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1. 发明授权

US07659078B1 Method and kit for determination of prostacyclin in plasma 失效
标题翻译：血浆前列环素测定方法及试剂盒
公开(公告)号：US07659078B1
公开(公告)日：2010-02-09
申请号：US10620806
申请日：2003-07-17
申请人： Sylvia Daunert , Michael Poon , Urvee Desai , Sapna K. Deo
发明人： Sylvia Daunert , Michael Poon , Urvee Desai , Sapna K. Deo
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543 , G01N33/88 , C12Q1/66 , C07K16/18 , C07K16/26
CPC分类号： G01N33/88 , G01N2800/12 , Y10S435/971 , Y10S435/975 , Y10S530/807
摘要： A solid-phase immunoassay for 6-keto-Prostaglandin F1α, the stable hydrolysis product of prostacyclin (Prostaglandin I2) is disclosed. Prostacyclin, a potent vasodilator with anti-platelet and anti-proliferative properties is an effective treatment for primary pulmonary hypertension and pulmonary arterial hypertension associated with scleroderma and scleroderma-like syndrome. Levels of 6-keto-Prostaglandin F1α can be directly correlated with levels of prostacyclin. Therefore, 6-keto-Prostaglandin F1α has become the indicator of choice to measure prostacyclin levels. The single step immunoassay for 6-keto-Prostaglandin F1α uses the bioluminescent protein, aequorin as a label. Analyte-label conjugates were constructed by linking the carboxyl group of 6-keto-Prostaglandin F1α and lysine residues of aequorin by chemical conjugation methods. The binding properties of 6-keto-Prostaglandin F1α towards its antibody and the bioluminescent properties of aequorin are retained in the conjugate. The concentration of 6-keto-Prostaglandin F1α after extraction from plasma shows good correlation with the concentration of 6-keto-Prostaglandin F1α obtained without prior extraction of the same plasma sample. The assay allows the measurement of 6-keto-Prostaglandin F1α directly in plasma without any pre-treatment of the samples, which results in a much simpler method with a faster assay time.
摘要翻译：公开了前列环素（前列腺素I2）的稳定水解产物6-酮 - 前列腺素F1alpha的固相免疫测定。前列环素，具有抗血小板和抗增殖特性的强效血管扩张剂是与硬皮病和硬皮病样综合征相关的原发性肺动脉高压和肺动脉高压的有效治疗方法。 6-keto-Prostaglandin F1alpha的水平可以与前列环素的水平直接相关。因此，6-keto-Prostaglandin F1alpha已经成为衡量前列环素水平的首选指标。 6-keto-Prostaglandin F1alpha的单步免疫测定使用生物发光蛋白，水母发光蛋白作为标记。通过化学共轭方法连接6-酮基前列腺素F1al的羧基和水母发光蛋白的赖氨酸残基，构建了分析标记物缀合物。 6-酮前列腺素F1alpha对其抗体的结合性质和水母发光蛋白的生物发光性质保留在缀合物中。从血浆中提取6-keto-Prostaglandin F1alpha的浓度与未经提取相同血浆样品的6-酮 - 前列腺素F1al的浓度呈现良好的相关性。该测定允许直接在血浆中测量6-酮基前列腺素F1alpha，而没有对样品进行任何预处理，这导致以更快的测定时间简单的方法。

2. 发明授权

US08085670B2 Method and system for originating connectivity fault management (CFM) frames on non-CFM aware switches 有权
标题翻译：在非CFM感知交换机上发起连接故障管理（CFM）帧的方法和系统
公开(公告)号：US08085670B2
公开(公告)日：2011-12-27
申请号：US11313637
申请日：2005-12-21
申请人： John Osswald , Michael Poon
发明人： John Osswald , Michael Poon
IPC分类号： G01R31/08
CPC分类号： H04L41/06 , H04L43/0811
摘要： A system for originating connectivity fault management (CFM) frames on non-CFM aware switches is disclosed. In the disclosed system, an OAM (Operations Administration and Management) proxy networking device connected to a core Ethernet network operates with one or more CPE (Customer Premises Equipment) devices to which it is communicably connected to support CFM out to the CPE devices without requiring that the CPE devices themselves implement CFM functionality. The OAM proxy networking device generates Connectivity Check (CC) frames, Loopback reply frames, and Linktrace reply frames for MEPs (Maintenance End Points) or MIPs (Maintenance Intermediate Points) contained in communication ports on the CPEs. These CFM frames generated by the OAM proxy networking device are then sent within messages from the OAM proxy networking device to the appropriate CPE. When the CPE device receives a message from the OAM proxy networking device containing one of these CFM frames, it checks the operability of a communication port indicated by the message. If the port is operable, the CPE device extracts the CFM frame from the message and originates it through the OAM proxy networking device into the core Ethernet network. The OAM proxy networking device further operates to process Connectivity Check frames received from the core Ethernet network and addressed to the CPE devices by maintaining an MEP connectivity database. As a result, these received Connectivity Check frames are dropped without forwarding to the CPE devices.
摘要翻译：公开了一种用于在非CFM感知交换机上发起连接故障管理（CFM）帧的系统。在所公开的系统中，连接到核心以太网的OAM（操作管理和管理）代理网络设备与一个或多个CPE（客户驻地设备）设备操作，其可通信地连接到其上以将CFM支持到CPE设备，而不需要 CPE设备本身实现CFM功能。 OAM代理网络设备为CPE通信端口中包含的MEP（维护终点）或MIP（维护中间点）生成连通性检查（CC）帧，环回应答帧和Linktrace应答帧。然后，OAM代理网络设备生成的这些CFM帧在来自OAM代理网络设备的消息中发送到适当的CPE。当CPE设备从包含这些CFM帧中的一个的OAM代理网络设备接收到消息时，它检查由消息指示的通信端口的可操作性。如果端口可操作，则CPE设备从消息中提取CFM帧，并通过OAM代理网络设备将其发送到核心以太网。 OAM代理网络设备进一步操作以处理从核心以太网网络接收到的连接检查帧，并通过维护MEP连接数据库寻址到CPE设备。因此，这些接收到的连通性检查帧将被丢弃，无需转发到CPE设备。

