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1. 发明授权

US5391483A Ligand analogs for immunoassays derived from dicarboxylic acid oxidation products 失效
标题翻译：来自二羧酸氧化产物的免疫测定的配体类似物
公开(公告)号：US5391483A
公开(公告)日：1995-02-21
申请号：US907345
申请日：1992-07-01
申请人： Susan J. Danielson , Michael R. Detty
发明人： Susan J. Danielson , Michael R. Detty
IPC分类号： C07H15/04 , C07J19/00 , C07K14/00 , G01N33/53 , G01N33/535 , C12Q1/28 , C07H15/00 , C12Q1/00 , C12Q1/26
CPC分类号： G01N33/535 , C07J19/005
摘要： What is disclosed is a ligand analog comprising a dicarboxylic acid oxidation product of a immunologically reactive mono-or a polysaccharide having vicinal diols, to which a label or a support is appended through an amide or thioester linkage.
摘要翻译：所公开的是包含具有连位二醇的免疫反应性单糖或多糖的二羧酸氧化产物的配体类似物，通过酰胺或硫酯键连接有标记或载体。

2. 发明授权

US5308749A Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use 失效
标题翻译：从含琥珀酰亚胺的聚合物制备生物活性试剂的方法，分析元件和使用方法
公开(公告)号：US5308749A
公开(公告)日：1994-05-03
申请号：US646303
申请日：1991-01-25
申请人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson , Marsha D. B. Oenick
发明人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson , Marsha D. B. Oenick
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/545 , G01N33/531 , G01N33/546
CPC分类号： G01N33/54313 , G01N33/54386 , Y10S524/90 , Y10T428/2991 , Y10T428/2998
摘要： Biologically active reagents are prepared from particles of copolymers having highly active succinimid groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through amide groups by displacement of highly active succinimid groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods such as affinity chromatography.
摘要翻译：生物活性试剂由具有高活性琥珀酰亚胺基团的共聚物颗粒制备。试剂通过将颗粒表面上的高活性琥珀酰亚胺基团置换而直接或间接地通过酰胺基团将生物活性物质例如抗体共价连接而制备。这些试剂用于分析元件，检测特异性结合配体（例如免疫物质）和免疫测定的方法以及纯化方法如亲和层析中。

3. 发明授权

US5284948A Drug hapten analogues for immunoassays 失效
标题翻译：药物半抗原类似物用于免疫测定
公开(公告)号：US5284948A
公开(公告)日：1994-02-08
申请号：US851435
申请日：1992-03-16
申请人： Ignazio S. Ponticello , Marsha D. B. Oenick , Susan J. Danielson , David A. Hilborn
发明人： Ignazio S. Ponticello , Marsha D. B. Oenick , Susan J. Danielson , David A. Hilborn
IPC分类号： G01N33/535 , C07D403/12 , G01N33/532 , G01N33/94 , C07D403/00 , C07D233/72 , C07D239/02
CPC分类号： C07D403/12 , G01N33/532 , G01N33/94 , G01N33/948
摘要： The invention is directed to new drug hapten analogues comprising:(A) an active ester group;(B) a drug hapten nucleus selected from a hydantoin nucleus or a barbiturate nucleus and(C) a linking chain linking the 3-position of the drug hapten nucleus to the active ester group.
摘要翻译：本发明涉及新的药物半抗原类似物，其包括：（A）活性酯基; （B）选自乙内酰脲核或巴比妥酸核的药物半抗原核和（C）连接药物半抗原核的3位与活性酯基的连接链。

4. 发明授权

US5601994A Immunoassay with novel labeled drug hapten analogues 失效
标题翻译：用新型标记的药物半抗原类似物免疫测定
公开(公告)号：US5601994A
公开(公告)日：1997-02-11
申请号：US235114
申请日：1994-04-28
申请人： Marsha D. B. Oenick , Ignazio S. Ponticello , Susan J. Danielson , Barbara A. Brummond , David A. Hilborn
发明人： Marsha D. B. Oenick , Ignazio S. Ponticello , Susan J. Danielson , Barbara A. Brummond , David A. Hilborn
IPC分类号： G01N33/535 , G01N33/532 , G01N33/543 , G01N33/94
CPC分类号： G01N33/532 , G01N33/54386 , G01N33/94 , G01N33/948 , Y10S436/816
摘要： The invention is directed to labeled drug hapten analogues comprising:(A) a label, of the type used in immunoassays, having an amine or sulfhydryl group;(B) a drug hapten nucleus selected from barbiturates or hydantoins and(C) a linking chain linking the 3-position of the drug hapten nucleus to the label through a carbonyl bridge.
摘要翻译：本发明涉及标记的药物半抗原类似物，包括：（A）在免疫测定中使用的具有胺或巯基的类型的标记; （B）选自巴比妥酸盐或乙内酰脲的药物半抗原核，（C）通过羰基桥连接药物半抗原核的3位与衔接标记的连接链。

