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1. 发明申请

US20100136524A1 TARGET PROTEIN AND TARGET GENE IN DRUG DESIGNING AND SCREENING METHOD 失效
标题翻译：药物设计和筛选方法中的目标蛋白质和目标基因
公开(公告)号：US20100136524A1
公开(公告)日：2010-06-03
申请号：US11577350
申请日：2005-10-18
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
IPC分类号： C12Q1/68 , C07D403/12 , C07D401/12 , C07K14/00 , C12N15/63
CPC分类号： C07D211/22 , C07D235/30 , C07D235/32 , C07D295/08 , C07D409/06 , C07D417/04 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.
摘要翻译：本发明提供了一种新的靶蛋白和用于药物发现的基因，并且是通过使用它们能够开发新型药剂的方法。更具体地，本发明提供CARP及其基因; 药物筛选方法（如抗过敏药物）; 疾病调节剂（如过敏性疾病）; 药物衍生物生产方法; 包含药物和CARP的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发病或发病风险的方法，对药物易感性的测定方法和用于所述方法的测定试剂盒等。

2. 发明授权

US08153385B2 Target protein and target gene in drug designing and screening method 失效
标题翻译：靶蛋白和靶基因在药物设计筛选中的应用
公开(公告)号：US08153385B2
公开(公告)日：2012-04-10
申请号：US11577350
申请日：2005-10-18
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
IPC分类号： G01N33/53
CPC分类号： C07D211/22 , C07D235/30 , C07D235/32 , C07D295/08 , C07D409/06 , C07D417/04 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.
摘要翻译：本发明提供了一种新的靶蛋白和用于药物发现的基因，并且是通过使用它们能够开发新型药剂的方法。更具体地，本发明提供CARP及其基因; 药物筛选方法（如抗过敏药物）; 疾病调节剂（如过敏性疾病）; 药物衍生物生产方法; 包含药物和CARP的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发病或发病风险的方法，对药物易感性的测定方法和用于所述方法的测定试剂盒等。

3. 发明授权

US08178077B2 Drug development target protein and target gene, and method of screening 失效
标题翻译：药物开发靶蛋白和靶基因，筛选方法
公开(公告)号：US08178077B2
公开(公告)日：2012-05-15
申请号：US11577575
申请日：2005-10-19
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
IPC分类号： A61K49/00 , A01N43/64 , C07D207/00
CPC分类号： C07C211/27 , A61K31/40 , C07H21/00 , C07J71/00 , C07K14/47 , G01N33/53 , G01N33/6896 , G01N33/9406 , G01N2800/2821
摘要： The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.
摘要翻译：本发明提供用于药物发现的新型靶蛋白和靶基因，以及能够开发使用其的新药物的方法。更具体地说，本发明提供了NCS蛋白质及其基因; 药物筛选方法（如抗中枢神经病药物）; 用于调节疾病（例如中枢神经疾病）的药剂; 药物衍生物的生产方法; 包含药物和NCS蛋白质的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发作或发病风险的方法，对药物易感性的测定方法和用于测定方法的测定试剂盒; 等等。

4. 发明申请

US20090143285A1 TARGET PROTEIN AND TARGET GENE FOR DRUG DISCOVERY AND SCREENING METHOD 审中-公开
标题翻译：用于药物发现和筛选方法的目标蛋白质和目标基因
公开(公告)号：US20090143285A1
公开(公告)日：2009-06-04
申请号：US11909634
申请日：2006-03-24
申请人： Hideaki Sueoka , Tadakazu Yamauchi , Kouichi Tsuchiya , Katsuhisa Murayama , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Kazuo Komiya , Noriyuki Inomata , Yorimasa Suwa , Ken Horiuchi
发明人： Hideaki Sueoka , Tadakazu Yamauchi , Kouichi Tsuchiya , Katsuhisa Murayama , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Kazuo Komiya , Noriyuki Inomata , Yorimasa Suwa , Ken Horiuchi
IPC分类号： A61K38/16 , C12Q1/68 , G01N33/566
CPC分类号： G01N33/5023 , G01N33/68 , G01N2500/00
摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译：本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。

5. 发明申请

US20090233274A1 DRUG DEVELOPMENT TARGET PROTEIN AND TARGET GENE, AND METHOD OF SCREENING 失效
标题翻译：药物发展目标蛋白质和目标基因，以及筛选方法
公开(公告)号：US20090233274A1
公开(公告)日：2009-09-17
申请号：US11577575
申请日：2005-10-09
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Koichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Koichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
IPC分类号： C12Q1/68 , C12Q1/02 , C12N15/63 , G01N33/566 , G01N33/68 , C07K2/00 , C07K16/18 , C07K1/107 , C07H21/00 , C07J71/00 , C07D498/14 , C07D207/34
CPC分类号： C07C211/27 , A61K31/40 , C07H21/00 , C07J71/00 , C07K14/47 , G01N33/53 , G01N33/6896 , G01N33/9406 , G01N2800/2821
摘要： The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.
摘要翻译：本发明提供用于药物发现的新型靶蛋白和靶基因，以及能够开发使用其的新药物的方法。更具体地说，本发明提供了NCS蛋白质及其基因; 药物筛选方法（如抗中枢神经病药物）; 用于调节疾病（例如中枢神经疾病）的药剂; 药物衍生物的生产方法; 包含药物和NCS蛋白质的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发作或发病风险的方法，对药物易感性的测定方法和用于测定方法的测定试剂盒; 等等。