3. 发明申请

US20200297574A1 EXTERNAL COUNTERPULSATION SYSTEM 审中-公开
公开(公告)号：US20200297574A1
公开(公告)日：2020-09-24
申请号：US16884402
申请日：2020-05-27
申请人： Michael Poon
发明人： Michael Poon
IPC分类号： A61H9/00 , A61H31/00 , A61M21/00
摘要： Improved systems and methods for performing external counterpulsation (ECP) treatment are described. The system can be more compact and portable than conventional devices and, in some cases, can be incorporated into a pair of pants or a jumpsuit, such that the user can remain ambulatory during treatment. In various instances, the ECP techniques can include applying complex pulse sequences and treating conditions including cognitive disorders, diabetes, and renal disease, among others. The various techniques can also be used in emergency cardiac situations. The techniques can also be used to provide users with the benefits of exercise, without needing to experience the strain and difficulty associated with conventional cardiovascular exercise routines.

4. 发明授权

US09474500B2 Method and system for transfer of cardiac medical image data files 有权
标题翻译：转移心脏医学图像数据文件的方法和系统
公开(公告)号：US09474500B2
公开(公告)日：2016-10-25
申请号：US13146465
申请日：2010-02-05
申请人： Michael Poon , Satya P. Sharma , Arie Kaufman , Rong Zhao , Jacob Sharony
发明人： Michael Poon , Satya P. Sharma , Arie Kaufman , Rong Zhao , Jacob Sharony
IPC分类号： G06K9/00 , G06K9/36 , A61B6/00 , A61B6/03 , G06F19/00
CPC分类号： A61B6/563 , A61B6/032 , A61B6/503 , G06F19/00 , G06F19/321
摘要： A system and method is provided which allows for the transfer of an image data file such as a medical image data file. Device scan slices of an object are acquired per time point. A portion of the device scan slices of the object, e.g., live body organ, per time point which illustrate a change in the object from a previous time point is selected. At least one optical temporal image in spiral fashion per time interval is formed from the selected portion. The at least one optical temporal image is transmittable as an image data file to a location.
摘要翻译：提供了允许传送诸如医学图像数据文件的图像数据文件的系统和方法。每个时间点获取对象的设备扫描切片。选择器件的一部分扫描对象的切片，例如活体器官，每个时间点示出来自先前时间点的对象的变化。从所选择的部分形成每个时间间隔的螺旋形式的至少一个光学时间图像。所述至少一个光学时间图像可作为图像数据文件发送到位置。

5. 发明申请

US20130024213A1 METHOD AND SYSTEM FOR GUIDED, EFFICIENT TREATMENT 审中-公开
标题翻译：用于指导，有效治疗的方法和系统
公开(公告)号：US20130024213A1
公开(公告)日：2013-01-24
申请号：US13638487
申请日：2011-03-24
申请人： Michael Poon
发明人： Michael Poon
IPC分类号： G06Q50/24
CPC分类号： A61B6/566 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/0263 , A61B5/0402 , A61B5/411 , A61B5/7292 , A61B6/504 , A61B6/56 , G06F19/3418 , G16H40/20
摘要： A system and method is provided in which medical treatment of a patient is effected in a systematic and guided fashion. From a patient's symptoms and electronic medical record, a specific diagnostic test may be recommended. Upon execution of the diagnostic test, the diagnostic scan results may be forwarded to a remote location for assistance in analysis. Once analyzed, the results are transmitted to the attending medical personnel. The results, and information which led to the decision to have a diagnostic test, are also sent to a repository for use in future diagnoses and other determinations. A monitor or dashboard is used to keep track of the various steps of the procedure, to provide on the job guidance in using a diagnostic test device, and the ensure a specific efficiency and protocol are followed. A remote location of experts may also be monitoring the dashboard, as a quality control.
摘要翻译：提供了一种系统和方法，其中以系统和指导的方式实现对患者的医疗。从患者的症状和电子病历，可能会推荐一个特定的诊断测试。执行诊断测试后，可将诊断扫描结果转发到远程位置以进行分析帮助。一经分析，结果将转交给主治医务人员。导致决定进行诊断测试的结果和信息也被发送到存储库以供将来诊断和其他确定使用。监视器或仪表板用于跟踪程序的各个步骤，提供使用诊断测试设备的工作指导，并确保遵循特定的效率和协议。专家的偏远地区也可能正在监控仪表板，作为质量控制。

