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1. 发明申请

US20080214533A1 Cyclic Iminocarbamates And Their Use 审中-公开
标题翻译：循环下列腺素和其使用
公开(公告)号：US20080214533A1
公开(公告)日：2008-09-04
申请号：US11792108
申请日：2005-11-22
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
IPC分类号： A61K31/5355 , C07D401/14 , C07D413/14 , A61K31/4439 , C07D417/14 , A61K31/497 , A61P7/00
CPC分类号： C07D413/14
摘要： The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z, and n have the meanings recited in the description, to a method for the production thereof, to pharmaceutical compositions containing such materials, and to methods for the treatment and/or prophylaxis of thromboembolic diseases using them.
摘要翻译：本发明涉及式（I）的新型环状亚氨基化物，其中R 1，R 2，R 3，A，Z和n 具有本说明书中所述的含义，其制备方法，含有这些材料的药物组合物，以及使用它们治疗和/或预防血栓栓塞性疾病的方法。

2. 发明申请

US20060287315A1 Pyrazinedicarboxamides and their use 审中-公开
标题翻译：吡嗪二甲酰胺及其用途
公开(公告)号：US20060287315A1
公开(公告)日：2006-12-21
申请号：US11299342
申请日：2005-12-08
申请人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
发明人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
IPC分类号： A61K31/5377 , A61K31/497 , C07D413/02 , C07D403/02
CPC分类号： C07D491/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译：本发明涉及新的吡啶二酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

3. 发明申请

US20100041646A1 Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants 审中-公开
标题翻译：苯二酚 - 双恶唑烷衍生物及其作为抗凝剂的用途
公开(公告)号：US20100041646A1
公开(公告)日：2010-02-18
申请号：US12084267
申请日：2006-10-20
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
IPC分类号： A61K31/422 , C07D413/14 , A61K31/5355 , A61P7/02 , C12N5/00
CPC分类号： C07D413/14
摘要： The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译：本申请涉及新的1,4-亚苯基 - 双恶唑烷衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防的药物的用途的疾病，特别是血栓栓塞性疾病。

4. 发明授权

US08691850B2 Substituted phenylaminothiazoles and use thereof 失效
标题翻译：取代的苯基氨基噻唑及其用途
公开(公告)号：US08691850B2
公开(公告)日：2014-04-08
申请号：US11661820
申请日：2005-08-30
申请人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号： A61K31/4436 , C07D417/12
CPC分类号： C07D417/12
摘要： The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译：本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。

5. 发明申请

US20080269300A1 Substituted Phenylaminothiazoles and Use Thereof 失效
标题翻译：取代的苯基氨基噻唑及其用途
公开(公告)号：US20080269300A1
公开(公告)日：2008-10-30
申请号：US11661820
申请日：2005-08-30
申请人： Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人： Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号： A61K31/4439 , C07D417/12 , A61P9/12
CPC分类号： C07D417/12
摘要： The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译：本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。

6. 发明授权

US07842517B2 Method and compositions for the detection of protein glycosylation 有权
标题翻译：用于检测蛋白质糖基化的方法和组合物
公开(公告)号：US07842517B2
公开(公告)日：2010-11-30
申请号：US11763834
申请日：2007-06-15
申请人： Linda Hseih-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
发明人： Linda Hseih-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
IPC分类号： G01N33/532 , C07H19/10 , C12Q1/48
CPC分类号： C12Q1/48 , C07H19/10 , C07K19/00 , C12N9/96 , G01N33/68 , G01N33/6803 , G01N33/6842
摘要： The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
摘要翻译：本发明提供用于快速和灵敏检测翻译后修饰的蛋白质，特别是具有翻译后糖基化的蛋白质的方法和组合物。该方法可用于检测蛋白质上的O-GlcNAc翻译后修饰，其中使用其它技术检测不到这些修饰。在一个实施方案中，该方法利用了工程化突变体的-1,4'-半乳糖基转移酶选择性将非天然酮官能团转移到O-GlcNAc糖基化蛋白质上的能力。一旦转移，酮部分用作生物素附着的通用手段，从而能够检测修饰的蛋白质。该方法允许使用传统方法快速显示处于检测极限的蛋白质。此外，优选的实施方案可用于检测某些疾病状态，例如癌症，阿尔茨海默病，神经变性，心血管疾病和糖尿病。

7. 发明申请

US20080312424A1 METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION 有权
标题翻译：用于检测蛋白质糖蛋白的方法和组合物
公开(公告)号：US20080312424A1
公开(公告)日：2008-12-18
申请号：US11763834
申请日：2007-06-15
申请人： Linda Hseih-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
发明人： Linda Hseih-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
IPC分类号： C07K14/00 , C07H17/02
CPC分类号： C12Q1/48 , C07H19/10 , C07K19/00 , C12N9/96 , G01N33/68 , G01N33/6803 , G01N33/6842
摘要： The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
摘要翻译：本发明提供用于快速和灵敏检测翻译后修饰的蛋白质，特别是具有翻译后糖基化的蛋白质的方法和组合物。该方法可用于检测蛋白质上的O-GlcNAc翻译后修饰，其中使用其它技术检测不到这些修饰。在一个实施方案中，该方法利用了β-1,4-半乳糖基转移酶的工程突变体选择性将非天然酮官能团转移到O-GlcNAc糖基化蛋白质上的能力。一旦转移，酮部分用作生物素附着的通用手段，从而能够检测修饰的蛋白质。该方法允许使用传统方法快速显示处于检测极限的蛋白质。此外，优选的实施方案可用于检测某些疾病状态，例如癌症，阿尔茨海默病，神经变性，心血管疾病和糖尿病。

