专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120177669A1 PHOSPHOPEPTIDES AS MELANOMA VACCINES 有权
标题翻译：磷酸盐作为微生物疫苗
公开(公告)号：US20120177669A1
公开(公告)日：2012-07-12
申请号：US13318821
申请日：2010-05-04
申请人： Suzanne L. Topalian , Florence Depontieu , Donald Hunt , Jeffrey Shabanowitz , Jie Qian , Victor Engelhard , Angela Zaring
发明人： Suzanne L. Topalian , Florence Depontieu , Donald Hunt , Jeffrey Shabanowitz , Jie Qian , Victor Engelhard , Angela Zaring
IPC分类号： A61K39/00 , A61K35/12 , C07K16/30 , A61P35/00 , A61P35/04 , A61P37/04 , C12N5/0784 , C07K7/08 , C07K14/74 , C07K14/47 , G01N33/566 , C07K7/06 , C12N5/0783
CPC分类号： C07K14/4748 , A61K39/0011 , A61K39/39 , A61K2039/5154 , A61K2039/5158 , G01N33/5743
摘要： We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were expressed exclusively by either melanomas or transformed B cells, suggesting the potential to define cell type-specific phosphatome “fingerprints”. We generated HLA-DRβ1*0101-restricted CD4+ T cells specific for a phospho-MART-1 peptide identified in two melanoma cell lines. These T cells showed specificity for phosphopeptide-pulsed antigen presenting cells as well as for intact melanoma cells. MHC II-restricted phosphopeptides recognizable by human CD4+ T cells are potential targets for cancer immunotherapy.
摘要翻译：我们使用顺序亲和分离，生物化学富集，质谱测序和比较分析鉴定了总共175个HLA-DR相关磷酸肽。许多来源于可能在癌症发展，生长和转移中起作用的源蛋白质。大多数仅由黑素瘤或转化的B细胞表达，表明定义细胞类型特异性磷酸酯“指纹”的潜力。我们产生HLA-DR和bgr。1 * 0101限制性CD4 + T细胞，特异于在两个黑素瘤细胞系中鉴定的磷酸化MART-1肽。这些T细胞对磷酸肽脉冲的抗原呈递细胞以及完整的黑素瘤细胞显示出特异性。人CD4 + T细胞可识别的MHC II限制性磷酸肽是癌症免疫治疗的潜在靶标。

2. 发明授权

US09279011B2 Phosphopeptides as melanoma vaccines 有权
标题翻译：磷酸肽作为黑素瘤疫苗
公开(公告)号：US09279011B2
公开(公告)日：2016-03-08
申请号：US13318821
申请日：2010-05-04
申请人： Suzanne L. Topalian , Florence A Depontieu , Donald F. Hunt , Jeffrey Shabanowitz , Jie Qian , Victor H. Engelhard , Angela Lee Zarling
发明人： Suzanne L. Topalian , Florence A Depontieu , Donald F. Hunt , Jeffrey Shabanowitz , Jie Qian , Victor H. Engelhard , Angela Lee Zarling
IPC分类号： A61K39/00 , A61K47/00 , C07K14/47 , G01N33/574 , C12Q1/68 , A61K39/39
CPC分类号： C07K14/4748 , A61K39/0011 , A61K39/39 , A61K2039/5154 , A61K2039/5158 , G01N33/5743
摘要： We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were expressed exclusively by either melanomas or transformed B cells, suggesting the potential to define cell type-specific phosphatome “fingerprints”. We generated HLA-DRβ1*0101-restricted CD4+ T cells specific for a phospho-MART-1 peptide identified in two melanoma cell lines. These T cells showed specificity for phosphopeptide-pulsed antigen presenting cells as well as for intact melanoma cells. MHC II-restricted phosphopeptides recognizable by human CD4+ T cells are potential targets for cancer immunotherapy.
摘要翻译：我们使用顺序亲和分离，生物化学富集，质谱测序和比较分析鉴定了总共175个HLA-DR相关磷酸肽。许多来源于可能在癌症发展，生长和转移中起作用的源蛋白质。大多数仅由黑素瘤或转化的B细胞表达，表明定义细胞类型特异性磷酸酯“指纹”的潜力。我们产生HLA-DR和bgr。1 * 0101限制性CD4 + T细胞，特异于在两个黑素瘤细胞系中鉴定的磷酸化MART-1肽。这些T细胞对磷酸肽脉冲的抗原呈递细胞以及完整的黑素瘤细胞显示出特异性。人CD4 + T细胞可识别的MHC II限制性磷酸肽是癌症免疫治疗的潜在靶标。