6. 发明申请

US20090098568A1 Method for immobilizing proteins 失效
标题翻译：固定蛋白质的方法
公开(公告)号：US20090098568A1
公开(公告)日：2009-04-16
申请号：US10569883
申请日：2004-08-24
申请人： Tsuyoshi Yamada , Yorimasa Suwa , Takeshi Tsutsumi
发明人： Tsuyoshi Yamada , Yorimasa Suwa , Takeshi Tsutsumi
IPC分类号： G01N33/53 , C12M1/34 , C07K16/46
CPC分类号： G01N33/543 , Y10T436/25 , Y10T436/255
摘要： This invention provides a method for immobilizing proteins comprising: step 1 of purifying target proteins to be immobilized, which have a first tag portion and a second tag portion, with the use of the first tag portion; step 2 of activating reactive groups capable of covalently binding to the proteins on a carrier for immobilization; and step 3 of allowing a solution containing the proteins purified in step 1 to react with the carrier after step 2, wherein, in step 3, the proteins are immobilized on the carrier via interactions between the second tag portion and the site of the carrier to which the second tag portion binds and via covalent binding between the reactive groups and the proteins. This method enables the stable immobilization of various types of target proteins on a carrier regardless of the amounts of target proteins and without nonspecific immobilization of contaminating proteins.
摘要翻译：本发明提供了一种固定蛋白质的方法，包括：使用第一标签部分纯化具有第一标签部分和第二标签部分的待固定的靶蛋白质的步骤1; 启动能够共价结合载体上的蛋白质以进行固定的反应性基团的步骤2; 和步骤3，使步骤2中纯化的蛋白质溶液与载体反应，其中在步骤3中，蛋白质通过第二标签部分和载体位点之间的相互作用固定在载体上，其中第二标签部分结合并且通过反应性基团和蛋白质之间的共价结合。这种方法可以使各种类型的靶蛋白稳定地固定在载体上，而不管靶蛋白的量如何，并且不污染蛋白质的非特异性固定。

7. 发明授权

US07754497B2 Method for immobilizing proteins 失效
标题翻译：固定蛋白质的方法
公开(公告)号：US07754497B2
公开(公告)日：2010-07-13
申请号：US10569883
申请日：2004-08-24
申请人： Tsuyoshi Yamada , Yorimasa Suwa , Takeshi Tsutsumi
发明人： Tsuyoshi Yamada , Yorimasa Suwa , Takeshi Tsutsumi
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , Y10T436/25 , Y10T436/255
摘要： This invention provides a method for immobilizing proteins comprising: step 1 of purifying target proteins to be immobilized, which have a first tag portion and a second tag portion, with the use of the first tag portion; step 2 of activating reactive groups capable of covalently binding to the proteins on a carrier for immobilization; and step 3 of allowing a solution containing the proteins purified in step 1 to react with the carrier after step 2, wherein, in step 3, the proteins are immobilized on the carrier via interactions between the second tag portion and the site of the carrier to which the second tag portion binds and via covalent binding between the reactive groups and the proteins. This method enables the stable immobilization of various types of target proteins on a carrier regardless of the amounts of target proteins and without nonspecific immobilization of contaminating proteins.
摘要翻译：本发明提供了一种固定蛋白质的方法，包括：使用第一标签部分纯化具有第一标签部分和第二标签部分的待固定的靶蛋白质的步骤1; 启动能够共价结合载体上的蛋白质以进行固定的反应性基团的步骤2; 和步骤3，使步骤2中纯化的蛋白质溶液与载体反应，其中在步骤3中，蛋白质通过第二标签部分和载体位点之间的相互作用固定在载体上，其中第二标签部分结合并且通过反应性基团和蛋白质之间的共价结合。这种方法可以使各种类型的靶蛋白稳定地固定在载体上，而不管靶蛋白的量如何，并且不污染蛋白质的非特异性固定。

