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1. 发明申请

US20050204719A1 Composite yarn and textile fabric 审中-公开
标题翻译：复合纱和纺织面料
公开(公告)号：US20050204719A1
公开(公告)日：2005-09-22
申请号：US11089291
申请日：2005-03-24
申请人： Syu Ono , Makoto Shiozaki , Masayuki Sugiyama , Shigeo Horikoshi
发明人： Syu Ono , Makoto Shiozaki , Masayuki Sugiyama , Shigeo Horikoshi
IPC分类号： D01H7/46 , D01H7/92 , D01H13/26 , D02G3/28 , D02G3/36 , D03D15/00
CPC分类号： D02G3/28
摘要： The invention is a composite yarn fabricated by double-twisting a S-twisted single yarn and a S-twisted single yarn in a Z-twisting mode in a ratio of from 100% to 300% of the count of twist of the S-twisted single yarns, or a textile fabric.
摘要翻译：本发明是一种复合纱线，其制造方法是以Z捻方式将S捻合单纱和S捻单纱双捻，比例为S捻合捻度计的100％〜300％单纱或纺织织物。

2. 发明申请

US20110136778A1 NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF 有权
标题翻译：含氮的螺旋化合物及其药物用途
公开(公告)号：US20110136778A1
公开(公告)日：2011-06-09
申请号：US12847025
申请日：2010-07-30
申请人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
发明人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
IPC分类号： A61K31/397 , C07D471/10 , A61K31/519 , C07D487/10 , A61K31/55 , A61P37/06 , A61P37/08 , A61P19/02 , A61P17/06
CPC分类号： C07D487/10 , A61K31/437 , A61K31/438 , A61K31/519 , A61K31/55 , C07D471/10 , C07D519/00
摘要： A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.
摘要翻译：下列通式[I]的化合物：其中每个符号具有如本文所定义的相同含义，或其药学上可接受的盐或其溶剂合物，以及其用于治疗器官移植排斥，移植物抗宿主移植后反应，自身免疫性疾病，过敏性疾病和慢性骨髓增生性疾病。

3. 发明授权

US5142475A A system for controlling damping force of shock absorbers by adaptively adjusting the desired acceleration expansion/contraction of the shock absorbers 失效
标题翻译：通过自适应地调整减震器的加速膨胀/收缩来控制减震器的阻尼力的系统
公开(公告)号：US5142475A
公开(公告)日：1992-08-25
申请号：US391283
申请日：1989-08-09
申请人： Eiju Matsunaga , Makoto Shiozaki , Yutaka Suzuki , Masatoshi Kuroyanagi , Toshinobu Ishida
发明人： Eiju Matsunaga , Makoto Shiozaki , Yutaka Suzuki , Masatoshi Kuroyanagi , Toshinobu Ishida
IPC分类号： B60G17/015 , B60G17/019
CPC分类号： B60G17/01941 , B60G2202/24 , B60G2202/42 , B60G2204/80 , B60G2400/102 , B60G2400/204 , B60G2400/5182 , B60G2400/821 , B60G2401/10 , B60G2500/102 , B60G2600/14 , B60G2600/184 , B60G2600/60 , B60G2600/602 , B60G2600/604 , B60G2600/90
摘要： The expanding/contracting accelerations of shock absorbers on a motor vehicle are detected and compared with preset accelerations, respectively, by an electronic controller, which individually varies the damping forces of the shock absorbers as a result of the comparison. The electronic controller corrects the preset accelerations so that the damping forces of the shock absorbers will be switched over at a uniform frequency or the damping forces of the front left and rear left shock absorbers and the damping forces of the front right and rear right shock absorbers will be switched over at a constant frequency.
摘要翻译：通过电子控制器分别检测机动车辆上的减震器的膨胀/收缩加速度，并将其与预设加速度进行比较，电子控制器通过比较结果单独改变减震器的阻尼力。电子控制器校正预设的加速度，使得减震器的阻尼力将以均匀的频率或前左后减震器的阻尼力和前右右后减震器的阻尼力切换将以恒定频率切换。

