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    • 6. 发明授权
    • Polymer ligands for nanoparticles
    • 纳米粒子的聚合物配体
    • US09580560B2
    • 2017-02-28
    • US14672436
    • 2015-03-30
    • The Florida State University Research Foundation, Inc.
    • Hedi MattoussiWentao WangGoutam Palui
    • C08F8/32C08G81/02C09D123/36C09D187/00G01N33/50G01N33/58C09D135/00
    • C08G81/025C08F8/32C09D123/36C09D135/00C09D187/005G01N33/5005G01N33/582
    • The disclosure is directed to polymer ligands that are optimally suited for surface-functionalizing magnetic nanoparticles. The amphiphilic polymers are prepared by coupling several amine-terminated anchoring groups, polyethylene glycol moieties, and reactive groups onto a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. The reaction of maleic anhydride groups with amine-containing molecules is highly-efficient and occurs in one-step. The availability of several dopamine groups in the same ligand greatly enhances the ligand affinity, via multiple-coordination, to the magnetic NPs, while the hydrophilic and reactive groups promote colloidal stability in buffer media and allow subsequent conjugation with target biomolecules. Nanoparticles ligated with terminally reactive polymers have been easily coupled to target dyes and tested in live cell imaging with no measurable cytotoxicity.
    • 本发明涉及最适合用于表面官能化磁性纳米颗粒的聚合物配体。 通过将几个胺封端的锚定基团,聚乙二醇部分和反应性基团偶联到聚(异丁烯 - 邻 - 马来酸酐)(PIMA)链上制备两亲性聚合物。 马来酸酐基团与含胺分子的反应是高效的并且发生在一步中。 同一配位体中几个多巴胺基团的可用性通过多重配位大大增强了配体对磁性NPs的亲和力,而亲水和反应性基团则促进了缓冲介质中的胶体稳定性,并允许随后与目标生物分子共轭。 与末端反应性聚合物连接的纳米颗粒已经容易地与目标染料偶联并且在活细胞成像中测试,没有可测量的细胞毒性。
    • 7. 发明申请
    • POLYMER LIGANDS FOR NANOPARTICLES
    • 聚合物纳米粒子配体
    • US20150284517A1
    • 2015-10-08
    • US14672436
    • 2015-03-30
    • The Florida State University Research Foundation, Inc.
    • Hedi MattoussiWentao WangGoutam Palui
    • C08G81/02C09D135/00G01N33/58C09D187/00G01N33/50C08F222/06C09D123/36
    • C08G81/025C08F8/32C09D123/36C09D135/00C09D187/005G01N33/5005G01N33/582
    • The disclosure is directed to polymer ligands that are optimally suited for surface-functionalizing magnetic nanoparticles. The amphiphilic polymers are prepared by coupling several amine-terminated anchoring groups, polyethylene glycol moieties, and reactive groups onto a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. The reaction of maleic anhydride groups with amine-containing molecules is highly-efficient and occurs in one-step. The availability of several dopamine groups in the same ligand greatly enhances the ligand affinity, via multiple-coordination, to the magnetic NPs, while the hydrophilic and reactive groups promote colloidal stability in buffer media and allow subsequent conjugation with target biomolecules. Nanoparticles ligated with terminally reactive polymers have been easily coupled to target dyes and tested in live cell imaging with no measurable cytotoxicity.
    • 本发明涉及最适合用于表面官能化磁性纳米颗粒的聚合物配体。 通过将几个胺封端的锚定基团,聚乙二醇部分和反应性基团偶联到聚(异丁烯 - 邻 - 马来酸酐)(PIMA)链上制备两亲性聚合物。 马来酸酐基团与含胺分子的反应是高效的并且发生在一步中。 同一配位体中几个多巴胺基团的可用性通过多重配位大大增强了配体对磁性NPs的亲和力,而亲水和反应性基团则促进了缓冲介质中的胶体稳定性,并允许随后与目标生物分子结合。 与末端反应性聚合物连接的纳米颗粒已经容易地与目标染料偶联并且在活细胞成像中测试,没有可测量的细胞毒性。
    • 10. 发明申请
    • PHOTOLIGATION OF AN AMPHIPHILIC POLYMER WITH MIXED COORDINATION PROVIDES COMPACT AND REACTIVE QUANTUM DOTS
    • 具有混合协调的AMPHIPHILIC聚合物的光刻提供了紧凑和反应量子点
    • US20150284493A1
    • 2015-10-08
    • US14672462
    • 2015-03-30
    • The Florida State University Research Foundation, Inc
    • Hedi MattoussiWentao WangGoutam Palui
    • C08F222/06C09D135/00
    • C08G81/025C08F8/32C09D123/36C09D135/00C09D187/005G01N33/5005G01N33/582
    • The disclosure is directed to multi-coordinating polymers as ligands that combine two distinct metal-chelating groups, lipoic acid and imidazole, for the surface functionalization of QDs. These ligands combine the benefits of thiol and imidazole coordination to reduce issues of thiol oxidation and weak binding affinity of imidazole. The ligand design relies on the introduction of controllable numbers of lipoic acid and histamine anchors, along with hydrophilic moieties and reactive functionalities, onto a poly(isobutylene-alt-maleic anhydride) chain via a one-step nucleophilic addition reaction. We further demonstrate that this design is fully compatible with a novel and mild photoligation strategy to promote the in-situ ligand exchange and phase transfer of hydrophobic QDs to aqueous media under borohydride-free conditions. Ligation with these polymers provides highly fluorescent QDs that exhibit great long-term colloidal stability over a wide range of conditions.
    • 本公开涉及多配位聚合物作为将两个不同金属螯合基团(硫辛酸和咪唑)组合的配体,用于量子点的表面官能化。 这些配体结合了硫醇和咪唑配位的优点,以减少巯基氧化和咪唑结合亲和力弱的问题。 配体设计依赖于通过一步亲核加成反应将可控数量的硫辛酸和组胺锚定物以及亲水部分和反应性官能团引入到聚(异丁烯 - 马来酸酐 - 马来酸酐)链上。 我们进一步证明,该设计完全兼容新型和温和的光引发策略,以促进在无硼氢化物条件下疏水量子点的原位配体交换和相转移到含水介质中。 与这些聚合物的连接提供了高度荧光的量子点,其在宽范围的条件下表现出巨大的长期胶体稳定性。