标题翻译：交互分析与交互分析仪的方法
公开(公告)号：US20070009895A1
公开(公告)日：2007-01-11
申请号：US10569951
申请日：2004-10-14
申请人： Tadakazu Yamauchi , Kouichi Tsuchiya , Hideaki Sueoka
发明人： Tadakazu Yamauchi , Kouichi Tsuchiya , Hideaki Sueoka
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N30/88 , G01N2030/8813
摘要： A method is provided in which an extremely small amount of a solution containing a substance to be analyzed can be analyzed with high throughput and without any loss of the solution. The method comprises the steps of introducing into a separation channel a first solution containing a substance that is eluted from the separation channel faster and a second solution containing a substance that is eluted from the separation channel more slowly, wherein at least a portion of the first solution is introduced into the separation channel after introducing at least a portion of the second solution thereinto, and detecting a chromatogram of the substances eluted from the separation channel.
摘要翻译：提供了一种方法，其中可以以高通量分析极少量含有待分析物质的溶液，并且不会有溶液的任何损失。该方法包括以下步骤：将分离通道中含有从分离通道洗脱的物质的第一溶液和含有从分离通道中缓慢洗脱的物质的第二溶液引入分离通道，其中第一溶液的至少一部分在将至少一部分第二溶液引入其中之后，将溶液引入分离通道，并检测从分离通道洗脱的物质的色谱图。

5. 发明授权

US08153385B2 Target protein and target gene in drug designing and screening method 失效
标题翻译：靶蛋白和靶基因在药物设计筛选中的应用
公开(公告)号：US08153385B2
公开(公告)日：2012-04-10
申请号：US11577350
申请日：2005-10-18
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
IPC分类号： G01N33/53
CPC分类号： C07D211/22 , C07D235/30 , C07D235/32 , C07D295/08 , C07D409/06 , C07D417/04 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.
摘要翻译：本发明提供了一种新的靶蛋白和用于药物发现的基因，并且是通过使用它们能够开发新型药剂的方法。更具体地，本发明提供CARP及其基因; 药物筛选方法（如抗过敏药物）; 疾病调节剂（如过敏性疾病）; 药物衍生物生产方法; 包含药物和CARP的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发病或发病风险的方法，对药物易感性的测定方法和用于所述方法的测定试剂盒等。

6. 发明申请

US20090233274A1 DRUG DEVELOPMENT TARGET PROTEIN AND TARGET GENE, AND METHOD OF SCREENING 失效
标题翻译：药物发展目标蛋白质和目标基因，以及筛选方法
公开(公告)号：US20090233274A1
公开(公告)日：2009-09-17
申请号：US11577575
申请日：2005-10-09
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Koichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Koichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
IPC分类号： C12Q1/68 , C12Q1/02 , C12N15/63 , G01N33/566 , G01N33/68 , C07K2/00 , C07K16/18 , C07K1/107 , C07H21/00 , C07J71/00 , C07D498/14 , C07D207/34
CPC分类号： C07C211/27 , A61K31/40 , C07H21/00 , C07J71/00 , C07K14/47 , G01N33/53 , G01N33/6896 , G01N33/9406 , G01N2800/2821
摘要： The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.
摘要翻译：本发明提供用于药物发现的新型靶蛋白和靶基因，以及能够开发使用其的新药物的方法。更具体地说，本发明提供了NCS蛋白质及其基因; 药物筛选方法（如抗中枢神经病药物）; 用于调节疾病（例如中枢神经疾病）的药剂; 药物衍生物的生产方法; 包含药物和NCS蛋白质的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发作或发病风险的方法，对药物易感性的测定方法和用于测定方法的测定试剂盒; 等等。

7. 发明申请

US20110269141A1 TARGET PROTEIN AND TARGET GENE FOR DRUG DISCOVERY, AND SCREENING METHOD 审中-公开
标题翻译：目标蛋白质和目标药物发现基因，筛选方法
公开(公告)号：US20110269141A1
公开(公告)日：2011-11-03
申请号：US12528190
申请日：2008-02-20
申请人： Katsuhisa Murayama , Tadakazu Yamauchi , Kouichi Tsuchiya , Kazuo Komiya , Morikazu Kito , Yuko Isono , Noriyuki Inomata , Yorimasa Suwa , Ai Wakamatsu , Junichi Yamamoto , Takao Isogai
发明人： Katsuhisa Murayama , Tadakazu Yamauchi , Kouichi Tsuchiya , Kazuo Komiya , Morikazu Kito , Yuko Isono , Noriyuki Inomata , Yorimasa Suwa , Ai Wakamatsu , Junichi Yamamoto , Takao Isogai
IPC分类号： C12Q1/68 , C07H21/04 , G01N33/50 , C07K16/00 , C07K14/00 , G01N33/68 , C07H21/02 , C12N15/63
CPC分类号： A61K31/7088 , A61K38/00 , A61K45/06 , A61K48/00 , C07K14/47 , C12Q1/6897 , G01N33/68 , G01N33/94 , G01N2500/04 , Y10T436/143333
摘要： The problems of the present invention are to provide target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. The present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译：本发明的问题是提供用于生物活性物质如药物的靶蛋白和靶基因，以及能够开发使用其的新型生物活性物质的手段。本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

