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1. 发明申请

US20230083005A1 METHODS OF KILLING OR INHIBITING THE GROWTH OF CANCER CELLS 有权
公开(公告)号：US20230083005A1
公开(公告)日：2023-03-16
申请号：US17798421
申请日：2021-02-12
申请人： TISSUETECH, INC.
发明人： Scheffer TSENG , Hua HE , Sean TIGHE , Kaustuv BASU
IPC分类号： A61K47/62 , A61K47/61 , A61K45/06 , A61P35/00 , A61P13/08
摘要： Provided herein, in certain embodiments, are compositions comprising an isolated heavy chain-hyaluronan/pentraxin 3 (“HC-HA/PTX3”) complex for use in methods of killing cancer cells. Also provided herein, are methods of inhibiting cancer cell regrowth of a tumor in an individual in need thereof, comprising contacting an area surrounding the tumor after a surgical procedure with an isolated HC-HA/PTX3 complex. Combinations and kits for use in practicing said methods also are provided herein.

2. 发明申请

US20160376305A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20160376305A1
公开(公告)日：2016-12-29
申请号：US15214706
申请日：2016-07-20
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Hua HE , Sean TIGHE , Suzhen ZHANG , Ying-Tieng ZHU
IPC分类号： C07K1/36 , C07K19/00 , C07K14/47
CPC分类号： C07K1/36 , A61K38/00 , A61K38/191 , A61K47/55 , A61K47/69 , A61K47/6957 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/236 , A61L2300/252 , A61L2300/41 , A61L2300/412 , A61L2300/426 , C07K14/47 , C07K14/525 , C07K14/81 , C07K19/00
摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

3. 发明申请

US20160243288A1 APPARATUSES AND METHODS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：治疗眼科疾病和疾病的方法和方法
公开(公告)号：US20160243288A1
公开(公告)日：2016-08-25
申请号：US15051477
申请日：2016-02-23
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Ek Kia TAN
IPC分类号： A61L31/00 , A61N1/04 , A61F9/00 , A61L31/14 , A61L31/16
CPC分类号： A61L31/005 , A61F9/0017 , A61L31/146 , A61L31/16 , A61L2300/406 , A61L2430/16 , A61N1/0452 , A61N1/36003
摘要： The invention relates generally to the fields of biology and health sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in amniotic membrane tissue and umbilical cord tissue preparations.
摘要翻译：本发明一般涉及生物学和健康科学领域。更具体地，本发明涉及使用可以在羊膜组织和脐带组织制剂中发现的化合物的组合来调节细胞生理学和病理学处理的组合物和方法。

4. 发明申请

US20130344128A1 METHOD FOR TREATING OCULAR DEMODEX 有权
标题翻译：用于治疗眼科DEMODEX的方法
公开(公告)号：US20130344128A1
公开(公告)日：2013-12-26
申请号：US13856638
申请日：2013-04-04
申请人： TissueTech, Inc.
发明人： Ying-Ying GAO , Scheffer TSENG
IPC分类号： A61K9/70 , A61K31/045
CPC分类号： A61K9/70 , A61K31/045 , A61K36/23 , A61K36/61 , A61K2300/00
摘要： The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex-induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a compositions comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; (+)-Carvone; alpha-Terpineol; Cardinene; d-Carvone; 1-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Ci mene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.
摘要翻译：本发明涉及一种治疗有需要的患者中选自眼部Demodex，Demodex诱导的睑炎炎，红斑痤疮，痤疮和睑板腺功能障碍的病症的方法，包括向患者施用包含治疗有效量的选自至少一种异戊二烯精油如茶树油的物质; 萜品烯-4-醇; （+） - Carvone; α-萜品醇卡迪琳 d-carvone; 1-Carvone; γ-萜品烯; α-萜品烯 1,8-可乐乐; α-萜品醇对 - α-蒎烯; 柠檬烯（R） - （+） - 柠檬烯; α-凝乳酶桉树脑（+） - Ledene; 孜然酸和月桂烯; 所述施用包括用所述组合物接触或洗涤患者的皮肤或毛发的受影响区域或眼睑边缘和睫毛; 还公开了一种用于治疗哺乳动物的螨虫和螨虫感染的方法; 和用于在家和家庭治疗疾病的工具包。

5. 发明申请

US20180064764A1 COMPOSITIONS OF MORSELIZED UMBILICAL CORD AND/OR AMNIOTIC MEMBRANE AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20180064764A1
公开(公告)日：2018-03-08
申请号：US15727445
申请日：2017-10-06
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Lorraine CHUA
IPC分类号： A61K35/50 , A61L27/54 , A61K35/51 , A61K35/28 , A61L15/44 , A61L15/40 , A61L27/38 , A61L27/36 , A61K9/70
CPC分类号： A61K35/50 , A61K9/7007 , A61K35/28 , A61K35/51 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/38 , A61L27/54 , A61K2300/00
摘要： The invention relates generally to the fields of biology and life sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in morselized amniotic membrane tissue and morselized umbilical cord tissue preparations.