4. 发明授权

US4136645A Electric air-to-fuel ratio control system 失效
标题翻译：电力空燃比控制系统
公开(公告)号：US4136645A
公开(公告)日：1979-01-30
申请号：US795910
申请日：1977-05-11
申请人： Osamu Ito , Nobuhito Hobo , Yutaka Suzuki , Itsushi Kawamoto , Takashi Naitou , Makoto Shiozaki , Yoshimune Konishi
发明人： Osamu Ito , Nobuhito Hobo , Yutaka Suzuki , Itsushi Kawamoto , Takashi Naitou , Makoto Shiozaki , Yoshimune Konishi
IPC分类号： F02D41/34 , F02D41/14 , F02M7/12 , F02B3/08 , F01N3/08
CPC分类号： F02D41/1489 , F02D41/1487 , F02D2200/501 , Y10S261/74
摘要： A function signal having a desired characteristic curve is generated through the logical operation on a vehicle speed signal indicative of the speed of a vehicle, a ratio signal indicative of the air-to-fuel of the mixture supplied to the engine mounted on the vehicle, and a pressure signal indicative of the pressure in the intake manifold of the engine. The position of an electromagnetic valve for adjusting the amount of fuel supplied to the engine is controlled in response to the function signal, thereby controlling the air-to-fuel of mixtures in accordance with the various driving conditions of the vehicle including the vehicle speed.
摘要翻译：具有期望特性曲线的功能信号通过对表示车辆速度的车辆速度信号的逻辑运算产生，表示提供给安装在车辆上的发动机的混合物的空气对燃料的比率信号，以及指示发动机的进气歧管中的压力的压力信号。响应于功能信号控制用于调节供应给发动机的燃料量的电磁阀的位置，从而根据包括车速的车辆的各种行驶条件来控制混合物的空气对燃料。

5. 发明授权

US08604069B2 Amide compound and medicinal use thereof 有权
标题翻译：酰胺化合物及其药用
公开(公告)号：US08604069B2
公开(公告)日：2013-12-10
申请号：US13457844
申请日：2012-04-27
申请人： Takaki Maeba , Katsuya Maeda , Masayuki Kotoku , Kazayuki Hirata , Noriyoshi Seki , Hiroshi Yamanaka , Takayuki Sakai , Shintaro Hirashima , Shingo Obika , Makoto Shiozaki , Masahiro Yokota
发明人： Takaki Maeba , Katsuya Maeda , Masayuki Kotoku , Kazayuki Hirata , Noriyoshi Seki , Hiroshi Yamanaka , Takayuki Sakai , Shintaro Hirashima , Shingo Obika , Makoto Shiozaki , Masahiro Yokota
IPC分类号： A61K31/42 , C07D261/08
CPC分类号： A61K31/4192 , A61K31/42 , C07D249/04 , C07D261/08 , C07D417/06
摘要： A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
摘要翻译：式[I-W]化合物或其药学上可接受的盐，其中每个符号如说明书中所定义。

6. 发明申请

US20100105894A1 Cyclopropane compounds and pharmaceutical use thereof 审中-公开
标题翻译：环丙烷化合物及其药物用途
公开(公告)号：US20100105894A1
公开(公告)日：2010-04-29
申请号：US12457391
申请日：2009-06-09
申请人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafuml Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
发明人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafuml Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
IPC分类号： C07D243/08 , C07C229/02 , C07C307/00 , C07D409/02 , C07D231/10 , C07D401/02 , C07D261/06 , C07D333/34 , C07D241/04 , C07D271/06 , C07D257/04 , C07D295/00 , C07D215/14 , C07D205/04 , C07D413/02 , C07D241/36 , C07D413/14 , C07D223/14
CPC分类号： C07C311/29 , C07C311/13 , C07C311/20 , C07C311/22 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07C2603/08 , C07C2603/18 , C07C2603/30 , C07D205/04 , C07D207/48 , C07D209/44 , C07D211/58 , C07D211/96 , C07D213/18 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/82 , C07D217/08 , C07D231/12 , C07D233/64 , C07D237/12 , C07D239/22 , C07D243/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/107 , C07D277/26 , C07D277/36 , C07D277/82 , C07D295/26 , C07D307/79 , C07D307/91 , C07D333/18 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）所示的环丙烷化合物：其中，R 1为 - （CH 2 ）m-X-（CH 2）n -Al等，其中m和n相同或不同，各自为0〜6，X为单键等，而A1为取代的C3-14烃环基，等等。; R2和R3相同或不同，各自为氢原子， - （CH2）p-X1-（CH2）q-A2等，其中p和q相同或不同，各自为0至6，X1 是单键等，A2是任选取代的C 3-14烃环基等; R4是-CO 2 R 9等，其中R9是氢原子等; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2）m 12 -X 12 - （CH 2）m 12 -R 30等，其中m12和m12相同或不同，各自为0至6， X12为单键等，R30为氢原子等; 或其前药或其药学上可接受的盐。