8. 发明申请

US20080102457A1 Target Protein And Target Gene In Drug Designing And Screening Method 失效
标题翻译：靶蛋白和靶基因在药物设计与筛选中的应用
公开(公告)号：US20080102457A1
公开(公告)日：2008-05-01
申请号：US11718946
申请日：2005-11-09
申请人： Yorimasa Suwa , Tadakazu Yamauchi , Tsuyoshi Yamada , Hironori Oosaki , Morikazu Kito
发明人： Yorimasa Suwa , Tadakazu Yamauchi , Tsuyoshi Yamada , Hironori Oosaki , Morikazu Kito
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C07K16/00
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/502
摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. To be specific, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译：本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。具体而言，本发明提供了用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

9. 发明授权

US5723345A Method and device for specific binding assay 失效
标题翻译：用于特异性结合测定的方法和装置
公开(公告)号：US5723345A
公开(公告)日：1998-03-03
申请号：US495028
申请日：1995-06-27
申请人： Tadakazu Yamauchi , Hideyuki Terasawa
发明人： Tadakazu Yamauchi , Hideyuki Terasawa
IPC分类号： G01N33/53 , G01N33/543 , G01N33/558 , G01N33/536
CPC分类号： G01N33/53 , G01N33/543 , G01N33/558 , Y10S435/817 , Y10S436/805 , Y10S436/806
摘要： The present invention provides a general purpose specific binding assay method which has the advantages of highly accurate and quick measurements which exclude the effects of various factors that decrease reliability of the measured values, such as non-specific reactants in test samples, assay conditions and inactivation and the like changes in the activity of reagents. The present invention is further drawn to a specific binding assay device suitable for the practice thereof. The binding assay of the present invention is achieved by allowing a signal substance generator which takes part in a specific binding reaction and generates a signal substance, together with a liquid sample, to flow through a predetermined channel in a predetermined direction, thereby effecting generation of the specific binding reaction of a substance to be assayed to form a distribution of the signal substance generator in the channel in response to the concentration of the substance to be assayed, allowing the signal substance generator distributed in the channel to generate the signal substance, detecting the generated signal substance by a plurality of detection means arranged at different positions in the liquid flow direction, and arithmetically processing the plural detection results to minimize influence of other factors than the concentration of the substance to be assayed upon the assay result.
摘要翻译：本发明提供了一种通用特异性结合测定方法，其具有高精度和快速测量的优点，其排除了降低测量值的可靠性的各种因素的影响，例如测试样品中的非特异性反应物，测定条件和灭活等等，试剂活性的变化。本发明进一步涉及适用于其实践的特异性结合测定装置。本发明的结合试验通过使参与特异性结合反应的信号物质发生器与液体样品一起产生信号物质，以预定方向流过预定通道，从而实现要测定的物质的特异性结合反应，以响应待测物质的浓度，在通道中形成信号物质发生器的分布，允许分布在通道中的信号物质发生器产生信号物质，检测所生成的信号物质由布置在液体流动方向的不同位置的多个检测装置进行运算，并对多个检测结果进行算术处理，以最大限度地减少除了待检测物质的浓度以外的其他因素对测定结果的影响。

10. 发明申请

US20090136482A1 DRUG TARGET PROTEIN AND TARGET GENE, AND SCREENING METHOD 审中-公开
标题翻译：药物靶标蛋白和目标基因，筛选方法
公开(公告)号：US20090136482A1
公开(公告)日：2009-05-28
申请号：US12065303
申请日：2006-09-01
申请人： Yorimasa Suwa , Tadakazu Yamauchi , Morikazu Kito , Yuko Isono , Tsuruki Tamura , Motoi Tobita
发明人： Yorimasa Suwa , Tadakazu Yamauchi , Morikazu Kito , Yuko Isono , Tsuruki Tamura , Motoi Tobita
IPC分类号： A61K39/395 , G01N33/00 , C12Q1/68 , G01N33/566 , A61K38/02 , A61K31/7088 , A61K31/7105
CPC分类号： G01N33/68 , A61K45/06 , C07K14/47 , G01N33/5008 , G01N33/502 , G01N33/6845 , G01N33/94 , G01N2500/00 , Y10T436/143333
摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译：本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

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