5. 发明授权

US4752572A Lipid vesicles containing labeled species and their analytical uses 失效
标题翻译：含有标记物质的脂质囊泡及其分析用途
公开(公告)号：US4752572A
公开(公告)日：1988-06-21
申请号：US771548
申请日：1985-08-30
申请人： Michael W. Sundberg , David F. O'Brien , Susan J. Danielson
发明人： Michael W. Sundberg , David F. O'Brien , Susan J. Danielson
IPC分类号： G01N33/52 , G01N33/532 , G01N33/543 , G01N33/544 , G01N33/549 , G01N33/58 , G01N33/92 , G01N33/53 , G01N33/535
CPC分类号： G01N33/525 , G01N33/532 , G01N33/54386 , G01N33/544 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/808 , Y10S436/81 , Y10S436/829 , Y10T428/2984
摘要： Vesicles comprising a matrix of lipid membranes prepared from lipid materials are useful in biomedical studies and immunoassays. A labeled species is encapsulated within the vesicles and released when the vesicles are lysed with a surface active agent. The outer surface of the vesicles is essentially free of the labeled species. Immunoassays can be carried out in solution or with a dry analytical element.
摘要翻译：包含由脂质材料制备的脂质膜基质的囊泡可用于生物医学研究和免疫测定。标记的物质被包封在囊泡内并且当囊泡与表面活性剂裂解时被释放。泡囊的外表面基本上没有标记的物种。免疫测定可以在溶液中或用干的分析元件进行。

6. 发明授权

US5401633A Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use 失效
标题翻译：由含醛聚合物，试剂盒，分析元素和使用方法制备的生物活性试剂
公开(公告)号：US5401633A
公开(公告)日：1995-03-28
申请号：US955167
申请日：1992-10-01
申请人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson
发明人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson
IPC分类号： G01N33/50 , C12Q1/68 , G01N33/543 , G01N33/545 , G01N33/68 , G01N33/546
CPC分类号： C12Q1/6834 , G01N33/54313 , G01N33/54386 , G01N33/545
摘要： A biologically active reagent is prepared by reacting a biologically active substance covalently to a polymeric particle having pendant aldehyde groups. Such groups are provided by a polymerizable monomer represented by the structure: ##STR1## wherein Ar is arylene, R and R.sup.1 are independently hydrogen, halo or lower alkyl, R.sup.2 and R.sup.3 are independently alkylene of 1 to 4 carbon atoms in the chain, R.sup.4 is arylene, m is 0 or 1, and n is an integer of 1 to 4. These reagents can be used in a variety of specific binding and affinity purification methods, and in both solution assays and dry analytical elements.
摘要翻译：通过将生物活性物质共价反应到具有侧基醛基的聚合物颗粒来制备生物活性试剂。这样的基团由以下结构表示的可聚合单体提供：其中Ar是亚芳基，R和R 1独立地是氢，卤素或低级烷基，R 2和R 3独立地是链中具有1至4个碳原子的亚烷基，R 4 是亚芳基，m是0或1，n是1至4的整数。这些试剂可以用于各种特异性结合和亲和纯化方法，以及在溶液测定和干燥分析元件中。

7. 发明授权

US5397695A Attachment of compounds to polymeric particles using carbamoylonium compounds and a kit containing same 失效
标题翻译：使用氨基甲酸铵化合物将化合物与聚合物颗粒附着，以及含有它们的试剂盒
公开(公告)号：US5397695A
公开(公告)日：1995-03-14
申请号：US373304
申请日：1989-06-29
申请人： Richard C. Sutton , Susan J. Danielson , Pranab Bagchi , Patricia M. Scensny
发明人： Richard C. Sutton , Susan J. Danielson , Pranab Bagchi , Patricia M. Scensny
IPC分类号： B01D61/18 , B01D67/00 , B01D69/12 , G01N33/53 , G01N33/543 , C12Q1/70 , C12N11/08 , C07K3/00
CPC分类号： B01D67/0088 , B01D61/18 , B01D69/12 , G01N33/5302 , G01N33/54366 , Y10S435/81 , Y10S435/975
摘要： Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl groups to polymeric particles having pendant carboxyl groups on the outer surfaces. Such reactive compounds include biologically reactive species, such as enzymes, polypeptides and proteins. This attachment is carried out using carbamoylonium compounds which react with the carboxyl groups to form intermediate reactive groups which then react with the amino or sulfhydryl groups to form a covalent linkage between particle and reactive compound. A kit comprises polymeric particles having carboxyl groups on the outer surfaces, and a carbamoylonium compound.
摘要翻译：用于诊断测试，亲和层析，酶促反应和免疫测定的有用材料通过将包含反应性氨基或巯基的反应性化合物共价连接到在外表面上具有侧基羧基的聚合物颗粒来制备。这种反应性化合物包括生物反应性物质，例如酶，多肽和蛋白质。该连接使用与羧基反应形成中间反应基团的氨基甲酰胺化合物进行，然后与氨基或巯基反应形成颗粒和反应性化合物之间的共价连接。试剂盒包括在外表面上具有羧基的聚合物颗粒和氨基甲酰胺化合物。