3. 发明申请

US20130259883A1 CLASS I MHC PHOSPHOPEPTIDES FOR CANCER IMMUNOTHERAPY AND DIAGNOSIS 审中-公开
标题翻译：第一类MHC磷酸化酶对于癌症的免疫和诊断
公开(公告)号：US20130259883A1
公开(公告)日：2013-10-03
申请号：US13699563
申请日：2011-05-24
申请人： Donald F. Hunt , Jeffrey Shabanowitz , Jennifer Cottine , Ann M. English , Andrew Norris , Victor H. Engelhard , Mark Cobbold , Kara L. Cummings , Angela Zarling , Rebecca C. Obeng , Jie Qian
发明人： Donald F. Hunt , Jeffrey Shabanowitz , Jennifer Cottine , Ann M. English , Andrew Norris , Victor H. Engelhard , Mark Cobbold , Kara L. Cummings , Angela Zarling , Rebecca C. Obeng , Jie Qian
IPC分类号： C07K7/06 , C07K16/18 , G01N33/68 , C07K7/08 , A61K39/00
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0011 , C07K7/08 , C07K14/70539 , C07K16/18 , G01N33/5743 , G01N33/57492 , G01N33/6893 , G01N2333/70539 , G01N2440/14
摘要： A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.
摘要翻译：一组磷酸化肽由黑素瘤细胞表面上的HLA A * 0101，A * 0201，A * 0301，B * 4402，B * 2705，B * 1402和B * 0702呈现。它们有可能（a）刺激对癌症的免疫应答，（b）在过继性T细胞治疗或疫苗中起到免疫治疗的作用，（c）促进外科病理样本中肿瘤边界的抗体识别，和（d）作为早期检测疾病的生物标志物。磷酸化肽也可用于其他癌症。

4. 发明申请

US20100153157A1 METHOD AND SYSTEM FOR PROVIDING NETWORK RESOURCE GROWTH MANAGEMENT 审中-公开
标题翻译：提供网络资源增长管理的方法和系统
公开(公告)号：US20100153157A1
公开(公告)日：2010-06-17
申请号：US12332887
申请日：2008-12-11
申请人： Brian T. Wade , Sambasiva R. Bhatta , Murali Krishnaswamy , Darshan Mehta , Jie Qian
发明人： Brian T. Wade , Sambasiva R. Bhatta , Murali Krishnaswamy , Darshan Mehta , Jie Qian
IPC分类号： G06Q10/00 , G06Q50/00
CPC分类号： G06Q10/0631 , H04L41/0806 , H04L41/0893 , H04L43/0876 , H04L43/16
摘要： An approach is provided for network resource growth management. Utilization of a network resource that is hierarchically associated with one or more other network resources is determined. If the utilization exceeds a first predetermined threshold, a growth notification is triggered. The growth notification specifies additional network resources required to modify the utilization of the network resource according to a second predetermined threshold.
摘要翻译：为网络资源增长管理提供了一种方法。确定与一个或多个其他网络资源分层关联的网络资源的利用。如果利用率超过第一预定阈值，则触发增长通知。增长通知指定根据第二预定阈值修改网络资源的利用所需的附加网络资源。

5. 发明申请

US20090083818A1 SEARCHING CHANNEL PATH DISPLAY OF A VIDEO NETWORK 有权
标题翻译：搜索视频网络的频道路径显示
公开(公告)号：US20090083818A1
公开(公告)日：2009-03-26
申请号：US11860995
申请日：2007-09-25
申请人： Govinda Puthalapat , Jie Qian , Tim Hunniecutt
发明人： Govinda Puthalapat , Jie Qian , Tim Hunniecutt
IPC分类号： H04N7/173
CPC分类号： H04N21/222 , H04N21/6338
摘要： A device may provide for display equipment associated with a channel path of a video network, receive selection of one of the equipment, provide for display the selected equipment, receive selection of a port of the selected equipment, and provide for display other equipment of the video network connected to the selected port.
摘要翻译：设备可以提供与视频网络的信道路径相关联的显示设备，接收设备中的一个的选择，提供显示所选择的设备，接收所选设备的端口的选择，以及提供显示所选设备的其他设备视频网络连接到所选端口。

6. 发明申请

US20090083800A1 CHANNEL PATH DISPLAY OF A VIDEO NETWORK 有权
标题翻译：视频网络的通道路径显示
公开(公告)号：US20090083800A1
公开(公告)日：2009-03-26
申请号：US11860968
申请日：2007-09-25
申请人： Govinda Puthalapat , Jie Qian , Tim Hunniecutt
发明人： Govinda Puthalapat , Jie Qian , Tim Hunniecutt
IPC分类号： H04N5/445
CPC分类号： H04L12/2852 , H04L12/2861 , H04N21/431 , H04N21/4383 , H04N21/482
摘要： A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user.
摘要翻译：设备可以接收由视频网络提供的信道的选择，确定与所选择的信道相关联的视频网络的设备，确定相关联的设备的状态信息，确定相关联的设备的端口级别细节，组合相关联的设备，状态信息和端口级细节转换成所选通道的路径，并将所选择的通道路径提供给用户。