6. 发明申请

US20170072102A1 METHODS OF MODULATING BONE REMODELING 有权
标题翻译：调整骨重塑的方法
公开(公告)号：US20170072102A1
公开(公告)日：2017-03-16
申请号：US15348736
申请日：2016-11-10
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Ek Kia TAN , Hua HE
IPC分类号： A61L27/38 , A61L27/36 , A61K35/54
CPC分类号： A61L27/365 , A61K9/0019 , A61K31/728 , A61K33/06 , A61K35/50 , A61K35/51 , A61K35/54 , A61K38/57 , A61L27/20 , A61L27/26 , A61L27/34 , A61L27/3604 , A61L27/3847 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/434 , A61L2300/45 , A61L2300/606 , A61L2430/02 , C08L5/08 , C08L89/00
摘要： Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.
摘要翻译：在某些情况下，本文公开的是在有需要的个体中抑制破骨细胞分化，骨吸收，骨形成和骨重塑的方法，包括向个体施用包含基本上胎儿支持组织产品的组合物，包括羊膜和脐带，或或其包含基本上分离的HC-HA复合物的组合物。

7. 发明申请

US20160106785A1 UMBILICAL CORD PRODUCTS 审中-公开
公开(公告)号：US20160106785A1
公开(公告)日：2016-04-21
申请号：US14886946
申请日：2015-10-19
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Ek Kia TAN , Amy TSENG
IPC分类号： A61K35/51
CPC分类号： A61K35/51 , A61K35/44 , A61K35/50 , A61L15/40 , A61L15/42 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/365 , A61L27/3675 , A61L27/3679 , A61L27/3839 , A61L27/3886 , A61L31/005 , A61L2300/412 , A61L2400/06 , A61L2430/02 , A61L2430/14 , A61L2430/16 , A61L2430/20 , A61L2430/22 , A61L2430/32 , A61L2430/34 , C12N5/0605 , Y02A50/393
摘要： Disclosed herein, in certain instances, are tissue grafts derived from UCAM. Further disclosed herein, in certain instances, are use for tissue grafts derived from UCAM.

8. 发明申请

US20160008295A1 COMPOSITIONS AND METHODS FOR TREATING ROSACEA 审中-公开
标题翻译：用于治疗ROSACEA的组合物和方法
公开(公告)号：US20160008295A1
公开(公告)日：2016-01-14
申请号：US14798807
申请日：2015-07-14
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Sean TIGHE
IPC分类号： A61K31/045 , A61K47/10 , A61K47/38 , A61K47/34 , A61K45/06 , A61K9/70
CPC分类号： A61K31/045 , A61K9/0014 , A61K9/7007 , A61K47/10 , A61K47/34 , A61K47/38
摘要： The present invention relates to terpine-4-ol containing pharmaceutical compositions, dermatological delivery systems and methods of treatment that are useful for treating rosacea, to include ocular rosacea, papulopustular rosacea, phymatous rosacea, acne rosacea, rosacea associated with Demodex infections, erythematelangiectatic rosacea, steroid induced rosacea, and combinations thereof, acne vulgaris and related conditions in a patient in need thereof.
摘要翻译：本发明涉及含萜烯-4-醇的药物组合物，可用于治疗酒渣鼻的皮肤病学输送系统和治疗方法，包括眼酒渣鼻，葡萄糖喷发性红斑痤疮，幽门型酒渣鼻，痤疮性红斑痤疮，与Demodex感染相关的红斑痤疮，红斑狼疮红斑痤疮，类固醇诱导的红斑痤疮及其组合，寻常痤疮和有需要的患者中的相关病症。

9. 发明申请

US20200308219A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20200308219A1
公开(公告)日：2020-10-01
申请号：US16898309
申请日：2020-06-10
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Hua HE , Sean TIGHE , Suzhen ZHANG , Ying-Tieng ZHU
IPC分类号： C07K1/36 , C07K14/47 , A61K47/69 , A61K38/19 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , C07K14/525 , C07K19/00 , A61K47/55
摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

10. 发明申请

US20190169231A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20190169231A1
公开(公告)日：2019-06-06
申请号：US16274123
申请日：2019-02-12
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Hua HE , Sean TIGHE , Suzhen ZHANG , Ying-Tieng ZHU
IPC分类号： C07K1/36 , C07K19/00 , A61L27/54 , A61K47/55 , A61L31/16 , C07K14/47 , A61L31/10 , A61L27/34 , A61K47/69 , A61L29/16 , A61L29/08 , C07K14/525 , A61K38/19
摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

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