7. 发明申请

US20080081818A1 New Piperazine Compound and Use Thereof as a HCV Polymerase Inhibitor 有权
标题翻译：新的哌嗪化合物及其用途为HCV聚合酶抑制剂
公开(公告)号：US20080081818A1
公开(公告)日：2008-04-03
申请号：US11736064
申请日：2007-04-17
申请人： Hiroyuki Abe , Masahiro Tanaka , Kazuyuki Sugimoto , Akira Suma , Masahiro Yokota , Makoto Shiozaki , Kiyosei Iio , Kazuhito Ueyama , Dai Motoda , Toru Noguchi , Tsuyoshi Adachi , Junichiro Tsuruha , Satoki Doi
发明人： Hiroyuki Abe , Masahiro Tanaka , Kazuyuki Sugimoto , Akira Suma , Masahiro Yokota , Makoto Shiozaki , Kiyosei Iio , Kazuhito Ueyama , Dai Motoda , Toru Noguchi , Tsuyoshi Adachi , Junichiro Tsuruha , Satoki Doi
IPC分类号： A61K31/4965 , A61P43/00 , C07D241/04
CPC分类号： C07D241/04 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D475/00 , C07D487/04 , C07D491/052 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof and an anti-HCV agent and an HCV polymerase inhibitor containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
摘要翻译：本发明涉及由下式[I]表示的化合物，其中每个符号如本说明书中所定义，或其药学上可接受的盐，或其溶剂合物，抗HCV药剂和含有该化合物的HCV聚合酶抑制剂。本发明化合物基于HCV聚合酶抑制活性显示抗HCV活性，可用作预防或治疗丙型肝炎的药剂。

8. 发明申请

US20050136056A1 Pharmaceutical composition for the treatment of thrombocytopenia 审中-公开
标题翻译：用于治疗血小板减少症的药物组合物
公开(公告)号：US20050136056A1
公开(公告)日：2005-06-23
申请号：US11044198
申请日：2005-01-28
申请人： Shunsuke Kageyama , Ken Hirose , Hiroshi Yamamoto , Makoto Shiozaki , Junko Matsushita
发明人： Shunsuke Kageyama , Ken Hirose , Hiroshi Yamamoto , Makoto Shiozaki , Junko Matsushita
IPC分类号： C07K16/28 , C07K16/36 , A61K39/395
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/36
摘要： The present invention provides a drug for the treatment of thrombocytopenia caused by hepatic failure, preferably a drug with few adverse drug reactions. A substance that inhibits binding between glycoprotein Ib (GPIb) and von Willebrand factor (vWF), for example, anti-GPIb antibody or anti-vWF antibody that inhibits binding between GPIb and vWF is an active ingredient of the drug for the treatment of thrombocytopenia.
摘要翻译：本发明提供了用于治疗由肝功能衰竭引起的血小板减少症的药物，优选药物反应少的药物。抑制糖蛋白Ib（GPIb）和血管性血友病因子（vWF）之间的结合的物质，例如抑制GPIb和vWF结合的抗GPIb抗体或抗vWF抗体是用于治疗血小板减少症的药物的活性成分。