6. 发明申请

US20120087560A1 METHOD AND SYSTEM FOR TRANSFER OF IMAGE DATA FILES 有权
标题翻译：图像数据文件传输方法与系统
公开(公告)号：US20120087560A1
公开(公告)日：2012-04-12
申请号：US13146465
申请日：2010-02-05
申请人： Michael Poon
发明人： Michael Poon
IPC分类号： G06K9/46
CPC分类号： A61B6/563 , A61B6/032 , A61B6/503 , G06F19/00 , G06F19/321
摘要： A system and method is provided which allows for the transfer of an image data file such as a medical image data file. Device scan slices of an object are acquired per time point. A portion of the device scan slices of the object, e.g., live body organ, per time point which illustrate a change in the object from a previous time point is selected. At least one optical temporal image in spiral fashion per time interval is formed from the selected portion. The at least one optical temporal image is transmittable as an image data file to a location.
摘要翻译：提供了允许传送诸如医学图像数据文件的图像数据文件的系统和方法。每个时间点获取对象的设备扫描切片。选择器件的一部分扫描对象的切片，例如活体器官，每个时间点示出来自先前时间点的对象的变化。从所选择的部分形成每个时间间隔的螺旋形式的至少一个光学时间图像。所述至少一个光学时间图像可作为图像数据文件发送到位置。

7. 发明申请

US20070140126A1 Method and system for originating connectivity fault management (CFM) frames on non-CFM aware switches 有权
标题翻译：在非CFM感知交换机上发起连接故障管理（CFM）帧的方法和系统
公开(公告)号：US20070140126A1
公开(公告)日：2007-06-21
申请号：US11313637
申请日：2005-12-21
申请人： John Osswald , Michael Poon
发明人： John Osswald , Michael Poon
IPC分类号： H04L12/26
CPC分类号： H04L41/06 , H04L43/0811
摘要： A system for originating connectivity fault management (CFM) frames on non-CFM aware switches is disclosed. In the disclosed system, an OAM (Operations Administration and Management) proxy networking device connected to a core Ethernet network operates with one or more CPE (Customer Premises Equipment) devices to which it is communicably connected to support CFM out to the CPE devices without requiring that the CPE devices themselves implement CFM functionality. The OAM proxy networking device generates Connectivity Check (CC) frames, Loopback reply frames, and Linktrace reply frames for MEPs (Maintenance End Points) or MIPs (Maintenance Intermediate Points) contained in communication ports on the CPEs. These CFM frames generated by the OAM proxy networking device are then sent within messages from the OAM proxy networking device to the appropriate CPE. When the CPE device receives a message from the OAM proxy networking device containing one of these CFM frames, it checks the operability of a communication port indicated by the message. If the port is operable, the CPE device extracts the CFM frame from the message and originates it through the OAM proxy networking device into the core Ethernet network. The OAM proxy networking device further operates to process Connectivity Check frames received from the core Ethernet network and addressed to the CPE devices by maintaining an MEP connectivity database. As a result, these received Connectivity Check frames are dropped without forwarding to the CPE devices.
摘要翻译：公开了一种用于在非CFM感知交换机上发起连接故障管理（CFM）帧的系统。在所公开的系统中，连接到核心以太网的OAM（操作管理和管理）代理网络设备与一个或多个CPE（客户驻地设备）设备操作，其可通信地连接到其上以将CFM支持到CPE设备，而不需要 CPE设备本身实现CFM功能。 OAM代理网络设备为CPE通信端口中包含的MEP（维护终点）或MIP（维护中间点）生成连通性检查（CC）帧，环回应答帧和Linktrace应答帧。然后，OAM代理网络设备生成的这些CFM帧在来自OAM代理网络设备的消息中发送到适当的CPE。当CPE设备从包含这些CFM帧中的一个的OAM代理网络设备接收到消息时，它检查由消息指示的通信端口的可操作性。如果端口可操作，则CPE设备从消息中提取CFM帧，并通过OAM代理网络设备将其发送到核心以太网。 OAM代理网络设备进一步操作以处理从核心以太网网络接收到的连接检查帧，并通过维护MEP连接数据库寻址到CPE设备。因此，这些接收到的连通性检查帧将被丢弃，无需转发到CPE设备。

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