8. 发明申请

US20050130235A1 Method and compositions for the detection of protein glycosylation 有权
标题翻译：用于检测蛋白质糖基化的方法和组合物
公开(公告)号：US20050130235A1
公开(公告)日：2005-06-16
申请号：US10990767
申请日：2004-11-17
申请人： Linda Hsieh-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
发明人： Linda Hsieh-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
IPC分类号： C12Q1/68 , G01N33/20 , G01N33/53 , G01N33/68
CPC分类号： C12Q1/48 , C07H19/10 , C07K19/00 , C12N9/96 , G01N33/68 , G01N33/6803 , G01N33/6842
摘要： The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
摘要翻译：本发明提供用于快速和灵敏检测翻译后修饰的蛋白质，特别是具有翻译后糖基化的蛋白质的方法和组合物。该方法可用于检测蛋白质上的O-GlcNAc翻译后修饰，其中使用其它技术检测不到这些修饰。在一个实施方案中，该方法利用了β-1,4-半乳糖基转移酶的工程突变体选择性将非天然酮官能团转移到O-GlcNAc糖基化蛋白质上的能力。一旦转移，酮部分用作生物素附着的通用手段，从而能够检测修饰的蛋白质。该方法允许使用传统方法快速显示处于检测极限的蛋白质。此外，优选的实施方案可用于检测某些疾病状态，例如癌症，阿尔茨海默病，神经变性，心血管疾病和糖尿病。

9. 发明授权

US08383425B2 Method and compositions for the detection of protein glycosylation 有权
标题翻译：用于检测蛋白质糖基化的方法和组合物
公开(公告)号：US08383425B2
公开(公告)日：2013-02-26
申请号：US12909402
申请日：2010-10-21
申请人： Linda Hsieh-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
发明人： Linda Hsieh-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
IPC分类号： G01N33/532 , G01N33/533 , G01N33/53 , C12Q1/54 , C12Q1/48
CPC分类号： C12Q1/48 , C07H19/10 , C07K19/00 , C12N9/96 , G01N33/68 , G01N33/6803 , G01N33/6842
摘要： The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
摘要翻译：本发明提供用于快速和灵敏检测翻译后修饰的蛋白质，特别是具有翻译后糖基化的蛋白质的方法和组合物。该方法可用于检测蛋白质上的O-GlcNAc翻译后修饰，其中使用其它技术检测不到这些修饰。在一个实施方案中，该方法利用了工程化突变体的-1,4'-半乳糖基转移酶选择性将非天然酮官能团转移到O-GlcNAc糖基化蛋白质上的能力。一旦转移，酮部分用作生物素附着的通用手段，从而能够检测修饰的蛋白质。该方法允许使用传统方法快速显示处于检测极限的蛋白质。此外，优选的实施方案可用于检测某些疾病状态，例如癌症，阿尔茨海默病，神经变性，心血管疾病和糖尿病。

10. 发明授权

US07332355B2 Method and compositions for the detection of protein glycosylation 有权
标题翻译：用于检测蛋白质糖基化的方法和组合物
公开(公告)号：US07332355B2
公开(公告)日：2008-02-19
申请号：US10990767
申请日：2004-11-17
申请人： Linda Hsieh-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
发明人： Linda Hsieh-Wilson , Nelly Khidekel , Hwan-Ching Tai , Sabine Arndt
IPC分类号： G01N33/532 , G01N33/53 , G01N33/573 , G01N33/533 , C07K1/13 , C12Q7/58 , C12Q1/54
CPC分类号： C12Q1/48 , C07H19/10 , C07K19/00 , C12N9/96 , G01N33/68 , G01N33/6803 , G01N33/6842
摘要： The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc post-translational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
摘要翻译：本发明提供用于快速和灵敏检测翻译后修饰的蛋白质，特别是具有翻译后糖基化的蛋白质的方法和组合物。该方法可用于检测蛋白质上的O-GlcNAc翻译后修饰，其中使用其它技术检测不到这些修饰。在一个实施方案中，该方法利用了β-1,4-半乳糖基转移酶的工程突变体选择性将非天然酮官能团转移到O-GlcNAc糖基化蛋白质上的能力。一旦转移，酮部分用作生物素附着的通用手段，从而能够检测修饰的蛋白质。该方法允许使用传统方法快速显示处于检测极限的蛋白质。此外，优选的实施方案可用于检测某些疾病状态，例如癌症，阿尔茨海默病，神经变性，心血管疾病和糖尿病。

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