7. 发明授权

US06895755B2 Nozzle with flow equalizer 有权
标题翻译：带流量均衡器的喷嘴
公开(公告)号：US06895755B2
公开(公告)日：2005-05-24
申请号：US10366304
申请日：2003-02-13
申请人： Erlendur Steinthorsson , Kiran Patwari , Jie Qian , Joseph S. Quadrone
发明人： Erlendur Steinthorsson , Kiran Patwari , Jie Qian , Joseph S. Quadrone
IPC分类号： F23D11/10 , F23R3/28 , F02C7/22 , F23R3/14
CPC分类号： F23D11/107 , F23R3/28
摘要： A fuel injector for a gas turbine engine has an inlet fitting, a fuel nozzle, and a housing stem with a pair of fuel conduits fluidly interconnecting the nozzle and fitting. The fuel nozzle includes an annular secondary fuel passageway directing fuel from one fuel conduit to an annular discharge orifice at a discharge end of the nozzle. The secondary fuel passageway is defined between an outer, annular fuel conduit portion and a primary adapter. The primary adapter has an outer surface with a distinct, radially-outwardly-projecting annular shoulder to restrict flow through the secondary passageway and provide substantially uniform distribution of flow through the passageway downstream of the shoulder, for improved combustion and flame stability.
摘要翻译：用于燃气涡轮发动机的燃料喷射器具有入口配件，燃料喷嘴和具有流体地互连喷嘴和配件的一对燃料管道的壳体杆。燃料喷嘴包括将燃料从一个燃料管道引导到在喷嘴的排放端处的环形排放孔的环形二次燃料通道。二次燃料通道限定在外部环形燃料导管部分和主适配器之间。主适配器具有外表面，其具有不同的径向向外突出的环形肩部，以限制流过次级通道的流动并且提供通过肩部下游的通道的流体的基本上均匀的分布，以改善燃烧和火焰稳定性。

8. 发明授权

US08929231B2 Channel path display of a video network 有权
标题翻译：视频网络的通道路径显示
公开(公告)号：US08929231B2
公开(公告)日：2015-01-06
申请号：US13185187
申请日：2011-07-18
申请人： Govinda Puthalapat , Jie Qian , Tim Hunniecutt
发明人： Govinda Puthalapat , Jie Qian , Tim Hunniecutt
IPC分类号： H04L12/24 , H04L12/28 , H04N21/431 , H04N21/438 , H04N21/482
CPC分类号： H04L12/2852 , H04L12/2861 , H04N21/431 , H04N21/4383 , H04N21/482
摘要： A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user.
摘要翻译：设备可以接收由视频网络提供的信道的选择，确定与所选择的信道相关联的视频网络的设备，确定相关联的设备的状态信息，确定相关联的设备的端口级别细节，组合相关联的设备，状态信息和端口级细节转换成所选通道的路径，并将所选择的通道路径提供给用户。

9. 发明申请

US20130210678A1 MOESIN FRAGMENTS AND USES THEREOF 有权
标题翻译： MOESIN片段及其用途
公开(公告)号：US20130210678A1
公开(公告)日：2013-08-15
申请号：US13878230
申请日：2011-10-08
申请人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68 , C07K14/705
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , C07K14/705 , C07K16/18 , G01N33/564 , G01N33/6854 , G01N2800/52
摘要： The present invention provides compositions and methods useful for detecting and monitoring autoimmune diseases.
摘要翻译：本发明提供了用于检测和监测自身免疫疾病的组合物和方法。

10. 发明申请

US20100107653A1 NOZZLE TIP ASSEMBLY WITH SECONDARY RETENTION DEVICE 有权
标题翻译：带有二次保持装置的喷嘴尖组件
公开(公告)号：US20100107653A1
公开(公告)日：2010-05-06
申请号：US12612977
申请日：2009-11-05
申请人： Stephen C. Paskevich , Bryan T. Runkle , Curtis F. Harding , Jeffrey R. Lehtinen , Jie Qian , Fady Bishara
发明人： Stephen C. Paskevich , Bryan T. Runkle , Curtis F. Harding , Jeffrey R. Lehtinen , Jie Qian , Fady Bishara
IPC分类号： F02C7/20 , B23P19/04
CPC分类号： F23R3/283 , F05B2230/80 , F23R3/286 , Y10T29/49721
摘要： A nozzle tip assembly and method characterized by the use of a retention device including at least one tab that cooperates with a ledge for coupling a nozzle shroud to a nozzle adaptor. The retention device can be used as a secondary retention feature to prevent nozzle separation and/or to enable the fuel injector to be repaired without having to replace the entire assembly. The latter advantage is of particular benefit when there is damage during assembly or when the nozzle tip assembly is being overhauled.
摘要翻译：一种喷嘴头组件和方法，其特征在于使用保持装置，所述保持装置包括与用于将喷嘴罩连接到喷嘴适配器的凸缘配合的至少一个突出部。保持装置可以用作辅助保持特征，以防止喷嘴分离和/或使燃料喷射器能够被修复而无需更换整个组件。当在组装期间或当喷嘴头组件被大修时存在损坏时，后一优点特别有益。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式