8. 发明申请

US20060056131A1 Charged particle beam application system 有权
标题翻译：带电粒子束应用系统
公开(公告)号：US20060056131A1
公开(公告)日：2006-03-16
申请号：US11221815
申请日：2005-09-09
申请人： Sayaka Tanimoto , Yasunari Soda , Masakazu Sugaya , Hiroshi Tooyama , Takeshi Tsutsumi , Yasuhiro Someda
发明人： Sayaka Tanimoto , Yasunari Soda , Masakazu Sugaya , Hiroshi Tooyama , Takeshi Tsutsumi , Yasuhiro Someda
IPC分类号： H01T23/00
CPC分类号： G03F7/2059 , H01J2237/0044 , H01J2237/3175 , H01L21/6833
摘要： During the writing operation, the wafer potential is dynamically detected and corrected. By doing so, the positional accuracy of the circuit patterns written on a wafer can be improved. After a contact resistance between a wafer and a earth pin is measured, the current flowing from the wafer to the ground potential via the earth pin is measured. Then, based on the measurement result, the potential difference is given between the wafer and the ground potential.
摘要翻译：在写入操作期间，动态地检测和校正晶片电位。通过这样做，能够提高写入晶片的电路图案的位置精度。在测量晶片和接地引脚之间的接触电阻之后，测量通过接地引脚从晶片流到接地电位的电流。然后，基于测量结果，在晶片和地电位之间给出电位差。

9. 发明授权

US08125858B2 Heat-assisted magnetic recording head including plasmon generator 有权
标题翻译：热辅助磁记录头包括等离子体发生器
公开(公告)号：US08125858B2
公开(公告)日：2012-02-28
申请号：US12728890
申请日：2010-03-22
申请人： Shinji Hara , Tsutomu Chou , Kosuke Tanaka , Eiji Komura , Koji Shimazawa , Daisuke Miyauchi , Susumu Aoki , Takeshi Tsutsumi
发明人： Shinji Hara , Tsutomu Chou , Kosuke Tanaka , Eiji Komura , Koji Shimazawa , Daisuke Miyauchi , Susumu Aoki , Takeshi Tsutsumi
IPC分类号： G11B11/00
CPC分类号： G11B5/314 , G11B5/3163 , G11B5/6088 , G11B2005/001 , G11B2005/0021
摘要： A plasmon generator has an outer surface including a plasmon exciting part, and has a near-field light generating part located in a medium facing surface. The plasmon exciting part faces an evanescent light generating surface of a waveguide's core with a predetermined distance therebetween. The outer surface of the plasmon generator further includes first and second inclined surfaces that are each connected to the plasmon exciting part. The first and second inclined surfaces increase in distance from each other with increasing distance from the plasmon exciting part. The plasmon generator includes a shape changing portion where the angle of inclination of each of the first and second inclined surfaces with respect to the evanescent light generating surface increases continuously with decreasing distance to the medium facing surface.
摘要翻译：等离子体发生器具有包括等离子体激元部分的外表面，并且具有位于介质面对表面中的近场光产生部分。等离子激元激发部分面对波导芯的渐逝光产生表面，其间具有预定的距离。等离子体发生器的外表面还包括各自连接到等离子体激元部分的第一和第二倾斜表面。第一和第二倾斜表面随距离等离激子激发部分的距离增加而彼此间距离增加。等离子体发生器包括形状改变部分，其中第一和第二倾斜表面中的每一个相对于ev逝光产生表面的倾斜角度随着到介质面向表面的距离的减小而连续增加。

10. 发明申请

US20110189789A1 NOVEL TARGET PROTEIN OF ANTICANCER AGENT AND NOVEL ANTICANCER AGENT (SPNAL) CORRESPONDING THERETO 审中-公开
标题翻译：新药抗体药剂和新型抗感染药物（SPNAL）相关药物的新目标蛋白
公开(公告)号：US20110189789A1
公开(公告)日：2011-08-04
申请号：US12632905
申请日：2009-12-08
申请人： Akito Tanaka , Akira Yamazaki , Takeshi Tsutsumi , Tomohiro Terada , Masayuki Haramura
发明人： Akito Tanaka , Akira Yamazaki , Takeshi Tsutsumi , Tomohiro Terada , Masayuki Haramura
IPC分类号： G01N33/53
CPC分类号： C07D231/12 , A61K45/06 , C07C317/44 , C07C323/62
摘要： The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound that specifically binds to KSRP or a functional fragment thereof, and a screening method for the compound. KSRP is a novel target protein for anticancer agents; a compound capable of regulating the expression and activity of such a protein and a pharmaceutical composition containing it are highly useful for proliferative diseases, particularly as anticancer agents. By providing the novel target protein, the mechanism behind the anticancer effect that has conventionally been unexplainable can be elucidated.
摘要翻译：本发明提供含有与KSRP或其功能片段特异性结合的化合物作为活性成分的药物组合物和该化合物的筛选方法。 KSRP是抗癌剂的新型靶蛋白; 能够调节这种蛋白质的表达和活性的化合物和含有该蛋白质的药物组合物对于增殖性疾病，特别是作为抗癌剂是非常有用的。通过提供新的靶蛋白，可以阐明通常不可解释的抗癌作用背后的机制。

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