8. 发明授权

US5298403A Labeled drug hapten analogues for immunoassays 失效
标题翻译：标记的药物半抗原类似物用于免疫测定
公开(公告)号：US5298403A
公开(公告)日：1994-03-29
申请号：US851439
申请日：1992-03-16
申请人： Susan J. Danielson , Barbara A. Brummond , Marsha D. B. Oenick , Ignazio S. Ponticello , David A. Hilborn
发明人： Susan J. Danielson , Barbara A. Brummond , Marsha D. B. Oenick , Ignazio S. Ponticello , David A. Hilborn
IPC分类号： G01N33/532 , G01N33/94 , C07D235/30 , C12N9/02 , C12N9/08 , C12Q1/00
CPC分类号： G01N33/948 , G01N33/532 , G01N33/94
摘要： The invention is directed to labeled drug hapten analogues comprising:(A) a label, of the type used in immunoassays, having an amine or sulfhydryl group;(B) a drug hapten nucleus selected from barbiturates or hydantoins and(C) a linking chain linking the 3-position of the drug hapten nucleus to the label through a carbonyl bridge.
摘要翻译：本发明涉及标记的药物半抗原类似物，包括：（A）在免疫测定中使用的具有胺或巯基的类型的标记; （B）选自巴比妥酸盐或乙内酰脲的药物半抗原核，（C）通过羰基桥连接药物半抗原核的3位与衔接标记的连接链。

9. 发明授权

US5155166A Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to carboxylated particles and a kit containing same 失效
标题翻译：使用1-（1-吡咯烷基亚苄基）吡啶鎓盐将化合物与羧甲基化的颗粒和包含其的试剂盒
公开(公告)号：US5155166A
公开(公告)日：1992-10-13
申请号：US539680
申请日：1990-06-18
申请人： Susan J. Danielson , Donald P. Specht
发明人： Susan J. Danielson , Donald P. Specht
IPC分类号： C08F8/32 , C12N11/08 , G01N33/543 , G01N33/545 , G01N33/547
CPC分类号： C12N11/08 , G01N33/54353 , G01N33/545 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl groups to polymeric particles having pendant carboxyl groups on the outer surfaces. Such reactive compounds include biologically reactive species, including enzymes, polypeptides and proteins. This attachment is carried out using specific carbamoylonium compounds, namely certain 1-(1-pyrrolidinylcarbonyl)pyridinium salts. These compounds react with the carboxyl groups on the particles to form intermediate reactive groups which then react with the amino or sulfhydryl groups to form a covalent linkage between particle and reactive compound. A kit comprises polymeric particles having carboxyl groups on the outer surfaces, and a 1-(1-pyrrolidinylcarbonyl)pyridinium salt.

10. 发明授权

US4997772A Water-insoluble particle and immunoreactive reagent, analytical elements and methods of use 失效
标题翻译：水不溶性颗粒和免疫反应试剂，分析元素和使用方法
公开(公告)号：US4997772A
公开(公告)日：1991-03-05
申请号：US098583
申请日：1987-09-18
申请人： Richard C. Sutton , Susan B. Littlehale , Susan J. Danielson
发明人： Richard C. Sutton , Susan B. Littlehale , Susan J. Danielson
IPC分类号： C08J3/215 , G01N33/543 , G01N33/569 , G01N33/58
CPC分类号： G01N33/54386 , C08J3/215 , G01N33/54313 , G01N33/56911 , G01N33/585 , Y10S525/902
摘要： A water-insoluble polymeric particle has an inner core comprising a detectable tracer material distributed in a first polymer for which the tracer material has a high affinity. This first polymer has a glass transition temperature (Tg.sub.1) less than about 100.degree. C. The particle also has an outer shell comprising a second polymer for which the tracer material has substantially less affinity relative to said first polymer. This second polymer has a glass transition temperature (Tg.sub.2) which is greater than or equal to the term [Tg.sub.1 -10.degree. C.]. It also contains groups which are either reactive with free amino or sulfhydryl groups of an immunoreactive species or which can be activated for reaction with such groups. Such a species can be covalently attached to this particle to form an immunoreactive reagent which is useful in analytical elements and various analytical methods including immunological methods, for example, agglutination assays.
摘要翻译：水不溶性聚合物颗粒具有包含分布在第一聚合物中的可检测示踪剂材料的内核，其中示踪材料具有高亲和力。该第一聚合物具有小于约100℃的玻璃化转变温度（Tg1）。该颗粒还具有包含第二聚合物的外壳，其中示踪材料相对于所述第一聚合物具有显着更小的亲和力。该第二聚合物的玻璃化转变温度（Tg2）大于或等于术语[Tg1-10℃]。它还含有与免疫反应物质的游离氨基或巯基反应的基团，或者可以与这些基团反应而被活化。这种物质可以共价连接到该颗粒上以形成免疫反应性试剂，其可用于分析元件和各种分析方法，包括免疫学方法，例如凝集测定法。

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