9. 发明授权

US4416232A Electrical fuel injection pump governor 失效
标题翻译：电动燃油喷射泵调速器
公开(公告)号：US4416232A
公开(公告)日：1983-11-22
申请号：US282955
申请日：1981-07-13
申请人： Makoto Shiozaki , Satoshi Haseda , Jun Tarui , Osamu Ito , Nobuhito Hobo , Yoshihiko Tsuzuki , Shizuo Kawai , Hiroshi Sami
发明人： Makoto Shiozaki , Satoshi Haseda , Jun Tarui , Osamu Ito , Nobuhito Hobo , Yoshihiko Tsuzuki , Shizuo Kawai , Hiroshi Sami
IPC分类号： F02B75/02 , F02D1/08 , F02D31/00 , F02D41/14 , F02D41/26 , F02D41/40 , F02M41/12 , F02D1/04
CPC分类号： F02D41/408 , F02D31/007 , F02M41/126 , F02B2075/027 , F02D2200/503 , Y02T10/44
摘要： An electrical governor for a fuel injection pump with a spill ring comprises an acceleration pedal operating amount (PA) detector, an engine rotational speed (N) detector, a spill ring displacement detector, a maximum limit injection amount pattern memory for storing the relation between the engine rotational speed (N) and the maximum smoke concentration generating injection amount (Qmax), a partial load injection amount pattern memory for storing the relation between the rotational speed (N) and the partial load injection amount (Qpar) corresponding to the acceleration pedal operating amount (PA) with the acceleration pedal operating amount (PA) as a parameter, a minimum limit injection amount pattern memory for storing the relation between the rotational speed (N) and the minimum limit injection amount (Qmin), a target position pattern memory for storing the relation between the target injection amount (Qf) and the spill ring displacement target position (V.sub.SN), microcomputer means for reading out the values Qmin, Qpar and Qmax for the detected values PA and N and calculating the values Qf' and V.sub.SN ' corresponding to the detected values PA and N by interpolation, and actuator drive means for correcting the spill ring displacement in accordance with the calculated target position V.sub.SN ', thereby correcting the change in the fuel injection amount caused by the change in rotational speed. The governor alternatively includes a target position pattern memory for storing the relation between the values PA, N and V.sub.SN for a corresponding value Qf.
摘要翻译：一种具有溢流环的燃油喷射泵的调速器包括加速踏板操作量（PA）检测器，发动机转速（N）检测器，溢流环位移检测器，最大限制喷射量模式存储器，用于存储发动机转速（N）和最大烟雾浓度产生喷射量（Qmax）），用于存储转速（N）和对应于加速度的部分负荷喷射量（Qpar）之间的关系的局部负荷喷射量模式存储器加速踏板操作量（PA）作为参数的踏板操作量（PA），用于存储转速（N）与最小限制喷射量（Qmin）之间的关系的最小限制喷射量图案存储器，目标位置用于存储目标喷射量（Qf）和溢出环位移目标位置（VSN）之间的关系的模式存储器，微机装置 r读出检测值PA和N的值Qmin，Qpar和Qmax，并通过插值计算与检测值PA和N相对应的值Qf'和VSN';以及致动器驱动装置，用于根据计算出的目标位置VSN'，从而校正由转速变化引起的燃料喷射量的变化。调速器或者包括用于存储对应值Qf的值PA，N和VSN之间的关系的目标位置模式存储器。

10. 发明授权

US08609647B2 Nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof 有权
标题翻译：含氮螺环化合物及其药物用途
公开(公告)号：US08609647B2
公开(公告)日：2013-12-17
申请号：US12847025
申请日：2010-07-30
申请人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
发明人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
IPC分类号： C07D487/04 , A61K31/519 , A61P19/02 , A61P37/00 , A61P17/06 , A61P27/04 , A61P29/00
CPC分类号： C07D487/10 , A61K31/437 , A61K31/438 , A61K31/519 , A61K31/55 , C07D471/10 , C07D519/00
摘要： A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.
摘要翻译：下列通式[I]的化合物：其中每个符号具有如本文所定义的相同含义，或其药学上可接受的盐或其溶剂合物，以及其用于治疗器官移植排斥，移植物抗宿主移植后反应，自身免疫性疾病，过敏性疾病和慢性骨髓增生性疾病。

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